Ganoderma atrum – mycolab.ai

Structural Elucidation, Modification, and Structure-Activity Relationship of Polysaccharides in Chinese Herbs: A Review

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This comprehensive review explains how the structure of plant polysaccharides from Chinese herbs determines their healing properties. The authors discuss various laboratory methods to identify polysaccharide structures and explain how chemical modifications can enhance their beneficial effects like boosting immunity and fighting tumors. The review provides guidance for researchers developing new polysaccharide-based medicines and shows that finding the right molecular size and chemical composition is key to maximizing therapeutic benefits.

Amylase-assisted extraction alters nutritional and physicochemical properties of polysaccharides and saponins isolated from Ganoderma spp

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Researchers studied how enzyme treatment improves extraction of beneficial compounds from reishi mushrooms. They found that using amylase enzyme significantly increased the amounts of healthy polysaccharides and saponins recovered, especially from cultivated black reishi canopies. These extracted compounds work as natural emulsifiers comparable to lecithin and remain stable even at very high temperatures, making them promising ingredients for functional foods and health products.

Neuroprotective Effects of Mushroom Biomass Digestive Fractions and Gut Microbiota Metabolites in Microglial and Caenorhabditis elegans Models of Neurodegeneration

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This study tested whether common and medicinal mushrooms could protect against Alzheimer’s disease by reducing harmful reactive oxygen species in brain cells. Researchers tested three mushroom types using digestive simulation to see what the body could absorb, plus key compounds made by gut bacteria. The mushroom extracts and certain bacterial metabolites successfully reduced cellular damage markers and improved behavior in disease-model worms, suggesting mushroom-rich diets may help prevent neurodegeneration.

Polysaccharides from fungi: A review on their extraction, purification, structural features, and biological activities

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Mushrooms contain special compounds called polysaccharides that have powerful health benefits. Scientists have found these polysaccharides can help fight cancer, boost immunity, reduce inflammation, and manage diabetes. This review explains different ways to extract and purify these beneficial compounds from mushrooms and describes how they work in the body to provide these health benefits.

Recent Advances in the Use of Ganoderma lucidum and Coriolus versicolor Mushrooms to Enhance the Anticancer Efficacy of EGFR-Targeted Drugs in Lung Cancer

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This review explores how two medicinal mushrooms traditionally used in Asian medicine—Lingzhi and Yunzhi—can enhance the effectiveness of lung cancer drugs (EGFR-TKIs) and help overcome drug resistance. These mushrooms contain special compounds that can fight cancer in multiple ways, boost the immune system, and reduce side effects. The research suggests that combining these mushrooms with standard cancer treatments may improve outcomes for lung cancer patients.

rFIP-GMI Suppresses IGF-1–Induced Invasion and Migration in Breast Cancer Cells via PI3K/Akt/β-Catenin Inhibition

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Researchers found that a protein from a medicinal mushroom called Ganoderma microsporum can fight aggressive breast cancer by blocking a cellular pathway that helps cancer cells spread. The protein works by stopping the activation of key molecules (PI3K and Akt) that cancer cells use to invade surrounding tissues and migrate to other parts of the body. By blocking this pathway, the mushroom protein also prevents another molecule called β-catenin from entering the cell nucleus, where it would trigger genes that promote cancer growth and spread.

Polysaccharide prediction in Ganoderma lucidum fruiting body by hyperspectral imaging

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Researchers developed a quick, damage-free method to measure the health-promoting polysaccharide content in Ganoderma lucidum mushrooms using special imaging technology that analyzes light reflection. This technology combines visible and near-infrared light imaging with computer learning to predict polysaccharide levels across the entire mushroom cap. The method achieved 92.4% accuracy and could help mushroom farmers determine the best time to harvest for maximum nutritional value.

Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review

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Ganoderma, a medicinal fungus used in traditional medicine for over 2000 years, contains many beneficial compounds including triterpenes and polysaccharides. Scientific research has confirmed its effectiveness in treating various conditions including cancer, diabetes, infections, and inflammation. The fungus works by boosting the immune system, reducing oxidative stress, and directly inhibiting disease-causing organisms. Modern cultivation methods have made Ganoderma products widely available as supplements and medicines worldwide.

Natural Neuroinflammatory Modulators: Therapeutic Potential of Fungi-Derived Compounds in Selected Neurodegenerative Diseases

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This comprehensive review explores how compounds found in mushrooms could help treat serious brain diseases like Alzheimer’s and Parkinson’s disease. Mushrooms contain natural substances such as certain carbohydrates, proteins, and fats that can reduce harmful inflammation in the brain and protect nerve cells from damage. Scientists have tested these mushroom-derived compounds in laboratory and animal models, finding they can improve memory, movement, and overall brain function. This research suggests mushrooms could become an important part of new treatments for these currently incurable neurological conditions.

Applied Modern Biotechnology for Cultivation of Ganoderma and Development of Their Products

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This research reviews modern methods for growing and processing Ganoderma (Lingzhi) mushrooms, which have been used in traditional Asian medicine for thousands of years. Scientists have developed advanced techniques to cultivate these mushrooms and extract their beneficial compounds for use in supplements and medicines. The research shows how modern biotechnology can help produce these valuable mushrooms more efficiently while maintaining their therapeutic properties. Impacts on everyday life: • Provides access to standardized, high-quality Ganoderma supplements and medicines • Enables sustainable production of medicinal mushrooms without depleting wild resources • Offers natural alternatives for immune system support and various health conditions • Creates environmentally friendly ways to recycle agricultural waste through mushroom cultivation • Makes traditional Asian medicine more accessible to global consumers through modern production methods

Fungal Species: Ganoderma atrum