This research examined wild mushrooms used as food by tribes in Northeast India to determine if they could fight harmful bacteria. The study found these mushrooms contain natural compounds that effectively kill or inhibit the growth of disease-causing bacteria, including some that are resistant to conventional antibiotics. The researchers used powerful microscopes to show how the mushroom extracts physically damage bacterial cells. Impacts on everyday life: • Provides scientific validation for traditional mushroom use in tribal medicine • Offers potential new sources of antibiotics to fight resistant infections • Demonstrates the value of preserving traditional knowledge about medicinal mushrooms • Suggests mushrooms could be cultivated as natural antimicrobial sources • Shows promise for developing new drugs from natural sources