This research examines how compounds from medicinal mushrooms interact with beneficial bacteria in our gut to improve health. These mushroom-derived substances can help maintain a healthy balance of gut bacteria, reduce inflammation, and potentially prevent or treat various diseases including diabetes, obesity, and inflammatory bowel conditions. The research has important implications for developing natural therapeutic approaches using mushrooms as functional foods or supplements. Key impacts on everyday life: – Eating medicinal mushrooms may help maintain healthy gut bacteria and improve digestion – Mushroom supplements could provide natural alternatives for managing metabolic conditions like diabetes and obesity – Understanding these interactions helps develop better prebiotic products for gut health – The findings support traditional uses of medicinal mushrooms in promoting overall wellness – This research provides scientific basis for including more mushrooms in a healthy diet