This research investigated how compounds extracted from shiitake mushrooms could help fight viral infections. The study found that different extracts from the mushroom were effective at preventing virus replication, particularly in the early stages of infection. This has important implications for developing natural antiviral treatments. Impacts on everyday life: • Potential development of natural antiviral medications from mushrooms • New ways to combat viral infections using food-derived compounds • Expanded understanding of shiitake mushrooms’ health benefits • Possible alternatives to synthetic antiviral drugs