This research explores how natural biological materials and colors have been used in art throughout human history, from ancient cave paintings to modern biotechnology-based fashion. The study shows how humans have consistently relied on nature for artistic expression, and how modern science is finding new sustainable ways to produce these materials. Impacts on everyday life: • Provides more sustainable and natural alternatives to synthetic dyes in clothing and accessories • Offers new environmentally friendly materials for fashion and textile industries • Helps preserve and restore important cultural artifacts and artworks • Creates new possibilities for artistic expression through biotechnology • Demonstrates how traditional knowledge can inform modern sustainable practices