Ganoderma lucidum – Page 15

Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation

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Researchers found that sporoderm-removed Ganoderma lucidum spore powder (S-GLSP) protects against Alzheimer’s disease by reducing brain inflammation. The supplement works by shifting immune cells in the brain called microglia from a harmful pro-inflammatory state to a protective anti-inflammatory state. This is accomplished by blocking the NLRP3 inflammasome, a key trigger of brain inflammation. In animal and cell studies, S-GLSP improved memory, reduced neuronal damage, and decreased harmful tau protein accumulation.

Chemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga (Inonotus obliquus) Growing on Betula pendula and Betula pubescens

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This study examined chaga mushroom, a traditional medicine used against cancer, grown on two types of birch trees. Researchers tested chaga extracts on 31 different cancer cell types and found they were moderately effective at inhibiting cancer cell growth, particularly against liver and thyroid cancers. The chaga from silver birch (B. pendula) worked slightly better than that from downy birch (B. pubescens) due to higher levels of a compound called inotodiol.

Tailoring the Mechanical Properties of Fungal Mycelium Mats with Material Extrusion Additive Manufacturing of PHBH and PLA Biopolymers

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Researchers have developed a novel method to make mushroom-based materials stronger by coating them with biodegradable plastics using 3D printing technology. This approach combines fungal mycelium from Fomes fomentarius with eco-friendly polymers to create composites that are significantly stronger than plain mycelium while remaining fully compostable. The resulting materials could be used for flexible devices, interior design, and other applications where both strength and environmental sustainability are important.

Genetic regulation of l-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis

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Researchers studied how magic mushrooms (Psilocybe mexicana) regulate their chemistry to produce psilocybin, the psychoactive compound. They found that when mushrooms start fruiting, they turn on genes that make tryptophan (an amino acid building block) and turn off genes that break it down, directing all the tryptophan toward psilocybin production. This coordinated genetic control ensures the mushroom has enough of this key ingredient. This knowledge could help grow these mushrooms in labs for legitimate medical research into treating depression.

PRMT5 promotes cellulase production by regulating the expression of cellulase gene eg2 through histone methylation in Ganoderma lucidum

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Scientists discovered that a protein called PRMT5 helps mushrooms (Ganoderma lucidum) produce more cellulase enzymes, which break down plant materials like corn straw and corn cobs. By controlling a specific gene called eg2 through a chemical modification on histone proteins, PRMT5 increases enzyme production. This discovery could help industries produce cellulase more efficiently and sustainably convert agricultural waste into useful sugars for biofuels and other products.

GlSlt2 positively regulates GlMyb-mediated cellulose utilization in Ganoderma lucidum

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Scientists discovered how a medicinal mushroom called Ganoderma lucidum breaks down cellulose from plant waste. The study found that a protein called GlSlt2 activates another protein called GlMyb, which then turns on genes that produce cellulase enzymes. These enzymes break down cellulose into sugar that the fungus can use for growth. This discovery could help improve the conversion of agricultural waste into biofuels and other useful products.

Edible Fungi Melanin: Recent Advances in Extraction, Characterization, Biological Activity and Applications

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Melanin from edible mushrooms like black wood ear and reishi offers a natural, sustainable alternative to synthetic melanins with impressive health benefits. These mushroom melanins demonstrate powerful antioxidant and antibacterial properties, protect against radiation damage, and can help maintain liver health. New extraction methods using special solvents are making it easier to obtain pure melanin from mushrooms efficiently, opening doors for its use in food, cosmetics, and medicines.

Anticancer Activity of Solvent Extracts of Hexogonia glabra against Cervical Cancer Cell Lines

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Researchers tested extracts from a wild mushroom species called Hexogonia glabra against cervical cancer cells in the laboratory. The ethanolic extract was most effective, killing cancer cells by triggering apoptosis (programmed cell death) and activating genes that fight cancer. The mushroom extracts showed strong anticancer effects without harming normal cells, suggesting it could be a promising source for developing new cancer drugs.

Tailoring the Mechanical Properties of Fungal Mycelium Mats with Material Extrusion Additive Manufacturing of PHBH and PLA Biopolymers

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Researchers developed a new way to make fungal mushroom mats stronger by printing biodegradable plastic patterns onto them using 3D printing technology. The resulting composite materials combined the sustainability of fungal products with improved strength, making them suitable for flexible applications like smart textiles and lightweight parts. Both tested polymers (PHBH and PLA) enhanced the mycelium’s mechanical properties, with PLA showing superior strength improvements while PHBH offered home compostability.

Towards engineering agaricomycete fungi for terpenoid production

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Mushroom-forming fungi, particularly species like shiitake and oyster mushrooms, naturally produce valuable compounds called terpenoids used in medicines, food, and cosmetics. Scientists are learning to genetically engineer these fungi to produce even larger amounts of these beneficial compounds, potentially making them as important to biotechnology as baker’s yeast and mold have been historically. This could create new sustainable sources for medicinal compounds and industrial chemicals.

Fungal Species: Ganoderma lucidum