This research explored how to optimize the extraction of selenium-enriched compounds from mushroom mycelia and tested their potential anti-aging benefits. The study found that these compounds had strong antioxidant properties and could help prevent aging-related damage in mice. This has important implications for everyday life: • Could lead to new natural dietary supplements for healthy aging • Provides a safer alternative to synthetic antioxidants • Offers a new way to address selenium deficiency through mushroom-based products • May help develop functional foods that protect against oxidative stress • Demonstrates potential for using mushrooms as natural medicine sources