Fungal Species:  Coprinopsis cinerea

The first described case of Fomitiporella micropora infection in humans: A heart transplant recipient diagnosed by fungal PCR

A patient who received a heart transplant developed a small, slowly-growing lump on his shin over many years. After surgical removal, genetic testing revealed it was caused by a rare fungus never before identified in humans. The surgical removal likely cured the infection, and the case shows how important advanced genetic testing methods are for identifying unusual infections in transplant patients.

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Low temperature, mechanical wound, and exogenous salicylic acid (SA) can stimulate the SA signaling molecule as well as its downstream pathway and the formation of fruiting bodies in Flammulina filiformis

Researchers studied how cooling, physical damage, and a plant hormone called salicylic acid can trigger fruiting body formation in an edible mushroom called Flammulina filiformis. They discovered that these treatments activate specific genes in the mushroom that control fruit production. This research helps explain why mushroom farmers use these methods and could improve mushroom cultivation efficiency.

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Whole Genome Sequence of the Commercially Relevant Mushroom Strain Agaricus bisporus var. bisporus ARP23

Researchers sequenced the complete genome of a wild button mushroom strain (ARP23) that has been successfully bred with commercial mushrooms to create the ‘Heirloom’ variety. This strain is larger and contains more genes than other known button mushroom strains, making it valuable for breeding disease-resistant varieties. The genome sequence reveals that all button mushroom strains share core genes for breaking down plant material in compost, but have diverse collections of optional genes. This genetic resource provides a foundation for developing mushrooms more resistant to diseases and viruses.

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Fungal Innovations—Advancing Sustainable Materials, Genetics, and Applications for Industry

Fungi can be engineered to create sustainable, eco-friendly materials that could replace traditional plastics and leather. Scientists are using advanced genetic tools to control how fungi grow and what they produce, enabling the creation of customized materials with specific properties. These fungal-based materials are biodegradable, require less water and energy to produce, and show promise for applications in packaging, clothing, and building materials. With improved manufacturing processes and genetic engineering, fungi could revolutionize how we make everyday products.

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Integration of ATAC-Seq and RNA-Seq Identifies Key Genes in Light-Induced Primordia Formation of Sparassis latifolia

Researchers studied how light triggers the formation of mushroom fruiting bodies in Sparassis latifolia using advanced molecular techniques. They identified 30 key genes that become more or less active during this light-induced transformation, particularly those involved in vitamin and amino acid metabolism. The genes identified are associated with pathways that help convert simple fungal threads into the complex mushroom structures we eat. These findings could help improve mushroom cultivation methods and deepen our understanding of how mushrooms develop.

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Proteins from Edible Mushrooms: Nutritional Role and Contribution to Well-Being

Mushrooms are highly nutritious foods containing proteins as complete and high-quality as meat, with unique compounds that boost immunity, fight infections, and may help prevent diseases like cancer and diabetes. Different types of mushroom proteins have specific health benefits, from strengthening immune systems to lowering blood pressure and fighting viruses. Scientists are finding new ways to grow mushrooms and extract their proteins for use in sports nutrition, medicines, and fortified foods, making them increasingly valuable for human health and sustainability.

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Proteomic Analysis of Coprinopsis cinerea under Conditions of Horizontal and Perpendicular Gravity

Researchers studied how mushrooms respond to gravity using Coprinopsis cinerea, a common lab fungus. They found that while the fungal threads (mycelium) don’t respond to gravity, the fruiting bodies do by growing away from the direction gravity pulls. Using advanced protein analysis techniques, they identified 51 proteins that change their levels depending on gravity direction, suggesting that gravity response is connected to how mushrooms develop their fruiting bodies.

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Structural and Functional Analysis of Peptides Derived from KEX2-Processed Repeat Proteins in Agaricomycetes Using Reverse Genetics and Peptidomics

Scientists studied special proteins in mushrooms that get cut up into small functional peptides by fungal enzymes. They created a method to find and identify these peptides in mushroom fruiting bodies and growth materials. When they removed the enzymes that cut these proteins, the mushrooms had problems growing and forming fruiting bodies, suggesting these enzymes are important for normal development.

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New insights into temperature-impacted mycovirus-fungus interactions regulated by a microRNA in Lentinula edodes

When shiitake mushrooms are infected with a virus and exposed to heat stress, the virus replicates more aggressively, which makes the mushrooms more susceptible to heat damage and competitive fungi. Researchers discovered that a small regulatory RNA molecule called led-milR-21 plays a key role in this process by suppressing the mushroom’s heat defense mechanisms when the virus is present. This discovery is important because it shows how viruses can exploit heat stress to overcome fungal defenses, with implications for mushroom cultivation in a warming climate.

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Whole Genome Sequence of an Edible Mushroom Stropharia rugosoannulata (Daqiugaigu)

Scientists have decoded the complete genetic blueprint of the wine cap mushroom (Stropharia rugosoannulata), a popular edible mushroom grown worldwide. The research identified over 12,000 genes and discovered the mushroom contains powerful enzymes that break down plant material, explaining why it grows so well on straw and corn stalks. The study also revealed that different parts of the mushroom (cap and stem) have different functions, with stems focusing on energy production and caps on growth and development.

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