This research investigated the potential anticancer properties of a Malaysian mushroom species called Donkioporiella mellea. The study found that extracts from this mushroom could selectively kill lung cancer cells while causing minimal harm to normal lung cells. This discovery has important implications for everyday life: • Could lead to new natural cancer treatments with fewer side effects • Demonstrates the untapped potential of Malaysian biodiversity for medicine • Shows promise for developing new dietary supplements from mushrooms • Highlights the importance of preserving forest ecosystems where medicinal mushrooms grow • Opens possibilities for sustainable production of natural medicines