Cordyceps militaris – Page 10

Integrated Transcriptomic and Proteomic Analyses Reveal Molecular Mechanism of Response to Heat Shock in Morchella sextelata

mycolabadmin

Morels are delicious mushrooms that are difficult to grow because they are very sensitive to high temperatures. Scientists compared two different morel strains to understand why one variety can tolerate heat better than the other. By studying the genes and proteins expressed at normal and high temperatures, researchers discovered that the heat-tolerant strain activates specific protective mechanisms, particularly through a protein called Rsp5 that helps boost other protective proteins. This research provides valuable information for breeding morel varieties that can survive warmer growing conditions in the age of climate change.

Hypoglycemic Effect of Pleurotus citrinopileatus and Hericium erinaceus Buccal Tablets on Diabetic Mice

mycolabadmin

Researchers created special tablets from two edible mushrooms (yellow oyster mushroom and lion’s mane) enriched with trace elements (chromium, zinc, germanium) to treat diabetes in mice. After three weeks of treatment, the high-dose tablets reduced blood sugar levels by 29%, improved cholesterol levels, boosted the body’s natural antioxidant defenses, and shifted the gut bacteria toward beneficial types that support metabolic health. These results suggest that mushroom-based treatments could potentially offer a natural way to help manage diabetes.

Natural Neuroinflammatory Modulators: Therapeutic Potential of Fungi-Derived Compounds in Selected Neurodegenerative Diseases

mycolabadmin

This comprehensive review explores how compounds found in mushrooms could help treat serious brain diseases like Alzheimer’s and Parkinson’s disease. Mushrooms contain natural substances such as certain carbohydrates, proteins, and fats that can reduce harmful inflammation in the brain and protect nerve cells from damage. Scientists have tested these mushroom-derived compounds in laboratory and animal models, finding they can improve memory, movement, and overall brain function. This research suggests mushrooms could become an important part of new treatments for these currently incurable neurological conditions.

Integration of ATAC-Seq and RNA-Seq Identifies Key Genes in Light-Induced Primordia Formation of Sparassis latifolia

mycolabadmin

Researchers studied how light triggers the formation of mushroom fruiting bodies in Sparassis latifolia using advanced molecular techniques. They identified 30 key genes that become more or less active during this light-induced transformation, particularly those involved in vitamin and amino acid metabolism. The genes identified are associated with pathways that help convert simple fungal threads into the complex mushroom structures we eat. These findings could help improve mushroom cultivation methods and deepen our understanding of how mushrooms develop.

Advances in Fungal Natural Products: Insights into Bioactivity and Therapeutic Potential

mycolabadmin

Medicinal mushrooms and fungi contain powerful natural chemicals that can boost immunity, reduce inflammation, fight cancer, and protect the brain. Scientists are now better able to identify and study these compounds using advanced techniques, and some are being tested as supplements or alongside traditional medicines. This research shows that mushrooms could become important tools in treating diseases like inflammatory bowel disease, rheumatoid arthritis, and cancer.

Quest for Anti-SARS-CoV-2 antiviral therapeutics: in-silico and in-vitro analysis of edible mushroom- Cordyceps militaris

mycolabadmin

Researchers tested an edible mushroom called Cordyceps militaris to see if it could fight SARS-CoV-2, the virus that causes COVID-19. Using computer modeling and laboratory experiments, they found that a compound in the mushroom called cordycepin strongly attached to the virus’s spike protein and reduced viral numbers by about 50% in cell cultures. The study supports traditional uses of this mushroom and suggests it could be helpful in managing COVID-19 as the disease becomes endemic.

The Transformation and Protein Expression of the Edible Mushroom Stropharia rugosoannulata Protoplasts by Agrobacterium-tumefaciens-Mediated Transformation

mycolabadmin

Researchers successfully developed a method to genetically modify the edible mushroom Stropharia rugosoannulata using Agrobacterium tumefaciens bacteria. This technique allows scientists to insert and express foreign genes in the mushroom, providing tools to study how specific genes control mushroom growth and the production of health-promoting compounds. The study demonstrates that both artificial and natural resistance markers can be used to identify successfully transformed mushrooms, offering a foundation for improving mushroom cultivation and breeding.

Cordyceps militaris and Armillaria mellea formula alleviates depressive behaviors via microglia regulation in an unpredictable chronic mild stress animal model

mycolabadmin

Two medicinal mushrooms, Cordyceps militaris and Armillaria mellea, when combined as a formula, can help reduce depression-like symptoms in stressed animals. The formula works by balancing immune cells in the brain called microglia and restoring normal chemical messenger function. This treatment shows promise as a natural alternative to conventional antidepressants with fewer side effects.

Identification and functional analysis of the SET domain-containing gene family in Cordyceps militaris

mycolabadmin

Researchers identified 22 genes in the medicinal fungus Cordyceps militaris that control how genetic information is accessed through histone modifications. By studying how these genes respond to salt and amino acid treatments, they found that two specific genes (CmSET14 and CmSET16) are linked to cordycepin production, a compound with potential anti-cancer properties. When these genes were enhanced in the fungus, cordycepin production increased significantly, offering a new strategy to boost production of this valuable medicinal compound.

Comparing the Cosmetic Effects of Liquid-Fermented Culture of Some Medicinal Mushrooms Including Antioxidant, Moisturizing, and Whitening Activities

mycolabadmin

This research examined how three different medicinal mushrooms could be used in skincare products. Scientists found that these mushrooms, especially Coprinus comatus, have powerful benefits for skin health including antioxidant properties, moisturizing effects, and ability to brighten skin tone. Impacts on everyday life: • Provides new natural alternatives for anti-aging skincare products • Offers potential for safer, natural skin whitening treatments • Creates opportunities for sustainable, mushroom-based beauty products • Helps advance development of more effective natural moisturizers • Supports the growing trend toward natural cosmetic ingredients

Fungal Species: Cordyceps militaris