Fungal Species: mushroom tyrosinase

Antioxidant and Enzyme Inhibitory Potential of Streptomyces sp. G-18 Grown in Various Media

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Researchers studied bacteria called Streptomyces that were isolated from high mountains in Nepal to see if they could produce useful compounds. They grew these bacteria in four different types of growth media and tested the resulting extracts for antioxidant properties and ability to block harmful enzymes. They found that the choice of growth medium significantly affected what compounds the bacteria produced, with one medium (R2YE) being especially effective at producing compounds that could help treat diseases like Alzheimer’s and diabetes.

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Synergistic impact of arbutin and kaempferol-7-O-α-l-rhamnopyranoside from Nephelium lappaceum L. on whitening efficacy and stability of cosmetic formulations

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This research demonstrates that a natural compound from rambutan seeds works synergistically with arbutin to create more effective skin whitening products. The combination is 35 times more potent than arbutin alone at preventing melanin production in skin cells. The resulting cosmetic formulation maintains its effectiveness and stability for approximately 5.2 months, offering a safer natural alternative to conventional skin lightening agents that can cause irritation.

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Biological and Cheminformatics Studies of Newly Designed Triazole Based Derivatives as Potent Inhibitors against Mushroom Tyrosinase

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Researchers developed new chemical compounds based on triazole structures to inhibit tyrosinase, an enzyme that produces melanin in skin. One compound (9h) proved particularly effective at blocking this enzyme, working 170 times better than the standard drug kojic acid. Computer modeling showed how this compound fits into the enzyme’s active site. These findings could lead to safer and more effective treatments for skin discoloration disorders like melasma and age spots.

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