Fungal Species:  Dendrothele bispora

The First Whole Genome Sequence and Methylation Profile of Gerronema lapidescens QL01

Scientists have sequenced the complete genome of Lei Wan (Gerronema lapidescens), a medicinal mushroom used in traditional Chinese medicine for treating parasitic infections and digestive problems. The research reveals the mushroom’s genetic blueprint, including genes responsible for producing beneficial compounds and adapting to rocky mountain environments. This foundational work aims to enable sustainable cultivation of this rare fungus and development of new medicinal treatments, addressing current conservation threats from over-harvesting.

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The First Whole Genome Sequence and Methylation Profile of Gerronema lapidescens QL01

Researchers sequenced the complete genome of Lei Wan (Gerronema lapidescens), a medicinal mushroom used in Chinese traditional medicine for treating parasites and digestive issues. The study reveals the mushroom’s genetic makeup, including 15,847 genes and over 3 million methylation marks that may control gene expression. They identified 67 gene clusters that could produce medicinal compounds and 521 enzymes for breaking down organic matter. This genetic blueprint will help scientists understand how to cultivate this threatened species sustainably and develop its health benefits.

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The First Whole Genome Sequence and Methylation Profile of Gerronema lapidescens QL01

Scientists have sequenced the complete genetic code of Lei Wan (Gerronema lapidescens), a medicinal mushroom used in traditional Chinese medicine for treating parasitic infections and digestive problems. The research revealed how this mushroom produces beneficial compounds and how its genes are regulated through a process called methylation. This information could help develop better ways to cultivate this increasingly rare mushroom sustainably rather than harvesting it from the wild, making it available for future medical research and treatment.

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Identification, Heterologous Production and Bioactivity of Lentinulin A and Dendrothelin A, Two Natural Variants of Backbone N-methylated Peptide Macrocycle Omphalotin A

This research discovered and produced two new peptide molecules from mushrooms that could help protect plants from harmful parasitic worms. The scientists developed a way to make these complex molecules in yeast cells, which is more efficient than extracting them from mushrooms. This work has important implications for agriculture and drug development. Impacts on everyday life: – Could lead to new environmentally-friendly pesticides to protect crops from nematode parasites – Demonstrates a sustainable way to produce complex molecules using yeast instead of chemical synthesis – Opens possibilities for developing new peptide-based medicines with improved properties – Helps understand how mushrooms naturally defend themselves against pests – Could reduce reliance on harmful chemical pesticides in agriculture

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