Hericium erinaceus (Lion’s Mane)

Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder

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This review examines how edible mushrooms, particularly Lion’s mane, Reishi, and Caterpillar mushroom, might help treat depression as part of a dietary approach. These mushrooms contain compounds that may influence brain chemistry, especially serotonin levels, which are important for mood regulation. While early studies show promising results, especially for Lion’s mane, more research is needed to confirm these benefits in larger groups of patients.

Fungal Bioactive Compounds as Emerging Therapeutic Options for Age-Related Neurodegenerative Disorders

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Mushrooms contain special compounds that may help protect our brains as we age. These fungal compounds fight inflammation, reduce harmful free radicals, and help clear out damaged cellular parts—all things that slow down brain aging and diseases like Alzheimer’s and Parkinson’s. While the research looks very promising in lab and animal studies, scientists still need to figure out how to make these compounds work better in the human body and prove they’re safe and effective in patients.

In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents

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This research examined how Lion’s Mane mushroom extracts made with different liquids can fight infections and oxidative damage. The water-based extract was best at preventing viruses and free radical damage, while the ethyl acetate extract worked best against bacteria and fungi. The study identified 16 beneficial compounds in the mushroom and suggests it could be used as a daily supplement to protect against infections and oxidative stress.

Metabolomics Profiling of White Button, Crimini, Portabella, Lion’s Mane, Maitake, Oyster, and Shiitake Mushrooms Using Untargeted Metabolomics and Targeted Amino Acid Analysis

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Researchers analyzed seven popular mushroom varieties to understand their chemical makeup. They found over 10,000 different compounds across all mushrooms, with each variety having its own unique set of chemicals. Lion’s mane and oyster mushrooms were particularly rich in L-ergothioneine, a special amino acid thought to have antioxidant and anti-aging properties. The common white button, crimini, and portabella mushrooms had similar nutrient profiles, while specialty mushrooms had distinct chemical signatures.

Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls

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This study followed nearly 1000 people who microdose psilocybin (small regular doses of psilocybin mushrooms) and compared them to 180 people who don’t microdose over one month. Microdosers showed greater improvements in mood, depression, anxiety, and stress compared to the control group. Interestingly, when older adults combined psilocybin with lion’s mane mushrooms and niacin, they showed better improvements in motor control and speed. The effects were fairly consistent across different ages and genders, suggesting psilocybin microdosing may have real benefits for mental health.

Triacetin and a Mushroom Blend Restore Butyrate Production by IBS Microbiomes Ex Vivo, Thus Promoting Barrier Integrity

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Researchers tested two natural products—triacetin and a mushroom blend—to see if they could help people with IBS by improving their gut bacteria and strengthening their intestinal lining. Both products successfully increased beneficial short-chain fatty acids and improved barrier integrity, with triacetin having the added advantage of producing less uncomfortable gas. These findings suggest these products could offer a new dietary approach to managing IBS symptoms.

Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production—A Review

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Medicinal mushrooms like Reishi, Lion’s Mane, and Shiitake contain powerful compounds that may help fight cancer, boost immunity, and reduce inflammation. These mushrooms are low in calories and can be added to everyday foods like bread, pasta, and meat products to boost their nutritional value. While promising, more research is needed to confirm how much people should consume and whether they interact safely with medications.

The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study

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This study examined whether Lion’s mane mushroom supplements could improve thinking speed and reduce stress in healthy young adults. Researchers found that a single dose improved how quickly people completed a mental challenge, and four weeks of daily supplements showed a trend toward reducing subjective stress. However, the study was small and found mixed results, including some negative effects on memory tasks, so more research with larger groups is needed to confirm these findings.

Recent advances and role of melatonin in post-harvest quality preservation of shiitake (Lentinula edodes)

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Shiitake mushrooms are nutritious but spoil quickly after harvest due to their high water content and lack of protective skin. This review explores how melatonin and various preservation methods like proper cooling, special packaging, and drying can extend shelf life and maintain quality. Different techniques work by controlling moisture, slowing respiration, preventing browning, and controlling microbial growth. Combining multiple methods, such as vacuum cooling with special packaging, provides the best results for preserving the mushrooms’ taste, nutrition, and appearance.

Assessment of Cosmetic Properties and Safety of Use of Model Washing Gels with Reishi, Maitake and Lion’s Mane Extracts

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Researchers tested three medicinal mushrooms (Maitake, Lion’s Mane, and Reishi) as ingredients in washing gels to improve their safety and effectiveness. The study found that these mushroom extracts reduced skin irritation, improved skin moisturization, and boosted antioxidant protection better than gels without them. Maitake extract performed particularly well, showing the strongest antioxidant properties. These findings suggest mushroom extracts could be valuable natural alternatives in everyday skincare products.

Fungal Species: Hericium erinaceus (Lion's Mane)