This research provides the first detailed genetic blueprint of Cyathus olla, a medicinal mushroom shaped like a bird’s nest. The study reveals how this fungus produces various compounds that could be beneficial for human health. Impacts on everyday life: • Helps develop new medicines from natural sources • Advances our understanding of how medicinal mushrooms produce beneficial compounds • Could lead to more efficient production of natural therapeutic compounds • May help develop better treatments for neurodegenerative diseases • Could contribute to the development of new antimicrobial treatments