Fungal Species:  Lentinula edodes

The Effect of Fungal Nutraceutical Supplementation on Postoperative Complications, Inflammatory Factors and Fecal Microbiota in Patients Undergoing Colorectal Cancer Surgery with Curative Intent: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial

Researchers tested whether a supplement made from nine different medicinal mushroom types could reduce complications after colorectal cancer surgery. While the supplement didn’t significantly reduce overall complications, it did appear to boost immune function in patients undergoing traditional surgery and favorably changed the composition of gut bacteria. The supplement was well-tolerated with no serious side effects.

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Insights into the evolution and mechanisms of response to heat stress by whole genome sequencing and comparative proteomics analysis of the domesticated edible mushroom Lepista sordida

Researchers sequenced the complete genome of Lepista sordida, a delicious edible mushroom valued for its health benefits, and studied how this mushroom responds to heat stress at the molecular level. Using advanced analysis techniques, they identified key proteins and signaling pathways that help the mushroom survive high temperatures. These findings can help farmers develop better-performing strains that are more resistant to heat, improving mushroom production.

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Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer’s Disease

Mushrooms contain special compounds that may help protect the brain from Alzheimer’s disease. Research shows that eating mushrooms regularly could reduce the risk of memory problems and cognitive decline in older adults. These compounds work by reducing brain inflammation, protecting nerve cells, and helping the brain clear out harmful proteins. While these findings are promising, more human studies are needed to confirm how effective mushrooms are as an Alzheimer’s treatment.

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The Lignicolous Fungus Hericium erinaceus (Lion’s Mane Mushroom): A Promising Natural Source of Antiradical and DPPH Inhibitory Agents

Lion’s Mane mushrooms grown on a special mixture of agricultural waste materials showed the best antioxidant properties in this study. Researchers found that combining sawdust, wheat straw, bagasse, rice bran, and corn flour created the ideal growing environment. The mushrooms produced high levels of protective compounds called phenolics and flavonoids that help fight harmful free radicals in the body. This research shows how we can turn agricultural waste into valuable medicinal mushrooms with strong health benefits.

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Edible Mushrooms as Functional Ingredients for Development of Healthier and More Sustainable Muscle Foods: A Flexitarian Approach

This comprehensive review explains how edible mushrooms can be added to meat and fish products to make them healthier and more environmentally friendly. Mushrooms are rich in protein, fiber, vitamins, and natural compounds that fight disease and prevent spoilage. By replacing part of the meat with mushrooms, food makers can create products with better nutrition, longer shelf-life, and reduced salt content, while supporting those pursuing flexitarian diets.

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Genome-wide identification and transcriptome analysis of the cytochrome P450 genes revealed its potential role in the growth of Flammulina filiformis

Scientists identified 59 cytochrome P450 genes in the golden needle mushroom (Flammulina filiformis), an economically important edible fungus. These genes appear to control the mushroom’s growth and development, particularly the elongation of the stalk. By understanding how these genes work, researchers can potentially improve mushroom cultivation and develop new varieties with better growth characteristics. This research provides valuable insights into the genetics of mushroom growth and development.

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Mycoremediation: Expunging environmental pollutants

Fungi can be used to clean up environmental pollution from industrial waste, pesticides, and heavy metals. Unlike expensive chemical treatments, fungal mycoremediation is cost-effective and environmentally friendly. Fungi produce natural enzymes that break down harmful pollutants into harmless substances, making it a promising solution for protecting soil and water contamination.

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The Effect of Mushroom Culture Filtrates on the Inhibition of Mycotoxins Produced by Aspergillus flavus and Aspergillus carbonarius

Researchers tested extracts from 42 different mushroom species to find ones that could prevent harmful toxins produced by mold from contaminating our food and animal feed. They discovered that two mushroom species—turkey tail mushroom and a species called Schizophyllum commune—produced compounds that blocked over 90% of toxin production. These mushroom compounds work by boosting the mold’s natural defense systems, essentially making it unable to produce the dangerous toxins.

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Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability

This comprehensive review explores how scientists can use modern genetic engineering tools to improve filamentous fungi (molds and mushrooms) for producing valuable products like antibiotics, enzymes, and sustainable food and materials. The authors explain that while these fungi naturally excel at breaking down plant material and producing useful compounds, they haven’t received as much attention from genetic engineers as other microorganisms. By applying techniques like CRISPR gene editing, computational modeling, and directed evolution, researchers can make fungal strains grow faster, produce higher yields, and use cheaper feedstocks, making industrial production more efficient and environmentally friendly.

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Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products

Mushrooms have been used for health for thousands of years and contain special compounds that help boost the immune system and fight cancer. Scientists have identified several key active ingredients in mushrooms like polysaccharides and proteins that can activate immune cells and reduce tumors. Some mushroom products like lentinan from shiitake mushrooms have already been approved as cancer treatments in Japan. While most evidence comes from lab studies, ongoing research suggests mushroom-based medicines could become important therapeutic options.

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