Fungal Species:  Lentinula edodes (Shiitake)

Multidisciplinary Integrative Medicine Approach for Cancer Patients: A Multicenter Retrospective Study

This study shows that when cancer patients use complementary treatments like mushroom supplements, vitamins, and probiotics alongside their cancer medications under doctor supervision, they experience fewer side effects and better quality of life. Almost 93% of patients had no side effects from these supplements, and many reported less fatigue and better overall wellness. The key finding is that patients should work with their medical team rather than self-prescribing these treatments to avoid dangerous interactions.

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Valorization of agro-forest wastes (oak acorns, vineyard pruning, and olive pruning) through the cultivation of shiitake (Lentinula edodes) mushrooms

Researchers tested growing shiitake mushrooms on locally available waste materials like oak acorns, olive pruning, and grape vine pruning instead of the traditionally used oak sawdust. The study found that mushrooms grown on oak acorns or combinations with grape pruning produced similar quantities while having better nutritional content and faster harvest times. This approach helps reduce environmental impact by using agricultural waste and offers sustainable alternatives for mushroom farmers.

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Nutritional strategies in supporting immune checkpoint inhibitor, PI3K inhibitor, and tyrosine kinase inhibitor cancer therapies

This review examines how nutrition and food-based interventions can improve cancer treatment outcomes for patients receiving targeted cancer therapies. A Mediterranean-style diet with plenty of fiber (30-50g daily) appears beneficial for patients on immune checkpoint inhibitor therapies by promoting healthy gut bacteria that support immune function. The review also discusses promising research on fermented foods, specific bacterial supplements, mushroom extracts, and fasting approaches as complementary strategies to enhance cancer treatment effectiveness while reducing side effects.

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Impact of Dehydration Techniques on the Nutritional and Microbial Profiles of Dried Mushrooms

This comprehensive review examines different methods for drying mushrooms and how each technique affects their nutritional value and safety. Freeze drying maintains the best nutritional quality but is expensive, while microwave and hot air drying are faster and more cost-effective while still reducing harmful bacteria. The study helps consumers and food producers understand which drying methods produce the highest quality dried mushrooms for cooking and health benefits.

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In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents

This research examined how Lion’s Mane mushroom extracts made with different liquids can fight infections and oxidative damage. The water-based extract was best at preventing viruses and free radical damage, while the ethyl acetate extract worked best against bacteria and fungi. The study identified 16 beneficial compounds in the mushroom and suggests it could be used as a daily supplement to protect against infections and oxidative stress.

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Medicinal Mushrooms as Multicomponent Mixtures—Demonstrated with the Example of Lentinula edodes

Shiitake mushrooms are more than just tasty food—they contain numerous compounds that work together to improve health. Unlike single isolated drugs, whole mushroom preparations offer multiple benefits including boosting immunity, protecting the heart, and potentially supporting cancer treatment. These mushrooms have been used safely in Asian medicine for over 2000 years and are becoming recognized worldwide for their health-promoting properties.

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Metabolomics Profiling of White Button, Crimini, Portabella, Lion’s Mane, Maitake, Oyster, and Shiitake Mushrooms Using Untargeted Metabolomics and Targeted Amino Acid Analysis

Researchers analyzed seven popular mushroom varieties to understand their chemical makeup. They found over 10,000 different compounds across all mushrooms, with each variety having its own unique set of chemicals. Lion’s mane and oyster mushrooms were particularly rich in L-ergothioneine, a special amino acid thought to have antioxidant and anti-aging properties. The common white button, crimini, and portabella mushrooms had similar nutrient profiles, while specialty mushrooms had distinct chemical signatures.

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Domestication Cultivation and Nutritional Analysis of Hericium coralloides

Researchers successfully grew a rare medicinal mushroom called Hericium coralloides from a wild sample found on the Tibetan Plateau. The mushroom is nutrient-rich, containing good amounts of protein and fiber while being low in fat, making it a healthy food choice. The mushroom’s compounds showed strong antioxidant properties and the ability to slow the growth of certain cancer cells, particularly breast cancer cells, suggesting potential health benefits.

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Triacetin and a Mushroom Blend Restore Butyrate Production by IBS Microbiomes Ex Vivo, Thus Promoting Barrier Integrity

Researchers tested two natural products—triacetin and a mushroom blend—to see if they could help people with IBS by improving their gut bacteria and strengthening their intestinal lining. Both products successfully increased beneficial short-chain fatty acids and improved barrier integrity, with triacetin having the added advantage of producing less uncomfortable gas. These findings suggest these products could offer a new dietary approach to managing IBS symptoms.

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Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production—A Review

Medicinal mushrooms like Reishi, Lion’s Mane, and Shiitake contain powerful compounds that may help fight cancer, boost immunity, and reduce inflammation. These mushrooms are low in calories and can be added to everyday foods like bread, pasta, and meat products to boost their nutritional value. While promising, more research is needed to confirm how much people should consume and whether they interact safely with medications.

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