Fungal Species:  Calocybe indica

Interplay of precision therapeutics and MD study: Calocybe indica’s potentials against cervical cancer and its interaction with VEGF via octadecanoic acid

Researchers discovered that an extract from the Calocybe indica mushroom effectively kills cervical cancer cells while leaving healthy immune cells unharmed. Using computer simulations, they identified that a compound in this mushroom called octadecanoic acid strongly binds to and blocks VEGF, a protein that helps cancer cells grow and spread. The extract reduced cancer cell movement by 50% and prevented cancer cells from forming colonies, suggesting this mushroom could become a new treatment option for cervical cancer.

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Carcinogenic and Non-Carcinogenic Risk Assessment of Consuming Metal-Laden Wild Mushrooms in Nigeria

This research investigated the health risks of consuming wild mushrooms in Nigeria that may contain toxic metals. The study found concerning levels of various metals that could pose both cancer and non-cancer health risks, especially for children. This has important implications for everyday life: • People should be cautious about collecting and eating wild mushrooms, particularly from potentially contaminated areas • Children are at higher risk from metal exposure through mushroom consumption than adults • Regular consumption of contaminated wild mushrooms could increase cancer risk over time • Better monitoring and regulation of wild mushroom collection/sale may be needed • Education about safe mushroom sourcing could help reduce health risks

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