Fungal Species:  Isaria sinclairii

Fungi: Pioneers of chemical creativity – Techniques and strategies to uncover fungal chemistry

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This review explores how fungi produce remarkable chemical compounds that have been transformed into important medicines for over a century. Starting with penicillin in the 1940s, scientists have discovered dozens of fungal-derived drugs used to treat infections, prevent organ rejection, lower cholesterol, and fight cancer. Modern technology now allows researchers to discover and analyze these compounds much faster and with smaller samples than ever before.

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Fungal Drug Discovery for Chronic Disease: History, New Discoveries and New Approaches

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This article examines how fungi have provided humanity with some of the most important medicines ever created, including penicillin, drugs that prevent organ rejection, and cholesterol-lowering statins. Many of these fungal compounds work as medicines because they target processes that are similar in both fungi and humans, helping them survive competition with other fungi while coincidentally treating human diseases. New researchers are now using modern genetic tools to discover additional fungal medicines, with several promising candidates currently being tested in clinical trials for cancer, depression, and other chronic diseases.

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Emerging paradigms for target discovery of traditional medicines: A genome-wide pan-GPCR perspective

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Traditional medicines from plants, animals, and fungi contain chemical compounds that can interact with specific proteins in our cells called G protein-coupled receptors (GPCRs). These receptors control many important body functions and are targeted by about one-third of all FDA-approved medications. This review explains how scientists are discovering new therapeutic compounds from traditional medicines by systematically screening them against the complete library of human GPCRs, using advanced techniques to identify which compounds bind to which receptors. Famous examples include morphine from poppies for pain relief and compounds from ginseng that help regulate blood sugar.

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Isaria tenuipes Peck, an Entomopathogenic Fungus from Darjeeling Himalaya: Evaluation of In-vitro Antiproliferative and Antioxidant Potential of its Mycelium Extract

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This research examined the medicinal properties of Isaria tenuipes, a fungus found in the Darjeeling Himalaya region. The study found that extracts from this fungus have strong antioxidant properties and can kill cancer cells. This has important implications for everyday life: • Could lead to new natural antioxidant supplements to help prevent oxidative stress-related diseases • May contribute to development of new cancer treatments with fewer side effects than current options • Demonstrates the value of preserving biodiversity in the Himalayan region as a source of medicinal compounds • Shows potential for sustainable production of natural medicines through fungal cultivation • Validates traditional Asian medicine practices that have used this fungus as a health supplement

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