This research examined 30 samples of medicinal mushrooms from the Phellinus genus collected across Europe, including Poland, Italy, Portugal, Kosovo, and North Macedonia. Scientists found that three species—Phellinus igniarius, Fomitiporia robusta, and Porodaedalea pini—are particularly rich in beneficial compounds, especially polysaccharides and antioxidants. These mushroom extracts showed impressive abilities to fight antibiotic-resistant bacteria and protect cells from oxidative damage, suggesting they could become valuable sources for new medicines and functional foods.