This research investigated how Lion’s Mane mushroom supplements affect mice with features of Alzheimer’s disease. The study found that while the mushroom didn’t improve memory or daily activities, it did significantly reduce anxiety-like behaviors in the mice. This is important because anxiety is a common symptom in Alzheimer’s disease that affects quality of life. Impacts on everyday life: • Lion’s Mane supplements might help reduce anxiety in Alzheimer’s patients • The mushroom appears safe for long-term consumption as a dietary supplement • Natural alternatives like Lion’s Mane could provide anxiety relief without pharmaceutical side effects • Caregivers might find this as a helpful addition to care routines • The findings support traditional uses of medicinal mushrooms for mental health