Aspergillus terreus – mycolab.ai

Innovative fungal bioagents: producing siderophores, IAA, and HCN to support plants under salinity stress and combat microbial plant pathogens

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Scientists discovered two beneficial fungi that help wheat plants survive in salty soil and resist diseases. These fungi work by producing growth-promoting substances and natural compounds that fight harmful plant pathogens. When used to treat wheat seeds, these fungi significantly improved plant growth even under high salt stress conditions, offering a natural alternative to chemical fertilizers and pesticides for farming in salt-affected areas.

A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment

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Fungi naturally produce complex chemical compounds called secondary metabolites that have powerful effects against diseases and pests. These include well-known medicines like penicillin and compounds that can fight cancer, reduce inflammation, and lower cholesterol. Scientists are now using advanced genetic and biotechnology techniques to increase production of these fungal compounds, making them more available and affordable for medical, agricultural, and environmental applications. This research shows how fungi could be important sources of new medicines and sustainable alternatives to synthetic chemicals.

Fungal Drug Discovery for Chronic Disease: History, New Discoveries and New Approaches

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This article examines how fungi have provided humanity with some of the most important medicines ever created, including penicillin, drugs that prevent organ rejection, and cholesterol-lowering statins. Many of these fungal compounds work as medicines because they target processes that are similar in both fungi and humans, helping them survive competition with other fungi while coincidentally treating human diseases. New researchers are now using modern genetic tools to discover additional fungal medicines, with several promising candidates currently being tested in clinical trials for cancer, depression, and other chronic diseases.

Adaptive Changes and Genetic Mechanisms in Organisms Under Controlled Conditions: A Review

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Organisms adapt to their environments through changes in their genes and how genes are expressed, processes that can happen over many generations even in laboratory settings. Scientists study these adaptations in fungi, insects, and plants grown under controlled conditions to understand how evolution works over shorter timeframes. The research shows that both genetic mutations and modifications to how genes work (without changing DNA itself) drive these adaptive changes. Understanding these mechanisms helps scientists improve crop productivity, develop disease resistance, and address environmental challenges like climate change.

Potential Bioactivities, Chemical Composition, and Conformation Studies of Exopolysaccharide-Derived Aspergillus sp. Strain GAD7

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Scientists discovered a marine fungus called Aspergillus sp. strain GAD7 that produces a special type of sugar-like substance with medicinal properties. This substance can help prevent blood clotting and fight harmful substances in the body that cause damage. The research shows this fungal product could potentially be used as a therapeutic treatment for conditions related to blood clotting and oxidative stress.

Fungal Infections – a Stealthy Enemy in Patients with Chronic Granulomatous Disease: a 28-years’ Experience from North India

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Patients with chronic granulomatous disease (CGD), a rare immune system disorder, are highly susceptible to serious fungal infections. This study of 99 patients over 28 years found that 40% developed fungal infections, mostly caused by Aspergillus fungi affecting the lungs. These infections were life-threatening, with over half the infected patients dying despite aggressive treatment with antifungal medications. Doctors need to screen for fungal infections early, even in patients without obvious symptoms, and treat infants and males more aggressively.

Halotolerant Endophytic Fungi: Diversity, Host Plants, and Mechanisms in Plant Salt–Alkali Stress Alleviation

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Salty and alkaline soil is destroying farmland worldwide, but special fungi living inside plants can help crops survive these harsh conditions. These fungi work like a team with plants, producing protective substances and helping plants manage salt and reduce damage from stress. Scientists reviewed 150 studies and found these fungi boost crop yields by 15-40%, offering a natural way to farm on degraded land without more chemicals.

Halotolerant Endophytic Fungi: Diversity, Host Plants, and Mechanisms in Plant Salt–Alkali Stress Alleviation

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Over 1 billion hectares of farmland worldwide suffer from salt damage, drastically reducing crop yields. Special fungi called halotolerant endophytic fungi live inside plant tissues and help plants survive salty, alkaline soil conditions without harming them. These fungi work by balancing salt ions in plants, boosting their natural antioxidant defenses, and producing helpful compounds. Research shows they can increase crop yields by 15-40% in salt-affected fields, offering a natural and sustainable solution to one of agriculture’s biggest challenges.

New bioactive secondary metabolites from fungi: 2024

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Scientists discovered 907 new compounds from fungi in 2024, with most being terpenoids and polyketides that show promise as medicines. These fungal compounds demonstrate strong activity against bacteria, fungi, and inflammation, with some showing potential against cancer and diabetes. The research uses advanced techniques like genome mining and metabolomics to find these compounds more efficiently. This accelerating discovery rate suggests fungi could be a major source for developing new drugs to treat various diseases.

Diversity and bioprospecting activities of endophytic Fungi associated with different Egyptian medicinal plants

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Scientists studied fungi that live inside Egyptian medicinal plants and found that one type called Aspergillus terreus produces compounds with powerful healing properties. These compounds can fight harmful bacteria, reduce oxidative damage, and even kill cancer cells while being safe for normal cells. This discovery suggests that fungi living in medicinal plants could be valuable sources of new medicines, offering hope for developing new treatments for infections and cancer.

Fungal Species: Aspergillus terreus