This research review examines natural compounds from plants, fungi, and marine organisms that could help fight HIV infection. These natural substances work by blocking different steps of how HIV infects and reproduces in human cells. The study is important because current HIV treatments can have serious side effects and may become less effective over time as the virus develops resistance. Impacts on everyday life: • Could lead to development of new HIV medications with fewer side effects • May provide more affordable treatment options, especially in developing countries • Demonstrates the importance of preserving biodiversity as a source of new medicines • Shows potential for natural dietary supplements to support HIV treatment • Could help reduce stigma by providing more manageable treatment options