Candida albicans – mycolab.ai

Bacterial–Fungal Interactions: Mutualism, Antagonism, and Competition

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Bacteria and fungi in animal bodies interact in three main ways: they help each other (mutualism), fight each other (antagonism), or compete for resources. These interactions happen in the gut, rumen, and skin of animals. Understanding how to balance these relationships can help create better probiotics and natural alternatives to antibiotics for treating infections and improving animal health.

Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

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Researchers studied urinary tract infections caused by yeast (Candida species) in hospitalized patients. Using advanced molecular testing, they found that while the common yeast Candida albicans was most prevalent, other yeast species were increasingly showing resistance to antifungal medications, particularly to fluconazole. The study highlights the importance of identifying which specific yeast species is causing an infection to choose the most effective treatment.

Fungal Infections – a Stealthy Enemy in Patients with Chronic Granulomatous Disease: a 28-years’ Experience from North India

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Patients with chronic granulomatous disease (CGD), a rare immune system disorder, are highly susceptible to serious fungal infections. This study of 99 patients over 28 years found that 40% developed fungal infections, mostly caused by Aspergillus fungi affecting the lungs. These infections were life-threatening, with over half the infected patients dying despite aggressive treatment with antifungal medications. Doctors need to screen for fungal infections early, even in patients without obvious symptoms, and treat infants and males more aggressively.

Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

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Researchers studied fungal infections in urine samples from hospitalized patients and found that while the common yeast Candida albicans was most prevalent, other Candida species were increasingly resistant to antifungal medications. Using advanced genetic testing methods, they identified seven different Candida species and tested their resistance to three common antifungal drugs. The findings highlight the growing problem of drug-resistant fungal infections and the need for better diagnostic tools to identify which species is causing infection so appropriate treatment can be selected.

Revealing structure and shaping priorities in plant and fungal cell wall architecture via solid-state NMR

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This review explains how scientists use a special type of microscopy called solid-state NMR to study the protective outer layers of fungi and plants. The research shows that fungal pathogens can cleverly rearrange their cell walls to resist antifungal medicines, and that plants carefully organize their cell walls during growth by forming specific connections between different molecules. Understanding these structures at the molecular level could help develop better antifungal treatments and improve how we use plant biomass for biofuels and materials.

Invasive Candidiasis in Contexts of Armed Conflict, High Violence, and Forced Displacement in Latin America and the Caribbean (2005–2025)

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Invasive candidiasis, a serious fungal blood infection caused by Candida species, is a major health crisis in Latin America and the Caribbean with death rates reaching 60% in vulnerable populations. The disease is worsening in areas affected by armed conflict, violence, and displacement where poor living conditions, overcrowding, malnutrition, and lack of healthcare create ideal conditions for the infection to develop and spread. Antifungal drugs are often unavailable or too expensive, and drug-resistant strains of Candida are becoming increasingly common, making treatment extremely challenging in these regions.

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity

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This research shows that a protein called PTP1B plays an important role in protecting the body against dangerous fungal infections caused by Candida albicans. When mice lacked this protein in their immune cells, they were much more susceptible to the infection and showed severe illness. The study found that PTP1B helps immune cells like macrophages and neutrophils fight the fungus effectively, and blocking this protein could actually make fungal infections worse.

Antimicrobial Activity of Extracts of the Oyster Culinary Medicinal Mushroom Pleurotus ostreatus and Identification of a New Antimicrobial Compound

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Scientists discovered that the common oyster mushroom (Pleurotus ostreatus) contains powerful antimicrobial compounds that can fight both harmful bacteria and fungi. They identified a new compound that could potentially be developed into natural medicines. Impact on everyday life: • Could lead to new natural antibiotics for treating infections • Demonstrates additional health benefits of including oyster mushrooms in diet • Shows potential for developing natural food preservatives • Provides evidence for traditional medicinal uses of mushrooms • Opens possibilities for eco-friendly antimicrobial treatments

Clinical and Microbiological Diagnosis of Oral Candidiasis

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This research reviews the diagnosis of oral yeast infections (candidiasis), which affect many people worldwide. The study explains how doctors can identify these infections through clinical examination and laboratory tests. Impact on everyday life: • Helps doctors make faster and more accurate diagnoses of oral yeast infections • Guides healthcare providers in choosing the most appropriate diagnostic tests • Enables better treatment selection for different types of oral candidiasis • Improves understanding of when additional testing beyond visual examination is needed • Helps reduce unnecessary laboratory testing and associated healthcare costs

Candida albicans and Pseudomonas aeruginosa Interaction, with Focus on the Role of Eicosanoids

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This research examines how two common disease-causing microorganisms – a fungus (Candida albicans) and a bacterium (Pseudomonas aeruginosa) – interact with each other and affect human health. The study reveals that these microbes engage in chemical warfare, producing various compounds that can either harm each other or alter their behavior, while simultaneously affecting the human immune system. Impacts on everyday life: – Helps explain why some infections, particularly in cystic fibrosis patients, are difficult to treat – Provides insights that could lead to better treatments for mixed fungal-bacterial infections – Demonstrates why some common medications like aspirin might affect infection outcomes – Shows how understanding microbial interactions could improve hospital infection control – Highlights the importance of considering multiple organisms when treating infections

Fungal Species: Candida albicans