This research examined how combining three medicinal mushrooms (Reishi, Shiitake, and Maitake) could enhance immune system function. The scientists found that when used together, these mushrooms worked better at stimulating immune cells than when used individually. This synergistic effect could lead to improved immune support supplements. Impacts on everyday life: • Better understanding of how natural supplements can support immune health • More effective mushroom-based immune support products • Potential for improved natural alternatives for immune system support • Enhanced value from combining specific mushroom species • Scientific validation of traditional mushroom medicine practices