This research explores how a specially adapted mushroom species can help clean up toxic selenium pollution from the environment. Scientists developed a more resilient version of the medicinal mushroom Ganoderma lucidum that can tolerate and accumulate high levels of selenium without being harmed. The study reveals the biological mechanisms that allow this fungus to safely process selenium, which could lead to better methods for cleaning contaminated soil and water. Key impacts on everyday life: • Provides a natural solution for cleaning up toxic selenium pollution from soil and water • Demonstrates how beneficial fungi can be adapted to solve environmental problems • Offers potential for developing safer and more cost-effective environmental cleanup methods • Could help prevent selenium contamination from entering the food chain • Advances our understanding of how organisms can adapt to handle toxic substances