This research investigated how selenium-enriched mushroom compounds could help combat obesity and related health issues. Scientists found that giving mice a high dose of selenium-rich mushroom extract helped reduce fat accumulation, lower cholesterol levels, and improve gut bacteria balance. This has important implications for human health: • Could provide a natural alternative to current obesity medications with fewer side effects • Offers potential new functional food ingredients for managing weight and cholesterol • Demonstrates how enriching mushrooms with selenium can enhance their health benefits • Shows promise for developing safer, natural treatments for metabolic disorders • Highlights the connection between gut bacteria and metabolic health