Lentinus edodes (Shiitake)

Leveraging polysaccharide-derived nanocarriers to open new horizons in oral vaccine activation

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Oral vaccines are easier to administer than injections, but the stomach’s harsh environment destroys them before they work. Scientists are developing special nanocarrier particles made from natural plant materials, especially those used in traditional Chinese medicine, that protect vaccine ingredients and trigger stronger immune responses in the gut. These carriers work like protective vehicles that deliver vaccines safely to immune cells in the intestines, potentially revolutionizing how we vaccinate people worldwide.

Enokitake Mushroom and Its Active Component, Adenosine, Which Restores Testosterone Production in Impaired and Fatigued Mouse Models

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Enokitake mushrooms and their active compound adenosine can boost testosterone production in mice experiencing fatigue and aging-related decline. The study shows that consuming adenosine-rich mushrooms may help restore testicular function and provide anti-aging benefits. This finding suggests that commonly available edible mushrooms like enokitake could be a natural functional food for managing fatigue and age-related hormone decline. However, human studies are needed to confirm these effects.

Formulation of functional noodles by adding Lentinus edodes mushroom powder: Physiochemical attributes, cellular mineral uptake and improved glycemic index

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Researchers developed a healthier version of noodles by adding shiitake mushroom powder at 4% concentration. These mushroom noodles had better nutritional content with more protein and minerals like iron and calcium that the body could actually absorb. Most importantly, the mushroom noodles caused a slower, more gradual rise in blood sugar compared to regular noodles, making them potentially beneficial for people managing diabetes.

The Effect of Natural-Based Formulation (NBF) on the Response of RAW264.7 Macrophages to LPS as an In Vitro Model of Inflammation

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Researchers tested a natural mixture of five medicinal mushrooms combined with cannabidiol (CBD) on immune cells exposed to bacterial endotoxins. The formulation effectively reduced inflammatory response markers without harming the cells. These findings suggest the mixture could potentially be used to treat inflammatory conditions like asthma and arthritis, though more research is needed.

Valorization of various lignocellulosic wastes to Ganoderma lucidum (Curtis) P. Karst (Reishi Mushroom) cultivation and their FT-IR assessments

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This research demonstrates how agricultural and forestry waste materials can be effectively converted into nutritious Reishi mushrooms through sustainable cultivation practices. Oak wood substrates produced the highest mushroom yields, while various agricultural wastes showed promising results for producing medicinal mushrooms. Using specialized spectroscopy techniques, scientists confirmed that the Reishi mushroom effectively breaks down and utilizes the complex plant materials in these waste substrates. This approach offers an environmentally friendly solution to waste management while producing valuable medicinal mushrooms.

Astragalus Shiitake—A Novel Functional Food with High Polysaccharide Content and Anti-Proliferative Activity in a Colorectal Carcinoma Cell Line

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Scientists developed a new type of Shiitake mushroom by growing it on a special substrate enriched with Astragalus root. This novel mushroom contains significantly more beneficial polysaccharides than regular Shiitake. When tested against colorectal cancer cells, extracts from this mushroom showed strong cancer-fighting properties, with the ultrasound extraction method being most effective. This research suggests Astragalus Shiitake could become a powerful functional food for cancer prevention and treatment.

Modern Pro-Health Applications of Medicinal Mushrooms: Insights into the Polyporaceae Family, with a Focus on Cerrena unicolor

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This research explores how medicinal mushrooms, especially a species called Cerrena unicolor, could be used to improve human health through functional foods and dietary supplements. These mushrooms contain natural compounds that fight cancer, bacteria, viruses, and free radicals that damage our cells. Scientists have found that incorporating these mushroom extracts into foods, particularly dairy products, could create powerful health-promoting foods that help with cancer treatment, diabetes management, and wound healing.

Heat Treatment of Reishi Medicinal Mushroom (Ganoderma lingzhi) Basidiocarp Enhanced Its β-glucan Solubility, Antioxidant Capacity and Lactogenic Properties

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This study shows that heating dried Reishi mushrooms at 150°C for 20 minutes improves their health benefits. The heat treatment increases antioxidant compounds, makes the beneficial β-glucans more available, and enhances prebiotic effects that feed good gut bacteria while suppressing harmful bacteria. These findings suggest that properly heated Reishi mushroom products could be more effective as functional food ingredients without losing their medicinal properties.

Synergistic target network construction and dynamic simulation analysis based on a prospective systems pharmacology strategy

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Researchers used computer-based methods to study how Sang Huang, a traditional medicinal fungus, might help treat type 2 diabetes. They identified 17 active compounds in the fungus and found that a key component called estradiol dipropionate could improve insulin sensitivity and glucose control by activating specific protein pathways. The study suggests Sang Huang could be a promising natural treatment for diabetes, though more laboratory and animal testing is needed.

A characteristic rash caused by Shiitake mushrooms – An emerging concern?

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Eating raw or undercooked Shiitake mushrooms can cause a distinctive whip-like rash in some people called Shiitake mushroom dermatitis. This dramatic rash appears 2-5 days after consumption but is not dangerous and goes away on its own in 10-14 days. The condition is caused by a compound called Lentinan that breaks down when mushrooms are cooked at higher temperatures, so properly cooking Shiitake mushrooms prevents the reaction.

Fungal Species: Lentinus edodes (Shiitake)