Fungal Species:  Grifola frondosa

The Effect of Fungal Nutraceutical Supplementation on Postoperative Complications, Inflammatory Factors and Fecal Microbiota in Patients Undergoing Colorectal Cancer Surgery with Curative Intent: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial

Researchers tested whether a supplement made from nine different medicinal mushroom types could reduce complications after colorectal cancer surgery. While the supplement didn’t significantly reduce overall complications, it did appear to boost immune function in patients undergoing traditional surgery and favorably changed the composition of gut bacteria. The supplement was well-tolerated with no serious side effects.

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Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer’s Disease

Mushrooms contain special compounds that may help protect the brain from Alzheimer’s disease. Research shows that eating mushrooms regularly could reduce the risk of memory problems and cognitive decline in older adults. These compounds work by reducing brain inflammation, protecting nerve cells, and helping the brain clear out harmful proteins. While these findings are promising, more human studies are needed to confirm how effective mushrooms are as an Alzheimer’s treatment.

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Edible Mushrooms as Functional Ingredients for Development of Healthier and More Sustainable Muscle Foods: A Flexitarian Approach

This comprehensive review explains how edible mushrooms can be added to meat and fish products to make them healthier and more environmentally friendly. Mushrooms are rich in protein, fiber, vitamins, and natural compounds that fight disease and prevent spoilage. By replacing part of the meat with mushrooms, food makers can create products with better nutrition, longer shelf-life, and reduced salt content, while supporting those pursuing flexitarian diets.

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The Effect of Mushroom Culture Filtrates on the Inhibition of Mycotoxins Produced by Aspergillus flavus and Aspergillus carbonarius

Researchers tested extracts from 42 different mushroom species to find ones that could prevent harmful toxins produced by mold from contaminating our food and animal feed. They discovered that two mushroom species—turkey tail mushroom and a species called Schizophyllum commune—produced compounds that blocked over 90% of toxin production. These mushroom compounds work by boosting the mold’s natural defense systems, essentially making it unable to produce the dangerous toxins.

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The Nearly Complete Genome of Grifola frondosa and Light-Induced Genes Screened Based on Transcriptomics Promote the Production of Triterpenoid Compounds

Researchers sequenced the complete genetic code of maitake mushroom (Grifola frondosa) and discovered how light exposure influences the production of beneficial compounds called triterpenoids. The high-quality genome assembly revealed 12,526 genes and showed that light triggers specific genes involved in making these medicinal compounds. This breakthrough provides a scientific foundation for growing maitake mushrooms with optimized levels of health-promoting substances.

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Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products

Mushrooms have been used for health for thousands of years and contain special compounds that help boost the immune system and fight cancer. Scientists have identified several key active ingredients in mushrooms like polysaccharides and proteins that can activate immune cells and reduce tumors. Some mushroom products like lentinan from shiitake mushrooms have already been approved as cancer treatments in Japan. While most evidence comes from lab studies, ongoing research suggests mushroom-based medicines could become important therapeutic options.

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Current Uses of Mushrooms in Cancer Treatment and Their Anticancer Mechanisms

This comprehensive review examines how medicinal mushrooms can help treat cancer. Certain mushroom species and their compounds, particularly polysaccharides, can boost the immune system to fight cancer cells, reduce chemotherapy side effects, and overcome drug resistance. Multiple mushrooms are currently in clinical trials showing promise in improving cancer patient outcomes when used alongside conventional treatments.

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Mushroom-Based Supplements in Italy: Let’s Open Pandora’s Box

Researchers tested 19 mushroom supplement products sold in Italy and found serious quality problems. Many supplements didn’t actually contain the mushroom species listed on their labels. Some products also contained toxic substances or inconsistent amounts of beneficial compounds. The study highlights the need for better regulation and manufacturing standards to ensure these popular health products are safe and effective.

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From Nature to Design: Tailoring Pure Mycelial Materials for the Needs of Tomorrow

Scientists are developing new materials made from mushroom mycelium that could replace leather, foam, and plastic products. These fungal-based materials grow on simple agricultural waste, are completely biodegradable, and have a much smaller environmental footprint than traditional materials. Companies like MycoWorks are already producing mycelium leather for major fashion brands, showing this technology is moving from laboratories into real products.

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Immune regulatory functions of biologically active proteins from edible fungi

This research compared how proteins from 22 different edible mushrooms affect immune system cells called macrophages. The study found that all the mushroom proteins tested boosted immune function by making macrophages more active and productive. Interestingly, expensive rare mushrooms like cordyceps and ganoderma lucidum had stronger immune-boosting effects than common grocery store mushrooms like oyster and button mushrooms.

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