This research demonstrates how a medicinal mushroom called Ganoderma tsugae can be grown on rice to produce compounds that protect the liver from damage. The scientists developed an efficient method to grow the mushroom and extract beneficial substances that help reduce liver inflammation and oxidative stress. Impacts on everyday life: • Provides a potential natural supplement option for supporting liver health • Demonstrates a sustainable way to produce medicinal compounds from mushrooms • Offers new insights into preventing and treating liver diseases using natural products • Could lead to development of functional foods with liver-protective properties • Shows promise for more efficient production of traditional Asian medicines