Ganoderma lucidum – Page 5

Extraction Optimization and Bioactivity of Polysaccharides from Ganoderma leucocontextum Spores

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Researchers developed an improved method to extract beneficial polysaccharides from Ganoderma leucocontextum (white Ganoderma), a rare mushroom from the Tibetan plateau. The extracted compound GLSP-A1 showed strong anti-inflammatory effects by reducing inflammatory markers and reduced signs of aging in test organisms by decreasing harmful reactive oxygen species and cellular aging pigments. This work suggests the mushroom polysaccharide could potentially be used in dietary supplements to help slow aging.

Mechanism Underlying Ganoderma lucidum Polysaccharide Biosynthesis Regulation by the β-1,3-Glucosyltransferase Gene gl20535

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Researchers studied a gene called gl20535 in the medicinal mushroom Ganoderma lucidum that controls how the fungus makes beneficial polysaccharides. When they increased this gene’s activity, the mushroom produced significantly more polysaccharides with improved composition. The gene works by controlling sugar pathways and related enzyme production, and the mushroom compensates when this gene is reduced. These findings could help improve the production of medicinal mushroom products for food and health applications.

Benzothiazole—An Antifungal Compound Derived from Medicinal Mushroom Ganoderma lucidum against Mango Anthracnose Pathogen Colletotrichum gloeosporioides

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Scientists discovered that a chemical called benzothiazole found in the medicinal mushroom Ganoderma lucidum can effectively kill the fungus that causes mango anthracnose, a major disease affecting mango crops. The research showed that this natural compound completely stops fungal growth at very low concentrations (50 ppm) and prevents spore germination. This discovery offers a promising eco-friendly alternative to synthetic fungicides that can cause environmental pollution and drug resistance.

Hypoglycemic Properties of Leccinum scabrum Extracts—An In Vitro Study on α-Glucosidase and α-Amylase Inhibition and Metabolic Profile Determination

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Researchers tested birch bolete mushrooms (Leccinum scabrum) for diabetes-fighting properties. They found that extracts from this edible mushroom were exceptionally effective at blocking enzymes that break down carbohydrates, potentially helping control blood sugar levels. The study identified key beneficial compounds including healthy fats and plant alkaloids, suggesting the mushroom could become a functional food or dietary supplement for managing type-2 diabetes.

The impact of continuous cultivation of Ganoderma lucidum on soil nutrients, enzyme activity, and fruiting body metabolites

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This study examined how growing Ganoderma lucidum (a medicinal mushroom) on the same land for two consecutive years affects the soil and the mushroom’s beneficial compounds. Researchers found that continuous cultivation depleted soil nutrients and reduced enzyme activity, particularly in the top layer of soil. The mushrooms grown in the first year had more beneficial compounds than those grown in the second year, with differences linked to changes in soil quality and microbial activity.

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

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This review examines how natural products from plants, fungi, and marine organisms can help treat liver cancer more safely and effectively than current drugs. These natural compounds work through multiple pathways such as triggering cancer cell death, stopping cell growth, and boosting the immune system. The research found that seven categories of natural products show promise, with sources ranging from ginseng and turmeric to mushrooms and seaweed, offering potential new treatment options that could reduce side effects and drug resistance.

Harnessing mushrooms for poultry nutrition: Boosting health, immunity, and productivity

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Mushrooms and mushroom stems are emerging as natural feed additives that can significantly improve poultry health, growth, and egg/meat quality while reducing the need for antibiotics. These fungi contain beneficial compounds that boost immune function, reduce harmful bacteria, and protect against cellular damage. By using mushroom byproducts that are typically discarded, farmers can create more sustainable and environmentally friendly poultry production systems while improving overall bird health and productivity.

Changes of Active Substances in Ganoderma lucidum during Different Growth Periods and Analysis of Their Molecular Mechanism

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Scientists studied how the medicinal mushroom Ganoderma lucidum changes as it grows, discovering that different growth stages contain different beneficial compounds. The budding stage was found to have the highest levels of powerful healing compounds called triterpenoids and steroids. This research helps identify the best time to harvest the mushroom to get maximum health benefits, improving both quality and standardized production for medicinal use.

Synergy of de-walled Ganoderma Lucidum spore powder (GLSP) on targeted therapy in advanced non-squamous non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutant: protocol for a randomized, double-blind, placebo-controlled study

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This study tests whether Ganoderma lucidum spore powder, a traditional Chinese medicine supplement, can help reduce fatigue in lung cancer patients taking the drug Osimertinib. Fatigue is a major side effect that affects most patients on this medication. The 140-patient trial compares patients receiving the supplement plus Osimertinib with those receiving a placebo plus Osimertinib, measuring fatigue levels and quality of life over 8 weeks.

The potential of fungi in the bioremediation of pharmaceutically active compounds: a comprehensive review

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Pharmaceutical drugs that we take end up in our water systems because our bodies don’t fully process them. Fungi, especially types of mushrooms, have powerful enzymes that can break down these drug residues and clean contaminated water. Scientists are studying how to use these fungi in treatment systems to remove medications from hospital wastewater and drinking water sources.

Fungal Species: Ganoderma lucidum