Fungal Species: Cunninghamella echinulata

Cunninghamella echinulata DSM1905 biofilm-based L-asparaginase production in pneumatically-driven bioreactors

Scientists tested different types of bioreactors to grow a fungus called Cunninghamella echinulata that produces L-asparaginase, an enzyme used to treat leukemia and lymphoma. They found that a special hybrid bioreactor with a mesh scaffold allowed the fungus to form a biofilm, which produced significantly more of the therapeutic enzyme than other reactor types. This discovery could improve the production of cancer-fighting medications.

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Submerged Fermentation of Rhizopus sp. for l-asparaginase Production in Lymphoma Therapy

Researchers developed a new way to produce an anti-cancer enzyme called L-asparaginase using a fungus called Rhizopus, which could offer a safer alternative to current bacterial sources. They designed and tested a special bioreactor system that allows the fungus to grow as a biofilm, significantly increasing enzyme production. The system achieved enzyme activity levels much higher than previous laboratory methods, suggesting it could be scaled up for industrial pharmaceutical production.

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