Fungal Species:  Haemonchus contortus

An Appraisal of Natural Products Active Against Parasitic Nematodes of Animals

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This review examined natural compounds that could potentially be developed into new drugs to treat parasitic worm infections in humans and animals. The researchers found relatively few promising new compounds, with most studies focusing on plant sources despite bacteria historically providing better drug candidates. The findings have important implications for addressing growing drug resistance in parasitic worm treatments. Key impacts on everyday life: • Growing resistance to existing dewormers threatens both human health and livestock production • New drug development is crucial to maintain effective treatment options for parasitic infections • Natural compounds remain an important source of potential new medicines • Better research infrastructure could accelerate discovery of new treatments • Sustainable sourcing of natural compounds affects medicine availability and cost

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Metabolites from Nematophagous Fungi and Nematicidal Natural Products from Fungi as Alternatives for Biological Control. Part II: Metabolites from Nematophagous Basidiomycetes and Non-nematophagous Fungi

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This research examines natural compounds produced by fungi that could help control harmful nematode worms that damage crops and affect livestock. These fungal compounds offer potential environmentally-friendly alternatives to chemical pesticides. Impacts on everyday life: – Could lead to safer, natural methods for protecting food crops from nematode damage – May provide new treatments for controlling parasitic worms in livestock – Offers more environmentally sustainable alternatives to synthetic chemical pesticides – Could help reduce crop losses and improve food security – May lower pesticide residues in food products

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The Possible Biotechnological Use of Edible Mushroom Bioproducts for Controlling Plant and Animal Parasitic Nematodes

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This research explores how edible mushrooms could provide a natural and environmentally-friendly way to control harmful parasitic worms that damage crops and livestock. The study found that certain mushrooms produce compounds that can paralyze or kill these parasitic worms, offering a potential alternative to chemical pesticides and medications. Impacts on everyday life: – Could lead to safer and more sustainable food production methods – May reduce chemical residues in food and environment – Could help farmers protect crops and livestock more naturally – Might lower food production costs by reducing pest damage – Shows potential for recycling mushroom growing waste into useful products

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Low-Molecular-Weight Secondary Metabolites from Fungi: Cerrena unicolor as a New Proposal of an Effective Preparation Against Rhabditis Nematodes

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This research explores how compounds extracted from the fungus Cerrena unicolor could potentially be used to combat parasitic worm infections. The study found that certain molecules produced by this fungus effectively killed or paralyzed harmful nematodes in laboratory tests, performing better than some existing medications. This discovery could lead to new and safer treatments for parasitic infections. Impacts on everyday life: • Could provide new treatment options for the 1.5 billion people affected by parasitic worm infections • May help reduce reliance on chemical pesticides in agriculture and livestock farming • Could lead to development of more environmentally friendly anti-parasitic treatments • May help address growing drug resistance issues in current parasite treatments • Could provide economic benefits by reducing livestock losses to parasitic infections

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