Fungal Species: magic mushrooms (psilocybin source)

Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology

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This comprehensive study analyzed three classic psychedelic drugs—LSD, psilocybin (from magic mushrooms), and DMT—across three levels: how people experience them, how they affect brain activity, and how they interact with brain receptors. Researchers found that LSD produces more intense visual experiences than psilocybin, and all three drugs significantly alter brain connectivity patterns. The study highlights the importance of standardizing research methods to better understand how these compounds might help treat depression and addiction.

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Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia

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Schizophrenia involves excessive loss of connections between brain cells in areas responsible for emotion and thinking, leading to negative symptoms and cognitive problems. Research shows that small doses of psychedelics like psilocybin can promote the growth of new brain connections and reduce inflammation. The authors suggest that microdosing psychedelics alongside standard treatments might help restore these lost connections and improve symptoms that don’t respond well to current medications.

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