Research by Anti-Therapeutic Actions
A
- A. auricula-judae showed incongruous EDX results suggesting potential purity issues (1)
- A. hemibapha subsp. javanica is edible but easily confused with toxic species (1)
- abandonment (1)
- abdominal discomfort (1)
- abdominal pain (1)
- aberrant immune activation (1)
- aberrant pigmentation (1)
- abnormal dreams (1)
- abnormal immune responses (1)
- Abscisic acid accumulation inhibits plant defense (1)
- abscisic acid suppresses plant defense responses (1)
- absence of flucytosine (1)
- absorbs reactive oxygen species (1)
- absorption variability based on food matrix (1)
- Abuse liability (1)
- abuse potential (2)
- abuse potential in recreational settings (1)
- Acalabrutinib associated with increased fungal infection risk (1)
- accelerated aging (1)
- accelerated mycelial development (1)
- Accumulation in liver (1)
- accumulation in water systems (1)
- accumulation of antibiotic residues in drinking water sources (1)
- accumulation of arsenic and cadmium (1)
- accumulation of azole antifungals in environment (1)
- accumulation of toxic compounds in food chain (1)
- Acetaminophen at supratherapeutic doses causes hepatocyte necrosis (1)
- Acetoacetanilide acts as an inhibitor of acetoacetyl-CoA synthetase (1)
- Acetylcholinesterase inhibition (1)
- acid mine drainage formation (1)
- acid mine drainage generation (1)
- acidification and alkalinization effects (1)
- acquired amphotericin B resistance (1)
- acquired resistance (2)
- Actinomucor elegans (1)
- activates inflammatory pathways (1)
- active acute stress disorder (1)
- Active Cn induces metabolic stress and mitochondrial dysfunction in host cells (1)
- activity diminished above 75°C (1)
- acute and chronic side effects (1)
- acute and chronic toxicities (1)
- acute and chronic toxicity from mycotoxin consumption (1)
- Acute anxiety and dysphoria during experience (1)
- Acute anxiogenic-like effects at 15 minutes post-administration (1)
- acute cognitive impairment (1)
- Acute cognitive impairment (short-term) (1)
- acute delusions (1)
- Acute disease progression (1)
- acute encephalopathy (1)
- Acute headache (1)
- acute hepatitis (1)
- acute kidney injury (4)
- acute kidney injury associated with amphotericin B therapy (1)
- acute liver damage (1)
- acute liver injury (2)
- acute perceptual changes (1)
- acute poisoning from mephedrone (1)
- acute poisoning symptoms include edema (1)
- acute poisoning with gastrointestinal symptoms (1)
- acute psychological effects reported in ~20% of microdosing users (1)
- acute respiratory distress syndrome (1)
- acute rhabdomyolysis (1)
- Acute substance-induced psychotic disorder (rare) (1)
- acute suicidality (1)
- Acute sympathetic response (1)
- acute tachycardia (1)
- acute toxicity (1)
- acute toxicity (1)
- adaptive cell wall remodeling (1)
- Addiction potential (2)
- addictive potential (1)
- Addictive potential of opioids (1)
- addictive properties (disputed) (1)
- addresses concerns about negative effects of chemical fungicides (1)
- adenosine reported to have pro-inflammatory effects on testes in some studies (1)
- ADP addition reduced anticancer effects compared to controls (1)
- adrenal insufficiency (1)
- adrenal insufficiency (3)
- adult vitamin D deficiency impairs spatial memory (1)
- Advanced age (1)
- Advanced HIV disease with CD4 <200/µL significantly increases risk and severity of histoplasmosis (1)
- Advanced immunosuppression increases susceptibility to severe disseminated disease (1)
- adverse cardiovascular effects (1)
- adverse drug interactions (1)
- Adverse drug reactions from antifungals (1)
- adverse effects (2)
- adverse effects at higher doses (1)
- adverse effects from conventional pharmacological interventions including dizziness (1)
- Adverse effects from conventional treatments including trismus (1)
- adverse effects from high saturated fat and ultra-processed foods (1)
- adverse effects from long-term drug administration (1)
- adverse effects from potassium iodide (salivary gland enlargement, rash) (1)
- Adverse effects from prolonged antifungal therapy (1)
- adverse effects from prophylactic treatment (1)
- Adverse effects from psilocybin include headache (1)
- adverse effects from unsubstantiated claims (1)
- adverse effects include salivary gland enlargement and rash (1)
- Adverse effects limiting treatment duration (1)
- adverse effects more common in younger individuals (1)
- adverse effects of amphotericin B in high doses (1)
- Adverse effects of clotrimazole including burning sensation and skin irritation (1)
- adverse effects of targeted therapy (1)
- Adverse effects of trimethoprim/sulfamethoxazole including rashes (1)
- Adverse effects on aquatic organisms and human health (1)
- adverse effects on offspring mood and sociability (1)
- adverse effects on offspring mood and sociability (1)
- adverse effects on plant development (1)
- adverse effects rarely observed in clinical practice (1)
- adverse effects requiring discontinuation (1)
- adverse effects typically manageable according to included studies (1)
- adverse events (1)
- Adverse events (minor and temporary) (1)
- Adverse events include headache (1)
- Adverse events requiring medication switch (1)
- Adverse events requiring medication switch (1)
- Adverse events requiring treatment discontinuation in escitalopram group (1)
- adverse events with extended antiviral use (1)
- Adverse food reactions (1)
- adverse health effects from fungal cell wall components and enzymes (1)
- adverse mental health effects (1)
- adverse neurological outcomes (1)
- adverse reactions (1)
- adverse reactions to systemic azole therapy (1)
- AFB1 carcinogenicity (1)
- affective distress (1)
- Aflatoxin B1 contamination risk (mitigated in PN strain) (1)
- Aflatoxin B1 is a carcinogenic and hepatotoxic mycotoxin (1)
- Aflatoxin B1 is carcinogenic and immunosuppressive (1)
- Aflatoxin B1 is carcinogenic and immunosuppressive (1)
- aflatoxin B1 production (1)
- Aflatoxin B1 production (A. terreus) (1)
- Aflatoxin B1 toxicity (1)
- aflatoxin contamination in food (1)
- Aflatoxin production (1)
- aflatoxin production (toxic metabolite) (1)
- Aflatoxin production associated with cancer and liver failure (1)
- Aflatoxin production associated with toxicity (1)
- Aflatoxin production potential (1)
- Aflatoxin toxicity including anorexia (1)
- aflatoxins are carcinogenic and hepatotoxic (1)
- Aflatoxins cause liver damage in livestock and poultry (1)
- AFM1 (aflatoxin metabolite in milk) is toxic (1)
- age-dependent lack of therapeutic response to psilocybin in younger subjects (1)
- AGE-induced myotube atrophy (1)
- AGE-induced myotube atrophy (1)
- agglomeration potential at high concentrations (1)
- Aggregation and precipitation (1)
- aggressive behavior (1)
- Aggressive debridement poses severe morbidity without proven additional efficacy (1)
- agitation (3)
- AgNPs did not inhibit fungal growth (1)
- AgNPs did not inhibit mycelial fungi development (1)
- AgNPs do not inhibit mycelial fungi development (1)
- agricultural productivity loss (1)
- AHCC did not cause immediate monocyte toxicity in healthy donors (1)
- air pollution through incineration (1)
- Airway obstruction by fungal mucus plugs (1)
- airway remodeling (4)
- akinesia (1)
- alginate can leave fibers at wound site causing inflammation if inadequate liquid present (1)
- algorithmic bias (1)
- alkaline hydrolysis of compound 3 under high pH conditions (1)
- alkaloid degradation under improper storage (1)
- alkaloid toxicity at high concentrations (1)
- all fractions showed low toxicity at tested concentrations (1)
- all Mucorales species show intrinsic resistance to short-tailed azoles like voriconazole (1)
- allenic norleucine (1)
- Allergen concerns (1)
- allergen production (2)
- allergenic potential (1)
- allergenic potential in crustacean-derived sources (1)
- Allergenic protein contamination from crustacean sources (not from fungal/microalgal sources) (1)
- allergenic protein contamination in crustacean-derived chitin (1)
- allergenic reactions (1)
- allergenic reactions in sensitive individuals (1)
- allergenic responses (1)
- allergenicity of β-lactoglobulin (1)
- Allergens from Pleurotus ostreatus spores causing respiratory problems and allergic reactions (1)
- allergic reaction risk from crustacean tropomyosin protein (1)
- allergic reaction to vancomycin (1)
- Allergic reaction to voriconazole (1)
- Allergic reactions (7)
- allergic reactions (4.4%) (1)
- Allergic reactions (animal-derived chitosan from crustaceans) (1)
- Allergic reactions including anaphylaxis (1)
- Allergic reactions including asthma and contact dermatitis (1)
- Allergic reactions possible (1)
- Allergic reactions reported with Armillaria mellea consumption (1)
- Allergic reactions to antibiotic residues (1)
- allergic reactions to trehalose (1)
- allergic responses (1)
- allergies (1)
- Allochthonous fungi increased arsenic accumulation under alternate wetting and drying (1)
- Allodynia (1)
- allopurinol associated kidney damage and inflammatory cell infiltration (1)
- alopecia (3)
- alpha radiation exposure (1)
- alpha radiation exposure (1)
- alter texture (1)
- Alterations in phospholipid composition can enhance antifungal resistance and immune evasion (1)
- altered conidiation patterns (1)
- Altered consciousness (1)
- Altered cortical activity (1)
- altered feeding behavior (1)
- altered flavor characteristics (1)
- altered fungal-bacterial co-abundance patterns contribute to gut dysbiosis (1)
- altered mental status (1)
- altered perception (4)
- altered sclerotia production patterns (1)
- altered sensory properties (1)
- altered sexual reproduction (1)
- altered space-time perception (1)
- Altered state of consciousness (1)
- Amanita muscaria is toxic and ingestion can be extremely dangerous or fatal with unpredictable effects including nausea (1)
- Amanita muscaria toxicity (muscimol and ibotenic acid causing dizziness, dysphoria, hallucinations, seizures, coma) (1)
- Amanita phalloides is highly poisonous when consumed (1)
- Amanita species generally contain cyclopeptide toxins (α-amanitin, β-amanitin, phalloidin) (1)
- Amanitin toxin causes hepatocyte necrosis (1)
- Amanitin toxin causes hepatocyte necrosis (1)
- amatoxin (1)
- Amatoxin-induced hepatocyte apoptosis and necrosis (1)
- Ambrosia fungi associated with beetle-caused tree damage and disease transmission (1)
- aminoglycosides (1)
- ammonium ions in MS medium can inhibit root growth and spore germination (1)
- ammonium-containing media can negatively affect root growth (1)
- amnesia (1)
- AMP instability and toxicity concerns (1)
- AmpC modifications (1)
- Ampelopsis grossedentata (1)
- amphotericin (1)
- amphotericin B (4)
- Amphotericin B and azoles show variable efficacy in Fusarium species (1)
- amphotericin B and voriconazole resistance in some species (1)
- Amphotericin B deoxycholate formulation more inflammatory than liposomal form (1)
- Amphotericin B deoxycholate not recommended due to toxicity and poor prognosis (1)
- amphotericin B deoxycholate toxicity (1)
- amphotericin B has high MIC values and insufficient fungicidal activity (1)
- Amphotericin B hypokalemia (1)
- amphotericin B infusion-related reactions including pyrexia and hypotension (1)
- Amphotericin B insufficiency against Scedosporium (1)
- amphotericin B insufficient for Scedosporium sensitivity (1)
- amphotericin B lipid complex caused severe adverse reactions (chills, dyspnea, shock) (1)
- Amphotericin B monotherapy without surgical intervention led to treatment failure (1)
- Amphotericin B nephrotoxicity (3)
- Amphotericin B nephrotoxicity requiring dose adjustment (1)
- amphotericin B resistance (7)
- amphotericin B resistance (1)
- Amphotericin B resistance documented in over 50% of cases (1)
- amphotericin B resistance in A. terreus (5)
- amphotericin B resistance in C. albicans strains (1)
- amphotericin B resistance in C. auris (1)
- amphotericin B resistance in select species (1)
- Amphotericin B showed elevated MIC (8 μg/ml) (1)
- Amphotericin B showed poor response and was discontinued (1)
- Amphotericin B showed poor response in this case (1)
- Amphotericin B toxicity (4)
- amphotericin B toxicity concerns (1)
- amphotericin B toxicity remains a concern requiring dose reduction strategies (1)
- amyloid plaque accumulation (1)
- amyloid plaque formation (1)
- Amyloid-beta Osaka mutation induces cognitive decline (1)
- an anti-nutritional substance with negative effects on growth and reproductive performance (1)
- anaerobic conditions reduce hydrocarbon degradation efficiency (1)
- Anakinra caused injection site reactions (1)
- anaphylaxis (1)
- and 5-flucytosine (1)
- and 5-fluorocytosine (1)
- and aberrant cell-cycle reentry (1)
- and altered fungal morphology (1)
- and apoptotic-like cell death in mycelium (1)
- and Asp-hemolysin production (A. fumigatus) (1)
- and bat mortality (1)
- and bioaccumulation in food chains (1)
- and BTK degrader therapy increase immunosuppression and fungal infection risk (1)
- and C. albicans (1)
- and cadmium toxicity from contaminated traditional foods (1)
- and cancer (1)
- and carcinogenic effects (1)
- and carcinogenic toxins (1)
- and caspofungin (1)
- and children (1)
- and coma. Cortinarius violaceus has potential toxicity and direct consumption should be avoided. (1)
- and compromised marketability (1)
- and compromised product shelf-life (1)
- and contaminated surgical materials (1)
- and crop loss (1)
- and crop losses (1)
- and crude fiber (1)
- and cytotoxicity (1)
- and depressive states (1)
- and DNA (1)
- and dose (1)
- and elevated MICs to isavuconazole in some Mucor species (1)
- and enhances amyloid accumulation (1)
- and faba bean (2)
- and first-generation cephems (1)
- and fluconazole (1)
- and fruit (1)
- and fruit damage (1)
- and fumonisins causing food poisoning and immunosuppression (1)
- and genotoxic effects (1)
- and genotoxicity (1)
- and growth inhibition in fungi at high concentrations (1)
- and high MICs to isavuconazole (1)
- and humans (1)
- and immunotoxic (1)
- and impaired spatial working memory (1)
- and inaccurate pathogen identification (1)
- and increases risk of colorectal cancer and atherosclerosis (1)
- and infectious complications (1)
- and internal hyphal growth (1)
- and iron coverage when used alone (1)
- and kidneys (1)
- and leads to leaf yellowing and defoliation (1)
- and leaf blight in cypress trees (1)
- and lifespan shortening (1)
- and loss of appetite (1)
- and mercury (1)
- and mercury (1)
- and Micafungin (2)
- and Mucor species (1)
- and Mucor species (1)
- and muscle incoordination (1)
- and mutagenic effects (1)
- and mutagens (1)
- and nausea (1)
- and neurological complications (1)
- and neurotoxic (1)
- and neurotoxic effects (1)
- and nucleic acids (1)
- and nutrient deficiency (1)
- and olorofim (1)
- and organ transplantation increase PJP risk in non-HIV patients (1)
- and oxidative stress sensitivity (1)
- and palm death (1)
- and pathogen resistance development (1)
- and Penicillium species (1)
- and Phytophthora capsici (1)
- and plant decline (1)
- and plant disease (1)
- and plant mortality in pomegranate (1)
- and potatoes (1)
- and potential total crop loss (1)
- and processing environments (1)
- and promote antibiotic resistance (1)
- and promotes cancer cell metastasis (1)
- and psychological disorders (1)
- and rectal bleeding (1)
- and reduced plant growth (1)
- and reduced root growth (1)
- and reduces enzyme activity (1)
- and salty snacks did not show protective effects (1)
- and shortened shelf-life (1)
- and sodium hypochlorite (1)
- and stomach pain (1)
- and terbinafine (1)
- and tobacco (1)
- and tree death in untreated infections (1)
- and Vaccinium corymbosum (1)
- and yield losses (1)
- and yield/quality reduction (1)
- anemia (3)
- anger (1)
- angioinvasion (2)
- Angioinvasion and tissue necrosis in infection (1)
- angioinvasive fungal infection (1)
- anhedonia in offspring (1)
- anidulafungin (3)
- antagonism observed in one instance with anidulafungin (1)
- antagonism with salicylic acid-mediated defense responses (1)
- antagonistic bacterial effects inhibit mushroom growth (1)
- antagonistic bacterial effects on mushroom growth (1)
- antagonistic bacterial interactions (1)
- Antagonistic effects on beneficial ectomycorrhizal fungi under certain contact conditions (1)
- antagonistic interactions (1)
- Antagonistic interactions between biocontrol agent and beneficial fungi may reduce symbiotic effectiveness (1)
- antagonizes salicylic acid and jasmonic acid signaling (1)
- anthelmintics did not inhibit fungal growth or spore production (1)
- anti-cancer drugs (1)
- anti-nutritional compounds in some species (1)
- anti-nutritional compounds present (phytates, tannins, saponins) (1)
- anti-nutritional factors (phytates, oxalates, lectins) (1)
- Anti-tuberculosis therapy not tolerated (1)
- antibiotic failure with ceftriaxone monotherapy (1)
- Antibiotic overuse and resistance (1)
- antibiotic persistence (1)
- antibiotic resistance (2)
- Antibiotic resistance development (9)
- Antibiotic resistance development potential (1)
- antibiotic resistance dissemination (1)
- antibiotic resistance gene dissemination (1)
- Antibiotic resistance gene emergence (1)
- antibiotic resistance genes (1)
- antibiotic resistance genes detected in some strains (1)
- antibiotic-induced diarrhea (1)
- antibiotic-induced disruption (addressed through intervention) (1)
- Antibiotic-induced dysbiosis (1)
- anticholinergic effects (2)
- anticholinergic side effects (1)
- Antidepressant discontinuation syndrome (1)
- Antidepressant side effects include insomnia (1)
- antifungal activity (1)
- Antifungal activity of fluoxetine against Aspergillus flavus (1)
- Antifungal and steroid medications can suppress immune cell activity and lead to false negative culture results (1)
- antifungal compounds in milled LBS inhibit mycelial growth at high concentrations (1)
- antifungal drug resistance (6)
- antifungal drug resistance development (1)
- antifungal inadequacy (1)
- antifungal medication inaccessibility (1)
- antifungal medications can suppress immune cell activity (1)
- antifungal persistence (1)
- antifungal properties of fluoxetine against A. flavus (1)
- antifungal prophylaxis associated with increased resistance (1)
- antifungal prophylaxis-induced resistance selection (1)
- Antifungal resistance (46)
- Antifungal resistance (Amphotericin B, Voriconazole, Isavuconazole, Posaconazole) (1)
- antifungal resistance concerns (1)
- Antifungal resistance development (9)
- Antifungal resistance development in pathogenic species (1)
- Antifungal resistance development limiting treatment efficacy (1)
- Antifungal resistance emerging as significant challenge (1)
- antifungal resistance in Aspergillus (1)
- Antifungal resistance in Aspergillus fumigatus (2)
- Antifungal resistance in C. albicans to fluconazole and voriconazole (1)
- Antifungal resistance in C. auris limits treatment options (1)
- antifungal resistance in C. glabrata and C. krusei (2)
- Antifungal resistance in Candida auris (2)
- Antifungal resistance in Candida species (3)
- Antifungal resistance in Candida tropicalis to fluconazole and voriconazole (1)
- antifungal resistance in dermatophytes (1)
- Antifungal resistance in dermatophytes including N. gypsea is increasingly common (1)
- antifungal resistance in environmental isolates (2)
- antifungal resistance in Fusarium falciforme to multiple agents (1)
- Antifungal resistance in Fusarium species (1)
- Antifungal resistance in multiple species (1)
- Antifungal resistance in non-albicans Candida species (3)
- Antifungal resistance in non-albicans species (1)
- antifungal resistance in some isolates (1)
- Antifungal resistance in some yeast species (1)
- Antifungal resistance in terbinafine-resistant strains (1)
- antifungal resistance in Trichophyton indotineae and Aspergillus species (1)
- antifungal resistance in Trichosporon asahii to amphotericin B (1)
- Antifungal resistance limiting treatment efficacy (1)
- antifungal resistance mechanisms (3)
- antifungal resistance mechanisms in A. fumigatus (1)
- Antifungal resistance mechanisms in dermatophytes (1)
- Antifungal resistance noted as emerging concern (1)
- antifungal resistance patterns (1)
- Antifungal resistance potential (1)
- antifungal resistance to fluconazole and terbinafine (2)
- Antifungal resistance to itraconazole and amphotericin B documented in multiple Sporothrix species (1)
- Antifungal resistance to terbinafine (1)
- antifungal resistance with elevated MICs to multiple azoles (isavuconazole, itraconazole, voriconazole) (1)
- antifungal resistance with triazoles (1)
- antifungal therapy limitations in non-immunocompromised patients (1)
- antifungal therapy reduces antibody detection (1)
- antifungal tolerance (2)
- Antifungal tolerance in slow-growing cells (1)
- Antifungal tolerance in trisomic strains (1)
- Antifungal toxicity (2)
- antifungal treatment did not significantly improve outcomes (1)
- antifungal treatment failures (1)
- antimicrobial effects on symbiotic bacteria at high concentrations (1)
- antimicrobial properties (1)
- antimicrobial resistance (2)
- antimicrobial resistance development (1)
- antimicrobial resistance genes (1)
- antimicrobial resistance genes (1)
- Antimicrobial resistance in fungal pathogens (1)
- antimicrobial resistance patterns (1)
- antinutrients present but at negligible levels (1)
- antinutrients present in unfermented legumes reduce digestibility and nutrient absorption (1)
- antinutritional factors (1)
- Antinutritional factors present (tannins, phytic acid, hydrogen cyanide) but significantly reduced by fermentation (1)
- antioxidant antagonism with ROS-dependent therapies (1)
- antiviral drug resistance (oseltamivir and bamlanivimab) (1)
- antiviral ribavirin treatment reduces pathogenicity (1)
- anxiety (21)
- anxiety and apprehension (1)
- anxiety and panic attacks (1)
- Anxiety during dosing (1)
- anxiety during experience (1)
- Anxiety exacerbation (2)
- anxiety increases with certain drug combinations (1)
- anxiety induction at higher doses (1)
- anxiety-like behavior (1)
- anxious ego dissolution (2)
- Aokap7 disruption reduces antioxidant capacity and increases sensitivity to oxidative stress (1)
- aortic insufficiency (1)
- Apophysomyces species display decreased sensitivity to amphotericin B (2)
- apoptosis (1)
- apoptosis in neuronal cells and immune cells (1)
- apoptosis induction (4)
- apoptosis induction under hypoxia (1)
- apoptosis promotion (1)
- appetite changes (increase or decrease) (1)
- appetite changes (increase or decrease) (1)
- appetite loss (1)
- aquatic ecosystem toxicity (1)
- aquatic ecosystem toxicity (1)
- aquatic life damage (1)
- aquatic toxicity (1)
- aquatic toxicity (1)
- aqueous extracts showed weak cytotoxicity to non-cancerous cells (1)
- aromatic amine generation (1)
- arrhythmias (3)
- arsenic (2)
- arsenic accumulation at high peach wood proportions (1)
- Arsenic accumulation in plant tissues (1)
- arsenic accumulation in plant tissues poses safety concerns for medicinal applications (1)
- arsenic cardiovascular toxicity (1)
- arterial dissection (1)
- ascorbic acid degradation during drying process (1)
- ASIC1A disruption increases behavioral sensitivity to opioids (1)
- Aspergillus flavus (1)
- Aspergillus flavus mycotoxin production (aflatoxin B1) (1)
- Aspergillus fumigatus (1)
- Aspergillus fumigatus causes immunosuppression and destruction of parenchymal integrity (1)
- Aspergillus species act as opportunistic pathogens causing infections (1)
- Aspergillus udagawae showed reduced susceptibility to antifungal agents (1)
- associated with higher mortality rates (1)
- associated with rhabdomyolysis (1)
- Associated with toxic medicinal plant (Strychnos nux-vomica containing strychnine and brucine) (1)
- asthma (1)
- asthma exacerbation (1)
- asthma induction (1)
- astringent taste (1)
- astrocyte dysfunction (1)
- At concentrations above 200 µg/mL (1)
- At excessive doses (759 mg/kg) (1)
- At excessive doses (759 mg/kg) (1)
- At high concentrations (50+ μM) (1)
- ataxia (2)
- AtCEP5 renders plants more susceptible to certain fungi (1)
- attenuation by antipsychotics (1)
- attenuation of psychedelic effects by antipsychotics (1)
- Attenuation of vegetative growth in host organism (1)
- Attraction of sap-sucking insects (aphids) (1)
- attractive crops for wild boar (1)
- atypical presentations leading to misdiagnosis and treatment delays (1)
- auditory alterations (1)
- auditory hallucinations (1)
- auto-brewery syndrome (1)
- Autoclaving causes embrittlement and material degradation (1)
- autonomic dysfunction (1)
- Autotoxic compounds (ferulic acid, hydroxycinnamic acid derivatives, jasmonic acid) inhibit fruiting body formation (1)
- aversion to taste and texture (1)
- Avoids cardiovascular complications and osteoporosis associated with long-term vitamin E and pioglitazone use (1)
- Avoids cardiovascular complications and osteoporosis associated with long-term vitamin E and pioglitazone use (1)
- axonal repulsion (1)
- azole and echinocandin resistance through mitochondrial mutations (1)
- Azole drug interactions (2)
- azole drug resistance through ERG11 mutations and ABC transporter upregulation (1)
- azole intrinsic resistance in NAC and NCY species (1)
- azole resistance (19)
- azole resistance associated with biofilm formation (1)
- azole resistance development (2)
- azole resistance emergence (1)
- azole resistance in Aspergillus fumigatus (1)
- azole resistance in isolated strain (1)
- Azole resistance in non-albicans Candida species (1)
- azole resistance in non-albicans species (1)
- Azole resistance in some isolates (1)
- azole resistance mechanisms through CYP gene expansion (1)
- Azole resistance reducing treatment efficacy (1)
- azole tolerance (1)
- azole treatment failure in severe disease (1)
- Azoles contraindicated in pregnancy (1)
- Azoles contraindicated in pregnant patients (1)
- azoles not recommended in pregnancy (1)
- azotaemia (1)
B
- B-cell depletion impairs antibody response (1)
- B. cereus group pathogenicity to humans and animals (1)
- B. cinerea degrades epicuticular wax and suppresses defense enzyme activities (1)
- BACE1 inhibition impairs spine plasticity in healthy tissue (1)
- Bacillus-HT3 lacked antifungal metabolites and biocontrol activity (1)
- Bacterial activity inhibition at high Cr(III) concentrations (1)
- bacterial and fungal superinfections in severe influenza (1)
- bacterial co-infection present in 52.1% of cases (1)
- bacterial diseases (soft rot) (1)
- bacterial diversity loss (1)
- bacterial monocultures without natural microbes promote sterility phenotype in susceptible strains (1)
- bacterial survival challenges in concrete environments (1)
- Bacterial translocation (1)
- Bacterial translocation (1)
- bad drug effects (1)
- bad drug effects (1)
- bad trips (2)
- bad trips (intense fear, confusion, paranoia) (1)
- bark rot (1)
- bark ulceration (1)
- barley (1)
- barrier dysfunction (1)
- batch-to-batch variability (1)
- BBB disruption (1)
- bcltf1 mutation causes reduced pathogenicity under light conditions (1)
- bean aftertaste (1)
- beany odor (1)
- Beauveria bassiana infection increases susceptibility to subsequent fungal infections (1)
- behavioral abnormalities (1)
- behavioral alterations increasing predation risk (1)
- behavioral disruptions (1)
- behavioral issues (1)
- behavioral repellency (1)
- behavioral repellency to budworms (1)
- beneficial microbes may not induce resistance under unfavorable conditions (1)
- beta-HCH and delta-HCH induce growth inhibition (1)
- Betamethasone phosphate eye drops prolonged infection course (1)
- Bifidobacterium-associated bacteremia under specific conditions (1)
- Bilayer instability with excessive cholesterol (1)
- bioaccumulation (5)
- bioaccumulation concerns (3)
- bioaccumulation in aquatic environments (1)
- bioaccumulation in tissues (1)
- bioaccumulation of colored compounds on biomass (1)
- bioaccumulation of dyes (1)
- bioaccumulation of dyes (1)
- bioaccumulation of non-degradable compounds (1)
- bioaccumulation of toxic compounds (1)
- Bioaccumulation of toxic metals (Pb, Cd, Cr, Ni) (1)
- bioaccumulation potential (2)
- bioactivation of parent compounds (1)
- bioactivity constraints without modification (1)
- bioaugmentation alone shows limited effectiveness without plant presence (1)
- bioavailability and pharmacokinetic concerns noted (1)
- bioavailability challenges (1)
- bioavailability concerns (1)
- Bioavailability limitations (2)
- bioavailability of toxic chromium species (1)
- biocidal household products (1)
- biocontrol agent is non-toxic alternative to chemical fungicides (1)
- Biodegradability affected by temperature (1)
- biodeterioration of cultural artifacts (1)
- Biodeterioration of cultural heritage (1)
- biodeterioration of heritage materials (1)
- Biofilm cells resistant to antifungals and host immunity (1)
- biofilm disruption by pharmaceutical compounds (1)
- biofilm formation (2)
- biofilm formation and antifungal resistance (1)
- biofilm formation and antifungal resistance (1)
- biofilm formation prevents antifungal penetration (1)
- Biofilm formation protects against antifungal drugs (1)
- biofilm persistence (1)
- biofilm protection against antifungals (1)
- biofilm thickness and maturity can limit phage impact (1)
- Biofilm-associated antibiotic resistance (1)
- Biofilm-associated azole resistance (1)
- biofilm-associated resistance mechanisms (1)
- biofilm-enhanced drug resistance (1)
- biofilm-mediated antifungal resistance (2)
- Biofilm-mediated antimicrobial resistance (1)
- biofilm-mediated drug resistance (1)
- biofilm-mediated protection from antifungals (1)
- Biogenic amine accumulation (cadaverine, histamine, tyramine) – controlled through fermentation (1)
- biogenic amine accumulation in grapes (1)
- biogenic amine toxicity (1)
- biologic agents may depress immune system (1)
- biological activity decline (1)
- biological pollutants causing vascular inflammation and oxidative stress (1)
- biomagnification (1)
- biomagnification in food chain (1)
- biosafe for animal consumption (1)
- Biosafety concerns with immunocompromised individuals (1)
- biotic deterioration (1)
- Bioweapon development (1)
- bipolar disorder (3)
- bisphenol F exposure linked to hypertension (1)
- bisphosphonate-induced osteonecrosis (1)
- bitter taste (2)
- bitter taste at high concentrations (1)
- bitterness at high polydextrose concentrations (1)
- bitterness from saponins reduces palatability and sensory acceptability (1)
- bitterness in some formulations requiring flavor masking (1)
- black-box nature raises safety concerns (1)
- bladder neck sclerosis (1)
- Blastospore sensitivity to desiccation (1)
- bleeding events (1)
- Bleeding risk with anticoagulants (1)
- Blinding challenges in clinical trials (1)
- bloating from excessive gas production (1)
- blocking autophagy impairs growth regulation and increases cell death under stress (1)
- blocks epithelial immune responses (1)
- blood pressure changes (1)
- blood pressure elevation (2)
- blood products (2)
- bloodstream infection reported in immunocompromised individuals (1)
- Blue light increased deoxynivalenol and nivalenol production (1)
- blue-stain in sapwood (1)
- blue/red combined light nullified individual inhibitory effects (1)
- blueberry (1)
- blurred vision (1)
- Bone loss (1)
- bone marrow suppression (1)
- book deterioration (1)
- boundary violations (1)
- bradycardia (3)
- brain (1)
- brain development impairment in adolescents (1)
- brain edema (1)
- brain edema (1)
- brain edema associated with increased in-hospital mortality (1)
- branch canker formation (1)
- branch dieback (1)
- breakthrough candidemia (1)
- breakthrough candidemia occurred despite prophylactic coverage (1)
- Breakthrough fungemia during antifungal therapy (1)
- Breakthrough IFI occurs in 11.2% of patients on fluconazole prophylaxis (1)
- breakthrough infection (1)
- breakthrough infection (1)
- Breakthrough infection despite therapy (1)
- breakthrough infections (3)
- Breakthrough infections despite prophylaxis (2)
- Breakthrough infections during antifungal prophylaxis (1)
- breakthrough infections with antifungal prophylaxis (1)
- breakthrough infections with echinocandin-resistant strains (1)
- breakthrough invasive mold diseases despite antifungal prophylaxis (1)
- Breakthrough invasive mold diseases during antifungal prophylaxis (1)
- breakthrough trichosporonosis following ineffective antifungal therapies (1)
- brittle nails (2)
- broad antifungal resistance observed (1)
- broad non-selective kinase inhibition leading to adverse effects (1)
- broad toxicity at low concentrations (1)
- Broad-spectrum antibiotic administration and glucocorticoids contributed to immunosuppression and microbial substitution disease (1)
- broad-spectrum antibiotics as predisposing factor (1)
- Broad-spectrum antibiotics cause microbiota depletion and impair immune function (1)
- broad-spectrum antimicrobial applications (1)
- Broad-spectrum IV antibiotics ineffective (1)
- Broccoli and mushroom fortification resulted in less favorable taste responses (1)
- bronchorrhea (1)
- brown blight (1)
- Bruton's Tyrosine Kinase Inhibitor ibrutinib increases cryptococcal risk (1)
- bruxism (1)
- BTEX exposure causes health risks (1)
- BTK degrader (1)
- BTK inhibition (ibrutinib) impairs neutrophil antifungal responses and increases invasive aspergillosis risk (1)
- BTK rs5951308 polymorphism associated with increased aspergillosis risk (1)
- bulb tissue decay (1)
- Burkholderia gladioli potential pathogenicity noted as requiring further assessment (1)
- burning (1)
- burnt flavor development (1)
- but higher doses may achieve comparable results (1)
- but these did not predict negative long-term outcomes (1)
C
- C. albicans pathogenicity (1)
- C. fructicola shows resistance to fludioxonil fungicide (1)
- C. gattii infections may require more aggressive treatment than C. neoformans (1)
- C. glabrata (1)
- Ca2+ alone inhibits bacterial oxidation ability and mineral formation (1)
- Cadmium accumulation (1)
- cadmium accumulation at high concentrations (1)
- Cadmium accumulation in crops (1)
- cadmium and lead cause tubular and glomerular injury (1)
- cadmium and nickel toxicity with excessive consumption (1)
- Cadmium exposure causes growth reduction (1)
- Cadmium induces oxidative stress (1)
- cadmium toxicity (3)
- Cadmium toxicity to bacteria (1)
- caffeine-related jitters and crashes (addressed through combination with adaptogenic mushrooms) (1)
- Calcimycin induces calcium-dependent cell death (1)
- Calcimycin inhibits spore germination and hyphal growth (1)
- calcium depletion (2)
- calcium ions attenuate AFP activity (1)
- calcium oxalate crystal deposition (1)
- cambial damage (1)
- cambial damage (1)
- Can cause diseases in immunosuppressed humans (1)
- cancer risk (1)
- Candida albicans secretes candidalysin activating NLRP3 inflammasome and pro-inflammatory cytokines (1)
- Candida glabrata (1)
- Candida krusei (1)
- Candida parapsilosis (1)
- Candidalysin-induced epithelial damage (1)
- canker development (1)
- canker diseases (1)
- canker formation (3)
- cankers (1)
- cankers (1)
- Cannabis use associated with exacerbation and potential triggering of psychotic symptoms and delusions (1)
- capsule perforation (1)
- CAPZA2 deficiency leads to impaired learning and memory (1)
- carbon footprint from processing (1)
- carcinogenesis (1)
- carcinogenic (2)
- carcinogenic (aflatoxin B1, ochratoxin A) (1)
- carcinogenic and mutagenic effects (1)
- Carcinogenic and mutagenic effects of PAHs (1)
- carcinogenic and neurotoxic effects from heavy metals (1)
- carcinogenic byproducts (1)
- carcinogenic compounds (1)
- carcinogenic compounds (1)
- carcinogenic effects (4)
- carcinogenic risk from Cd and Cr exposure (1)
- carcinogenicity (12)
- carcinogenicity of Cr(VI) (1)
- carcinogens (1)
- Cardiac arrhythmia risk with itraconazole (2)
- Cardiac arrhythmias (4)
- cardiac complications in those with dangerous weight extremes (1)
- cardiac complications in those with dangerous weight extremes (1)
- cardiac dysfunction (1)
- cardiac effects (increased heart rate and contractility potentially leading to arrhythmias) (1)
- cardiac risks (ibogaine) (1)
- cardiac valvulopathy risk (1)
- Cardiac valvulopathy risk from ergolines (1)
- Cardiotoxic activity (1)
- cardiotoxicity (4)
- cardiotoxicity (1)
- cardiotoxicity induction (1)
- cardiovascular (1)
- cardiovascular (1)
- cardiovascular and immunological toxicity (1)
- Cardiovascular and physiological arousal side effects (1)
- cardiovascular collapse at high doses (1)
- Cardiovascular complications (1)
- cardiovascular disease (2)
- cardiovascular effects (blood pressure and heart rate elevation) (1)
- cardiovascular elevation (1)
- cardiovascular irregularities (1)
- cardiovascular reactions (1)
- cardiovascular risks with MDMA (1)
- caries (1)
- carotid artery occlusion (1)
- Carrageenan pro-inflammatory effects (1)
- carvacrol classified as GRAS (Generally Recognized as Safe) by FDA (1)
- cascade of unnecessary interventions (1)
- Caspofungin (4)
- caspofungin ineffectiveness (1)
- caspofungin resistance (47.05% in NAC) (1)
- Cassia cinnamon contains hepatotoxin coumarine at up to 5% concentration versus trace amounts in C. verum (1)
- CAT enzyme activity inhibition at specific time points (1)
- catabolite repression from certain carbon sources like fructose (1)
- causes biomass reduction (1)
- causes bulb rot and significant economic loss (1)
- causes dendritic spine loss (1)
- causes dendritic spine loss (1)
- causes destructive plant pathogenesis in Vaccinium crops (1)
- Causes green mold disease and crop losses in cultivated mushrooms (1)
- causes invasive infections in immunocompromised patients (1)
- causes leaf drying (1)
- causes loss of fur pigmentation through BACE2 inhibition (1)
- causes multiple organ damage (1)
- causes pulmonary inflammation and tissue damage (1)
- causes root rot (1)
- causes root rot and plant death (1)
- causes serious disease in forestry plantations (1)
- causes severe acute and chronic toxicities (1)
- causes severe post-harvest losses in apple and pear crops (1)
- causes significant economic losses (1)
- causes significant economic losses (1)
- causes vascular discoloration and plant wilting (1)
- causing cellular injury to lipids (1)
- causing green mold disease in cultivated mushrooms (1)
- caution needed for larger sample safety confirmation (1)
- cautioned use at elevated doses (1)
- cave ecosystem impacts (1)
- cavernous sinus thrombosis (1)
- CBC deletion mutants show reduced pathogenicity but BcCBP80 deletion completely abolishes sclerotia formation and conidiation (1)
- cell death at elevated concentrations (1)
- cell differentiation regulation (1)
- cell division disruption (1)
- cell lysis (1)
- cell membrane damage (1)
- cell membrane disruption (2)
- cell toxicity (1)
- cell viability reduction at high concentrations (1)
- cell viability reduction in both fibroblasts and keratinocytes at higher doses (1)
- cell wall breakdown (1)
- cell wall components resistant to antifungal drugs (1)
- cell wall degradation (3)
- cell wall degradation during infection (1)
- cell wall degradation mechanisms (1)
- cell wall disruption (1)
- cell wall stress can compromise protein secretion efficiency (1)
- cell-free fermentation broth showed no antifungal activity (1)
- cellular abnormalities and structural changes in treated cells (1)
- cellular cytotoxicity (1)
- cellular damage (3)
- cellular damage from reactive oxygen species (1)
- cellular dysfunction (1)
- cellular membrane destruction (1)
- cellular stress (1)
- cellular stress induction (1)
- cellular stress response (1)
- cellular toxicity (1)
- Cellular toxicity through oxidative stress (1)
- Cellulose degradation by pathogens (1)
- Central nervous system depression (1)
- Central sensitization (1)
- ceramide synthase inhibition (2)
- cereals (1)
- cerebral edema (1)
- cerebrovascular incidents (1)
- Certain amino acid substitutions shown to increase PrP misfolding and neurotoxicity (1)
- certain bile acids exhibit antimicrobial activity that may require careful modulation (1)
- certain fermentation processes may produce antifeedants (1)
- certain fungal taxa produce mycotoxins and compromise epithelial barrier function (1)
- certain personality disorders (1)
- certain species are plant pathogens (onion green mold rot, maize ear rot) (1)
- Cgm1 inhibition leads to temperature sensitivity and reduced fungal growth (1)
- challenge of controlling pathogen spread (1)
- challenges in culturing strict anaerobes and slow-growing species (1)
- Challenges in distinguishing species due to overlapping fluorescence signatures (1)
- challenges in reproducibility (1)
- challenges with blinding and expectation bias (1)
- challenges with emerging pollutants (1)
- challenges with long-term efficacy (1)
- Challenging experiences (2)
- Challenging experiences during acute use (1)
- challenging experiences during psychedelic administration (1)
- challenging experiences including fear (1)
- challenging experiences may be attenuated (1)
- challenging experiences with anxiety and despair (1)
- challenging moments during session (1)
- challenging psychological experiences including grief and physical distress (1)
- challenging/negative experiences (1)
- challenging/negative experiences (1)
- chemical and physical treatment methods produce hazardous by-products (1)
- chemical contamination (1)
- chemical fungicide alternative to reduce environmental contamination (1)
- Chemical fungicide dependence reduction (1)
- chemical fungicide overuse may negatively impact human health and environment (1)
- chemical fungicide suppresses beneficial bacterial taxa (1)
- chemical fungicides cause environmental pollution and health consequences (1)
- chemical fungicides cause pathogen resistance (1)
- Chemical instability under light (1)
- chemical pesticide use creates residues and pathogen resistance (1)
- chemical stability of mycotoxins resists food processing (1)
- chemoresistance (1)
- chemoresistance promotion (1)
- chemoresistance promotion (1)
- chemotherapy-induced immunosuppression (1)
- Chernobyl disaster in 1986 caused temporary concern about Cesium-137 contamination (1)
- chewy mushrooms (1)
- chilling injury if stored below 0°C (1)
- chills (1)
- chills (1)
- Chitinase silencing reduced fungal sporulation and growth rate (1)
- chitosan dampening of inflammatory immunity in some contexts (1)
- chitosan is GRAS approved (1)
- chitosan-containing composites showed accelerated fungal degradation (1)
- chlorine dioxide instability to light and heat (1)
- Chlorine gas exposure causes respiratory difficulties (1)
- chlorophyll depletion (1)
- chlorosis (1)
- ChnagG enzyme degrades salicylic acid (1)
- cholesterol (1)
- Chromate-induced reactive oxygen species generation (1)
- chromatin remodelling complex mutations can lead to growth defects and stress sensitivity (1)
- chromium genotoxicity (1)
- chromium genotoxicity (1)
- chromium toxicity (1)
- Chromium toxicity (Cr(VI) formation from Cr(III)) (1)
- chromosomal aberrations (1)
- chromosomal damage (1)
- chromosomal instability (1)
- chromosomal instability (1)
- Chronic administration showed no sustained therapeutic benefits (1)
- chronic bacterial infections trigger neuroinflammation (1)
- chronic downregulation of 5-HT2AR may contribute to PTSD-related symptoms and cognitive impairment (1)
- chronic inflammation (4)
- chronic kidney disease (1)
- chronic lower respiratory tract infections with long-term steroid use (1)
- chronic metal exposure causing neurological disorders (1)
- Chronic microbial infections trigger neuroinflammation (1)
- chronic respiratory infections (1)
- chronic stress effects (1)
- Chronic stress exacerbation (1)
- chronic wood infection (1)
- chronic wood infections (1)
- Ciclosporin and glucocorticoid-induced immunosuppression leading to opportunistic fungal infections (1)
- circadian clock disruption (1)
- circDS-1 overexpression causes morphological dysplasia and abnormal growth (1)
- citric acid (1)
- citric acid calcium metabolism interference (1)
- citrinin contamination risk in some Monascus species (1)
- citrinin production (mycotoxin) (1)
- citrus (1)
- Clarithromycin and lascufloxacin were ineffective (1)
- Clarithromycin and lascufloxacin were ineffective as initial antibiotic treatments (1)
- clastogenic effects (1)
- Claustrophobia concerns with MRI (1)
- Climate change and drought conditions promote fungal growth (1)
- clinical failures with amphotericin B and fluconazole monotherapy (1)
- clinical resistance (1)
- Clinical resistance due to underlying disease (1)
- Clinical resistance due to underlying diseases (1)
- Clinical resistance potential (1)
- Clonostachys rosea causes plant disease and tuber rot in Gastrodia elata (1)
- closely related species difficult to distinguish individually (1)
- clotrimazole in C. kreiselii strain (1)
- clove EO was GRAS classified (1)
- clove EO was GRAS classified (1)
- CNS invasion risk (1)
- CNS involvement associated with poor prognosis (1)
- Co-precipitation of unwanted substances during purification (1)
- CO2-tolerant strains show reduced susceptibility to certain therapeutic interventions (1)
- coagulopathy (1)
- coating designed for food safety applications (1)
- cobalt leaching into solution (1)
- cognitive and emotional demands on participants (1)
- cognitive confusion (1)
- cognitive decline (1)
- cognitive disruption (1)
- cognitive impairment (5)
- Cognitive impairment at high doses (1)
- cognitive impairments at microdose levels (1)
- cognitive problems (1)
- Cognitive rigidity perpetuation (1)
- cold chain requirements (1)
- cold chain requirements (1)
- Cold stress induces oxidative damage through ROS generation (1)
- cold-induced oxidative stress damage (1)
- colitis (1)
- Colletotrichum tofieldiae infection reduces plant growth (1)
- colonization inhibition under high contamination (1)
- color instability during processing and storage (1)
- community disruption under certain conditions (1)
- Comorbidities obscuring diagnosis (1)
- Compartment syndrome causes ischemia and impedes healing (1)
- compensatory cell wall remodeling under drug treatment (1)
- compensatory mechanisms reduce therapeutic potential (1)
- compensatory mechanisms reduce therapeutic potential (1)
- competing microorganisms reduce fungal cultivation success (1)
- competition for nutrients (1)
- competition from other anions reduces efficiency (1)
- competition with indigenous microorganisms (1)
- competitive nutrient absorption interactions (1)
- complement activation-related pseudoallergy (1)
- complete azole resistance (1)
- Complete growth inhibition of contaminating fungi (Penicillium italicum, Rhizopus stolonifer, Fusarium oxysporum, Trichoderma sp.) and bacteria (Bacillus, Serratia, Staphylococcus species) (1)
- complete inhibition not achieved at tested concentrations (1)
- complete suppression of cuticle penetration capability (1)
- Complex etiology and quiescent infections complicate diagnosis (1)
- Complex mutations can confer stress tolerance and drug resistance in pathogenic fungi (1)
- complexity of herbal formulas limiting mechanism clarity (1)
- complicated drug-drug interactions (1)
- Complications from prolonged antifungal therapy (1)
- complications from severe immunosuppression (1)
- Compost alone showed limited effectiveness (1)
- compost-introduced heavy metals (Cd, Zn) (1)
- compound 9d caused cell morphology disruption in PSA bacteria (1)
- compound selectively targets fungal mating pathway (1)
- compromise microbial network stability (1)
- compromised BBB transcytosis (1)
- Compromised gut barrier function (1)
- compromised immune function (2)
- compromised nutrient homeostasis (1)
- compromises adaptive decision-making (1)
- compromises pathogen clearance (1)
- compromising fruit quality and shelf life (1)
- compromising host clearance of infection (1)
- compulsion for repeated use (1)
- concentrations above 20% may negatively impact sensory and technological properties (1)
- concern regarding open wound exposure (1)
- concerns about abuse potential (1)
- Concerns about addiction with MDMA (1)
- concerns about ecosystem stability (1)
- concerns about long-term effects (1)
- concerns about potential dangers (1)
- concerns about psychedelic actions in schizophrenia context (1)
- concerns about substance use disorder (1)
- Concerns raised about validity of claimed antiviral properties due to methodological issues (1)
- concerns regarding scalability and cost-effectiveness (1)
- concomitant infections exacerbate respiratory disease (1)
- condensate formation exacerbates pathology (1)
- confabulation risk (1)
- confusion (5)
- confusion with other pathogens (1)
- constipation (3)
- constipation from unabsorbed fatty acids (1)
- Constitutive dephosphorylation prevents neurite outgrowth (1)
- Consumer acceptance barriers (2)
- consumer privacy concerns with digital tracking (1)
- consumer resistance to genetically modified organisms (1)
- consumer skepticism regarding efficacy (1)
- contaminant-induced mycotoxicity (1)
- contaminants causing allergic reactions and pathogenic infections (1)
- contaminated gases (1)
- contaminated pistachios pose serious health risks (1)
- contaminated soils affect agricultural productivity and human health through food chain contamination (1)
- contamination accumulation in soils (1)
- Contamination causes misannotation of genes (1)
- contamination challenges in culture systems (1)
- Contamination from mold growth (1)
- contamination migration (1)
- contamination risk (1)
- contamination risk from green mold in some substrate conditions (1)
- contamination risks (1)
- contamination risks during production (1)
- contamination susceptibility at −20°C treatment (1)
- contamination with PCR inhibitors (1)
- Context dependency limits field effectiveness (1)
- context-dependent benefits (1)
- context-dependent effectiveness (1)
- Context-dependent results (1)
- continued drainage (1)
- continuous cropping increases disease incidence and pathogen abundance (1)
- continuous cultivation leads to decreased bioactive compound production (1)
- Continuous cultivation reduces yield (1)
- Continuous monocropping increases disease incidence and pathogen proliferation (1)
- Contraindicated in bipolar disorder and psychosis (1)
- contraindicated in patients with family history of psychotic disorders or suicidality (1)
- Contraindicated in pregnancy/nursing (1)
- contraindicated in psychiatric illness history (1)
- Contraindicated in psychosis spectrum disorders and mania (1)
- contraindicated in psychotic disorders (3)
- contraindicated in psychotic or bipolar disorder history (1)
- contraindicated in schizophrenia and psychotic features (1)
- Contraindicated in uncontrolled hypertension (1)
- Contraindicated in uncontrolled hypertension (1)
- contraindicated psychoactive medications (antidepressants, anxiolytics) required discontinuation (1)
- contraindicated with antipsychotics and mood stabilizers (1)
- contraindicated with MAOIs (1)
- contraindications include brain-organic conditions (1)
- Contraindications include diabetes mellitus (1)
- Contraindications include psychosis (1)
- contraindications noted for some repurposed drugs when used off-label (1)
- control group showed highest mortality and tissue damage (1)
- controlled stomatal closure (1)
- controlled substance classification (1)
- conventional breeding time-consuming and costly (1)
- conventional progesterone shows poor bioavailability (1)
- conventional treatment methods ineffective at eliminating these compounds (1)
- convulsions (4)
- copper contamination (1)
- copper deficiency risk (zinc excess) (1)
- copper toxicity (2)
- copper toxicity (1)
- Copper toxicity at elevated concentrations (1)
- Copper toxicity at elevated concentrations (1)
- Copper toxicity causing nausea and vomiting (1)
- copper toxicity to bacteria limits Cu²⁺ removal (1)
- coprine (1)
- Coral reef disease causative agent (2)
- corneal damage (1)
- corneocyte detachment (1)
- Corneodesmosome protein degradation (1)
- coronary vasoconstriction (1)
- cortical cankers (1)
- Corticosteroid misuse increases risk (1)
- corticosteroid side effects including infection risk (1)
- Corticosteroid therapy associated with unchecked fungal overgrowth and increased mortality in invasive fungal disease (1)
- corticosteroid therapy contributed to immunosuppression (1)
- Corticosteroid therapy increases disease severity and progression (1)
- corticosteroid therapy may increase susceptibility to invasive fungal infections (1)
- corticosteroid use as potential risk factor (1)
- corticosteroid use as risk factor for aspergillosis (1)
- corticosteroid use associated with higher mortality (1)
- Corticosteroid use associated with increased IPA mortality (1)
- corticosteroid use can increase risk (1)
- corticosteroid use can worsen tinea incognito (1)
- corticosteroid use complications (1)
- corticosteroid use exacerbates fungal keratitis (1)
- Corticosteroid use for COVID-19 management increased mucormycosis risk (1)
- corticosteroid use may impair CAR T-cell therapy efficacy (1)
- Corticosteroid-induced hyperglycemia (1)
- corticosteroid-induced hyperglycemia and diabetes (1)
- Corticosteroid-induced immune suppression (1)
- Corticosteroid-induced immunosuppression (2)
- Corticosteroid-induced immunosuppression increasing fungal infection risk (1)
- Corticosteroid-related immunosuppression (1)
- Corticosteroids increase IFI risk (1)
- Corticosteroids increase infection risk (1)
- cotton bandages shed fibers and stick to wound surface (1)
- Cottonseed contains gossypol (1)
- Cr (III) toxicity causes oxidative stress (1)
- cracking (1)
- Cravings leading to increased use (1)
- Crohn's disease (1)
- crop damage (1)
- crop failure (1)
- crop failure (1)
- crop lavage contraindicated for oily or caustic materials and hydrocarbons (1)
- crop loss (1)
- crop losses (1)
- crop susceptibility (1)
- Crop yield and quality losses in wheat (1)
- Cross-contamination in non-sterile samples affecting BDG specificity (1)
- Cross-contamination risk during culture if protocols not followed properly (1)
- cross-contamination risks (1)
- Cross-reactivity of B. helicus with Histoplasma antigen assays causing diagnostic ambiguity (1)
- cross-reactivity with cholesterol in mammalian cell membranes (1)
- cross-reactivity with closely related species (1)
- cross-resistance (4)
- Cross-resistance among azole agents (1)
- cross-resistance among azoles (1)
- cross-resistance between antifungal classes (1)
- cross-resistance between azoles (1)
- cross-resistance development (1)
- cross-resistance selection potential between agricultural fungicides and medical compounds (1)
- cross-resistance to clinical azoles (3)
- cross-resistance to medical azoles from agricultural fungicide exposure (1)
- cross-resistance to other fungicide classes (1)
- cross-resistance to other polyenes (nystatin, natamycin) (1)
- cross-resistance to related fungicides (1)
- cross-resistance to triazoles (1)
- cross-resistance with agricultural fungicides (1)
- Cross-resistance with existing treatments (1)
- crude ash (1)
- crude essential oil showed limited efficacy (1)
- crude essential oil showed limited efficacy (1)
- crude essential oil showed no therapeutic benefit (1)
- crude fat (1)
- crude protein content (1)
- cryptic infections in host fungi (1)
- cryptic infections in host fungi (1)
- Cryptococcal antigen test negative in C. albidus infections (2)
- Cu2+ (1)
- cultural heritage deterioration risk (1)
- culture degeneration leading to altered antifungal susceptibility (1)
- culture degeneration reducing drug efficacy (1)
- culture-negative sepsis complications (1)
- curcumin showed no protective effect in some studies (1)
- Current antifungal therapy (itraconazole) shows only 67.6% cure rate with 6.1% amputation rate in clinical practice (1)
- cyanic toxicity (1)
- Cyathostoma americana causes granulomatous inflammation and necrosis (1)
- cycling pattern of depressive and euphoric mood states (1)
- cyclocybene may exhibit antifungal properties limiting biosynthesis in fungal hosts (1)
- Cycloheximide inhibits fungal growth (1)
- Cycloheximide inhibits spore germination and mycelial growth (1)
- Cyclopentanone inducer showed potential toxicity at high concentrations (1)
- cyclophosphamide-induced side effects including immunosuppression and oxidative stress (1)
- Cyclopiazonic acid is a fungal neurotoxin with potential negative effects (1)
- cyclopiazonic acid is toxic (1)
- cylindrospermopsin from certain cyanobacteria species (1)
- CYP3A4 inhibition potential (ganoderic acid A and ganoderenic acid B) (1)
- cytochrome P450 3A4 inhibition with potential drug interactions (1)
- cytochrome P450 enzyme inhibition (1)
- cytokine storm (1)
- cytokine storm from immune overactivity (1)
- cytoplasmic leakage (1)
- Cytospora pyri causes tissue necrosis (1)
- cytotoxic (1)
- Cytotoxic activity (C. xiphidipus sterol) (1)
- cytotoxic chemotherapy (1)
- cytotoxic effects (2)
- cytotoxic effects from ionophore activity (1)
- cytotoxic effects in some peptides (1)
- cytotoxic effects on cancer cell lines at therapeutic doses (1)
- Cytotoxic effects on cancer cells (intended) (1)
- Cytotoxic effects on cancer cells only (1)
- Cytotoxic mushrooms causing liver/kidney damage (1)
- cytotoxic potential requires careful dosing (1)
- cytotoxic to brine shrimp at LC50 of 192.23 µg/mL (indicating some toxicity at high concentrations) (1)
- cytotoxicity (4)
- Cytotoxicity against human cell lines (1)
- Cytotoxicity at high concentrations (4)
- cytotoxicity at high concentrations (≥2.5%) (1)
- cytotoxicity at high concentrations (800 µg/mL) (1)
- cytotoxicity at high concentrations (Maitake at 1000 µg/mL) (1)
- cytotoxicity at high concentrations in Caco-2 cells (1)
- cytotoxicity at high concentrations in keratinocytes above 500 µg/mL (1)
- Cytotoxicity concerns (1)
- cytotoxicity concerns with some synthetic polymers (1)
- cytotoxicity effects limited (1)
- cytotoxicity in human fibroblasts (1)
- cytotoxicity in mammalian cells (1)
- cytotoxicity observed at 2000 µg/mL for some extracts (1)
- cytotoxicity observed at concentrations above 50 μg/mL (1)
- Cytotoxicity observed at concentrations above 80 µg/mL CFEO (1)
- Cytotoxicity observed at concentrations exceeding 150 μg/mL (1)
- cytotoxicity observed at highest concentrations tested (5 mg/mL for fractions, 50 mM for GABA, 100 µM for SCFAs) (1)
- Cytotoxicity observed in 2-methyl tetrahydrofuran extract at low concentrations (1)
- cytotoxicity of some nanomaterials (1)
- cytotoxicity to activated CD4+ T cells (C. albicans DNA alone) (1)
- cytotoxicity to fibroblast cells at high concentrations (above 50 μg/mL) (1)
- Cytotoxicity to human cells (1)
- cytotoxicity to human embryonic stem cells (1)
- Cytotoxicity to human esophageal epithelial cells (76.7% at highest concentration after 72 hours) (1)
- cytotoxicity to HUVEC and MC3T3-E1 cells (1)
- Cytotoxicity to mammalian cells (2)
- cytotoxicity to mammalian cells (MDCK, macrophages, keratinocytes, fibroblasts) (1)
- cytotoxicity to normal cells at high concentrations (1)
- Cytotoxicity to normal cells at higher concentrations (1)
D
- D1 dopamine receptor antagonism impairs approach memory formation (1)
- dam passage failures (1)
- damage from soil tillage (1)
- dangerous behavior (1)
- Dark toxicity concerns with photosensitizers (1)
- Database limitations for rare species identification (1)
- DBP accumulation causes delayed plant growth (1)
- DCA may contribute to colorectal carcinogenesis through DNA damage induction (1)
- Dcir deficiency predisposes to autoimmune diseases such as arthritis (1)
- death (1)
- death (1)
- debilitation (1)
- declined biological activity with increased soil salinity (1)
- declining adsorption capacity with repeated cycles (1)
- declining probiotic viability after day 14 due to nutrient depletion and metabolic by-product accumulation (1)
- declining reactivity over time (1)
- decreased activity in commercial supplements over time (1)
- decreased albumin and alanine aminotransferase levels compared to control (1)
- decreased amino acid absorption (1)
- decreased amphotericin B susceptibility (1)
- Decreased antibody levels during effective antifungal treatment (1)
- decreased antifungal susceptibility (1)
- decreased appetite (2)
- decreased appetite (1)
- decreased ATP production (1)
- decreased carbohydrate degradation pathways in some groups (1)
- decreased disease severity (1)
- decreased DNA repair capacity (1)
- Decreased Firmicutes (1)
- decreased forage digestibility (1)
- decreased GABA transmission (1)
- decreased germination capacity (1)
- decreased indole and skatole production (1)
- decreased macrophage phagocytosis and killing capacity (1)
- decreased mechanical strength upon polysaccharide addition (1)
- decreased metabolite synthesis with temperature fluctuations (1)
- decreased mood when combined with cannabis (1)
- decreased mycorrhization (1)
- decreased organic acids (1)
- decreased physical activity levels (1)
- decreased polyunsaturated fatty acids (1)
- decreased productivity (1)
- decreased quality (1)
- decreased root development (1)
- decreased secondary metabolite production (1)
- decreased secondary metabolite production (1)
- decreased serum IgM at higher AGP doses (1)
- decreased sociability (1)
- Decreased solubility and water/oil holding capacity with multiple freeze-thaw cycles (1)
- decreased stress resistance (1)
- decreased survival (1)
- decreased susceptibility to amphotericin B (2)
- decreased tensile strength with ultrasonic treatment (1)
- decreased vaccine efficacy (1)
- decreased viability at low shear conditions (1)
- decreased virulence (1)
- decreased virulence in mouse model (1)
- decreased vitamin B12 metabolism pathways in some groups (1)
- decreased voriconazole susceptibility (1)
- decreases chlorophyll content (1)
- decreases fruit yield and quality (1)
- decreases mushroom yield and quality (1)
- decreases quality components (1)
- defective CFTR chloride channel compromises innate immunity (1)
- defective DC maturation (1)
- defective DC maturation (1)
- defective serum survival (1)
- deferoxamine enhances Mucorales pathogenicity by providing accessible iron (1)
- Deferoxamine enhances Mucorales pathogenicity despite clinical use (1)
- Deficiency in dectin-1/dectin-2 increases susceptibility (2)
- defoliation (2)
- defoliation and flower damage in almond crops (1)
- deformity (1)
- deformity (1)
- degradation during storage (1)
- degradation during storage (1)
- Degradation in BALF at 37°C renders samples unsuitable for analysis (1)
- degradation of scaffold structure under certain conditions (1)
- Degradation under elevated temperatures compromises diagnostic accuracy (1)
- delayed access to effective treatment for non-responders (1)
- delayed antibody response may limit early detection utility (1)
- Delayed antifungal therapy (1)
- Delayed antifungal therapy associated with poor outcomes (1)
- delayed antifungal treatment led to mortality (1)
- Delayed antigen testing may result in progression to symptomatic disease (1)
- delayed antimicrobial therapy (1)
- Delayed antiretroviral therapy initiation (concern expressed by 10% of respondents) (1)
- Delayed antiretroviral therapy initiation concerns (1)
- Delayed antiretroviral therapy initiation due to screening concerns (1)
- Delayed ART initiation concerns (1)
- delayed biogas peak (1)
- delayed diagnoses (1)
- delayed diagnosis (5)
- delayed diagnosis and treatment (1)
- delayed diagnosis and treatment initiation (1)
- delayed diagnosis complications (1)
- Delayed diagnosis due to culture difficulties (1)
- delayed diagnosis due to lack of infrastructure and trained personnel (1)
- Delayed diagnosis due to prolonged culture times can result in poor visual outcomes (1)
- Delayed diagnosis due to prolonged culture times can result in poor visual outcomes (1)
- Delayed diagnosis in tinea incognito (1)
- Delayed diagnosis increases mortality (1)
- Delayed diagnosis increases mortality risk (1)
- delayed diagnosis leading to complications (1)
- delayed diagnosis leading to increased mortality (1)
- delayed diagnosis leading to prolonged bleeding episodes and complications (1)
- delayed diagnosis leads to excessive antibiotic use and ineffective treatment (1)
- Delayed diagnosis leads to ineffective therapeutics and development of multidrug resistance (1)
- Delayed diagnosis leads to poor outcomes (1)
- delayed diagnosis worsens prognosis (1)
- delayed fungal killing (1)
- Delayed germination observed with nanocoated conidia initially (1)
- delayed germination of nanocoated conidia (1)
- delayed germination of nanocoated conidia (1)
- delayed identification due to negative Biofire panel results (1)
- delayed initiation of antifungal treatment (1)
- delayed metamorphosis (1)
- Delayed or inappropriate antifungal therapy associated with high mortality rates (1)
- delayed primordia initiation (1)
- delayed primordia initiation (1)
- delayed recognition of actual pathogens (1)
- Delayed recognition of fungal infection complications (1)
- Delayed results impact clinical decision-making (1)
- Delayed surgical intervention increases mortality (1)
- delayed targeted therapy (1)
- delayed therapeutic effects (1)
- Delayed therapy initiation (1)
- delayed transplantation increases neurological complications (1)
- Delayed treatment associated with increased mortality (1)
- Delayed treatment increases mortality to 14% (1)
- delayed treatment initiation (1)
- delayed treatment leading to disease progression (1)
- delayed wound excision (1)
- Delayed wound healing (1)
- delays in detection and lack of effective case management contribute to disease progression (1)
- delays in diagnosis and treatment (1)
- Delays in diagnosis and treatment initiation (1)
- deletion of BbStp13 reduces virulence and biocontrol effectiveness (1)
- Deletion of lon1 increases heat sensitivity (1)
- Deletion of Lon1 protease or autophagy genes increases sensitivity to heat stress and cellular damage (1)
- Deletion of PratfA increases oxidative stress susceptibility (1)
- deletion of SsSR or SsCYP51 reduces pathogen virulence and stress tolerance (1)
- deletion of STPs causes attenuated virulence reducing pathogenicity (1)
- Delignification causing structural weakness (1)
- delirium (1)
- delusion (1)
- delusional thinking (1)
- delusional thinking (1)
- delusions (1)
- demonstrates low acute toxicity with no evidence of neurotoxicity (1)
- dendritic atrophy (1)
- dendritic spine loss (1)
- density variations affecting structural integrity (1)
- deoxyarbutin cytotoxicity (1)
- deoxynivalenol (1)
- Deoxynivalenol and fumonisins are emetic (1)
- dependency on AI (1)
- dependency on dissociative experiences (1)
- dependency on strain virulence (1)
- depersonalization (9)
- Depersonalization and derealization (1)
- depletes nitric oxide levels (1)
- Depolymerization reducing molecular weight and bioactivity (1)
- depression-like behavior (1)
- depression-like symptoms (1)
- depressive episodes (1)
- derealization (5)
- dermatitis (3)
- dermatophyte infections cause itching (1)
- destabilization (1)
- Detection of non-relevant organisms can reduce sequencing efficiency without enrichment steps (1)
- deteriorated flavor and taste (1)
- detrimental effects from intensive tillage (1)
- Development of antifungal resistance (2)
- Development of azole resistance (1)
- Development of azole resistance reducing efficacy of medical azoles (1)
- Development of cross-resistance to clinical triazoles (1)
- Development of drug resistance (1)
- development of fungicide resistance (2)
- Development of multi-fungicide resistance reduces treatment efficacy (1)
- Development of peptide resistance in certain mutants (1)
- development of resistant strains (1)
- developmental defects (1)
- developmental defects (1)
- developmental defects in zebrafish (1)
- developmental delays (1)
- developmental effects (1)
- developmental impairment (1)
- developmental neurotoxicity (1)
- dexamethasone increases IFI risk (1)
- Dextran anaphylaxis risk with parenteral use (1)
- diabetes (1)
- diabetes (1)
- diabetes increases fungal growth and CotH3 expression (1)
- diabetes mellitus as negative prognostic factor (1)
- diabetes mellitus associated with lower odds of complete recovery (1)
- diagnostic delays (2)
- diagnostic delays due to misidentification as bacterial cellulitis (1)
- diagnostic delays of several months noted in literature (1)
- Diagnostic errors due to atypical histopathological features (1)
- diagnostic gaps (1)
- diagnostic limitations (1)
- Diagnostic limitations in antifungal susceptibility testing (1)
- diagnostic tool for pathogen detection (1)
- diarrhea (5)
- dibenzofuran toxicity to bacteria (1)
- DIC triggers systemic hematologic dysfunction and life-threatening hemorrhage (1)
- did not cause hypoglycemia or weight gain (1)
- did not directly inhibit spore germination or fungal surface development (1)
- did not induce hypersensitivity reactions characteristic of complete resistance (1)
- Did not restore impaired glucose-stimulated insulin secretion (1)
- dieback (2)
- diesel and hydrocarbon toxicity to human health and ecosystems (1)
- difenoconazole toxicity to non-target organisms (1)
- differential efficacy between Candida species (1)
- differential inhibitory effects dependent on concentration (1)
- difficulties in compound purification (1)
- difficulty maintaining blinding in trials (1)
- digestive issues (1)
- digestive system (1)
- digestive system (1)
- dilution effects during fractionation (1)
- dimensional instability (1)
- diminished intracellular survival capacity (1)
- diminished melanin production (1)
- diminished reward sensitivity with some antidepressants (1)
- dioxins (1)
- disassociation (1)
- discoloration (1)
- discoloration (yellowing, browning) (1)
- discoloration of surimi with higher FVP concentrations (1)
- discomfort (1)
- discomfort (1)
- discomfort and pain during treatment (1)
- discontinuation rates comparable to placebo (1)
- discontinuation rates comparable to placebo (1)
- discontinuation syndrome with missed doses (1)
- Discontinued HLH therapy due to clinical decline (1)
- discontinuity of consciousness (1)
- Discordant biomarker results complicating diagnosis (1)
- disease causation (1)
- disease causation through rhizome and root rot (1)
- Disease causative agents identified (1)
- disease causes necrotic lesions (1)
- Disease causes yield losses up to 70% (1)
- disease emergence (1)
- disease exacerbated by fire events (1)
- disease exacerbation (2)
- disease induction (1)
- disease manifestation under environmental stress (1)
- disease manifestation under environmental stress (1)
- disease pathogenicity (1)
- disease progression (2)
- disease progression despite appropriate therapy (1)
- Disease progression despite itraconazole therapy (1)
- Disease progression despite itraconazole therapy and therapeutic drug levels (1)
- disease progression despite treatment (1)
- Disease progression under itraconazole therapy (1)
- Disease relapse upon treatment discontinuation (1)
- disease severity up to 70% infection rates (1)
- disease susceptibility (1)
- Disease-induced crop loss and reduced plant quality (1)
- disembodiment (1)
- Disinfectant resistance (2)
- disorganized thinking (1)
- disorientation (1)
- dispersants can cause secondary contamination (1)
- disrespectful care (1)
- disrupt plant-microbe symbiosis (1)
- disrupted gluten network structure (1)
- disrupted gut barrier integrity (1)
- disrupted mycelial metabolism due to high sugar content (1)
- disrupted navigation (1)
- disrupted physiological processes (1)
- disrupted physiological processes (1)
- disrupted stress-response resolution (1)
- disrupted synaptic function (1)
- disrupted traditional food systems (1)
- disruption by excessive nitrogen and phosphorus fertilizers (1)
- Disruption of gut microbiota (1)
- disruption of microbial communities (2)
- Disruption of Mo insertase linkage regions impairs nitrate utilization and cellular growth (1)
- disruption of native microbial communities (1)
- Disruption of nitrogen assimilation and IAA biosynthesis blocks germination (1)
- Disruption of primary cilia components causes cognitive deficits (1)
- disruption reduces kojic acid production and oxidative stress tolerance (1)
- disrupts cell structure (1)
- disrupts inflammatory balance (1)
- disrupts Sez6 processing (1)
- disrupts trans-synaptic gene expression (1)
- dissemination of antibiotic resistance genes via horizontal gene transfer (1)
- Dissociation (7)
- dissociation reported in some cases (1)
- dissociative disorders (1)
- dissociative disorders (1)
- dissociative effects (4)
- dissociative experiences (when unwanted) (1)
- dissociative experiences (when unwanted) (1)
- dissociative side effects (1)
- dissociative states (2)
- dissociative symptoms (2)
- dissociative symptoms monitored (1)
- distressing sensory experiences (1)
- Dizziness (16)
- DNA damage (16)
- DNA damage (1)
- DNA damage at elevated doses (1)
- DNA damage potential (1)
- DNA degradation (1)
- DNA mutagenic properties (1)
- DNA strand breaks (2)
- DNA/RNA damage (1)
- does not affect bacterial pathogens (1)
- does not detect pseudo-dermatophytes or non-dermatophyte molds that may cause infections (1)
- dopamine depletion effects (1)
- dopamine disruption (1)
- dose variability (1)
- dose-dependent cytotoxicity at concentrations >5 mg/kg in some studies (1)
- dose-dependent cytotoxicity at high concentrations (1)
- dose-dependent effects require careful consideration (1)
- dose-dependent inhibitory effects on PC12 cells at high concentrations (>200 µg/mL) (1)
- dose-dependent toxicity observed (1)
- dose-dependent toxicity reported with green tea polyphenols in fasted dogs (1)
- dose-limiting toxicity (1)
- Dread of ego dissolution (2)
- Dread of ego dissolution (1)
- dread of ego dissolution (aversive experience component) (1)
- drought intolerance (1)
- drought stress causes cell dehydration and ROS accumulation (1)
- drowsiness (1)
- Drug discontinuation due to toxicity (1)
- drug discontinuation due to toxicity (6.0%) (1)
- drug efflux-mediated resistance (1)
- drug interactions (5)
- Drug interactions between ciclosporin and itraconazole (1)
- Drug interactions between ciclosporin and itraconazole affecting drug metabolism (1)
- drug interactions compromising patient safety (1)
- Drug interactions limiting efficacy (1)
- drug interactions via CYP450 (1)
- Drug interactions with antacids (sucralfate and omeprazole) reducing itraconazole bioavailability (1)
- Drug interactions with azoles (1)
- drug interactions with conventional antifungals (1)
- drug interactions with itraconazole (1)
- drug interactions with voriconazole and remdesivir (1)
- drug interactions with voriconazole and remdesivir (1)
- drug intolerance (1)
- Drug metabolism acceleration (1)
- drug metabolism inhibition (1)
- drug resistance (7)
- Drug resistance development (1)
- drug resistance in Candida auris (1)
- Drug resistance in environmental isolates (1)
- Drug resistance in non-albicans Candida species (1)
- Drug resistance in some cases (1)
- Drug resistance in standard cancer treatments (1)
- drug resistance induction (1)
- drug resistance mechanisms (1)
- Drug resistance potential with treatment discontinuation (1)
- drug resistance promotion (1)
- drug resistance risks (1)
- Drug resistance to azoles (1)
- drug resistance to fluconazole and echinocandins (1)
- drug resistance to itraconazole (1)
- Drug resistance with prolonged triazole use (1)
- drug toxicity (3)
- drug toxicity and interactions (1)
- drug toxicity from inappropriate antifungal use (1)
- drug-drug interactions (11)
- drug-drug interactions (minimal with CYP3A4) (1)
- drug-drug interactions between antifungal agents and chemotherapeutics (2)
- Drug-drug interactions including cytochrome P450-mediated interactions (1)
- drug-drug interactions with CYP3A4 (compared to voriconazole) (1)
- Drug-drug interactions with fluconazole including cytochrome P450 interactions and QT prolongation (1)
- drug-drug interactions with fluconazole including cytochrome P450-mediated interactions (1)
- drug-drug interactions with tacrolimus (1)
- drug-drug interactions with tacrolimus (1)
- Drug-induced clinical resistance (1)
- drug-induced wall restructuring (1)
- drug-related electrolyte disturbances (1)
- drug-supplement interactions with antibiotics and anticoagulants (1)
- drug-to-drug interactions (2)
- dry matter loss during fungal colonization treatment (1)
- dry mouth (1)
- dry mouth (3)
- dry texture (1)
- duloxetine and pregabalin do not affect social pain despite reducing physical pain (1)
- dura tear (1)
- dust inhalation hazards (1)
- Dutch elm disease potential (1)
- dye toxicity (1)
- dye toxicity to aquatic fauna and flora (1)
- Dyes are mutagenic and carcinogenic compounds (1)
- dysbiosis (5)
- dysbiosis and poor-quality diets cause multitude of diseases (1)
- dysbiosis development (1)
- dysbiosis from environmental contamination (1)
- dysbiosis from medical interventions (1)
- dysbiosis leads to reduced nutrient absorption (1)
- Dysbiosis leads to reduced SCFA production (1)
- Dysbiosis reduces protective bacterial function (1)
- Dysbiosis-induced inflammation (1)
- Dysbiosis-related compromised barrier function (1)
- dysphoria (2)
- dysphoric experiences (bad trips) (1)
- Dysphoric reactions (1)
- Dysregulation leads to neurodegeneration (1)
- dysregulation of APA associated with cancer progression and neurological disease pathogenesis (1)
E
- E. coli growth on fermented samples was suppressed compared to non-fermented rice (1)
- E. coli toxin production (1)
- E. corrodens resistance to macrolides (1)
- earlier onset of fungal spore seasons increases exposure risk and potential for allergic reactions in susceptible populations (1)
- Early MALDI-TOF systems showed poor performance (1)
- early senescence in high NHP conditions (1)
- early sporulation (1)
- echinocandin fungistatic activity only (1)
- echinocandin resistance (14)
- echinocandin resistance (1)
- echinocandin resistance development (1)
- echinocandin resistance in Candida glabrata (1)
- echinocandin resistance in Candida species (1)
- echinocandin resistance in L. elongisporus (1)
- echinocandin resistance in some species (1)
- echinocandin resistance in wild-type strains (1)
- echinocandin tolerance (1)
- echinocandin under-utilization (1)
- echinocandins (1)
- echinocandins (caspofungin, micafungin, anidulafungin) (1)
- Echinocandins have negligible activity against mucormycosis (1)
- echinocandins have poor in vitro activity against Mucorales (1)
- echinocandins show inherent resistance (1)
- ecological damage (1)
- ecological disruption (1)
- ecological impacts on non-target organisms (1)
- ecological invasion risks (1)
- economic crop loss (1)
- economic crop losses (1)
- economic loss in avocado production (1)
- economic losses in commercial Vaccinium crops (1)
- economic losses in forest productivity (1)
- economic losses in timber production (1)
- economic losses to timber (1)
- ecosystem damage (2)
- ecosystem degradation (1)
- ecosystem disruption (1)
- ecosystem disruption with certain fungicide applications (1)
- ecosystem toxicity (1)
- Ecotoxicity to vertebrates (1)
- ecotoxicological effects on aquatic organisms (1)
- ecotoxicological effects on ecosystems (1)
- edema (1)
- EEG desynchronization (1)
- effector-mediated suppression of OPR3 and WRKY33 expression (1)
- Effects abolished by chronic glucocorticoid elevation (1)
- effects on non-target cells (1)
- efflux pump-mediated drug efflux (2)
- efflux pump-mediated drug resistance (2)
- efflux pump-mediated resistance in some strains (1)
- Ego dissolution (6)
- Ego dissolution (1)
- EGT excess or deficiency effects on skin not fully characterized (1)
- electrode saturation effects (1)
- electrode surface fouling (1)
- electrolyte imbalances (1)
- elevated airway resistance (1)
- elevated alkaline phosphatase (1)
- Elevated amphotericin B MICs in A. flavus and A. citrinoterreus (1)
- elevated atmospheric CO2 (1)
- elevated BDG associated with severe mortality (91% in absence of AFT) (1)
- Elevated BDG without treatment associated with 91% mortality (1)
- elevated bilirubin (1)
- Elevated bitterness and astringency may reduce palatability for some consumers (1)
- Elevated blood pressure (4)
- Elevated blood pressure (systolic +19 mmHg, diastolic +8.66 mmHg) (1)
- elevated blood pressure and heart rate during dosing (normalized by end of treatment) (1)
- Elevated Cd(II) concentrations inhibit bacterial growth (1)
- Elevated concentrations of soluble salts in compost can negatively impact mushroom productivity (1)
- elevated fungal burden (1)
- elevated gamma-glutamyl transpeptidase (1)
- elevated liver enzymes (3)
- elevated liver enzymes from oral antifungals (1)
- elevated liver function tests (1)
- Elevated lysophospholipid levels increase susceptibility (1)
- elevated MICs in certain isolates (1)
- elevated minimum inhibitory concentrations (2)
- elevated minimum inhibitory concentrations limiting drug effectiveness (1)
- Elevated minimum inhibitory concentrations to itraconazole (1)
- elevated minimum inhibitory concentrations to itraconazole and fluconazole (1)
- Elevated minimum inhibitory concentrations to itraconazole and fluconazole indicating reduced antifungal susceptibility (1)
- elevated minimum inhibitory concentrations to itraconazole indicating reduced antifungal susceptibility in some isolates (1)
- Elevated NISCH expression leads to decreased mushroom spines (1)
- elevated plasma lipopolysaccharides (1)
- elevated presynaptic calcium signaling (1)
- Elevated protease expression in inflammatory bowel disease may require caution (1)
- elevated ROS production (1)
- Elevated systemic endotoxemia (1)
- Elevated temperatures negatively impact protoplast generation (1)
- elevated transaminases (2)
- elevated transaminases with caspofungin (1)
- elevated UBE2K causes GluN2B degradation (1)
- embolic complications (1)
- embryonic mortality (1)
- emergence agitation (1)
- Emergence of azole resistance (1)
- emergence of azole-resistant fungi (1)
- emergence of multidrug-resistant pathogens (1)
- Emergence of QoI-resistant isolates (1)
- emergence of resistant mutants (1)
- emergence of unusual yeasts and molds resistant to antifungals (1)
- emergency medical care seeking (1)
- Emerging contaminants cause altered immune function (1)
- emerging drug resistance (1)
- Emerging resistance during treatment through KPC mutations (1)
- emesis (1)
- emodin cytotoxic and skin-sensitizing effects (C. sanguineus) (1)
- emotional blunting from SRI use (1)
- emotional blunting with SSRIs (1)
- emotional distress (2)
- emotional dysregulation (1)
- emotional dysregulation (1)
- Emotional eating behaviors (1)
- Emotional eating behaviors (1)
- emotional lability (1)
- empirical antibacterial therapy inadequate for fungal infections (1)
- empirical antibiotics promoting resistance (1)
- empirical treatment with cefovecin and fluconazole showed no improvement in this case (1)
- encephalopathy (2)
- encephalopathy (1)
- endocrine abnormalities (1)
- endocrine disruption (11)
- endocrine disruption (BPA exposure counteracted by nutraceuticals) (1)
- endocrine disruption from chemical preservatives (1)
- Endocrine disruptors (EE2 and progesterone as contaminants) cause adverse effects on endocrine system function (1)
- Endogenous formaldehyde formation mentioned as food safety concern (1)
- endogenous psychoses (1)
- endophyte did not disrupt native microbiome (1)
- Endothelial dysfunction (1)
- enhanced adhesion to medical devices (1)
- enhanced energy metabolism may support fungal survival attempts (1)
- enhanced energy metabolism may support fungal survival attempts (1)
- enhanced enzyme activity reflects stress response in target organisms (1)
- Enhanced fungal growth (1)
- enhanced host immune recognition (1)
- enhanced immunopathology (1)
- Enhanced pathogen virulence (2)
- Enhanced pathogen virulence (1)
- enhanced pathogenicity (1)
- Enhanced pathogenicity under low temperature conditions (1)
- Enhanced pathogenicity under low temperature conditions (1)
- enhanced stress sensitivity to certain stimuli (1)
- enhanced stress tolerance (1)
- enhanced tumor progression (1)
- Enhanced zearalenone production when applied simultaneously with pathogen (1)
- Enhancement of fungal mycelial development (1)
- Enniatin toxicity (2)
- enrichment of pathogenic bacteria including Clostridium symbiosum and Enterocloster bolteae in hypertensive patients (1)
- Enterohepatic recirculation of toxins prolonging poison presence (1)
- entity encounters (1)
- entity encounters (1)
- enucleation of affected eye (1)
- environmental accumulation concerns (1)
- environmental and health concerns with chemical fungicides (1)
- environmental azole exposure selects for resistant strains (1)
- environmental concerns with chemical herbicides (1)
- environmental concerns with nanoparticle dispersion (1)
- environmental contamination (3)
- environmental contamination concerns (1)
- environmental contamination from conventional fungicides (1)
- environmental contamination from synthetic chelators (1)
- environmental contamination mitigation (1)
- Environmental copper accumulation and contamination with traditional copper-based fungicides (1)
- environmental damage (1)
- environmental damage (1)
- environmental degradation (1)
- environmental dispersion concerns (1)
- environmental fluctuations decrease metabolite synthesis (2)
- environmental influences on disease severity (1)
- Environmental isolate with potential pathogenic properties (1)
- environmental persistence (1)
- environmental persistence and fungal resistance concerns noted for synthetic alternatives (1)
- environmental persistence of some metabolites (1)
- Environmental persistence risks (1)
- environmental pollution (1)
- environmental pollution from chemical fungicides (1)
- environmental pollution from excessive fungicide use (1)
- environmental sensitivity (1)
- environmental stability limitations (1)
- environmental stress from competing growth requirements (1)
- environmental toxicity concerns (1)
- environmental toxicity in conventional burial practices (1)
- environmental toxin exposure (1)
- environmental unpredictability-induced distress (1)
- environmentally friendly alternative to chemical nematicides (1)
- enzymatic activity inhibition (1)
- enzymatic browning and oxidative degradation during storage leading to loss of bioactive compounds (1)
- enzymatic degradation affecting usability (1)
- enzyme activity loss (1)
- enzyme activity lower than papain (1)
- enzyme deactivation over time due to oxidation by hydrogen peroxide (1)
- enzyme induction requirements (1)
- enzyme inhibition (2)
- enzyme inhibition at high pesticide concentrations (1)
- enzyme inhibition at high temperatures (1)
- enzyme inhibition by validamycin A (1)
- enzyme inhibition under harsh conditions (1)
- enzyme-mediated degradation (1)
- eosinophil infiltration (1)
- eosinophilic infiltration (1)
- epilepsy (1)
- epimenorrhea (1)
- epithelial barrier disruption (1)
- Epithelial cell cytotoxicity (1)
- epithelial damage (1)
- epithelial dysfunction (1)
- epithelial monolayer disruption (1)
- epithelial-mesenchymal transition (1)
- erectile dysfunction deterioration (1)
- ergosterol accumulation requires careful environmental management (1)
- ergosterol deficiency leads to squalene accumulation and cell dysfunction (1)
- ergosterol loss during irradiation (1)
- ergot alkaloid production (1)
- ergotism (2)
- Eriobotrya japonica (1)
- essential oil acts as biofumigant preservative (1)
- essential oil components are considered food-safe at effective concentrations (1)
- essential oil quality variability (1)
- estrogenic effects (2)
- estrogenic effects (1)
- ethanol and acetaldehyde production impairs intestinal barrier (1)
- ethanol production (1)
- Ethylene inhibition in mushroom development (1)
- ethylene inhibits fungal colonization (1)
- EU restrictions on dimethyl fumarate concentration (maximum 0.1 mg/kg) (1)
- EU restrictions on DMF concentration (maximum 0.1 mg/kg) (1)
- euphoric properties with dependence risk (1)
- Euthanasia should only be used when animal fails all therapeutic options and shows irreversible deterioration (1)
- evaporation of ingredients (1)
- Evasion of host immune system through capsule masking (1)
- evasion of immune response (1)
- evasion of plant immunity (1)
- exacerbate disease through increased TNF-α and IFN-γ production (1)
- exacerbated asthma severity (1)
- exacerbated trauma symptoms (1)
- exacerbation of asthma (1)
- Exacerbation of cerebral edema (1)
- exacerbation of psychotic symptoms (1)
- exceeding critical environmental optima adversely impacts fruiting body eco-resilience (1)
- excellent tolerability with no erythema (1)
- excess ROS production causes cellular damage to lipids (1)
- Excess selenium intake can adversely affect human health (1)
- excess stevia (>45%) inhibited mycelial growth (1)
- Excessive Alk signaling induces cardiac arrhythmia (1)
- excessive amino acid supplementation (>0.5%) may suppress mycelial growth (1)
- Excessive ammonia production may be toxic (1)
- Excessive antibiotic use without proper fungal diagnosis (1)
- Excessive biochar addition (15%) inhibited growth due to altered C/N ratio (1)
- excessive biovolume causes water turbidity and algal cell dissociation (1)
- excessive blood pressure reduction (1)
- excessive boron can reduce yield (1)
- excessive boron can reduce yield (1)
- excessive butyrate production may impair enteric nerve cells and cause functional constipation (1)
- excessive cadmium accumulation in plants (1)
- Excessive calcium addition inhibits plant growth and causes soil compaction (1)
- excessive calcium release from endoplasmic reticulum (1)
- excessive chemical fertilizer use causes soil acidification (1)
- excessive complement activation impairs synapsis (1)
- Excessive copper can generate oxidative stress (1)
- excessive copper exposure leads to organ damage (1)
- excessive crosslinking density can increase brittleness (1)
- excessive defense response inhibition (1)
- Excessive defense responses may inhibit symbiosis (1)
- excessive dietary fiber may accelerate gut transit and reduce nutrient digestibility (1)
- excessive dietary fiber may compromise protein network integrity (1)
- excessive dry matter can result in overly firm (1)
- Excessive enzyme doses can lead to no improvements or undesirable effects (1)
- excessive extracellular matrix accumulation (1)
- excessive feeding behavior (1)
- excessive fertilizer use leading to soil acidification (1)
- excessive freeze-thaw cycles reduce protein solubility and water-holding capacity (1)
- excessive glial cell activation (1)
- excessive glucose concentration imposes metabolic burden (1)
- excessive glutamate signaling (1)
- Excessive glycolysis impairs synaptic function and social behavior (1)
- Excessive H2S production can damage intestinal cells (1)
- excessive heat causes protein misfolding and cellular dysfunction (1)
- excessive heat impedes mycelial growth above 27.5°C (1)
- excessive heat treatment at 180°C reduced total phenolic content compared to 150°C treatment (1)
- excessive heavy metal exposure causes weight loss (1)
- excessive immune response can damage host plant cells (1)
- excessive immune response in some cases with live strains (1)
- excessive immune system functioning causes autoimmune diseases and allergies (1)
- excessive inducers can produce toxin substances causing localized cell death (1)
- excessive inducers can produce toxin substances causing localized cell death (1)
- excessive laccase concentration decreases sorption properties and reduces UV barrier effectiveness (1)
- excessive lipid accumulation may inhibit mycelial growth (1)
- excessive maturity suppresses bioactive metabolites (1)
- Excessive micronization may impair gel-forming capacity and partial physiological activities (1)
- excessive neuronal excitation (1)
- excessive nitric oxide accumulation enhances cadmium toxicity and growth inhibition (1)
- Excessive nitrogen causes fungal community destabilization and reduced diversity (1)
- Excessive nitrogen enrichment adversely impacts fruiting body formation (1)
- Excessive nitrogen fertilization disrupts soil micro-ecological balance (1)
- Excessive nitrogen fertilization disrupts soil micro-ecological balance (1)
- excessive nitrogen reduction may lead to competition between cotton and AMF for nitrogen (1)
- Excessive nodule formation inhibition (1)
- excessive NOX activity leads to oxidative stress and mitochondrial damage (1)
- excessive nutrient accumulation can negatively impact ecosystems (1)
- excessive omega-6 fatty acids (1)
- Excessive oxidative stress inhibits carotenoid biosynthesis (1)
- Excessive phosphorus accumulation (1)
- Excessive root growth (1)
- excessive ROS accumulation (1)
- excessive ROS can cause irreversible damage to intracellular components and oxidative stress (1)
- excessive ROS causes cellular dysfunction and macromolecular damage (1)
- excessive SA (5 mM) paradoxically enhanced susceptibility (1)
- excessive salivation (1)
- Excessive selenium induces oxidative stress (1)
- excessive side chain removal reduces immunomodulatory activity (1)
- excessive sludge doses (100%) inhibited mycorrhization and enzymatic activity (1)
- excessive sludge doses (100%) inhibited mycorrhization and enzymatic activity (1)
- Excessive sodium intake from MSG linked to hypertension and cardiovascular complications (1)
- excessive stevia (>45%) inhibited mycelial growth and delayed fruiting (1)
- excessive sucrose consumption linked to dental caries and health risks for diabetes and obesity patients (1)
- excessive surfactant causes cellular stress and metabolic disruption (1)
- excessive synaptic pruning (1)
- excessive temperatures may denature cell wall proteins limiting biosorption (1)
- Excessive tenderness and juiciness at high mycelium replacement levels may negatively affect consumer acceptance (1)
- excessive trace mineral supplementation requires monitoring (1)
- excessive trace mineral supplementation requires monitoring (1)
- excessive Treg differentiation impairs fungal control (1)
- excessive vitamin C/E suppress gene expression (1)
- excessive zinc sulfate concentration inhibits biocontrol efficacy (1)
- excessively high concentrations may reduce plant growth (1)
- excessively high concentrations may reduce plant growth (1)
- excessively high sulfate levels induce metabolic stress (1)
- excitotoxicity (1)
- exclusion of patient voices from decision-making (1)
- exclusion of patients with psychosis history (1)
- existential crisis (1)
- existential crisis (1)
- exogenous ochronosis development (1)
- exogenous progesterone hypersensitivity (1)
- expectation bias in open-label studies (1)
- Experiences of contact with malevolent entities (1)
- experimental autoimmune encephalomyelitis (1)
- exposure causes health hazards and ecosystem damage (1)
- exposure causes health hazards and ecosystem damage (1)
- exposure to PM2.5 (1)
- Extended AMF inoculation may reduce soil nitrogen stocks and inhibit microbial hydrolase synthesis (1)
- extensive bilateral disease precluded surgical intervention (1)
- extensive fungal colonization (1)
- extrapyramidal side effects (1)
- extreme distress (1)
- extreme obesity (1)
- extreme pH and temperature conditions reduce degradation efficiency (1)
- extreme pH stress (1)
- eye disorders (1)
- eye irritation (1)
- eye redness (1)
F
- F. acuminatum produces mycotoxins (DON, T-2 toxin, HT-2 toxin) causing plant diseases (1)
- F. equiseti is noted as a known pathogen in some crops though no tree decay observed in this 12-month study (1)
- F. solani-ASGV infection reduces apple plant growth (1)
- F. tonkinense showed only 44.44% external fungal growth on soil-treated adults (1)
- Failed clinical response to itraconazole after 4 weeks (1)
- failure of conventional antibiotics (1)
- failure of neutrophil recovery (1)
- false identifications could lead to inadequate therapy (1)
- False negative results in specimens with low parasitic load (1)
- False negatives from prior antifungal use (1)
- false negatives in immunosuppressed patients with some techniques (1)
- false negatives possible with FFPE specimens and low blood fungal load (1)
- false negatives possible with low fluorescence intensity (1)
- False negatives potentially delaying diagnosis (1)
- false positive and false negative results in divergent cases (1)
- False positives and false negatives in molecular testing (1)
- false positives in detection of colonization versus active infection (1)
- false predictions (1)
- False-negative Histoplasma serology in advanced HIV disease patients (1)
- False-negative Histoplasma serology in advanced HIV disease reduces diagnostic sensitivity to approximately 50% (1)
- False-negative PCR results in 5.4% of cases may delay treatment initiation (1)
- False-negative results in cases with Apophysomyces elegans (1)
- False-negative results may delay diagnosis (1)
- false-positive biomarker results (1)
- false-positive diagnosis leading to unwarranted treatment (1)
- false-positive results in BDG assays from hemodialysis (1)
- false-positive results in BDG assays possible from hemodialysis (1)
- False-positive results in coexisting bacterial infections (1)
- False-positive results in coexisting bacterial infections (1)
- False-positive results in coexisting infections (1)
- false-positive results in patients with coexisting bacterial infections (1)
- false-positive results leading to unnecessary antifungal therapy (1)
- false-positive results leading to unnecessary antifungal therapy (1)
- false-positive results with coexisting infections (1)
- family history of psychotic disorders (1)
- farnesol has immunomodulatory effects that suppress cellular adaptive immunity (1)
- farnesol promotes azole resistance through upregulation of multidrug efflux pumps (1)
- fatal intoxication (1)
- fatal outcome in this case (1)
- fatal outcome in this case despite treatment initiation (1)
- fatal poisoning potential (1)
- fatigue (5)
- fatty acid alteration with cooking (1)
- fauna (1)
- favorable safety profile compared to NSAIDs and COX-2 inhibitors (1)
- Fe2+ (1)
- fear (2)
- feeding deterrent (1)
- feelings of isolation or claustrophobia (1)
- Fereydounia khargensis resistance to amphotericin B and echinocandins (1)
- fermentation effectively reduces antinutrient factors (1)
- fermented foods associated with increased depressive and anxiety symptoms severity in some populations (1)
- fermented foods associated with increased depressive and anxiety symptoms severity in some populations (1)
- fertility degradation (1)
- fever (2)
- fever (1)
- few adverse effects reported (1)
- Fewer side effects compared to fluoxetine (1)
- Fg12 facilitates pathogen niche colonization (1)
- Fg12 induces plant cell death (1)
- Fg12 suppresses beneficial bacteria (1)
- Fg12 suppresses beneficial bacteria Bacillus and Pseudomonas (1)
- FgAsp deletion reduces virulence but also impairs fungal stress response mechanisms (1)
- FgKnr4 deletion results in reduced fungal stress tolerance and growth (1)
- FgPhm1 deletion reduces virulence and DON production but causes sensitivity to oxidative stress (1)
- FgPMT2 is essential for F. graminearum survival (1)
- field colonization rates decrease from 70-90% in labs to 30-50% in field conditions (1)
- field colonization rates drop significantly compared to laboratory conditions (1)
- Field performance instability due to environmental factors (1)
- field stability unclear (1)
- film dressings cause pain and damage upon removal (1)
- Financial constraints limited antifungal therapy duration (1)
- financial toxicity (1)
- fingolimod impairs macrophage function and increases disease risk (1)
- first-degree relatives with psychosis (1)
- fishy odor deterioration (1)
- fitness costs may impair virulence but selection pressure maintains resistance (1)
- Fitness penalties in high-stress environments (1)
- fitness reductions in nematode hosts when paired with non-native bacterial partners (1)
- fitness trade-off compensation (1)
- fitness trade-offs (1)
- FIV immunosuppression facilitates fungal dissemination and disease progression (1)
- FKS mutations conferring antifungal resistance (1)
- flashback episodes (1)
- flashback episodes (1)
- flashbacks (5)
- flashbacks (1)
- fluconazole (2)
- fluconazole (>64 μg/mL) (1)
- fluconazole and flucytosine lack activity against Alternaria (1)
- fluconazole and flucytosine showed resistance in both organisms (1)
- fluconazole and itraconazole exhibit resistance and are not recommended for M. capitatus treatment (1)
- Fluconazole and voriconazole lack in vitro activity against Mucorales (1)
- fluconazole ineffective due to intrinsic resistance in C. krusei (1)
- fluconazole ineffectiveness against molds (1)
- Fluconazole limited effectiveness (2)
- Fluconazole prophylaxis failure (1)
- Fluconazole prophylaxis failure despite administration at therapeutic doses (1)
- Fluconazole resistance (17)
- fluconazole resistance (10%) (1)
- fluconazole resistance (MIC >64) (1)
- Fluconazole resistance in all isolates (1)
- Fluconazole resistance in all M. canis strains (1)
- Fluconazole resistance in C. glabrata (1)
- Fluconazole resistance in C. krusei (1)
- fluconazole resistance in C. parapsilosis and C. auris (1)
- fluconazole resistance in Candida species (2)
- fluconazole resistance in NAC (1)
- fluconazole resistance in NAC species (29.41%) (1)
- Fluconazole resistance in non-albicans Candida species (2)
- Fluconazole worsened lung inflammation in non-fungal asthma (1)
- flucytosine dose-related toxicity and bone marrow suppression (1)
- Flucytosine resistance (1)
- fluoxetine showed activity against Aspergillus flavus (1)
- fluoxetine showed activity against Aspergillus flavus (1)
- FoCup promotes fungal pathogenicity and disease development (1)
- focus on beneficial antimicrobial properties (1)
- Follicular papules persisted despite successful antifungal treatment (1)
- food chain contamination (3)
- Food contamination (2)
- Food contamination (1)
- food insecurity (1)
- food neophobia (1)
- food neophobia in consumers (1)
- food product spoilage (1)
- food security concerns (1)
- food spoilage (1)
- food spoilage by preservative-resistant yeasts (1)
- food taboos (1)
- forest health decline (1)
- forest pathogenic causing white rot (1)
- formaldehyde emissions from traditional particleboard adhesives cause health problems (1)
- formation of inhibition zones affecting fungal growth patterns (1)
- formation of inhibition zones affecting mycelial spread (1)
- formation of resistant strains (1)
- formation of toxic metabolites (2)
- formulation challenges for lipophilic compounds (1)
- fouling susceptibility (1)
- fragile skeleton structure of silica aerogels (1)
- fragility of membranes in certain growth conditions (1)
- free radical generation (1)
- fructose (1)
- fructose in fruits associated with increased stone risk (1)
- fruit contamination (1)
- fruit decay (1)
- fruit deformities and reduced storage quality (1)
- fruit production loss (1)
- Fruit softening (1)
- Fruiting bodies of genus Gomphus generally considered indigestible in other species (1)
- fruiting body degeneration (1)
- fumagillin (1)
- fumigacin (1)
- fumonisin B1 classified as group 2B carcinogen by IARC (1)
- fumonisin B1 toxicity (1)
- fumonisins (1)
- Fumonisins are potentially carcinogenic (1)
- fumonisins trigger neurological and respiratory disorders (1)
- functional impairment (1)
- functional impairment from acute experiences (1)
- functional unblinding bias (1)
- functional unblinding in placebo-controlled trials (1)
- fungal adaptation mechanisms (1)
- Fungal adaptation to acidic environments (1)
- Fungal adaptation to macrophage killing (1)
- fungal adaptation to plant-derived compounds (1)
- fungal adaptations to acidic pH enhance virulence and reduce macrophage effectiveness (1)
- Fungal AGOs suppress plant immunity genes to promote infection (1)
- Fungal biofilm formation and colonization can interfere with targeted drug delivery (1)
- fungal cell membrane disruption (1)
- Fungal colonization associated with reduced post-bronchodilator FEV1 in asthma (1)
- fungal colonization increases risk of infection (1)
- fungal colonization of eggs (1)
- fungal contamination (4)
- fungal contamination reduces seed viability (1)
- Fungal decay of materials (1)
- fungal degradation (1)
- fungal degradation of composite materials (2)
- fungal disease causing leaf quality reduction (1)
- fungal dysbiosis (1)
- fungal evasion of host immune recognition (1)
- fungal growth inhibition (1)
- Fungal growth inhibition at extreme pH (2.5) and high temperature (37°C) (1)
- fungal hemolysins can cause hemolysis of red blood cells (1)
- fungal infection (1)
- Fungal infection and tissue necrosis in pomegranate fruits (1)
- fungal infection causing tissue damage (1)
- Fungal infection causing wing lesions (1)
- fungal infection reduces seed vigor (1)
- fungal infection risk following antibiotic treatment (1)
- fungal infections cause neuronal damage (1)
- fungal infections in animals and humans (1)
- fungal infections resistant to some antifungal agents requiring susceptibility testing (1)
- fungal inhibition (1)
- Fungal neuroinvasion causes neuronal damage (1)
- fungal overgrowth leads to pathogenic effects (1)
- fungal pathogen causes crop disease and yield losses (1)
- Fungal pathogen causes tissue necrosis (1)
- fungal pathogen causing disease (1)
- fungal pathogenesis (2)
- Fungal pathogenesis causing crop failure (1)
- fungal pathogenesis causing leaf spot disease in Panax notoginseng (1)
- Fungal pathogenesis causing pod necrosis (1)
- Fungal pathogenicity (13)
- Fungal pathogenicity causing leaf blight and leaf spot symptoms on Camellia japonica (1)
- Fungal pathogenicity causing plant disease and crop damage (1)
- Fungal pathogenicity causing yield losses in wheat and barley crops (1)
- fungal pathogenicity enhancement (1)
- Fungal pathogenicity in immunocompromised individuals (1)
- Fungal pathogenicity in sea turtle eggs (1)
- fungal pathogenicity on Cannabis sativa (1)
- Fungal pathogenicity on soybean causing stem necrosis and tissue damage (1)
- Fungal pathogenicity to buckwheat and other crops causing leaf spots (1)
- Fungal pathogenicity to Rosa xanthina (1)
- fungal pathogens can decimate plant and animal populations (1)
- fungal pathogens can negatively affect medicinal plant quality (1)
- Fungal pathogens cause egg failure (1)
- Fungal pathogens cause seed deterioration (1)
- Fungal pathogens cause significant economic losses in loquat fruit production (1)
- Fungal pathogens cause wood browning (1)
- Fungal pathogens causing crop damage and economic losses (1)
- Fungal pathogens causing disease in amphibians and crops (1)
- fungal pathogens causing plant diseases (1)
- fungal pathogens causing significant crop loss and fruit decay (1)
- fungal plant pathogens including Heterobasidion annosum (1)
- fungal resistance development (1)
- Fungal resistance to conventional antifungals (context for study motivation) (1)
- fungal resistance to ketoconazole and fluconazole (1)
- Fungal resistance to saponin toxicity (1)
- Fungal sensitivity to environmental conditions (1)
- fungal source (A. phalloides) is toxic if ingested (1)
- Fungal spore exposure causes respiratory disease (1)
- Fungal spore inhalation leading to infection (1)
- fungal toxicity (1)
- fungal toxicity to producers (1)
- Fungal virulence (4)
- Fungal virulence factors (1)
- Fungal virulence promotion (1)
- Fungal virulence promotion in space (1)
- fungal volatile organic compounds contributing to adverse health effects (1)
- fungal-induced immunosuppression (1)
- Fungi require mechanical wounding for infection in most cases (1)
- fungicidal and fungistatic effects leading to complete mycelial growth inhibition (1)
- fungicide and pesticide residues inhibit nematophagous fungal growth (1)
- Fungicide effectiveness is limited (1)
- Fungicide resistance (2)
- fungicide resistance considerations (1)
- fungicide resistance development (1)
- Fungicide resistance in D. citri isolates (1)
- fungicide resistance in pathogen noted (1)
- fungicide resistance in some strains (1)
- fungicide resistance limitations (1)
- fungicide-resistant pathogen strains (1)
- Fungicides may select for resistant pathogen populations (1)
- fungistatic rather than fungicidal activity (3)
- fungistatic rather than fungicidal at tested concentrations (1)
- fungistatic rather than fungicidal effects (1)
- fungus specifically pathogenic to target insect (1)
- Further testing needed to confirm phenotypic expression (1)
- fusarin C is highly mutagenic and estrogenic agonist causing breast cancer in vitro (1)
- Fusarium (1)
- Fusarium and Paecilomyces proliferation associated with disease risk (1)
- Fusarium avenaceum causes pathogenic infections in plant tissues (1)
- Fusarium causes stalk rot (1)
- Fusarium intrinsic resistance to natamycin and amphotericin B (1)
- Fusarium noted as opportunistic pathogen (1)
- Fusarium oxysporum (1)
- Fusarium oxysporum (1)
- Fusarium oxysporum causes root browning and wilting in tobacco plants (1)
- Fusarium oxysporum showed resistance to VOCs produced by K. cowanii Ch1 (1)
- Fusarium species (1)
- Fusarium species cause tissue necrosis and rot in potato tubers (1)
- Fusarium suttonianum causes severe plant pathogenicity (1)
- fusion with mental phenomena (1)
G
- G. purpuraceus reported to cause no physical discomfort (1)
- G. purpuraceus reported to cause no physical discomfort (1)
- GAG not detectable in human samples limiting clinical application (1)
- gangrene (1)
- Ganoderma ryvardenii causes progressive stem decay (1)
- gas formation (1)
- gas instability under light and heat (1)
- gastric aggravation (1)
- gastritis (1)
- gastrointestinal adverse effects from oral iron salts (1)
- gastrointestinal and alveolar hemorrhage (1)
- Gastrointestinal bleeding (1)
- Gastrointestinal damage (1)
- Gastrointestinal discomfort (1)
- gastrointestinal discomfort from oligosaccharides (1)
- Gastrointestinal disorders (1)
- Gastrointestinal disorders (from conventional diabetes drugs) (1)
- gastrointestinal distress (2)
- gastrointestinal disturbances (2)
- gastrointestinal irritation (1)
- gastrointestinal side effects (2)
- gastrointestinal side effects possible with some compounds (1)
- gastrointestinal symptoms (1)
- gastrointestinal symptoms from excess iron (1)
- Gastrointestinal symptoms from excessive iron (1)
- gastrointestinal symptoms including nausea (1)
- gastrointestinal symptoms including nausea (1)
- gastrointestinal toxicity (1)
- gastrointestinal toxicity in 5.5% of patients (1)
- GCN2 deficiency reduces pathogenicity and stress tolerance (1)
- GDF11 deletion induces neuronal senescence (1)
- gel viscosity reduction over time (1)
- gene deletions compromised trap integrity and adhesive capacity (1)
- Gene deletions in Rab proteins reduce pathogenic virulence against host plants (1)
- Gene deletions result in reduced pathogenicity and virulence (1)
- gene disruption impairs seed germination and nutrient uptake (1)
- gene expression alteration (1)
- general mention of need for safety assessment in clinical trials (1)
- generally recognized as safe by EFSA (1)
- genetic doping (1)
- genetic erosion (1)
- Genistein is an endocrine disruptor potentially affecting reproductive health and breast tissue development if improperly consumed (1)
- genomic instability (1)
- genotoxic (4)
- genotoxic (1)
- genotoxic and carcinogenic effects (1)
- genotoxic effects (2)
- genotoxicity (7)
- genotoxicity at high concentrations reported in some studies (1)
- Genotoxicity at specific concentrations (1)
- Genotoxicity reported at high concentrations (2.71-fold genetic damage at 5 mg/mL in some studies) (1)
- genotoxicity reported for related compounds (1)
- geographic disparities in antifungal availability affecting patient outcomes (1)
- geosmin causes disagreeable taste and odor (1)
- gliotoxin (2)
- gliotoxin cytotoxicity (1)
- Glucocorticoid dependency concerns (1)
- glucose (1)
- glucose ineffective (1)
- GluN2B depletion impairs addiction memory formation but paradoxically increases locomotor activity (1)
- glutamate dyshomeostasis (1)
- glycemic instability (1)
- Glycerin increases film permeability to water vapors due to its polar nature and water attraction (1)
- glycosylation divergence between host and pathogen (1)
- GO inhibits cotton seed germination and growth (1)
- Goliath cells demonstrate enhanced biofilm formation and adhesion to medical devices (1)
- GOS showed low gas production at tested doses (1)
- GOS showed low gas production at tested doses (1)
- grade 3 or 4 liver toxicity (1)
- graft failure (1)
- grafting labor-intensive and requires dual seeds (1)
- grain contamination (1)
- grain quality deterioration (2)
- grandiosity (1)
- Graphium basitruncatum causes skin lesions in leukemia patients and subcutaneous infections in heart transplant patients (1)
- grassland degradation (1)
- Grazing may reduce endemic fungal taxa and promote regional homogenization of fungal communities (1)
- Green mould epidemic in commercial mushroom production (T. aggressivum) (1)
- greenhouse effect (1)
- greenhouse gas emissions (1)
- Greenhouse gas emissions from composting (1)
- Greenhouse gas emissions from composting (1)
- griseofulvin (1)
- Griseofulvin ineffective in some cases (1)
- growth impairment from latent infection (1)
- Growth inhibition (2)
- growth inhibition at elevated acetamide concentrations (1)
- growth inhibition at extreme concentrations (1)
- growth inhibition at high concentrations (2)
- growth inhibition at high metal concentrations (2)
- growth inhibition in contaminated soils (1)
- growth inhibition of beneficial ectomycorrhizal fungi under certain conditions (1)
- growth inhibition of cancer cell lines may result in cytotoxicity (1)
- Growth inhibition under cadmium stress (1)
- Growth inhibition under certain nanoparticle and laser combinations (1)
- growth inhibition under specific conditions (1)
- growth inhibition under stress conditions (1)
- growth of drug-resistant fungi (1)
- growth rate reduction (1)
- growth reduction (2)
- Growth suppression at high NHP concentrations (1)
- Growth suppression of pine mushroom by certain Trichoderma species (1)
- growth-suppressing activity against various plants (1)
- gummosis (1)
- gut dysbiosis and microbial translocation (1)
- gut microbiota disruption (1)
- gynecomastia (1)
- gyromitrin (1)
H
- H. parviporum (1)
- habitat degradation threats (1)
- hair and nail loss (1)
- hair loss and birth defects (vitamin A excess) (1)
- hallucinations (20)
- hallucinogen persisting perception disorder (2)
- Hallucinogen persisting perception disorder (HPPD) (4)
- hallucinogen persisting perception disorder (HPPD) as adverse event of special interest (1)
- hallucinogenic effects (9)
- hallucinogenic effects (head-twitch response) (1)
- hallucinogenic effects (psilocybin) (1)
- Hallucinogenic effects causing confusion and anxiety in some patients (1)
- Hallucinogenic effects causing confusion and anxiety in some patients (1)
- Hallucinogenic effects from certain terpenoids (1)
- Hallucinogenic properties (2)
- hallucinogenic properties (in fruiting bodies) (1)
- harm to self/others at high doses (1)
- harmful microbiomes (1)
- harsh environmental conditions (1)
- HCN production suppressed at high salt concentrations (1)
- HDL (1)
- Head twitch response (HTR) as a psychedelic side effect (1)
- headache (15)
- headache (1)
- Headaches (9)
- Headaches (1)
- health concerns related to fungal origin (1)
- health hazards (1)
- health hazards (1)
- health hazards to consumers (1)
- Health risks from contaminated mushroom consumption (1)
- Health risks from misidentification of wild mushrooms (1)
- health risks from mycotoxin contamination (1)
- healthcare-associated infections (1)
- heart (1)
- heart problems (1)
- heart valve disease (1)
- heat (2)
- Heat and radiation stress can prevent mushroom maturation and sexual spore release (1)
- heat degradation of vitamins and bioactive compounds with some drying methods (1)
- Heat stress causes cell death and metabolic damage (1)
- Heat stress causes growth inhibition (1)
- heat stress causes lipid peroxidation (1)
- Heat stress inhibits growth (1)
- Heat stress inhibits mycelial growth and causes cell apoptosis (1)
- heat stress intolerance above 42°C (1)
- Heat stress reduces Collembola survival and reproduction (1)
- heat stress reduces GABA accumulation (1)
- heat-induced denaturation of bioactive molecules (1)
- heat-resistant mold strains (1)
- Heat-resistant mold strains can survive conventional heating methods (2)
- heat-resistant molds (1)
- heavy metal accumulation (2)
- heavy metal accumulation (1)
- heavy metal accumulation concerns at higher bottom ash concentrations (1)
- heavy metal accumulation in food chain (1)
- heavy metal accumulation in fruiting bodies (2)
- Heavy metal accumulation in fruiting bodies from contaminated substrates (1)
- Heavy metal accumulation in plants (1)
- heavy metal accumulation in polluted environments (cadmium, lead, arsenic, nickel, chromium, mercury) (1)
- heavy metal accumulation in tissues (1)
- Heavy metal accumulation particularly inorganic arsenic (10-100 ppm) (1)
- Heavy metal accumulation risk (1)
- Heavy metal bioaccumulation (2)
- Heavy metal bioaccumulation in food crops (1)
- heavy metal bioaccumulation risk at higher bottom ash concentrations (1)
- Heavy metal contamination poses health risks through food chain accumulation (1)
- heavy metal contamination risk (1)
- Heavy metal enrichment potential (1)
- Heavy metal exposure (arsenic, cadmium, lead, manganese, thallium) increases risk of adverse birth outcomes (1)
- Heavy metal exposure causes oxidative stress (1)
- Heavy metal exposure causes oxidative stress (1)
- Heavy metal exposure induces kidney damage (1)
- heavy metal inhibition of microbial growth (1)
- heavy metal mobilization (1)
- heavy metal residues (1)
- heavy metal stress (1)
- heavy metal toxicity (7)
- Heavy metal toxicity causing neurological damage (1)
- Heavy metal toxicity causing neurological damage (1)
- heavy metal toxicity to microorganisms (1)
- heavy metal toxicity to soil microorganisms (1)
- heavy metals (lead, cadmium, mercury) (1)
- Heavy metals cause cytotoxicity (1)
- heavy metals cause oxidative damage and growth inhibition in crops (1)
- heavy oil contains high-molecular compounds difficult to biodegrade (1)
- hedonic overeating (1)
- Heightened anxiety (2)
- heightened drug resistance in biofilm cells (1)
- heightened inflammatory responses (1)
- Heightened sensory sensitivities (1)
- hell realm experiences (1)
- hematological toxicity (2)
- hematotoxicity (1)
- hematuria (1)
- Hemolysis (3)
- hemolytic activity (1)
- hemolytic activity observed in some strains (1)
- Hemolytic effects at elevated doses (1)
- Hemolytic toxicity (though significantly reduced) (1)
- Hemolytic toxicity to mammalian cells (1)
- hemorrhagic diathesis (1)
- hemorrhagic effects (1)
- hemorrhagic shock (1)
- heparan sulfate-mediated neutrophil dysfunction (1)
- hepatic accumulation (1)
- Hepatic adverse events (20 patients with at least possibly related hepatotoxicity, 5 serious) (1)
- hepatic dysfunction (1)
- hepatic encephalopathy (1)
- hepatic failure (1)
- Hepatic impairment from voriconazole (1)
- hepatic injury (1)
- Hepatic injury associated with terbinafine (1)
- Hepatic injury with terbinafine (1)
- hepatic metabolism concerns with azole agents (standard therapy) (1)
- hepatic toxicity (2)
- hepatitis (1)
- hepatitis (1)
- hepatobiliary disorders (1)
- Hepatocarcinogenic toxin production (T. purpurogenus – rubratoxin) (1)
- hepatocellular toxicity (1)
- hepatocellular toxicity (1)
- hepatomegaly (1)
- hepatotoxic (4)
- hepatotoxic (1)
- hepatotoxic effects (2)
- hepatotoxicity (26)
- hepatotoxicity (lower incidence than voriconazole) (1)
- hepatotoxicity and hypersensitivity reactions (micafungin) (1)
- hepatotoxicity and nausea from oral azoles (1)
- hepatotoxicity and nephrotoxicity from coumarin at high levels (1)
- hepatotoxicity at high doses (1)
- Hepatotoxicity from antifungals (1)
- hepatotoxicity from azole fungicides (1)
- hepatotoxicity from azoles (1)
- hepatotoxicity from fluconazole (1)
- hepatotoxicity from lethal protein in some species (1)
- hepatotoxicity from mycotoxins (1)
- hepatotoxicity from prolonged antifungal agents (1)
- hepatotoxicity from voriconazole (1)
- hepatotoxicity risk with green tea extract (1)
- hepatotoxicity with elevated liver enzymes (1)
- hepatotoxicity with griseofulvin (1)
- hepatotoxicity with itraconazole (2)
- hepatotoxicity with olorofim (1)
- hepatotoxicity/liver function derangement (15.0%) (1)
- Herbicide adjuvant toxicity to fungi (1)
- herbicide application reduces AMF colonization and propagule formation (1)
- Herbicide contamination (1)
- heteroresistance (1)
- Hg2+ (1)
- high acidity environments (1)
- high amphotericin B MICs indicating potential treatment limitations (1)
- High antifungal resistance in Fusarium falciforme (1)
- High antifungal resistance in Fusarium oxysporum and dematiaceous fungi (1)
- high antifungal resistance of Fusarium species (1)
- High antifungal resistance patterns: 100% resistance to Fluconazole (1)
- High azole resistance in Rasamsonia argillacea (1)
- High azole resistance rates in Aspergillus fumigatus limit treatment options (1)
- High biochar concentrations (4-5%) showed reduced T. harzianum growth compared to 3% (1)
- High biogenic amine levels can cause adverse effects (1)
- high blood pressure (1)
- high caspofungin MIC in this isolate (1)
- high chloride concentrations inhibit cordycepin biosynthesis (1)
- high chloride concentrations potentially inhibit cordycepin biosynthesis (1)
- high chloride ions potentially inhibit cordycepin biosynthesis (1)
- High CO2 tolerance confers virulence advantage (1)
- high concentration SA (2 mM) inhibits mycelial growth (1)
- high concentrations (2.5%) less effective than optimal doses (1)
- high concentrations (2.5%) less effective than optimal doses (1)
- high concentrations may inhibit fungal growth and metabolite production (1)
- high concentrations may reduce effectiveness (1)
- high concentrations negatively affect sensory characteristics and consumer acceptance (1)
- High concentrations of abietic acid (1.2 g/L and above) inhibit fungal growth with antimicrobial effects (1)
- High concentrations of butanol extract reduced transformation (1)
- High concentrations of free essential oils can be toxic to operators and environment (1)
- high concentrations of inducers detrimental to mycelial growth (1)
- High concentrations of melatonin (50 μM) showed reduced protective effects (1)
- High concentrations of nanoparticles can cause oxidative stress and environmental toxicity (1)
- High concentrations of o-tolidine show slight growth limitation (1)
- High concentrations of ROS can cause oxidative damage (1)
- High concentrations of textile dyes can inhibit fungal decolourisation efficiency (1)
- high conformational dynamics correlates with increased disease propensity (1)
- high consumption of carbohydrates (1)
- high contaminant levels can exceed plant physiological tolerance (1)
- high contaminant levels can exceed plant physiological tolerance (1)
- High contamination rate in Miscanthus floridulus substrate (65%) (1)
- high Cr(VI) reduction constraints under certain conditions (1)
- high Cr(VI) reduction constraints under certain conditions (1)
- high cumulative dosing effects (1)
- high degree of substitution may reduce antioxidant activity in esterified fibers (1)
- high dose psilocybin decreased neurogenesis in some studies (1)
- high doses (2%) did not promote growth performance and showed adverse effects on feed conversion (1)
- high doses of soil amendments may alter pH unfavorably (1)
- high doses of soil amendments may alter pH unfavorably (1)
- high doses of unconverted mycotoxins induce cell death and apoptosis (1)
- High dye concentrations can be managed through adaptive fungal mechanisms (1)
- High enzymatic activity and biofilm formation contribute to antifungal resistance and treatment complications (1)
- High ethylene levels suppress fruiting (1)
- High false-negative rates with FFPE specimens (1)
- High farnesol production associated with enhanced virulence and pathogenicity (1)
- High fluconazole MIC (1)
- High fluconazole resistance (1)
- high HBT concentrations can inhibit enzyme activity (1)
- high heavy metal concentrations reduce microbial diversity (1)
- High humidity and warm temperatures promote disease progression (1)
- high humidity conditions favor pathogen development (1)
- high initial voriconazole plasma concentrations requiring dose reduction (1)
- high ink concentrations reduce biosorption efficiency (1)
- High iron availability can impose stress on gut microbiota (1)
- High lead concentrations inhibit fungal growth and reduce adsorption efficiency (1)
- high lead content exceeds permitted European limits (1)
- high levels of biogenic amines and ammonia can impair intestinal integrity (1)
- high LMM levels may reduce protein digestibility (1)
- high local recurrence rate (50-55%) (1)
- high MeJA concentrations (50-100 μM) lost protective efficacy (1)
- high melatonin concentrations may suppress glucose metabolism and fermentation in yeast (1)
- High methodological limitations (1)
- High MIC to echinocandins (1)
- high microbial load can slightly delay germination in early vegetative growth stages (1)
- high MICs against bacteria (1)
- High MICs for amphotericin-B and itraconazole (1)
- High MICs for certain antifungals in basidiomycetes (1)
- high MICs in some species complexes (1)
- high MICs observed for amphotericin B and griseofulvin (1)
- High minimal inhibitory concentrations for certain antifungals in basidiomycetes (1)
- high minimum inhibitory concentrations against bacteria (1)
- high minimum inhibitory concentrations to azole-based antifungals (1)
- High Mn2+ concentrations (15-30 mg/L) inhibit organic acid secretion and reduce Pb immobilization stability (1)
- high moisture and nutrients promote fungal growth (1)
- High mortality associated with Scedosporium infection in immunocompromised patients (1)
- high mortality despite treatment (2)
- high mortality rate (up to 90%) (1)
- high mortality rate despite appropriate antifungal therapy (1)
- High mortality rate despite therapeutic intervention (1)
- high mortality rate exceeding 50% (1)
- High mortality rate in untreated cases (1)
- high mortality rates (3)
- high mortality rates (up to 60% in vulnerable groups) (1)
- High mortality rates despite treatment (46.5% in cryptococcal meningitis) (1)
- High mortality rates in control groups (1)
- high mortality rates in crickets fed fermented substrates (1)
- High mortality rates in cryptococcal meningitis (1)
- high mortality rates in cryptococcal meningitis despite treatment (2)
- high mortality rates in cryptococcal meningitis despite treatment (1)
- high mortality rates without combined surgical and antifungal therapy (1)
- High mycotoxin concentrations may inhibit fungal growth (1)
- High mycotoxin concentrations may inhibit fungal growth (1)
- High natural sugar content in dates may require limited intake for blood sugar management (1)
- high non-identification rates delaying diagnosis (1)
- high nutrient media may inhibit spore germination (1)
- high nutrient soil concentrations may reduce AMF benefits (1)
- High oral doses may cause diarrhea and gastrointestinal problems (1)
- High oxalate concentration can induce nephropathy (1)
- High oxalate concentration can induce nephropathy (1)
- High oxalate content in some plant foods without adequate calcium intake may increase kidney stone risk (1)
- high pathogen resistance may reduce need for sterilization but requires further study (1)
- High pathogenic virulence (1)
- high pathogenicity of SHBP9 isolate (1)
- high peroxidase concentrations can increase dough viscosity undesirably (1)
- High pH or temperature can reduce bacterial efficiency (1)
- high pharmacokinetic variability (1)
- high phosphorus can inhibit calcium intake causing bone weakness (1)
- High plasma voriconazole concentration requiring dose adjustment (1)
- high potential for abuse due to euphoric effects (1)
- high prevalence of M. canis may reduce efficacy of certain antifungal regimens (1)
- High pro-inflammatory response contributes to immunopathology and tissue damage (1)
- high pro-inflammatory response may contribute to immunopathology (1)
- high purine content associated with elevated blood uric acid levels (1)
- high recombinant laccase expression inversely correlated with plant viability (1)
- High recurrence rate of infection (1)
- High recurrence rates (2)
- high recurrence rates (20-25%) (1)
- high recurrence risk with conventional treatments (1)
- High relapse rates with older agents (1)
- High resistance in some isolates (Pestalotiopsis sp.) (1)
- High resistance to fluconazole (MIC 64 µg/mL) (1)
- High resistance to voriconazole and fluconazole (1)
- High rhamnolipid concentrations inhibit phenanthrene degradation (1)
- high SA concentrations inhibit fungal growth (1)
- high salicylic acid concentration negatively affects fungal colonization (1)
- high salinity limits microbial adaptation (1)
- High salt concentration (>250 mM) reduces fungal colonization efficiency by 30-50% (1)
- High salt concentration inhibits lactic acid bacteria growth (1)
- High salt concentrations (>250 mM) reduce fungal colonization efficiency by 30-50% (1)
- high salt concentrations reduce fungal colonization efficiency (1)
- high saturated fatty acids increase LDL and diabetes risk (1)
- high secretion stress challenges cell wall integrity (1)
- High selenium concentrations induced oxidative stress (1)
- High shear stress can damage fungal cells and reduce growth (1)
- high sodium content (1)
- high sodium intake in traditional fermented foods (addressed through low-salt fermentation) (1)
- high SSR4 expression associated with poor prognosis and worse survival outcomes (1)
- High steroid substrate concentrations inhibit transformation efficiency (1)
- high substitution levels compromise protein quality and amino acid balance (1)
- high substrate stiffness can inhibit cell proliferation and differentiation (1)
- high sugar content disrupted mycelial metabolism (1)
- high sugar intake association not clearly established (1)
- High temperature (39°C) inhibits laccase gene expression and mycelial growth (1)
- high temperature drying destroys flavor and bioactive components (1)
- high temperature exposure may alter biological activity (1)
- High temperature extraction may degrade thermolabile compounds such as phenolic acids and vitamins (1)
- High temperature increases fungal pathogenicity and disease susceptibility in host mushroom (1)
- high temperature induces apoptosis and senescence (1)
- High temperature inhibits rhizomorph elongation and growth (1)
- High temperature sensitivity in morel cultivation (1)
- high temperature stress causes oxidative damage (1)
- High terbinafine resistance rates (1)
- high toxicity (AmB) (1)
- high toxicity of amphotericin B (1)
- High treatment toxicity risk (1)
- High treatment toxicity risk (1)
- high UV doses may injure fungal cells (1)
- high virulence (1)
- high viscosity causing production difficulties and increased costs (1)
- high viscosity limited concentration investigation in MTT assay (1)
- high voriconazole and isavuconazole MICs (1)
- high water absorption (1)
- High water activity and optimal pH conditions promote mycotoxin production (1)
- high water content may reduce storage stability (1)
- high-dose antioxidants impair training adaptations (1)
- high-dose corticosteroids and anti-TNF agents associated with increased infection severity (1)
- high-dose corticosteroids associated with increased infection severity (1)
- high-dose corticosteroids increased mucormycosis susceptibility (1)
- high-dose treatment required for efficacy (1)
- high-dose UP showed less efficacy than low-dose treatment (1)
- high-fat diet concerns in aquatic animals (1)
- high-fat diet induces anxiety-like behavior (1)
- high-fructose high-fat diets suppress IL-22 signaling and impair intestinal homeostasis (1)
- High-grade fever development (1)
- high-salt content in some products may relate to cardiovascular concerns (1)
- high-temperature cooking cannot eliminate toxins from over 30 toxic species (1)
- high-temperature cooking does not eliminate toxins (1)
- higher all-cause mortality risk at 300 µg/day dose (1)
- higher anxiety and depression scores in users (1)
- higher carbonyl content with mushroom powder addition may indicate increased protein oxidation potential (1)
- higher comorbidity index scores (1)
- Higher concentrations required than synthetic fungicides (1)
- Higher cost compared to conventional plastics (1)
- higher fat replacement (50%) resulted in reduced consumer preference (1)
- higher leachability in some tannin-only formulations (1)
- Higher moisture content increases degradation risk (1)
- higher mortality in invasive aspergillosis (1)
- higher mortality in severe immunodeficiency (1)
- higher PEG concentrations (>1.5 mol%) diminished therapeutic effects (1)
- higher potassium humate concentrations showed diminishing returns and potential osmotic stress (1)
- higher potassium humate concentrations showed diminishing returns and potential osmotic stress (1)
- higher risk of cavitary disease (1)
- higher supplementation decreased antioxidant potential compared to lower supplementation levels (1)
- higher thermal conductivity in flax-based composites (1)
- highlighting importance of early fungal diagnosis (1)
- highly pathogenic to oil palm (1)
- Histoplasma spp. causes systemic mycosis with potential for severe dissemination and neurological involvement in immunocompromised individuals (1)
- histrionic personalities with tendency to act out (1)
- HIV protease inhibitors alone show no antifungal activity at tested concentrations (1)
- horizontal gene transfer enabling pathogenicity (1)
- horizontal transmission capability (1)
- Hormesis effect in some treatments showing growth augmentation at low concentrations (1)
- hormonal disruption (1)
- hormone disruption in aquatic species (1)
- hormone-related effects (1)
- hospitalization (2)
- host colonization (1)
- host infection (1)
- Host mycelium inhibition at higher fungicide concentrations (1)
- Host mycelium inhibition at higher fungicide concentrations (1)
- host specificity limitations (1)
- host toxicity (2)
- host toxicity from antifungal drugs (1)
- host-fungal mismatches (1)
- host-fungal mismatches (1)
- hot flashes (1)
- however (2)
- HPA axis dysfunction (1)
- HPA axis dysregulation (1)
- HPPD (hallucinogen persisting perception disorder) (1)
- HPPD-type visual disturbances (1)
- HTL-AP toxicity from heavy metals and organic compounds (1)
- HTL-AP toxicity from heavy metals and organic nitrogen compounds (1)
- human health hazards (1)
- human pathogen (1)
- human pathogenicity (1)
- Hybrid breakdown (1)
- Hydrophilic nature may limit water resistance applications (1)
- hygroscopic moisture absorption in mycelium samples (1)
- Hymexazol and zhongshengmycin show limited effectiveness at lower concentrations (1)
- hyper-inflammatory lung response and early mortality with improperly cultured C. neoformans cells (1)
- hyper-inflammatory lung response in some growth conditions (1)
- Hyperalgesia (1)
- hyperconidiation (1)
- Hyperconidiation phenotype (1)
- hyperexcitability (1)
- hyperglycemia (2)
- hyperglycemia (1)
- hyperglycemia as risk factor for infection (1)
- hyperglycemia during anesthesia (1)
- hyperglycemia triggers oxidative stress (1)
- hyperglycemia with PI3K inhibitors (1)
- hyperhidrosis (1)
- Hyperinflammation in COVID-19 (1)
- hyperinflammation induced by Mucorales cell wall polysaccharides may contribute to disease progression and tissue damage (1)
- hyperinsulinemia (1)
- hyperkalaemia (1)
- Hyperkalemia (1)
- hypermethylation at certain sites associated with increased obesity risk (1)
- hypersensitivity reactions (1)
- hypersensitivity reactions (3)
- Hypersensitivity reactions including pruritic maculopapular rash (1)
- hypersensitivity to oxidative stress under light conditions (1)
- hypertension (7)
- hyperthermia (1)
- hyperthyroidism (1)
- hyperthyroidism (1)
- hypervigilance (1)
- hypervirulence in entomopathogenic fungi (1)
- Hyphal formation and translocation (1)
- Hyphopichia burtonii can cause serious infections in immunocompromised patients on peritoneal dialysis (1)
- hypocotyl necrosis (1)
- hypogammaglobulinemia (1)
- hypoglycemia (1)
- hypoglycemia (1)
- Hypoglycemia and related side effects from antidiabetic drugs (1)
- hypoglycemia with insulin (1)
- Hypokalaemia (1)
- Hypokalaemia (23.2%) (1)
- hypokalemia (3)
- hypokalemia and hypomagnesemia as adverse effects of liposomal amphotericin B treatment (1)
- Hypomagnesaemia (1)
- hypomagnesaemia (2.5%) (1)
- hypomagnesemia (1)
- hyponatremia (1)
- hyponatremia (1)
- hypotension (2)
- hypoxia markedly reduces cordycepin yields (2)
- hypoxia reduces cordycepin yields (1)
I
- IAA production decreased under increasing salinity stress (1)
- iatrogenic complications associated with bacterial L-ASNase (1)
- iatrogenic complications associated with bacterial L-ASNase (1)
- Ibuprofen persistence in environment (1)
- ICU admission associated with worse outcomes (1)
- idelalisib (2)
- identification of azole-resistant species (1)
- Identification of metabolites associated with fluconazole resistance (1)
- identity fragmentation (2)
- IL-10 antagonism may reduce anti-inflammatory response (1)
- IL-17 deficiency leads to tissue fibrosis and organ damage (1)
- IL-22 secretion promoting colon tumorigenesis (1)
- IL-4 suppression of Th17 cells (1)
- illness during pregnancy (1)
- imbalanced ROS promotes saprophytic pathogen growth (1)
- Immature synapse formation (1)
- Immature synapse formation (1)
- immersion in conceptual thought (1)
- immobilization reduces degradation efficiency compared to free enzyme (1)
- immune checkpoint antagonism (1)
- immune dysfunction (1)
- immune dysfunction increase mortality risk (1)
- Immune dysregulation (1)
- immune evasion (2)
- immune evasion (1)
- Immune evasion by Candida through β-glucan shielding (1)
- Immune evasion by cryptococcal capsule (1)
- immune evasion mechanisms (1)
- immune evasion through melanin and cell wall masking (1)
- immune evasion through morphological changes (1)
- immune evasion through morphological plasticity (1)
- immune overactivity leading to tissue damage (1)
- immune overshoot from immunomodulatory agents (1)
- Immune reconstitution inflammatory syndrome (3)
- Immune response overshoot with immunotherapy (1)
- Immune suppression (3)
- immune suppression from steroid treatment (1)
- immune system dysfunction in breastfeeding women (1)
- immune system impairment (1)
- immune system suppression (1)
- immune-mediated liver injury (1)
- immunocompromised status (1)
- immunodeficiency (1)
- immunodeficiency increases disease severity (1)
- Immunogenicity (1)
- immunological response to bacterial enzymes if not properly formulated (1)
- immunopathology from excessive inflammation (1)
- immunosuppression (10)
- Immunosuppression and corticosteroid use increases risk (1)
- Immunosuppression as predisposing factor to mycosis development (1)
- Immunosuppression from corticosteroid therapy (1)
- immunosuppression from obinutuzumab (1)
- immunosuppression in compromised patients (1)
- immunosuppression risk (mitigation strategies discussed) (1)
- immunosuppression with conventional chemotherapy (1)
- immunosuppression with current cancer treatments (1)
- immunosuppressive (2)
- Immunosuppressive drugs (1)
- immunosuppressive effects (1)
- Immunosuppressive medications (Dexamethasone) contributed to increased susceptibility to opportunistic infections (1)
- immunosuppressive mycotoxin production (1)
- Immunosuppressive therapy (corticosteroids, dexamethasone) increases cryptococcal infection risk (1)
- Immunosuppressive therapy as predisposing factor (1)
- Immunosuppressive therapy complications (1)
- immunosuppressive therapy increases fungal infection susceptibility (1)
- Immunosuppressive therapy increases risk of opportunistic infections (1)
- immunosuppressive therapy increases susceptibility to infection (1)
- Immunosuppressive therapy worsens fungal infection susceptibility (1)
- Immunosuppressive treatments (corticosteroids, anti-TNF agents) increase risk of breakthrough infections (1)
- immunosuppressive treatments increasing infection risk (1)
- immunotoxicity (1)
- impair macrophage internalization (1)
- impair pollen viability (1)
- impaired antifungal efficacy (1)
- impaired apoptosis (1)
- impaired autonomy in chronic pain populations (1)
- impaired autonomy in chronic pain populations (1)
- impaired autophagy (1)
- impaired autophagy-mediated nutrient recovery (1)
- impaired breathing and speech (1)
- impaired caregiving behavior (1)
- impaired cell membrane integrity (1)
- impaired cell surface expression of GABA_BRs (1)
- impaired cell wall integrity (1)
- Impaired cognition (1)
- impaired cognition reported in some microdosing studies (1)
- impaired cognition reported in some microdosing studies (1)
- impaired concentration (1)
- impaired concentration (1)
- impaired control and cognition (2)
- Impaired decision-making (1)
- impaired dendritic spine plasticity (1)
- impaired dopamine synthesis (cat-2 downregulation) (1)
- impaired drug absorption (1)
- impaired efficacy over time (1)
- Impaired executive functions (1)
- impaired fruiting body formation (1)
- impaired gas exchange (1)
- impaired growth (1)
- impaired growth and conidial germination (1)
- Impaired growth and development (1)
- Impaired growth and development (1)
- impaired growth performance (1)
- impaired humoral immunity (1)
- Impaired immune function (1)
- Impaired insulin signaling (1)
- impaired judgment (1)
- impaired judgment and vulnerability to therapist abuse (1)
- impaired learning and memory (1)
- Impaired macrophage control of fungal growth at high concentrations (1)
- impaired macrophage internalization (1)
- impaired macrophage phagocytic activity at high concentrations (1)
- impaired maternal care behaviors (1)
- impaired metabolic regulation (1)
- impaired metabolism (1)
- impaired neuronal development (1)
- impaired neutrophil clearance and excessive inflammation in CF (1)
- impaired neutrophil recruitment (1)
- Impaired nitrogen metabolism (1)
- impaired nutrient digestibility (1)
- impaired nutritional status (1)
- impaired parasitic capability when CmCH1 and CmCH10 are deleted simultaneously (1)
- impaired protein synthesis (1)
- impaired reproduction (1)
- impaired sexual reproduction (1)
- impairing fungal survival (1)
- impairs dopaminergic and glutamatergic neurons (1)
- impairs ergosterol production (1)
- impairs memory (1)
- impairs neutrophil and macrophage function (1)
- impairs root development (1)
- IMPDH inhibition (1)
- impeded gas exchange (1)
- implantable cardioverter defibrillator or pacemaker (1)
- improper casing composition can negatively affect texture and firmness (1)
- improper pesticide use delays effective treatment (1)
- improper storage conditions (1)
- improper treatment adherence (1)
- improved safety profile compared to some commercial prebiotics (1)
- improved safety profile compared to some commercial prebiotics (1)
- inability to directly penetrate egg shells (1)
- inability to distinguish viable from non-viable organisms (1)
- inability to form sclerotia (1)
- Inability to perform neurosurgical procedure (1)
- Inactivation through N-methylation (1)
- inadequate adherence to treatment guidelines (1)
- inadequate amphotericin B availability (1)
- inadequate amphotericin B availability in 16% of centers (1)
- Inadequate antibiotic response (1)
- Inadequate attention to fungal diseases (1)
- inadequate awareness leading to continued consumption of contaminated foods (1)
- Inadequate cleaning protocols (1)
- Inadequate coverage of treatment guidelines (1)
- Inadequate coverage of treatment protocols (1)
- inadequate diagnostic capability (1)
- inadequate dosing (1)
- inadequate drying facilitates fungal contamination (1)
- inadequate efficacy with fluconazole (1)
- inadequate efficacy with fluconazole (1)
- inadequate follow-up of hepatic inflammatory pseudotumor (1)
- inadequate foot hygiene (1)
- inadequate fungal species identification capacity (1)
- inadequate humidity control (1)
- inadequate monitoring (1)
- Inadequate sterilization during dental procedures increases infection risk (1)
- Inadequate sterilization practices in dental procedures facilitates infection (1)
- inadequate therapeutic support (1)
- inadequate therapy leading to increased mortality (1)
- inadequate treatment access in some regions (1)
- inadequate treatment with topical-only or short-term oral therapy (1)
- inadequate treatment with topical-only or short-term oral therapy (1)
- inappropriate ABPA diagnosis leading to glucocorticoid therapy in CPA patients (1)
- inappropriate antibiotic use (1)
- inappropriate antibiotic-only therapy without antifungal coverage (1)
- inappropriate antifungal drug use (2)
- inappropriate antifungal selection can promote drug-resistant strains (1)
- inappropriate antifungal use (2)
- Inappropriate dosages may not achieve intended effects (1)
- inappropriate empiric antibiotics associated with higher mortality (1)
- inappropriate empiric therapy (2)
- Inappropriate or prolonged use may disturb body's holistic balance and pose health risks (1)
- inappropriate prescribing leading to suboptimal patient outcomes (1)
- Inappropriate use of topical corticosteroids exacerbates fungal infection by suppressing immune response and facilitating fungal dissemination (1)
- inappropriate use of topical medications contributing to chronicity (1)
- incidental durotomy (1)
- Incision and drainage insufficient for cure (1)
- incoherent speech (1)
- incompatibility with abstinence-based recovery models (1)
- incomplete antifungal therapy led to relapse and dissemination (1)
- incomplete bacterial normalization in interdigital regions (1)
- incomplete bioavailability (1)
- incomplete contaminant degradation (1)
- incomplete contaminant degradation (1)
- incomplete in vivo evaluation (1)
- incomplete in vivo validation (1)
- incomplete inhibition of some pathogens (1)
- incomplete microbiome restoration (1)
- incomplete mineralization (1)
- incomplete mineralization of degradation products possible (1)
- incomplete penetration with some isolates (1)
- incomplete protection compared to conventional treatments (1)
- Incomplete resolution with initial monotherapy (1)
- Incomplete response to itraconazole monotherapy (1)
- incomplete treatment during first admission likely facilitated disease progression and fatal outcome (1)
- inconsistent effects across different conditions (1)
- inconsistent effects on chromium and copper accumulation (1)
- Inconsistent effects on microbial diversity in some studies (1)
- inconsistent field performance (1)
- inconsistent nomenclature may complicate clinical management and antifungal selection (1)
- inconsistent performance with direct transfer method (1)
- inconsistent results in some agricultural applications (1)
- inconspicuous fungal morphology (1)
- incorrect antimicrobial selection (1)
- incorrect dosing (1)
- incorrect duration of therapy (1)
- increase fungal burden in some models (1)
- increased A. fumigatus burden associated with mortality (1)
- increased acute amygdala reactivity in females (1)
- increased adipose inflammation (1)
- increased aggression (1)
- increased aggression (1)
- Increased alpha-synuclein aggregation (1)
- increased antifungal resistance in dormant populations (1)
- increased anxiety (2)
- increased anxiety during intoxication (1)
- increased anxiety in acute post-dosing period (1)
- increased anxiety in postpartum dams (1)
- increased anxiety-like behavior (1)
- Increased anxiety-like behaviors (1)
- increased arterial pressure (1)
- Increased bee and brood mortality (1)
- increased bioavailable Cd in some cases (1)
- increased biting midges (1)
- increased bleeding and death risk (vitamin E high doses) (1)
- increased bleeding risk (1)
- increased bleeding risk (1)
- increased blood pressure (1)
- increased blood pressure and heart rate (1)
- increased body temperature (1)
- increased cancer risk from processed meats (1)
- increased cancer risk from processed meats (1)
- increased cardiac arrhythmia risk (1)
- increased cardiovascular disease risk associated with reduced Kazachstania abundance (1)
- increased cardiovascular risk (1)
- increased cell proliferation in non-cancerous MCF-10A cells (1)
- increased chitosan content accelerated material destruction by fungi (1)
- Increased cholesterol deposition (1)
- increased diabetes prevalence in observational studies (1)
- increased disease severity and activity (1)
- increased disease susceptibility (3)
- increased drug efflux (1)
- increased dysphoria and suicidality in patients with comorbidities (1)
- Increased Enterobacteriaceae associated with dysbiosis risk (1)
- Increased exposure to airborne fungal spores causes respiratory disorders (1)
- increased fungal burden (1)
- increased fungal growth in infected macrophages (1)
- Increased gas production in study group (1)
- increased Gram-negative bacteria (1)
- increased hardness (1)
- increased hardness and chewiness at higher levels (1)
- increased healthcare resource utilization (1)
- increased heart rate (1)
- Increased heart rate and blood pressure (1)
- increased heart rate and blood pressure at systemic level (1)
- increased heart rate and blood pressure at systemic level (1)
- increased heat stress sensitivity (1)
- increased immune-mediated disease (1)
- Increased infection risk from immunotherapy (1)
- increased inflammatory cell infiltration (1)
- increased inflammatory responses (1)
- increased inflammatory responses (1)
- Increased intestinal permeability (3)
- increased lipid oxidation (1)
- increased mania severity (1)
- Increased methane production represents energy loss in ruminants (1)
- increased microbial contamination (1)
- increased microbial dysbiosis complications (1)
- increased moisture content in treated samples (1)
- increased mortality risk with high sugar consumption (1)
- increased negative affect (1)
- Increased neuronal toxicity (1)
- Increased neuronal toxicity (1)
- increased oxidative stress at concentrations ≥5.0% (1)
- increased packaging costs (1)
- increased packaging costs (1)
- increased pain sensitivity (1)
- increased pain symptoms (1)
- increased pathogenic fungal load during fruiting body stage (1)
- increased perioperative neurological deterioration (1)
- increased pigment biosynthesis (1)
- increased prevalence of chronic diseases (1)
- increased pro-inflammatory compounds (1)
- Increased Proteobacteria (1)
- increased Proteobacteria associated with colitis (1)
- increased Proteobacteria associated with colitis (1)
- increased reaction times (1)
- increased relapse risk (1)
- increased risk of behavioral impairments (1)
- increased risk of Crohn's disease in individuals with OCTN1 genetic variants (1)
- increased risk of Crohn's disease in individuals with OCTN1 genetic variants (1)
- increased risk of Crohn's disease with trehalose consumption (1)
- increased ROS levels (1)
- increased ROS levels (1)
- increased secondary infection susceptibility (1)
- increased sensitivity to antifungal drugs in mutant (1)
- Increased sensitivity to Congo Red and Calcofluor White in kre6 mutants (1)
- increased sensitivity to starvation (1)
- Increased serum triglycerides and cholesterol (1)
- increased social harm (1)
- increased stress sensitivity (2)
- Increased suicidal ideation with LSD use (1)
- increased susceptibility to early-stage degradation in modified wood compared to control (1)
- Increased susceptibility to environmental stressors in unsupplemented larvae (1)
- increased susceptibility to secondary pathogens (1)
- increased systemic toxicity (1)
- increased thin spines (1)
- Increased thrombosis risk (1)
- increased total oxidant status and oxidative stress index alongside antioxidant gains (1)
- increased translocation of pathogens and proinflammatory stimuli (1)
- Increased treatment failures in infections (1)
- increased type 2 diabetes risk above 80 µg daily intake (1)
- increased virulence (2)
- Increased virulence factors and pathogenicity under simulated microgravity (1)
- increased virulence risk from non-pathogenic species (1)
- increased water vapor permeability with higher AO concentrations (1)
- increases fungal toxin accumulation (1)
- increases maladaptive responses (1)
- increases neuronal apoptosis (1)
- increases opioid-seeking behavior (1)
- increases organ-specific fungal burdens (1)
- increases plant susceptibility to pathogens (1)
- increases susceptibility to fungal antagonists like Trichoderma atroviride (1)
- increasing antifungal resistance (1)
- increasing antifungal resistance in dermatophytes is noted as a concern despite susceptibility in this case (1)
- increasing antifungal resistance observed in dermatophytes including N. gypsea (1)
- Increasing antimicrobial resistance (1)
- increasing risk of persistent infections (1)
- increasing susceptibility to mucormycosis (1)
- indicating species-specific metabolic dependencies (1)
- indifferent responses (1)
- individual host differences (1)
- individual microbiota variation limiting effectiveness (1)
- individual variability in treatment response (1)
- indoor biodeterioration (1)
- indoor colonization causing biodeterioration (1)
- induced dysbiosis (1)
- induces graft incompatibility (1)
- Induction of allergic inflammatory responses (1)
- induction of asthmatic reactions (1)
- induction of asthmatic reactions (1)
- induction of filamentation in C. albicans (1)
- ineffective secondary fungal peritonitis prevention (1)
- ineffectiveness of iodide in disseminated cases (1)
- infection-induced growth reduction (1)
- infections (1)
- infiltration progression (1)
- inflammation (4)
- Inflammation induction with certain administration methods (1)
- Inflammatory cytokine elevation (1)
- inflammatory reactions (1)
- inflammatory response potential through arachidonic acid pathway (1)
- Inflammatory response with pharyngeal aspiration (1)
- inflammatory responses (1)
- inflammatory side effects from zinc supplementation (1)
- infrastructural damage from FOG accumulation (1)
- infusion reactions (1)
- infusion-related events (1)
- infusion-related reactions (3)
- infusion-related reactions (11.4%) (1)
- infusion-related reactions (rezafungin) (1)
- infusion-related reactions including pyrexia and rigors (1)
- Inherent antifungal resistance in Fusarium species (1)
- Inherent limitations in mechanical strength (1)
- Inherent resistance to multiple antifungal agents (1)
- inhibit bacterial activity at high concentrations (1)
- inhibited biomass accumulation (1)
- inhibited inflammasome activation (1)
- inhibited mycelial growth (1)
- inhibited seedling growth (1)
- inhibited Verrucomicrobiota (1)
- inhibition at high dye concentrations (1)
- inhibition by Al3+ (1)
- inhibition by gastric juice (1)
- inhibition by gastric juice (1)
- inhibition by mixed contaminants (1)
- inhibition of bone remodeling (1)
- inhibition of CYP2E1 enzyme metabolism (1)
- inhibition of energy metabolism (1)
- Inhibition of fungal growth at maximum metal levels (1)
- inhibition of growth under heat stress (1)
- inhibition of inflammasome activation (1)
- Inhibition of microalgal growth at high heavy metal concentrations (1)
- inhibition of mycelial growth (1)
- inhibition of nitrification (1)
- inhibition of organotrophic bacteria (1)
- inhibition of photosynthesis (1)
- inhibitory compounds present in stillage may limit initial growth (1)
- Inhibitory effects observed at high wastewater concentrations (75-100%) (1)
- inhibitory effects of high pharmaceutical concentrations on fungal growth (1)
- inhibits alpha-mannosidase and mannosidase II causing lysosomal storage disease (2)
- inhibits macrophage autophagy (1)
- inhibits RNA polymerase (1)
- inhibits TCA cycle (1)
- Initial acyclovir treatment for suspected HSV encephalitis showed only partial improvement and was not effective for the underlying fungal infection (1)
- Initial acyclovir treatment for suspected HSV was ineffective for fungal infection (1)
- initial antibiotic therapy failed (1)
- Initial antibiotic therapy was ineffective (1)
- initial antimicrobial therapy ineffective (1)
- initial empirical antibiotics were ineffective (1)
- initial failure of prednisolone and itraconazole combination (1)
- initial failure of prednisolone and itraconazole combination (1)
- Initial immunosuppressive therapy (methotrexate, leflunomide) potentially facilitating dissemination (1)
- Initial immunosuppressive treatment (belatacept, mycophenolate mofetil, prednisone) contributed to disease progression in immunocompromised patient (1)
- Initial misdiagnosis as HSV encephalitis requiring acyclovir therapy (1)
- Initial misdiagnosis as scalp folliculitis with ineffective antibiotic treatment (1)
- Initial misdiagnosis leading to treatment delay (1)
- Initial misdiagnosis leading to unnecessary orchiectomy (1)
- Initial misidentification as contaminant delayed appropriate treatment (1)
- Initial negative effect on root length at 4-5 DAS in some treatments (1)
- Initial reduction in microbial diversity under high selenium doses (1)
- innate immune suppression (1)
- innate resistance (1)
- inoculation reduced aerial biomass at highest salinity levels (1)
- insensitivity to certain fungicides (1)
- insomnia (8)
- instability at excessively high pH values (1)
- Instability in solution (1)
- insufficient contact time (1)
- insufficient early suspicion of fungal infection (1)
- insufficient echinocandin access (1)
- Insufficient fruit and vegetable intake associated with increased MCI risk (1)
- insufficient funding (1)
- insufficient long-term baseline diversity benefit (1)
- insufficient stability of tyrosinase-based electrode (1)
- insufficient therapeutic response (1)
- insufficient vitamin A (1)
- intensified unwanted experiences (1)
- intensive tillage reduces AMF diversity (1)
- intentional self-injury (5% of treatment-resistant depression participants) (1)
- interactions with medications (1)
- interference from non-phenolic compounds including ascorbic acid (1)
- interference with conventional antidepressant medications (1)
- interindividual variability in tolerance (1)
- Internal hemorrhage (1)
- internal hyphal growth (1)
- internal organ damage (1)
- intestinal obstruction from large mushroom pieces (1)
- intestinal permeability increase (2)
- intestinal permeability increase (1)
- intolerance issues (1)
- intracellular acidification (1)
- Intracerebral hemorrhage (1)
- Intravenous dexamethasone (high-dose) causes immune dysfunction and induced hyperglycemia (1)
- Intravenous posaconazole contraindicated in moderate-to-severe renal impairment (1)
- intravenous voriconazole avoided in CKD due to sulfobutyl-ether-β-cyclodextrin accumulation (1)
- Intrinsic amphotericin B resistance in A. terreus (1)
- intrinsic antifungal resistance (1)
- Intrinsic antifungal resistance in non-fumigatus species (2)
- intrinsic antifungal resistance in some fungal pathogens (1)
- intrinsic antifungal resistance of pathogens (1)
- Intrinsic echinocandin resistance (1)
- Intrinsic fluconazole resistance (1)
- Intrinsic fluconazole resistance in C. krusei (1)
- intrinsic resistance (2)
- intrinsic resistance in certain Fusarium species (1)
- Intrinsic resistance of L. prolificans to most antifungal agents (1)
- intrinsic resistance of M. capitatus to echinocandins (1)
- intrinsic resistance to azoles reported in some cases (1)
- intrinsic resistance to caspofungin (1)
- Intrinsic resistance to echinocandins (5)
- Intrinsic resistance to most antifungal drugs (1)
- intrinsic resistance to multiple antifungal classes (1)
- introduce undesirable flavors (1)
- intrusive thoughts (1)
- Invasive fungal infections (1)
- invasive fungal spread (1)
- Invasive plants decrease AMF diversity which negatively impacts native plant growth and ecosystem function (1)
- invasive species risks (1)
- invertebrates (1)
- Ionophore activity disrupting ion transport (1)
- iron stress (1)
- iron toxicity from excessive intake (1)
- irregular muscle contraction (1)
- irregular trap formation (1)
- irreversible depigmentation (1)
- irreversible liver and kidney damage (1)
- irreversible vision loss (1)
- irritation (1)
- isavuconazole (1)
- ischemia (1)
- ischemic stroke risk from elevated copper (1)
- Ischnoderma benzoinum can function as competitor reducing biocontrol efficacy (1)
- isolation (1)
- isolation during labor (2)
- ISR provides less protection than SAR alone (1)
- itching (1)
- itraconazole (7)
- itraconazole (1)
- Itraconazole bioavailability issues (1)
- Itraconazole caused lower limb edema leading to treatment discontinuation (1)
- Itraconazole ineffective against Scedosporium and may contribute to its isolation (1)
- itraconazole ineffective for P. bovis treatment despite in vitro susceptibility (1)
- itraconazole not experimentally effective against Rhizopus sp. (1)
- itraconazole poor response (1)
- itraconazole poor tolerability (1)
- itraconazole resistance (3)
- itraconazole resistance development in biofilm form (1)
- Itraconazole resistance in C. glabrata (1)
- Itraconazole resistance in C. glabrata isolates (1)
- itraconazole resistance in Madurella fahalii (1)
- Itraconazole resistance in Penicillium and Fusarium (1)
- itraconazole shows variable MICs (1)
- Itraconazole treatment failure (1)
- Itraconazole treatment failure despite therapeutic drug levels (1)
- its suppression damages cell wall integrity (1)
J
- jaundice (1)
K
- Kappa opioid agonists may have prodepressant effects (1)
- ketamine-induced uropathy (1)
- ketoconazole (1)
- ketoconazole hepatic toxicity (1)
- kidney (1)
- kidney and liver problems (1)
- Kidney dysfunction (1)
- kidney injury (1)
- kidney stone risk (vitamin C) (1)
- Kidney tissue damage (1)
- kidney toxicity observed in renal tissue (1)
- kidney toxicity observed in renal tissue (1)
- kidneys (1)
- kidneys (Tyrothricin) (1)
- Knockout of PlRab genes reduces pathogenicity and virulence of P. litchii (1)
- Knockout of Puf4 leads to vegetative growth defects and reduced reproductive capacity in oomycetes (1)
- knockout reduces pathogenic capacity (1)
- Known to cause opportunistic infections in humans (1)
L
- L-glutaminase-like activity causing adverse effects (1)
- L-glutamine showed inhibitory effects on S. thermophilus at low pH (1)
- laboratory test interference (biotin with TSH and troponin) (1)
- lack of access to appropriate medications (1)
- lack of activity against Mucorales and yeasts (1)
- lack of activity against yeasts and Mucorales (1)
- Lack of additional benefit from amphotericin B alone (1)
- lack of adequate laboratory capacity limits ability to diagnose infections and guide treatment (1)
- lack of appetite (1)
- lack of autonomy (2)
- lack of clinical evidence (1)
- lack of data on long-term cumulative effects and pharmacological interactions (1)
- Lack of diagnostic access leading to delayed treatment and increased mortality (1)
- Lack of diagnostic capacity leads to delayed diagnosis and treatment of serious fungal infections (1)
- lack of efficacy (1)
- lack of long-term safety data (1)
- lack of motivation for psychotherapy (1)
- lack of multiresistant fungal strain management (1)
- lack of neurodevelopmental follow-up (1)
- lack of nutritional counselling (1)
- lack of policy prioritization (1)
- lack of prevention guidance (1)
- Lack of preventive measures (1)
- lack of proper texture without added gelling agents (1)
- lack of prophylaxis in immunocompromised patients (1)
- lack of response maintenance (1)
- lack of standardized susceptibility breakpoints (1)
- lack of standardized susceptibility breakpoints for Fomitiporella micropora (1)
- lack of strict IPC implementation (1)
- lack of trained providers (1)
- Lactarius torminosus poisoning risk (1)
- lactobacillemia reported in immunocompromised patients (1)
- lactophenol blue staining inhibits dynamic signal due to fixation properties (1)
- land use change (1)
- larval mortality (1)
- lasiodiplodine (1)
- Latent infections difficult to detect and manage (1)
- LD50 not reached even at 1000 µg/kg dose (1)
- LDL (1)
- leachate infiltration (1)
- lead (2)
- Lead accumulation (1)
- lead bioaccumulation (1)
- lead neurotoxicity (1)
- lead toxicity (1)
- lead toxicity (1)
- Lead toxicity to bacteria and plants (1)
- Lead toxicity to bacteria and plants (1)
- lead-induced hematopoietic system effects (1)
- leading to self-discontinuation (1)
- leading to tremors (1)
- leads to lanosterol accumulation (1)
- leads to liver failure (1)
- leaf burning at low altitudes (1)
- leaf damage reducing photosynthesis (1)
- leaf discoloration (1)
- leaf necrosis (2)
- leaf spots (1)
- leaf wilting (1)
- leaf yellowing (2)
- leaves (1)
- Lectin resistance to digestion causing tissue accumulation (1)
- legal issues (1)
- Lesion development (1)
- lesion formation (1)
- Less potent than conventional antibiotics in some applications (1)
- leukopenia (1)
- Levonorgestrel from Skyla® IUD triggered or exacerbated chronic urticaria (1)
- lightheadedness (1)
- lignin biosynthesis disruptions in high-expression lines (1)
- likely related to underlying keratosis pilaris (1)
- lime suppresses white-rot fungi growth (1)
- limitations in host infection capability (1)
- limitations include single patient isolate and lack of in vivo testing (1)
- limitations noted in extraction technologies and clinical research advancement (1)
- limitations of biocontrol agents in complete disease control (1)
- limitations of current technologies restrict full investigation (1)
- limitations of direct microscopic examination with only 11.4% sensitivity (1)
- limitations of phenotypic identification methods (1)
- Limited access to advanced diagnostic tools (1)
- limited access to advanced diagnostics leading to underdiagnosis and delayed treatment (1)
- limited access to alternative antifungals (1)
- limited access to broad-spectrum antifungals (1)
- limited access to effective antifungals in resource-limited settings (1)
- limited access to quality antifungal drugs and diagnostics in resource-limited settings (1)
- Limited access to quality antifungal drugs in resource-limited settings (1)
- limited access to rehabilitation services (1)
- limited accuracy with commercial libraries alone (1)
- limited activity against certain species (1)
- limited antibacterial activity (3)
- Limited antibiotic resistance observed in strain characterization (1)
- limited antifungal drug classes (1)
- limited availability in some regions (1)
- limited availability of liposomal amphotericin B formulations (1)
- limited azole penetration to central nervous system (1)
- Limited bioavailability and stability of bioactive components in crude form (1)
- Limited bioavailability challenges (1)
- Limited bioavailability of curcumin (1)
- Limited blood-brain barrier penetration (1)
- limited clinical applicability in some cases (1)
- limited clinical bioavailability (1)
- Limited clinical efficacy data (1)
- Limited clinical efficacy for some conditions including COVID-19 (1)
- limited clinical trial data (1)
- limited CNS penetration (1)
- limited collagen hydrolysis (1)
- Limited corneal penetration with natamycin in deep stromal disease (1)
- Limited data (1)
- Limited data on treatment failures (1)
- Limited detection in human body fluids may prevent early diagnosis (1)
- limited dispersion of carbon materials in water (1)
- limited drug efficacy (1)
- limited durability compared to synthetic polymers (1)
- limited effectiveness against Gram-negative bacteria (2)
- Limited effectiveness against Verticillium dahliae and Neofusicoccum parvum in some bacterial isolates (1)
- limited effectiveness for anionic dyes (1)
- limited effectiveness in non-soil conditions for some isolates (1)
- limited effectiveness of fluconazole against molds (1)
- limited effectiveness of lysozyme against gram-negative bacteria (1)
- limited effectiveness of lysozyme against gram-negative bacteria (1)
- Limited effectiveness of some isolates in specific conditions (1)
- limited effectiveness of traditional serotonergic antidepressants for anhedonia (1)
- limited effectiveness on fresh diesel and white plastic substrates due to volatile hydrocarbon toxicity and polymer additives (1)
- Limited effectiveness under permanent flooding conditions (1)
- Limited effectiveness under severe salinity stress (2)
- limited effectiveness when vegetables are visible in dishes (1)
- limited efficacy in CD recurrence prevention (1)
- limited efficacy in immunocompromised patients (1)
- Limited efficacy in late growth stages (1)
- limited efficacy in severe onychomycosis (2)
- limited efficacy in some environmental conditions (1)
- limited efficacy of (1-3)-β-D-glucan assay (1)
- Limited efficacy of Akanthomyces muscarius on gall-making species (1)
- limited efficacy of amphotericin B relative to azoles (1)
- limited efficacy of amphotericin B relative to azoles (1)
- Limited efficacy of chloroisobromine cyanuric acid and dimethomorph (1)
- Limited efficacy of current antifungal therapy (1)
- Limited efficacy of first-line antifungals (1)
- Limited efficacy of some azoles as monotherapy (1)
- limited efficacy under severe salinity (1)
- Limited evaluation of long-term effects and chronic use safety (1)
- limited evidence of treatment benefit (1)
- Limited fungal specificity of Hsp90/calcineurin inhibitors (1)
- limited head circumference improvement (1)
- Limited horizontal transmission (1)
- Limited in vivo efficacy due to high plasma protein binding (1)
- limited in vivo efficacy in some models (1)
- Limited intraocular drug penetration requiring high-dose therapy (1)
- limited intraocular penetration (1)
- limited low molecular weight applications (1)
- Limited mechanical properties in some bioplastics (1)
- limited mitigation of severe salinity stress (1)
- limited monotherapy effectiveness (1)
- limited pathogenicity under natural unwounded conditions (1)
- limited penetration of topical antifungals in diffuse infections (1)
- limited pleural penetration of echinocandins (2)
- limited preparation knowledge (1)
- limited prognostic value of current BAL biomarkers (1)
- Limited recyclability of adsorbent material (1)
- limited role of echinocandins in intra-abdominal candidiasis (1)
- limited secondary effects noted with polysaccharides (1)
- limited skin permeability with traditional formulations (1)
- Limited specificity for pseudocysts versus mucinous cysts (1)
- Limited stability (1)
- limited stability of some formulations (1)
- limited stromal penetration (1)
- limited stromal penetration of natamycin (1)
- limited structural integrity (1)
- limited subsurface mobility (1)
- limited subsurface mobility (1)
- limited systemic concentrations with oral administration (1)
- Limited therapeutic options (1)
- Limited therapeutic success despite antifungal treatment (1)
- limited thermal stability at elevated temperatures (1)
- Limited tissue distribution (1)
- limited tissue penetration (2)
- limited to early infection stages (1)
- Limited toxicity concerns noted (1)
- Limited toxicity data available (1)
- Limited toxicity profile noted (1)
- Limited toxicity to host macrophage cells (1)
- limited treatment options (2)
- Limited treatment options for pediatric patients (1)
- limited understanding of nanoparticle field behavior (1)
- Limited viability during gastrointestinal passage (1)
- limiting immediate therapeutic application (1)
- limiting its use as sole therapeutic target (1)
- limiting their consumption (1)
- Linalool toxicity in high concentrations mentioned as potential issue (1)
- lipid and pathological changes from synthetic antioxidants (1)
- lipid degradation during high-temperature drying (1)
- Lipid emulsion may promote yeast proliferation (1)
- lipid oxidation during storage (1)
- lipid peroxidation (3)
- Lipopolysaccharide-induced immune activation impairs synaptic development (1)
- Liposomal amphotericin B adverse effects (1)
- liposomal amphotericin B treatment may affect antigen detection (1)
- liver (3)
- liver and intestinal damage (1)
- liver and kidney failures (1)
- liver and kidney impairment from mycotoxin exposure (1)
- liver failure (1)
- Liver injury from antifungal therapy (1)
- liver or kidney damage (1)
- liver toxicity (1)
- liver toxicity (nicotinamide at high doses) (1)
- liver toxicity in 1.8% of patients (1)
- Local application site reactions including erythema and exfoliation (1)
- Lomentospora isolate resistant to amphotericin B (1)
- long cooking times (1)
- long QT syndrome (1)
- long QT syndrome (1)
- Long-term contamination leaching with traditional methods (1)
- Long-term contamination leaching with traditional methods (1)
- long-term drug complications (1)
- long-term environmental persistence (1)
- Long-term fungicide use induces resistant strains (1)
- Long-term fungicide use may lead to pesticide residues (1)
- Long-term glucocorticoids and azathioprine increased susceptibility to opportunistic fungal infections (1)
- Long-term greenhouse cultivation may increase soil salinity and alter soil microbial communities (1)
- long-term health effect uncertainties (1)
- long-term health effects (under evaluation) (1)
- long-term health effects of novel foods (1)
- long-term stability issues (1)
- long-term stability maintained over 10 hours (1)
- Longer comedowns (1)
- Lophodermium species (1)
- loss of accessory chromosome 12 reduces pathogen virulence (1)
- loss of beneficial bacteria (1)
- loss of bioactive compounds during thermal processing (1)
- Loss of bioactivity through N-acetyl-cysteine conjugation (1)
- Loss of bioactivity upon heating or enzymatic treatment with proteinase K (1)
- loss of consciousness (2)
- loss of consciousness (1)
- loss of control (1)
- loss of efficacy during gastrointestinal transit (1)
- loss of ego (1)
- Loss of free amine group reduces bioactivity (1)
- Loss of function mutations causing genetic disorders (1)
- loss of functional metabolites (1)
- Loss of low-molecular-weight polysaccharides during membrane filtration (1)
- loss of microbial diversity (1)
- loss of MoGet1 and MoGet2 function impairs fungal pathogenesis (1)
- loss of mushroom-like odor compounds during drying (1)
- Loss of pathogenicity in mycovirus-free strains (1)
- loss of productivity (1)
- loss of productivity (1)
- loss of queen acceptance (1)
- loss of reality contact (1)
- loss of specialized metabolites (1)
- Loss of Spinophilin function impairs memory stabilization and presynaptic plasticity maintenance (1)
- loss of STRIPAK components can reduce virulence but also impairs fungal viability (1)
- loss of synthetic liver function (1)
- Loss of β1-integrin during adolescence impairs action-outcome learning (1)
- Low affinity for textile fibers (1)
- low anti-inflammatory activity in tested extracts (1)
- low antioxidant activity in OMP-CL despite other benefits (1)
- low bioavailability (1)
- Low bioavailability following oral administration (1)
- low bioavailability in Lignosus rhinocerotis requiring high dosages (1)
- low bioavailability of flavonoids (5-10% absorption) (1)
- low breeding efficiency with traditional methods (1)
- low breeding efficiency with traditional methods (1)
- Low concentrations of L-arginine (5 mM) enhanced fungal pathogenicity and disease severity (1)
- low cytotoxicity in healthy cells at therapeutic concentrations (1)
- low cytotoxicity observed (1)
- low dark toxicity mentioned as advantage (1)
- low digestibility in some plant proteins (1)
- low DNA yield from wood tissue samples (1)
- Low inhibitory effect on AChE and BChE compared to standards (1)
- low mood (1)
- low oral bioavailability (2)
- low pH and temperature inhibit bacterial activity (1)
- low product yield (1)
- low response rates (1)
- low selectivity index values (1)
- Low sensitivity of microscopy can underestimate disease prevalence (1)
- low susceptibility to azoles in Aspergillus section Nigri (1)
- low systemic concentrations after oral administration (1)
- Low temperature and high humidity conditions promote SLRD occurrence and Trichoderma proliferation (1)
- low water solubility limiting bioavailability (1)
- low-dose B. subtilis alone did not improve hatchability compared to controls (1)
- low-dose emodin may induce cellular senescence (1)
- lower activity against host-adapted pathogens (1)
- Lower antifungal efficacy compared to fluconazole (2)
- lower antimicrobial activity compared to conventional antibiotics (1)
- lower disease resolution rates (1)
- lower efficacy against certain pathogens like Z. tritici with some compounds (1)
- lower efficacy against Penicillium steckii (1)
- lower efficacy against Penicillium steckii (1)
- lower efficacy at mature biofilm stages (1)
- Lower efficacy compared to itraconazole at tested concentrations (1)
- Lower efficacy on older pupae (4-5 days) (1)
- Lower egg hatching rates on some diets (1)
- Lower immunostimulatory effect compared to some alternative supplements (1)
- lower mortality in greenhouse conditions compared to laboratory conditions (1)
- lower quality of life measures (1)
- lower quality of life measures (1)
- Lower sensitivity in blood specimens compared to tissue/BALF (1)
- lower short-chain fatty acid production (1)
- Lower susceptibility in older pupae (4-5 days old) (1)
- lower susceptibility to antifungals in A. welwitschiae (1)
- Lower than standard activity for urease and tyrosinase inhibition (1)
- lower thermal stability compared to native chitin (1)
- Lower toxicity to non-target organisms (1)
- LRFN5 knockdown induces depression-like behaviors and exacerbates stress-induced depressive phenotypes via synaptic damage (1)
- LtmilR2 expression suppression leads to increased pathogenicity (1)
- Lung accumulation with inhalation delivery (1)
- lung function decline (1)
- lysosomal storage disease in mammals (1)
M
- M2 macrophage polarization (1)
- M2 macrophage polarization (tumor-promoting) (1)
- Macrolide antibiotics increase Aspergillus colonization risk (1)
- macromolecule inactivation (1)
- madness (1)
- madness (1)
- magic mushroom ingestion caused acute kidney injury (1)
- magical ideation (1)
- magical ideation (1)
- maintaining over 90% cell viability at tested concentrations (1)
- maize (1)
- making protease inhibition a potential treatment strategy (1)
- Malassezia associated with Crohn's disease (1)
- Malassezia residual unsaturated fatty acids may induce skin inflammation (1)
- malformations (1)
- malignant hyperthermia (1)
- mania (3)
- mania history (1)
- manipulation vulnerability (1)
- mannitol effects were concentration-dependent (1)
- MAP substrate showed 1.92% contamination rate requiring additional precautions (1)
- marginal reduction in germination at highest concentrations (1)
- marital conflict reported in one case (1)
- market-dependent ultra-processed foods (1)
- material complexity (1)
- material deterioration (1)
- material strength variability during production (1)
- Maternal separation leads to excessive reduction of dendritic spines and further abnormalities (1)
- maternal withdrawal (1)
- matrix interference (1)
- may cause oxidative stress due to tannin content in certain conditions (1)
- may cause oxidative stress due to tannin content in certain conditions (1)
- may enhance inflammation in certain immune contexts through Th17 promotion (1)
- May inhibit beneficial ROS responses to physical activity (1)
- may not restore β-cell-specific biomarker levels (1)
- May protect cancer cells from doxorubicin toxicity (1)
- meaninglessness (1)
- mechanical circulatory support increases IFI risk (1)
- Mechanical damage increases pathogen infection risk (1)
- mechanical property deterioration under hygrothermal stress (1)
- mechanical property limitations of starch-based films (1)
- Mechanical ventilation facilitates fungal spread (1)
- mechanism requires further elucidation (1)
- median survival of 3 months for HIV-associated pulmonary aspergillosis (1)
- medicalization (1)
- medicalized control (1)
- medication non-compliance (1)
- meditation-related adverse effects (1)
- Medium toxicity (LD50 values reported) (1)
- Melanin accumulation interferes with DNA extraction quality (1)
- melanin can be oxidized and faded by strong oxidants such as hydrogen peroxide (1)
- melanin protection against antimicrobial compounds (1)
- melanin protects fungi from oxidative stress (1)
- melanin-mediated drug neutralization (1)
- melanocyte cytotoxicity (1)
- melleins (1)
- meloxicam ecotoxicity and persistence in environment (1)
- membrane damage (2)
- Membrane fouling causing flux decline and reduced separation efficiency (1)
- membrane rupture (1)
- membrane swelling (1)
- memory distortion (1)
- menadione is a redox cycler that can induce oxidative stress (1)
- menthol-induced drug resistance through MRP2 upregulation in hepatocellular carcinoma cells (1)
- mercury (1)
- Mercury accumulation (1)
- mercury accumulation causing neurotoxicity (1)
- Mercury accumulation toxic to flora (1)
- mercury poisoning (1)
- Mercury toxicity (1)
- MERTK-mediated phagocytosis causes synaptic loss and hinders neurological recovery after TBI (1)
- metabolic dysfunction (2)
- metabolic health risks from excessive phosphate intake (1)
- metabolic pathway interference (1)
- metabolic resistance (1)
- metabolic tolerance to antimicrobial agents (1)
- metabolic/endocrine disruption (1)
- metabolite instability under processing (1)
- metabolite toxicity (1)
- Metal contamination and high salinity reduce beneficial bacterial diversity (1)
- Metal contamination and salinity reduce beneficial bacterial diversity and antagonistic potential (1)
- Metal contamination and salinity reduce beneficial bacterial diversity and antagonistic potential (1)
- metal contamination reduces beneficial bacterial diversity (1)
- metal implants at treatment site (1)
- metal mixtures reduce decolorization efficiency (1)
- Metal toxicity at high concentrations (1)
- metal toxicity to cells (1)
- Metal toxicity to plants at high concentrations (1)
- metal-induced plant growth inhibition (1)
- methane production (1)
- methanol and aqueous extracts did not inhibit S. cerevisiae (1)
- Methodological errors initially overestimated benefits (1)
- methyldopa hepatotoxicity (1)
- Methylene blue dye is carcinogenic and mutagenic (1)
- methylene blue toxicity (1)
- micafungin (4)
- Micafungin breakthrough infection (1)
- microbial antagonism (1)
- microbial antagonism (1)
- microbial contamination if improperly processed (1)
- Microbial dysbiosis (1)
- microbial instability in monocultures (1)
- microbial quality variability (1)
- microbial substitution disease (1)
- microbial toxin production (1)
- microbiological vulnerability (1)
- microbiome disruption (1)
- microbiome disruption from broad-spectrum antibiotics (1)
- microbiota dysbiosis (1)
- microcosm structural failure (1)
- Microcystin accumulation in plants (1)
- microcystin-LR induces cytoskeletal disorganization (1)
- Microcystins are hepatotoxic and can accumulate in food chains (1)
- microglia M1 polarization (1)
- microglial hyperactivation (1)
- micronutrient depletion (1)
- microplastic bioaccumulation (2)
- microplastic contamination (1)
- microplastic formation from polymer degradation (1)
- microplastic ingestion (1)
- Microplastic pollution (1)
- microplastic pollution impairs nitrification (1)
- microplastics (1)
- Microplastics disrupt soil microbial communities (1)
- Microplastics disrupt soil microbial communities (1)
- migraine (1)
- migraine attacks (1)
- migration delays (1)
- mild adverse events including nausea (1)
- mild confusion (1)
- mild dyspepsia reported in 1 patient (2% adverse event rate) (1)
- Mild epigastric pain and dyspepsia reported in one control group patient (1)
- Mild epigastric pain and dyspepsia reported in one control group patient (1)
- Mild gastrointestinal discomfort (1)
- Mild gastrointestinal discomfort (1)
- Mild gastrointestinal reactions (2)
- mild headache (1)
- mild headaches with repeated dosing (1)
- Mild hemolytic activity at high concentrations (20 mg/mL showing 6.1-30% hemolysis) (1)
- Mild injection site reactions (1)
- Mild injection site reactions (1)
- mild irritation potential with certain fungicide-loaded formulations (1)
- Mild nausea (1)
- Mild pathogenicity on rapeseed (1)
- Mild pathogenicity to rapeseed (1)
- Mild phytotoxicity at highest concentrations (40 mg/mL caused 40% leaf damage) (1)
- Mild phytotoxicity at highest concentrations (40 mg/mL caused 40% leaf damage) (1)
- Mild to moderate adverse events including headache (1)
- Mild to moderate gastrointestinal discomfort occasionally reported with some herbal preparations (1)
- mild toxicity at higher concentrations (1)
- milR106 deletion increases pathogen sensitivity to oxidative stress and reduces virulence (1)
- mineral loss with microwave drying (1)
- mineral toxicity from certain biomass types (1)
- minimal adverse effects on surrounding tissues (1)
- Minimal adverse effects reported (1)
- Minimal adverse effects reported (1)
- Minimal cytotoxic effects at low concentrations (1)
- Minimal cytotoxicity at concentrations below 125 μg/mL (1)
- minimal cytotoxicity at examined dosages (1)
- minimal dark toxicity noted as positive attribute (1)
- minimal effect on pathogenic bacteria viability (1)
- minimal hemolysis (2)
- Minimal hemolysis at higher concentrations (35.64% at 200 µM) (1)
- minimal hemolytic activity (1)
- minimal individual antifungal activity (1)
- Minimal negative effects (1)
- Minimal negative effects (1)
- Minimal phytotoxicity observed (1)
- Minimal to negligible toxicity reported (1)
- Minimal to negligible toxicity reported (1)
- Minimal toxicity to healthy breast cells (MCF-10A) (1)
- minimal toxicity to healthy cells (1)
- Minimal toxicity to non-target earthworms (1)
- Minimal toxicity to normal cells (2)
- Minimal wood degradation observed with biocontrol strains compared to pathogenic fungi (1)
- minimal/no growth at 37°C limiting treatment options (1)
- minor adverse events in 32.6% of patients but no significant difference between groups (1)
- minor toxic and side effects reported (1)
- Minor transient adverse effects including short-term blood pressure increases (1)
- Minor yield reduction in intercropping systems compared to monoculture (1)
- misaligned therapeutic timing (1)
- misdiagnosis from corticosteroid use (1)
- Misdiagnosis resulting in inappropriate management (1)
- Misdiagnosis resulting in inappropriate management (1)
- misidentification between closely related species (1)
- Misidentification leading to inappropriate antifungal treatment (1)
- misidentification leading to inappropriate treatment (3)
- missed diagnostic window (1)
- misuse of over-the-counter antifungals (1)
- mitochondrial dysfunction (4)
- mitochondrial dysfunction (1)
- mitochondrial permeability concerns with some compounds (1)
- mitochondrial permeability concerns with some compounds (1)
- mitophagy activation (1)
- mitovirus infections associated with abnormal mitochondrial morphology and reduced fungal growth (1)
- mitral insufficiency (1)
- mixing wild mushrooms increases risk (1)
- Mo can suppress SRB respiration and limit microbial growth (1)
- MOB3 deletion paradoxically increases virulence (1)
- Model limitations with novel fungal strains (1)
- Model shows higher false positive rates with background noise (1)
- Moderate acute toxicity at high concentrations (1)
- Moderate acute toxicity at high concentrations (1)
- moderate efficacy with CuSO4 + Viodin (1)
- moderate gastrointestinal symptoms at wide dose ranges (1)
- Moderate irritant potential on chorioallantoic membrane (1)
- moderate peak serum concentration (1)
- moderate resistance to flucytosine (1)
- moderate resistance to flucytosine (1)
- modest antibacterial activity against C. neoformans (1)
- modest clinical efficacy in some cases (1)
- modest cytotoxicity to brain endothelial cells at high concentrations of Mpr1-functionalized nanoparticles (1)
- Modest cytotoxicity to brain endothelial cells at higher concentrations (1)
- moisture ingress (1)
- moisture susceptibility (1)
- moisture-related degradation (1)
- mold contamination (1)
- Mold contamination susceptibility at high moisture levels (1)
- mold toxicity (1)
- mold toxicity (1)
- Molybdenum inhibits sulfate reduction in sensitive bacteria (1)
- MoMad2 knockout reduces fungal virulence and pathogenicity (1)
- monacolin K adverse effects on musculoskeletal system and liver at high doses (1)
- Monascus kaoliang B6 produces red pigment with potential toxicity concerns limiting direct food applications (1)
- monotherapy with EV inhibitors alone showed minimal antifungal effects at clinically relevant concentrations (1)
- Monotonous diets (1)
- mood stabilizers (1)
- morphological cell damage (1)
- morphological changes under metal stress (1)
- morphology-dependent antifungal resistance (1)
- mortality (1)
- mortality at 45 mg/kg dose (1)
- mortality despite appropriate treatment (1)
- Mortality risk (2)
- Mortality risk (1)
- Mortality risk from non-pharmaceutical substances (1)
- mortality risk in immunocompromised CAR-T recipients (1)
- Motion artifacts in neuroimaging (1)
- motor dysfunction (2)
- MS medium at full strength may inhibit spore germination and fungal growth due to high ammonium content (1)
- MTT assay may underestimate cytotoxicity due to non-specific intracellular reduction (1)
- Mucorales exhibit rapid and destructive growth with angioinvasion causing tissue necrosis (1)
- Mucorales species show intrinsic resistance to short-tailed azoles such as voriconazole (1)
- mucosal inflammation (1)
- mucosal membrane stimulation (1)
- multi-drug resistance (1)
- Multi-drug resistance emerging in fungal pathogens (1)
- multi-drug resistance profile (1)
- multi-drug resistant bacterial strains (1)
- multi-organ dysfunction (1)
- Multi-organ failure (1)
- Multi-organ failure (1)
- multidrug resistance (1)
- multidrug resistance (4)
- multidrug resistance in bacteria (1)
- Multidrug resistance in C. auris (2)
- multidrug resistance in Fusarium species (1)
- multidrug resistance limiting therapeutic options (1)
- multidrug resistance mechanisms including upregulated efflux pumps (1)
- multidrug resistance to fluconazole (1)
- multidrug resistance to fluconazole (1)
- Multidrug resistance to triazoles (1)
- multidrug-resistant Candida auris (2)
- multiple anti-MM therapies associated with increased IFI incidence (1)
- multiple antibiotics were ineffective (1)
- Multiple drug class resistance (1)
- multiresistance patterns (1)
- multiresistant fungi strains (1)
- Musa spp. (1)
- muscarine (1)
- Muscle damage (1)
- Muscle damage (1)
- Muscle stiffness (1)
- Muscle tightness (1)
- mushroom becomes inedible at 84 hours with flavor deterioration (1)
- mushroom blend induced higher gas production compared to triacetin (1)
- mushroom dietary fiber may create associations with polyphenols affecting bioaccessibility (1)
- mushroom diets did not compromise growth performance or intestinal integrity (1)
- mushroom extract toxicity (1)
- mushrooms grown in industrial areas can accumulate heavy metals like cadmium (1)
- must be thoroughly cooked before consumption (1)
- mutagenic (1)
- mutagenic and carcinogenic effects at low concentrations (1)
- mutagenic effects (4)
- mutagenicity (5)
- Mutant tau expression causes mitochondrial dysfunction (1)
- mutational resistance to triazoles (1)
- mutations in critical residues impair fungal development and secondary metabolism (1)
- Mutations in MED20a increase susceptibility to fungal infection (1)
- mycelial colonization (1)
- mycelial deformation (1)
- Mycelial development (1)
- Mycelial mortality at extremely high temperatures (45°C) (1)
- mycelial overgrowth (1)
- Mycobacterium avium complex co-infection (1)
- Mycoparasitic agent causing crop contamination and yield reduction (1)
- Mycorrhizal switching under stress (1)
- mycotoxic properties (1)
- Mycotoxicity (1)
- mycotoxin accumulation (1)
- Mycotoxin accumulation (3-acetyl DON, DON, zearalenone, HT2, T2, enniatins, beauvericin) – potential health risks (1)
- Mycotoxin accumulation (nivalenol, zearalenone, beauvericin, diacetoxyscirpenol) (1)
- Mycotoxin accumulation causes immunosuppressive and mutagenic effects in humans and animals (1)
- mycotoxin accumulation in coffee (1)
- mycotoxin co-production risks (1)
- Mycotoxin contamination (1)
- Mycotoxin contamination (4)
- mycotoxin contamination in feed (1)
- mycotoxin contamination in food products (1)
- mycotoxin contamination of fruits and fruit products (1)
- mycotoxin contamination with deoxynivalenol and other trichothecenes (1)
- mycotoxin exposure (carcinogenic, genotoxic, teratogenic, nephrotoxic, hepatotoxic) (1)
- mycotoxin exposure causes acute and chronic health effects (1)
- mycotoxin production (14)
- mycotoxin production (aflatoxin B1) (1)
- Mycotoxin production (altenuene, alternariol, alternariol monomethyl ether) (1)
- Mycotoxin production (altertoxin III, potential ochratoxin A production) (1)
- Mycotoxin production (DON, zearalenone, HT2, T2, enniatins, beauvericin) – potential health risks (1)
- Mycotoxin production (fumonisins, beauvericin, moniliformin) (1)
- Mycotoxin production (fumonisins, beauvericin) associated with fungal virulence and potential human health hazards (1)
- Mycotoxin production (patulin and citrinin) causing hepatotoxicity (1)
- mycotoxin production (sterigmatocystin, norsolorinic acid, versicolorin) (1)
- mycotoxin production by certain fungal species (1)
- mycotoxin production including colletotrichum lactones (1)
- mycotoxin production inhibits germination (1)
- Mycotoxin production noted in certain Stachybotrys species with veterinary and medical significance (1)
- mycotoxin production regulation related to aflatoxin and sterigmatocystin formation (1)
- mycotoxin toxicity (1)
- mycotoxin-induced carcinogenesis (1)
- mycotoxin-producing species compromise epithelial barrier function (1)
- mycotoxins in by-products requiring careful processing (1)
- mycotoxins inhibit ceramide synthase disrupting sphingolipid pathway (1)
- Mycotoxins production (aflatoxin, deoxynivalenol) (1)
- mycovirus elimination reduces fungal fitness (1)
- mycovirus enhances pathogenicity and virulence (1)
- Mycovirus infection compromises thermotolerance (1)
- Mycovirus infection enhances fungal virulence and stress tolerance (1)
- mycovirus provides beneficial enhancement (1)
- mydriasis (2)
- Myeloid-derived suppressor cell expansion (2)
- myelotoxicity (1)
- myocarditis (1)
- myocarditis associated with some Cortinarius species (1)
- myoclonic jerks (1)
- myogenic potential inhibition (1)
- myotoxic effects including rhabdomyolysis (1)
- myxomycete colonization blocks photosynthesis and respiration (1)
N
- N-methylation reduces antimicrobial activity (1)
- N/A (6)
- nanoparticle accumulation in environment (1)
- nanoparticle dispersibility issues (1)
- nanoparticle dispersibility issues (1)
- nanoparticle soil accumulation (1)
- nanotoxicity (1)
- narrow host range limitations of some biocontrol agents (1)
- narrow range between effective and toxic doses (1)
- narrow spectrum of activity (1)
- narrow therapeutic margin (1)
- nausea (33)
- Nausea and vomiting at high doses (1)
- nausea/vomiting (1)
- NDMs and yeasts have varied antifungal susceptibility profiles and are associated with negative prognostic factors (1)
- NDRG2 deficiency aggravates cognitive dysfunction (1)
- necrosis (4)
- necrosis (1)
- necrosis in high concentrations (1)
- necrotic effects on yeast cells (1)
- necrotic lesion development (1)
- necrotic lesions (1)
- Necrotic tissue reduces drug delivery efficacy (1)
- necrotrophic pathogenesis causing plant disease and economic losses (1)
- need for molecular-level mechanism studies (1)
- need for optimization (1)
- need for strain optimization (1)
- needle degradation in susceptible trees (1)
- negative cross-resistance to other fungicides (1)
- negative cross-resistance to other fungicides (1)
- Negative effects from drought stress (1)
- negative effects from herbicide application (particularly glyphosate) (1)
- negative effects from industrial wastewater components (MEG, DEG, TEG, KHIs) (1)
- negative effects of fungicides on AM symbiosis (1)
- negative effects on resident flora (1)
- negative effects on short-term memory in healthy cohort (1)
- negative experiences (1)
- negative growth response in specific combinations (1)
- negative inotropic effects at high concentrations (1)
- negative inotropic effects at high concentrations (1)
- negative psychological responses (1)
- Negative responses to multiple stressors (1)
- negative results may not exclude disease in non-cavitary CPA subtypes (1)
- negative subconscious material emergence (1)
- Negative vaginal discharge cultures indicating inadequacy of superficial sampling (1)
- negative-pressure wound therapy application before fungal clearance may facilitate organism spread (1)
- neglect of daily responsibilities (1)
- Negligible antioxidant activity compared to reference standards (1)
- Negligible impact of ECN alone on microbiota diversity (1)
- Negligible toxicity to normal cells (HEK 293T) (1)
- nephrotoxic (2)
- nephrotoxic effects (2)
- Nephrotoxicity (22)
- nephrotoxicity (noted for alternative antifungals) (1)
- nephrotoxicity from amphotericin B (4)
- nephrotoxicity from amphotericin B deoxycholate (1)
- Nephrotoxicity from amphotericin B in patients with liver disease (1)
- nephrotoxicity from amphotericin B requiring discontinuation (1)
- Nephrotoxicity from conventional amphotericin B (1)
- nephrotoxicity of amphotericin B (1)
- nephrotoxicity with amphotericin B formulations (1)
- nephrotoxicity/renal impairment (10.2%) (1)
- Network fragility at elevated concentrations (1)
- neuroexcitatory effects (drowsiness, manic excitement) (1)
- neuroinflammation (1)
- neuroleptic malignant syndrome (1)
- neurological and cognitive alterations (MDMA in humans) (1)
- neurological damage to fetus and cognitive deficits (1)
- neurological disorders (2)
- neuronal death (1)
- neuronal degeneration (1)
- neuropathic effects (1)
- Neuropsychiatric syndrome poisoning (1)
- neuropsychological alterations including ego dissolution and auditory alterations (1)
- neurotoxic (3)
- neurotoxic effects (3)
- Neurotoxicity (14)
- neurotoxicity (MDMA in animal models) (1)
- neurotoxicity concerns with chronic use (1)
- neurotoxicity from quinolinic acid (1)
- Neurotoxicity from strychnine (1)
- Neurotoxicity not demonstrated in some compounds (1)
- neutrophil hyperactivation causing tissue damage (1)
- nickel at high levels causes toxicity and lung cancer risk (1)
- Nickel exposure induces oxidative stress (1)
- Nicotine inhibits fungal growth at high concentrations (1)
- nightmares (1)
- nightmares (1)
- nintedanib antifibrotic therapy deferred due to risk of opportunistic fungal infections (1)
- NipA induces blister formation and cuticle damage in host organisms (1)
- nitric oxide production (1)
- nitric oxide production in immune cells (1)
- nitrogen loss through denitrification (1)
- nitrogen uptake limitation (1)
- nitrogen/phosphorus deposition (1)
- NLRP3 inflammasome activation (1)
- No acute dermal toxicity observed (1)
- No acute dermal toxicity observed (1)
- No acute toxicity reported (1)
- no addiction liability (1)
- no adverse effects detected under intended use conditions (1)
- no adverse effects identified at recommended use levels (1)
- no adverse effects observed (2)
- No adverse effects observed in C. elegans toxicity studies (1)
- no adverse effects observed on host plants (1)
- no adverse effects observed under experimental conditions (1)
- No adverse effects on beneficial nitrogen-fixing bacteria (Bradyrhizobium) documented (1)
- no adverse effects on human skin or eyes reported at therapeutic doses (1)
- no adverse effects on normal colon epithelial cells (1)
- No adverse effects on plant growth reported (1)
- No adverse effects on plant growth reported (1)
- no adverse effects or contraindications reported at tested doses (1)
- No adverse effects reported (4)
- No adverse effects reported (1)
- No adverse effects reported at clinical doses (1)
- No adverse effects reported at tested concentrations (1)
- No adverse effects reported in either treatment group (1)
- No adverse effects reported in the study (1)
- No adverse effects reported on body weight or physiological condition (1)
- no adverse events reported (1)
- No adverse skin irritation or toxicity observed with either formulation (1)
- No anti-therapeutic actions noted (1)
- No antibacterial activity observed against tested bacterial species (2)
- No antibiotic resistance genes found (1)
- no antifungal activity observed against tested Candida and Aspergillus species (1)
- no antifungal agents were administered despite fungal infection (1)
- No antifungal therapy provided (1)
- no antimicrobial activity demonstrated against Aspergillus niger (1)
- no available cure once established (1)
- No contraindications documented in review (1)
- No contraindications identified (1)
- no contraindications mentioned (12)
- No contraindications noted (11)
- No contraindications noted in review (1)
- No contraindications or negative effects mentioned (1)
- No contraindications or negative effects reported (3)
- No contraindications or negative effects reported in study (2)
- No contraindications or negative effects reported in this review (1)
- No contraindications reported (6)
- No contraindications reported for the integrated treatment approach (1)
- no contraindications specified (1)
- No cytotoxic effect on cancer cells tested (1)
- no cytotoxic effects observed (2)
- no cytotoxic effects observed at tested concentrations (1)
- no cytotoxic effects observed at therapeutic concentrations (25-200 μg/mL) (1)
- No cytotoxic effects observed on normal human fibroblast cells at tested concentrations (1)
- no cytotoxic effects observed up to 100 μg/mL (1)
- no cytotoxic effects reported at therapeutic concentrations (1)
- No cytotoxicity observed against normal human lymphocytes at tested concentrations (1)
- no cytotoxicity observed at tested concentrations (1)
- No cytotoxicity reported at tested concentrations (1)
- No detrimental effects observed (1)
- No detrimental effects observed on plant development (1)
- No detrimental effects on A. bisporus growth observed (1)
- No direct contraindications mentioned (1)
- No direct contraindications mentioned (1)
- No direct immune suppressive effects observed on T cells or monocytes at physiological concentrations (1)
- No direct immune suppressive effects observed on T cells or monocytes at physiological concentrations (1)
- no direct toxicity to host cells or fungal cells reported (1)
- no effect on triglycerides or gastric inhibitory peptide (1)
- no effects on cognitive empathy accuracy (1)
- no efficacy in juvenile mice (1)
- No FLT3 kinase inhibition (2)
- no harmful effects observed at tested concentrations (1)
- No human contraindications noted (1)
- no hypersensitive reaction induction (1)
- no impairment of metamemory (1)
- No improvement observed with empiric cefovecin and fluconazole treatment (1)
- No increase in false memory susceptibility despite high acute effects (1)
- No inhibitory effects observed against Geotrichum citri-aurantii (1)
- No negative effects observed (1)
- No negative effects observed at tested inclusion levels (1)
- No negative effects on host plant observed (1)
- no negative effects on mushroom mycelial growth or fruiting body formation (1)
- No negative effects on probiotic bacteria (1)
- No negative effects reported (1)
- No negative effects reported in study (1)
- No negative therapeutic actions reported (1)
- no observed liver dysfunction (1)
- no ovicidal activity (1)
- no phenotype under axenic growth conditions (1)
- no physical dependence (1)
- No phytopathogenic effects on coffee plants (2)
- No phytotoxic effects reported (1)
- No phytotoxicity observed at tested concentrations (1)
- no protective effects under permanent flooding conditions (1)
- no protective effects under permanent flooding conditions (1)
- No PTP1B inhibition (1)
- No PTP1B phosphatase inhibition (1)
- No reported cases of toxicity with Ganoderma consumption (1)
- No reported contraindications mentioned in study (1)
- no reported contraindications to antifungal agents used (1)
- No rewarding properties observed (1)
- No safety concerns identified at proposed use levels (1)
- No safety concerns reported (1)
- NO scavenging inhibits fungal growth and delays development (1)
- NO scavenging inhibits fungal growth and delays development (1)
- No serious adverse events reported (1)
- No serious adverse events reported over 10 years (1)
- No significant activity against Staphylococcus epidermidis at tested concentration (1)
- No significant adverse effects observed (1)
- No significant adverse effects reported (1)
- no significant adverse effects reported in clinical trial (1)
- no significant biomass enhancement under high salt stress (1)
- no significant biomass enhancement under high salt stress (1)
- no significant biomass recovery under extreme salinity conditions (1)
- no significant contraindications mentioned (1)
- no significant contraindications mentioned (1)
- No significant contraindications noted (2)
- no significant cytotoxicity at tested concentrations (1)
- No significant cytotoxicity observed (1)
- no significant effect on adhesion or systemic virulence in tested models (1)
- no significant effects observed on fasting blood sugar (1)
- no significant effects on height gain in most analyses (1)
- No significant inhibitory effects on Candida albicans (1)
- no significant negative effects reported (1)
- No significant reduction in compulsive eating at tested dose (1)
- No significant reduction in postprandial glucose or insulin response (1)
- No significant resistance development noted (1)
- no significant safety concerns reported (1)
- No significant side effects reported (1)
- no significant toxicity noted in liver (1)
- no significant toxicity reported (1)
- no spore germination inhibition for most compounds (1)
- No synergistic activity against C. parapsilosis (1)
- No terbinafine resistance detected (1)
- No therapeutic actions (1)
- No toxic effects on liver (1)
- No toxic effects reported in animal studies (1)
- No toxicity observed at concentrations below 100 μg/mL (1)
- no toxicity observed at tested concentrations (2)
- No toxicity symptoms observed (1)
- No toxicity to host plant observed (1)
- Nomenclature confusion may lead to misidentification (1)
- non-albicans Candida species show fluconazole resistance (1)
- non-biodegradability (1)
- non-biodegradability (1)
- non-carcinogenic health risks (1)
- non-compliant treatment discontinuation leading to relapse (1)
- non-deterministic outcomes dependent on context (1)
- Non-fermented maca increased NO production in dose-dependent manner (1)
- non-hallucinogenic profile reduces typical psychedelic side effects (1)
- non-psychotic hallucinations (1)
- non-reporting of completed trials (1)
- Non-responsive to antifungal medications (1)
- Non-selective cytotoxicity against both cancer and normal fibroblast cells (1)
- Non-selective cytotoxicity against normal cells (1)
- non-selective cytotoxicity against normal fibroblast cells (MRC-5) (1)
- non-selective kinase inhibition (1)
- Non-specific clot lysis (1)
- Non-target effects on non-pathogenic fungi and beneficial bacteria at high concentrations (1)
- Non-target effects require further evaluation (1)
- Non-toxic as demonstrated in zebrafish embryotoxicity assays (1)
- non-toxic at experimental doses (1)
- Non-toxic in C. elegans model (1)
- non-toxic to normal lung fibroblasts at tested concentrations (1)
- non-uniform visual characteristics (1)
- non-wild-type susceptibility to itraconazole and caspofungin (1)
- none applicable (2)
- None documented (21)
- None documented in study (1)
- None documented in this study (4)
- none explicitly mentioned (3)
- None identified (4)
- None identified (1)
- None identified for human therapeutic use (1)
- None identified for the biocontrol agent itself (1)
- None identified in study (2)
- None mentioned (92)
- None mentioned for Trichoderma (1)
- None noted (17)
- None noted for beneficial organisms (1)
- None observed (2)
- None observed at tested concentration (1)
- None reported (79)
- None reported as negative effects (1)
- none reported at tested concentrations (1)
- None reported for plants (1)
- None reported for plants (1)
- None reported for the biocontrol agent (1)
- None reported in study (3)
- none reported in these cases (1)
- None reported in this study (1)
- None reported in tomato (1)
- None specific mentioned (1)
- none specifically mentioned (8)
- none specifically mentioned as contraindications (7)
- None specifically reported (1)
- none specified (9)
- nonspecific binding (1)
- Not applicable (89)
- Not applicable – educational study (1)
- Not applicable – mycological study (1)
- Not applicable – no adverse effects reported for plant treatment (1)
- Not applicable – no contraindications mentioned (1)
- Not applicable – no contraindications mentioned for medicinal use (1)
- Not applicable for this intervention (1)
- Not applicable for this study design (1)
- Not discussed (1)
- Not discussed in detail (1)
- Not documented in the review (1)
- Not identified in the review (1)
- not intended for use in microwave or conventional ovens (1)
- Not mentioned (19)
- not recommended for excessive consumption in elderly and children (1)
- not recommended for excessive consumption in elderly and children (1)
- Not specified (7)
- Not specified in correction (1)
- Not specified in the paper (1)
- Not specified in this study (2)
- not suitable for individuals with history of psychotic disorders or bipolar disorder (1)
- note that S. radiatum shows variable antifungal susceptibility patterns (1)
- note that toxicological studies of natural deep eutectic solvents (NaDES) are required for safety determination (1)
- novel toxins (1)
- noxious heat and cold sensation can cause pain and tissue damage (1)
- NSC23766 administration showed no negative effects on normal pain perception in control animals (1)
- Nuclear accumulation of HDAC4 impairs neuronal development and memory formation (1)
- nucleic acid leakage causing cell death (1)
- null findings on global cognitive performance (1)
- Nutraceutical 1 showed cell viability reduction in muscle cells at highest concentration (1 mg/mL) (1)
- nutrient competition with beneficial microorganisms (1)
- nutrient depletion (1)
- nutrient loss with prolonged high-temperature exposure (1)
- nutrient-poor diet (1)
- nutrient-rich conditions decrease antimicrobial metabolite production (1)
- nutritional imbalances from single biomass sources (1)
- nutritional loss from heating (1)
- nystatin (1)
- nystatin resistance (6.7%) (1)
O
- oats (1)
- obesity (1)
- obesity (1)
- Obinutuzumab (1)
- obstetric violence (3)
- occlusive footwear (1)
- Ocean water exposure increases risk of bacterial infection and altered skin microbiota in MF patients (1)
- Ochratoxin A is a Group 2B potential human carcinogen with immunotoxic (1)
- Ochratoxin A is carcinogenic (1)
- Ochratoxin A is carcinogenic (1)
- Ochratoxin A is carcinogenic and immunosuppressive (1)
- Ochratoxin A is classified as a Group 2B potential human carcinogen by IARC and causes immunotoxicity (1)
- ochratoxin A mycotoxin production (1)
- Ochratoxin A production (toxigenic effect of fungal strains) (1)
- Ochratoxin A production and accumulation in contaminated food products (1)
- Ochratoxin A production by Aspergillus species (1)
- Ochratoxin A production by fungal strains (1)
- ochratoxins are nephrotoxic (1)
- ochratoxins harm kidney function (1)
- odor production (1)
- oestrogens as endocrine disruptors causing physiological disorders (1)
- off-flavor compounds (1)
- off-flavor development (1)
- off-flavors (2)
- off-flavors limit consumer acceptance (1)
- Off-target effects of miRNA (noted as limitation) (1)
- Off-target effects of miRNA possible (1)
- off-target immunosuppressive effects (1)
- often shows decreased susceptibility to amphotericin B (1)
- oil contamination reduces prokaryotic diversity (1)
- older age meat shows increased saturated fatty acids (1)
- older pupae showed lower susceptibility (1)
- older pupae showed lower susceptibility (1)
- olorofim resistance (MIC >2) (1)
- One participant reported headaches after DMT-harmine administration (1)
- One participant reported headaches after DMT-harmine administration (1)
- one study showed no significant responses in multiple myeloma patients with AndoSan treatment (1)
- OPFRs exhibit neurotoxic (1)
- Ophiostoma novo-ulmi causes vascular wilt and tree death (1)
- opioid poisoning (1)
- Opportunistic human infections (1)
- opportunistic infection (2)
- opportunistic infection may result from candidiasis treatment and compromised immunity (1)
- Opportunistic infection risk from conventional probiotics (1)
- Opportunistic infections (1)
- opportunistic infections in humans including sinusitis (1)
- Opportunistic pathogen causing talaromycosis in immunocompromised patients (1)
- opportunistic pathogen overgrowth (2)
- opportunistic pathogen potential in cystic fibrosis patients (1)
- opportunistic pathogen presence (1)
- Opportunistic pathogen to plants and humans (1)
- opportunistic pathogenic infections in humans (1)
- opportunistic pathogenicity in some melanized fungal lineages (1)
- opportunistic pathogens associated with metabolic disorders (1)
- optimization challenges for different dye types (1)
- or body weight metrics (1)
- or burning (1)
- or family history of psychotic disorder (1)
- or heart disease (1)
- or hepatic steatosis predictors at the tested dose and duration (1)
- or lungs reported (1)
- or mutagenicity (1)
- oral allergy syndrome (1)
- Oral azole teratogenic risk in pregnancy (1)
- Oral azoles associated with teratogenic risk in pregnancy (1)
- Oral contraceptive pills may increase thrombophilic risk in EBV-infected patients (1)
- oral mucositis (1)
- Oral tolerance induction (1)
- orellanine causes acute nephritis (C. orellanus) (1)
- organ damage (2)
- organ dysfunction (1)
- organ-specific toxicity (1)
- organic acid salts are GRAS substances within allowable concentrations (1)
- Organophosphate and pyrethroid insecticides can inhibit fungal growth at high concentrations (1)
- Osimertinib-induced fatigue (1)
- Osimertinib-induced fatigue (1)
- Osteoarticular pain (1)
- osteocyte apoptosis (1)
- osteoporosis (1)
- osteoporosis risk (1)
- osteoradionecrosis (1)
- osteoradionecrosis (1)
- outdated therapeutic information (2)
- output homogenization (1)
- over-consumption (1)
- overactivation of Wnt signaling induces social deficits (1)
- overactive innate immune system may contribute to autoimmunity and neurodegenerative diseases if not properly regulated (1)
- Overdose toxicity (1)
- Overexpression of AfCFEM2 and AfCFEM3 reduced nematode mortality (2)
- Overexpression of AfCFEM2 and AfCFEM3 reduced nematode mortality compared to wild-type (1)
- overexpression of certain genes decreased ergosterol content through feedback regulation (1)
- overexpression of Cmhyd4 resulted in malformed fruiting bodies and reduced conidial production (1)
- Overfitting risk in model training (1)
- overstated health claims (1)
- Overuse of empirical antifungal therapy increases resistance (1)
- overwhelming experiences (1)
- oxalate-induced mineral chelation (1)
- oxalic acid production by fungus promotes virulence and tissue acidification (1)
- Oxidation issues (1)
- oxidation may degrade phenolic compounds (1)
- oxidation of lipids and proteins (1)
- oxidative conditions (1)
- oxidative damage (2)
- oxidative damage to membrane lipids and proteins (1)
- oxidative degradation (1)
- oxidative deterioration of biological macromolecules (1)
- oxidative stress (17)
- oxidative stress accumulation (2)
- oxidative stress at high Cd concentrations (1)
- oxidative stress during HA production (1)
- oxidative stress from gamma radiation (1)
- oxidative stress from pollutant exposure (1)
- oxidative stress from pollutant exposure (1)
- oxidative stress generation (1)
- oxidative stress in bacteria (1)
- Oxidative stress in organisms (2)
- Oxidative stress in organisms (1)
- oxidative stress induction (3)
- oxidative stress induction (1)
- oxidative stress through ROS generation (1)
- oxidized terpenes may cause sensitization in sensitive populations (1)
- oxygen depletion causing hypoxic conditions (1)
- oxytocin ineffective in ostracism conditions (1)
- ozone depletion (1)
P
- p-chloroaniline toxicity (1)
- P. allii pathogenic to garlic (1)
- P. chrysogenum sensitivity to pH and environmental conditions limits effectiveness (1)
- P. glabrum pathogenic to garlic/onion (1)
- Paecilomyces causes white mold (1)
- PAEs act as endocrine disruptors (1)
- Pain during treatment (6.5-7.8/10) (1)
- palpitations (3)
- palpitations (1)
- pan-antifungal resistance (1)
- pan-assay interference (1)
- Pan-echinocandin resistance (1)
- panfungal resistance in L. prolificans (1)
- panic (3)
- panic attacks (2)
- Panic episodes (1)
- Panic episodes (1)
- panic or paranoia during acute experience (1)
- Pantothenate transporter knockout leads to increased sensitivity to environmental stresses (1)
- paradoxical cognitive worsening in symptomatic patients (1)
- Paradoxical enhancement of fungal virulence despite growth reduction (1)
- paradoxical glutamatergic effects (1)
- Paradoxical growth effect at high caspofungin concentrations (1)
- Paradoxical increased amphotericin B MIC in A. flavus despite CFU reduction (1)
- paralysis (3)
- paranoia (3)
- paranoid ideation (1)
- parasitic fungal interactions under high nutrient conditions (1)
- parasitic infection of cultivated fungi (1)
- parasitic tendencies in certain plant-fungal pairings (1)
- parasympathetic stimulation (sweating, salivation, lachrymation) (1)
- partial degradation of thrombin (1)
- partial fungal recovery in some biofilm conditions (1)
- partial polyene resistance (1)
- partial restoration of hepatotoxic damage (1)
- particle aggregation (1)
- particle aggregation in nanoremediation (1)
- Particle shedding from photocatalytic membranes (1)
- particularly harmful to cells with rapid growth and division (1)
- particularly in immunocompromised individuals (1)
- particularly lysine deficiency (1)
- particularly NAC species showing 29.41% fluconazole resistance and 47.05% caspofungin resistance (1)
- particularly to fluconazole and caspofungin (1)
- Patent scope limitations (1)
- pathogen accumulation in some contexts (1)
- Pathogen causes seed decay (1)
- pathogen colonization (1)
- pathogen colonization (2)
- pathogen colonization of sapwood (1)
- Pathogen infection (2)
- pathogen proliferation (1)
- pathogen resistance development with long-term fungicide use (1)
- pathogen survival and persistence in food processing environments (1)
- Pathogen transmission via cockroach vectors (1)
- pathogen virulence (1)
- pathogen virulence enhancement (1)
- pathogen virulence factors (1)
- Pathogen virulence mechanisms that evade host recognition (1)
- Pathogen virulence mechanisms that evade host recognition (1)
- pathogen-induced dysbiosis (1)
- Pathogenic (1)
- Pathogenic bacteria causing yield reduction (1)
- pathogenic bacterial overgrowth (1)
- Pathogenic Colletotrichum species cause fruit necrosis and disease symptoms (1)
- Pathogenic colonization (1)
- Pathogenic colonization of potato tubers (1)
- Pathogenic corneal infection causing ulceration and vision threat (1)
- Pathogenic effects causing leaf blight (1)
- Pathogenic effects causing leaf spot lesions on grape plants and related vitaceous species (1)
- pathogenic effects in immunocompromised patients (1)
- Pathogenic effects including reduced seed germination (1)
- Pathogenic effects of F. acutatum and F. falciforme causing tissue necrosis and bulb rotting (1)
- Pathogenic effects of S. sclerotiorum on crop plants (1)
- pathogenic effects of Valsa sordida and Botryosphaeria dothidea on poplar trees (1)
- pathogenic effects on cacao (1)
- pathogenic effects on Camellia sinensis causing leaf damage and disease (1)
- pathogenic effects on conifers (1)
- pathogenic effects on crops (1)
- Pathogenic effects on grapevine canes (1)
- Pathogenic effects on leaf quality (1)
- pathogenic effects on palm plants (1)
- Pathogenic effects on plant hosts (1)
- pathogenic effects on plants and humans (1)
- pathogenic effects on plants and humans (1)
- Pathogenic effects on plants and potential human infections (1)
- Pathogenic effects on various host plants (1)
- Pathogenic effects on various plant hosts including chili peppers (1)
- pathogenic effects on various plants (1)
- Pathogenic enzyme secretion (1)
- Pathogenic fungal abundance (Fusarium, Alternaria) (1)
- pathogenic fungal activity (1)
- pathogenic fungal contamination inhibiting seed germination (1)
- pathogenic fungal contamination inhibiting seed germination (1)
- pathogenic fungal growth (1)
- Pathogenic fungal infection causing leaf spot (1)
- Pathogenic fungal infection causing photosynthesis inhibition (1)
- Pathogenic fungal infection causing root browning and wilting (1)
- Pathogenic fungal infection leading to tree mortality and economic losses (1)
- Pathogenic fungal infections (1)
- pathogenic fungal species inhibit seed germination and plant growth (1)
- Pathogenic fungal strains present in endophyte collection (1)
- Pathogenic fungi and diseases during morel cultivation mentioned (1)
- pathogenic fungi and viruses reduce flowering time (1)
- Pathogenic fungi cause branch dieback (1)
- Pathogenic fungi cause tree damage (1)
- Pathogenic fungi causing disease (1)
- Pathogenic fungi causing disease (1)
- Pathogenic fungi causing tree mortality (1)
- pathogenic fungi counteracts with upregulated metabolic enzymes (1)
- pathogenic fungi exacerbate disease severity and reduce crop yield (1)
- pathogenic fungi increase risk of disease (1)
- Pathogenic fungi invade plant tissues and reduce microbial diversity in susceptible cultivars (1)
- pathogenic fungi suppress fungal development (1)
- Pathogenic fungus causing plant disease (1)
- Pathogenic fungus causing severe crop damage and economic losses (1)
- Pathogenic infection (2)
- pathogenic infection by oomycetes and fungi (1)
- Pathogenic infection by Rhizoctonia solani (1)
- Pathogenic infection leading to tree mortality (1)
- Pathogenic infection of conifer roots (1)
- pathogenic mechanisms causing leaf blight and plant mortality (1)
- pathogenic mechanisms include phytotoxin production and zinc starvation stress on host plants (1)
- pathogenic microbe introduction (1)
- pathogenic microbes accelerate cognitive decline and neurodegeneration (1)
- Pathogenic microbial responses (1)
- pathogenic potential of black fungi (2)
- pathogenic potential of isolated Candida species in immunocompromised individuals (1)
- pathogenic potential of virulence genes (1)
- pathogenic RNase activity degrades RNA in target bacteria (1)
- Pathogenic to buckwheat (1)
- Pathogenic to coffee plants causing leaf lesions (1)
- Pathogenic to conifer trees (1)
- pathogenic to cultivated Ganoderma sichuanense and other mushroom species (1)
- Pathogenic to grapevines causing vascular infections (1)
- pathogenic to humans (1)
- Pathogenic to peanut and multiple crop species (1)
- Pathogenic to plants and rarely humans (1)
- Pathogenic virulence factors from C. mali (1)
- pathogenic yeast dispersal (1)
- pathogenic yeast exposure (1)
- pathogenicity (4)
- Pathogenicity and virulence mechanisms of chytrid fungi in host infections (1)
- pathogenicity enhancement (1)
- Pathogenicity factors including cell wall-degrading enzymes and secondary metabolite production (1)
- pathogenicity in immunocompromised patients (1)
- Patient developed edema in both lower limbs during itraconazole treatment (200mg/day) (1)
- patient had poor adherence to prophylaxis regimen (1)
- Patient mortality despite antimicrobial therapy (1)
- Patient preference for privacy may limit adoption (1)
- patient recovered without specific antifungal therapy (1)
- Patient with Madurella tropicana was lost to follow-up after four months of itraconazole treatment (1)
- Patulin is highly toxic (1)
- patulin levels increased in P. expansum under GCE stress (1)
- patulin produce adverse physiological effects (1)
- patulin production increased in P. expansum (1)
- patulin toxicity (3)
- patulin toxicity causes immunotoxic (1)
- patulin toxicity from some species (1)
- PBDE toxicity (1)
- PCR detects non-viable fungal cells limiting use for monitoring antifungal treatment efficacy (1)
- PCR detects non-viable fungal DNA so not suitable for monitoring antifungal treatment efficacy (1)
- PCR inhibition from polysaccharides and phenolic compounds (1)
- PD-L1 and PD-1 upregulation (1)
- pea (2)
- Pectinase activity facilitates disease development and fruit softening (1)
- Pellet cores may become inactive due to poor oxygen diffusion leading to cell lysis (1)
- Pellet cores may become inactive due to poor oxygen diffusion leading to cell lysis (1)
- Penicillium chrysogenum presence enhances Plasmodium falciparum infection rates (1)
- Penicillium spp. pathogenic to pear/apple/citrus (1)
- Penitrem A causes neurotoxicity through increased release of neurotransmitters (GABA, glutamate, aspartate) and inhibition of Ca2+-activated K+ channels (1)
- perceived addictive potential (1)
- Perception distortions (1)
- perception-altering effects (1)
- perceptual abnormalities reported (1)
- perceptual distortions (3)
- perceptual distortions in some contexts (1)
- perceptual disturbances (4)
- peripheral vascular disease (1)
- peripheral vascular occlusion (1)
- Persea americana (1)
- persistence and drug tolerance (1)
- persistence in environment (1)
- persistence of pharmaceuticals in environment (1)
- persistent candidemia (1)
- persistent disease (1)
- Persistent environmental reservoirs difficult to eradicate (1)
- Persistent fungal infection despite appropriate antifungal therapy (1)
- persistent fungal spores and hyphae during treatment (1)
- Persistent fungemia despite monotherapy (1)
- Persistent infection despite empirical anti-infective therapy (1)
- persistent infections with elevated MICs (1)
- persistent mental preoccupation (1)
- persistent neutropenia limiting therapeutic efficacy (1)
- persistent neutropenia reducing treatment efficacy (1)
- Persistent organic pollutant accumulation (1)
- persistent organic pollutants (2)
- persistent organic pollutants (1)
- persistent perceptual aberrations (1)
- Persistent positive blood cultures despite appropriate antifungal initiation (1)
- persistent positivity despite antifungal treatment (1)
- Persisting anxiety or panic (1)
- personal death experiences may be distressing (1)
- personality destabilization (1)
- personality disorders (2)
- personality shifts (1)
- pesticide residues (1)
- Pesticide toxicity (3)
- pesticide toxicity to fungal growth (1)
- pesticide toxicity to non-target organisms (1)
- pesticides (1)
- Petroleum hydrocarbons are toxic and carcinogenic (1)
- pH and chlorine concentration must be balanced to prevent phytotoxicity (1)
- PhAC affected biofilm formation by interfering with quorum sensing mechanisms (1)
- PhAC exhibited antifungal activity (1)
- PhAC interference with quorum sensing and biofilm formation (1)
- PhAC interference with quorum sensing and biofilm formation (1)
- PhAC toxicity effects on fungal biofilm formation (1)
- phage inactivation by immune responses in blood (1)
- phage inactivation by immune responses in blood (1)
- Phage-resistant S. aureus strains (1)
- Phallotoxin poisoning effects (hepatotoxicity, nephrotoxicity) (1)
- Pharmaceutical persistence in environment (1)
- pharmaceutical pollutant persistence in environment (1)
- phenol toxicity to organisms (1)
- phenolic acid accumulation (1)
- phenolic compounds can inhibit certain digestion enzymes (1)
- Phenylacetic acid promotes hepatic lipid accumulation (2)
- phosphate deficiency impairs nodule formation and nitrogen-fixing capacity (1)
- phospholipid degradation (1)
- phosphorus uptake inhibition (1)
- photo-inhibition under excessive light (1)
- photosensitivity risk in Caucasian populations (1)
- photosensitivity-induced growth inhibition (1)
- photosynthesis inhibition (2)
- photosynthesis reduction (1)
- photosynthetic capacity (1)
- Photosynthetic disruption (1)
- photosynthetic impairment (1)
- photothermal therapy limitations with tissue depth (1)
- phototoxicity (1)
- phototoxicity (voriconazole) (1)
- phototoxicity to host fungal cells (self-protection required) (1)
- PHS1 deletion results in reduced virulence and impaired pathogenic functions (1)
- Phthalates cause reproductive and developmental toxicity (1)
- Physical discomfort (in microdosing) (1)
- physical exertion and contact sports contraindicated due to splenic rupture risk (1)
- Physical strain (1)
- physiological effects (blood pressure increase, heart rate elevation) (1)
- physiological effects (blood pressure increase, heart rate elevation) (1)
- phytic acid (antinutrient factor, but successfully reduced through fermentation) (1)
- phytopathogenic effects (1)
- Phytopathogenic effects on host plants (1)
- phytopathogenic lesions on tubers (1)
- phytopathogenic properties causing common scab lesions on tubers (1)
- Phytophthora pathogenicity on ornamental plants causing crop losses and ecosystem damage (1)
- phytotoxic effects on host plants (1)
- phytotoxic effects on plant roots and growth (1)
- phytotoxic effects on root and tuber crops (1)
- phytotoxicity (4)
- Phytotoxicity at concentrations above 1% (1)
- phytotoxicity at concentrations above 1% can cause chlorosis (1)
- phytotoxicity at high concentrations (5)
- phytotoxicity concerns at high concentrations (1)
- phytotoxicity concerns with certain treatments (1)
- phytotoxicity from petrochemicals (1)
- phytotoxicity from raw SMS (1)
- phytotoxicity from targeting conserved plant pathways (1)
- Phytotoxicity risk with certain formulations (1)
- Phytotoxicity risk with improper fungicide use (1)
- phytotoxicity stress on plants (1)
- phytotoxicity to non-target plants at high concentrations (1)
- Phytotoxin-mediated plant necrosis (1)
- pituitary compression (1)
- placebo/nocebo confounding (1)
- Plant and animal pathogens (1)
- plant death (1)
- plant decline (3)
- plant disease (1)
- plant growth inhibition at high soil concentrations (1)
- plant growth suppression (1)
- plant infection (1)
- plant mortality (2)
- plant pathogenesis (1)
- Plant pathogenic (3)
- Plant pathogenic causing economic and environmental damage to susceptible hosts including Actinidia chinensis (1)
- Plant pathogenic effects causing canker and leaf spot diseases (1)
- Plant pathogenic effects causing crop damage (1)
- Plant pathogenic effects causing stress to forest and fruit trees (1)
- Plant pathogenic fungi causing economic damage (1)
- Plant pathogenic fungus causes crop losses and disease (1)
- plant pathogenic fungus causing disease in East Asian hogweed (1)
- plant pathogenic infection (1)
- Plant pathogenic potential (1)
- plant pathogenicity (3)
- plant pathogenicity on Cyperaceae and Juncaceae host plants (1)
- Plant pathogenicity when acting as pathogens (1)
- plant phototoxicity at excessive doses (1)
- Plant stress (1)
- Plant susceptibility without miRNA regulation (1)
- plant tissue colonization (1)
- plant tissue damage (1)
- plant tissue death (1)
- plant tissue invasion (1)
- plant tissue necrosis (4)
- plant trauma increases risk (1)
- plants and microbes (1)
- plasma membrane damage (1)
- plastic accumulation (1)
- Plastic pollution (1)
- plastic toxin emission (1)
- plasticizer toxicity (1)
- Pleurotus eryngii var. ferulae aqueous extract enhanced aflatoxin synthesis at higher concentrations (1)
- Pleurotus eryngii var. ferulae aqueous extract stimulated aflatoxin synthesis at tested concentrations (1)
- Pleurotus sp. showed no promising PAH degradation (1)
- PM2.5 exposure induces lung inflammation (1)
- Pneumocystis colonization associated with altered microbiota potentially predisposing to disease (1)
- pneumonia (1)
- pneumonitis (1)
- pneumonitis (1)
- poisoning (1)
- poisoning from Amanita phalloides and related toxic species (1)
- Poisoning from consumption of toxic mushroom species that are morphologically similar to edible varieties (1)
- poisoning risk (1)
- poisoning risk from Amanita muscaria complex (1)
- poisoning risk when consumed with mustard oil or cold stone water according to traditional records (1)
- poisonous mushrooms (1)
- pollutant toxicity (1)
- polonium toxicity (1)
- polonium toxicity (1)
- polychlorinated biphenyls (PCBs) (1)
- polyene resistance (2)
- polyethylene glycol-induced oxalate nephropathy (1)
- polymer degradation by fungus (1)
- polyphenol degradation during digestion (1)
- polyphenolic interference (1)
- polysaccharide content reduction in most conditions (1)
- polystyrene microplastics cause oxidative stress (1)
- PoMYB15 overexpression inhibits growth and heat stress tolerance (1)
- poor accessibility of antifungal drugs due to deep tissue penetration (1)
- Poor bioavailability (2)
- poor bioavailability limiting clinical efficacy (1)
- Poor bioavailability of itraconazole (1)
- poor bioavailability of polyphenols (1)
- poor candidate for transarterial embolization due to small caliber terminal artery (1)
- poor central nervous system penetration in some agents (1)
- poor central nervous system penetration with echinocandins (1)
- poor cerebral penetration of posaconazole (1)
- poor clinical outcomes despite aggressive therapy (1)
- poor correlation between in vitro susceptibility and clinical response (1)
- Poor efficacy of fluconazole (1)
- Poor efficacy with ivermectin + NaCl alone (1)
- Poor foot hygiene practices (1)
- poor glycemic control associated with increased complications (1)
- Poor glycemic control increases disease risk (1)
- Poor glycemic control increases disease severity and progression (1)
- poor interfacial compatibility (1)
- poor mechanical properties of chitosan alone (1)
- poor metabolism in CYP3A5 poor metabolizers (1)
- poor oral bioavailability (2)
- poor outcomes from delayed treatment (1)
- poor overall survival rates despite therapy (1)
- poor prognosis association (1)
- Poor prognosis despite antifungal therapy (1)
- poor prognosis in advanced infections (1)
- poor prognosis with delayed presentation or disseminated disease (1)
- poor prognosis with high mortality rates reaching 90% (1)
- poor prognosis with median survival of 3 months in HIV-associated aspergillosis (1)
- poor response in some cases (1)
- Poor response to chemotherapy in relapsed AML (1)
- poor response to conservative medical therapy in aggressive fungal infections (1)
- poor response to conservative medical therapy in aggressive fungal infections (1)
- poor response to empirical antibiotics (1)
- Poor response to itraconazole (2)
- poor response to itraconazole in 4.5% of cases (1)
- Poor response to multiple topical and oral antifungal treatments (1)
- Poor responsiveness to antifungal drugs (1)
- Poor responsiveness to antifungal drugs (1)
- poor seed quality (1)
- Poor single-agent efficacy of pyrvinium pamoate (1)
- poor skin penetration of topical formulations (1)
- Poor stability under physiological conditions (1)
- poor survival outcomes despite antifungal therapy (1)
- poor susceptibility to itraconazole and amphotericin B (1)
- Poor therapeutic response (1)
- poor tissue distribution (1)
- poor tolerance to antifungal therapy in some cases (1)
- Poor treatment response despite amphotericin B administration (1)
- Poor water solubility (1)
- poor water solubility in some fungal polysaccharides (1)
- poor water solubility in some fungal polysaccharides (1)
- poor water solubility of hypocrellin A (1)
- population decline (1)
- population decline in wildlife (1)
- porin loss (1)
- POS non-susceptible pathogens (1)
- posaconazole (5)
- posaconazole resistance (1)
- Posaconazole resistance in Arthrocladium tropicale isolate (1)
- possible accumulation in edible tissues (1)
- possible allergy or autoimmune disease development (1)
- possible bacterial contamination of solutions (1)
- Possible bloating and constipation at high doses (1)
- Possible emotional reactions including sadness and agitation (1)
- possible entry into food chain (1)
- Possible formation of secondary products from biosorbate-mycelia interactions that may affect organisms (1)
- possible gas and bloating from prebiotics in sensitive individuals (1)
- Possible inflammatory response with certain administration methods (2)
- possible interactions with medications and herbs (1)
- possible interference with steroidogenesis at high doses (1)
- possible lactose intolerance concerns (1)
- possible long-term ecological impacts requiring further investigation (1)
- Possible metal contamination in natural sources (1)
- possible negative effects on plant microbiome (1)
- possible negative effects on soil microorganisms (1)
- possible subtle changes in nuclear morphology with certain tissue types (1)
- Possible teratogenic and toxic effects (1)
- possible tissue damage including chlorosis and necrosis (1)
- Post-harvest crop diseases (1)
- Post-harvest crop diseases (1)
- post-harvest loss (1)
- Post-harvest spoilage by Pseudomonas spp. (1)
- post-inflammatory hyperpigmentation (1)
- post-mortem redistribution complications (1)
- postharvest fruit pathogens (P. digitatum, P. crustosum, P. expansum, P. solitum) (1)
- potassium iodide ineffective for disseminated cases (1)
- potassium permanganate (1)
- potassium sorbate reduced efficacy in neutral pH (1)
- Potential acceleration of decomposition through priming effects under certain conditions (1)
- potential accumulation of toxic metals depending on environmental conditions (1)
- potential addiction concerns (1)
- potential additive migration (1)
- potential adulteration in street forms (1)
- potential adverse effects in frail patients (1)
- potential adverse effects mitigated by paraprobiotic formulation (1)
- potential adverse effects related to eukaryotic targeting (1)
- potential adverse effects requiring further investigation (1)
- potential adverse effects with mood stabilizers (1)
- potential adverse events (1)
- potential adverse events difficult to detect in trial sample sizes (1)
- Potential adverse events in unmonitored use (1)
- potential adverse events mitigated through supportive psychotherapy (1)
- potential adverse psychological effects if set and setting not properly managed (1)
- Potential adverse psychological effects in adverse environments (1)
- potential adverse reactions (1)
- Potential adverse side effects from systemic antifungal agents (1)
- potential agglomeration of nano-materials (1)
- Potential aggregation (1)
- potential allergenicity (3)
- Potential allergenicity and virulence factors requiring safety assessment (1)
- potential allergenicity from oxidized limonene derivatives in topical applications (1)
- potential allergens (2)
- potential allergens and irritants from growth substrates (1)
- potential allergens in novel proteins (1)
- potential ammonia toxicity to crops at high concentrations (1)
- potential anaerobic stress conditions with prolonged MAP application (1)
- potential antagonism between antifungal agents in some cases (1)
- potential antagonistic bacterial interactions (1)
- Potential antagonistic interactions between actinobacteria and fungi (1)
- potential antagonistic interactions with certain compounds (1)
- Potential anti-nutritional factors (1)
- potential antibiotic and mycotoxin synthesis by fungi in quorum state (1)
- potential antibiotic and PFAS accumulation in fungi (1)
- Potential antibiotic resistance (1)
- Potential antifungal drug resistance through various gene targets (1)
- Potential antifungal drug resistance through various gene targets (1)
- potential antiproliferative effects from alpha-hydroxy acids (1)
- potential anxiety and dysphoria (1)
- potential anxiety and dysphoria (1)
- Potential arsenic mobility increase in unmodified biochar (1)
- potential bacterial dysbiosis persistence (1)
- potential bioaccumulation (2)
- potential bioaccumulation in food chain (1)
- potential bioaccumulation in pellets (1)
- potential biofilm formation challenges (1)
- Potential cadmium accumulation exceeded European Commission guidelines when grown on coffee grounds alone (1)
- potential carcinogenic effects (1)
- potential carcinogenic effects (1)
- Potential carcinogenic risk from Cd and Cr exposure (1)
- potential carcinogenicity (3)
- Potential cardiac valvulopathies from repeated serotonin 5-HT2b receptor activation (1)
- potential cell cycle delay at higher concentrations (1)
- potential chlorosis and necrosis in plant tissues (1)
- potential chlorosis and necrosis in plants (1)
- potential color alteration concerns (1)
- potential competition with native species in extreme habitats (1)
- potential competitive inhibition between bacterial strains (1)
- potential concerns regarding SHP2 inhibition effects on acetylcholine receptor cluster formation in muscle cells (1)
- potential concerns with uncontrolled fermentation (1)
- potential consumer acceptability concerns (1)
- potential contamination (1)
- potential contamination risk with microbial synthesis methods (1)
- potential contraindications in disease progression with increased protease expression (1)
- potential contraindications not explored in this study (1)
- potential contraindications not extensively discussed (1)
- potential counteraction of bortezomib effects (1)
- potential cross-reactivity to casein fractions in milk-allergic individuals (1)
- potential cross-reactivity with human DPP IV (1)
- potential cross-resistance among azole class drugs (1)
- Potential cytotoxicity (1)
- potential cytotoxicity at concentrations ≥400 μg/mL (1)
- potential cytotoxicity at elevated concentrations (1)
- Potential cytotoxicity at high concentrations (1)
- potential cytotoxicity at higher concentrations (1)
- potential cytotoxicity to normal cells at certain concentrations (1)
- potential damage to plant tissues causing chlorosis and necrosis (1)
- potential deaths (1)
- potential decrease in crispness and color with excessive substitution levels (1)
- potential delays in small/medium laboratories due to kit package constraints (1)
- potential denaturation of sensitive biomolecules (1)
- potential deviations in open-label designs (1)
- Potential disease agents (1)
- potential disruption of ant-aphid mutualism (1)
- potential disruption of gene expression if selectable markers are linked to target loci (1)
- potential distress from detailed recall in microphenomenology assessments (1)
- Potential drug interactions (2)
- potential drug interactions with chemotherapy agents (1)
- potential drug interactions with statins and other medications (1)
- Potential drug leakage (1)
- Potential drug-induced hepatotoxicity (1)
- potential dysbiosis from pathogenic bacterial inhibition (1)
- potential ecological competition effects (1)
- Potential ecological impacts on non-target species (1)
- potential ecological risks from non-native species introduction (1)
- potential economic losses from quality degradation (1)
- potential ecosystem disruption from introduced bacterial strains (1)
- potential ecosystem impacts from environmental probiotics require further validation (1)
- potential effects on non-target organisms (1)
- potential effects on non-target organisms require further study (1)
- potential electrode contamination from quinone polymerization (1)
- Potential emergence of terbinafine-resistant strains (1)
- potential endocrine disruption from isoflavones in hormone-sensitive conditions (1)
- Potential environmental accumulation concerns (1)
- potential environmental concerns from chemical agents (1)
- Potential environmental impact of large-scale application (1)
- potential environmental toxicity from carbon-based nanoparticles (1)
- potential enzyme alterations (1)
- Potential eosinophilic allergic inflammation in lungs (chitin) (1)
- potential exacerbation of psychosis (1)
- Potential exacerbation of psychotic or bipolar symptoms (contraindication) (1)
- potential false negatives in screening (1)
- Potential false negatives in screening process (1)
- potential false positives from surface contamination in respiratory samples (1)
- potential fatality (1)
- Potential fitness costs (1)
- Potential flare of erythema nodosum with antifungal therapy initiation (1)
- potential food contamination risk if fruit bodies consumed (1)
- Potential food safety risks from elevated toxin production (1)
- potential food safety risks including contamination (1)
- Potential for abuse (1)
- potential for abuse or misuse (1)
- potential for acquired resistance to disinfectants (2)
- potential for addiction and abuse (1)
- potential for adverse psychological effects (1)
- Potential for adverse psychological effects including dysphoric experiences or bad trip (1)
- potential for altered healing response through modified clotting mechanism (1)
- potential for antimicrobial resistance development (1)
- Potential for anxiety (1)
- Potential for anxiety and adverse events in hostile environments (1)
- potential for azole-resistant infections (1)
- Potential for bad trips (terrifying experiences) (1)
- potential for boundary transgressions (1)
- potential for challenging experiences (1)
- potential for challenging experiences or bad trips (1)
- potential for confusion regarding memory authenticity (1)
- Potential for contamination or colonization misinterpretation (1)
- potential for cultural appropriation of certain practices (1)
- potential for development of pathway inhibitors to suppress fungal pathogenicity and conidiation (1)
- potential for disease control through pathway inhibition (1)
- potential for drug cost burden and compliance challenges with long-term use (1)
- potential for drug resistance development with repeated use (1)
- potential for exploitation (1)
- potential for foodborne contamination (1)
- potential for fungal drug resistance with repeated use (2)
- Potential for fungal resistance development (1)
- Potential for hallucinogen persisting perception disorder (1)
- potential for heavy metal accumulation in mushroom material (1)
- potential for host immune modulation (1)
- potential for host immune modulation (1)
- potential for immunocompromised patient infections (1)
- potential for incomplete tenderization at low concentrations (1)
- potential for manic episode induction (1)
- Potential for misdiagnosis if used autonomously without clinical judgment (1)
- potential for misidentification with lower log scores (1)
- Potential for misuse (3)
- potential for misuse of engineered pathogens (1)
- potential for off-target effects (1)
- potential for protein inactivation through oligomeric forms (1)
- potential for psychological dependence despite lacking physical dependence (1)
- Potential for psychological discomfort during acute dosing (addressed through psychotherapeutic support) (1)
- Potential for psychosis in predisposed individuals (1)
- Potential for psychotic exacerbation at high doses (1)
- potential for radicalization with psychedelics (1)
- potential for reinforcing false beliefs (1)
- Potential for relapse (1)
- potential for resistance development with repeated use (1)
- potential for resistance development with single fungicide use (1)
- potential for serotonin syndrome with MDMA (1)
- potential for toxicity if not properly treated (1)
- potential for treatment failure (1)
- potential for treatment relapse (1)
- Potential for use without proper supervision or guidance (1)
- potential for UV-induced mutations (1)
- potential fungicide resistance development (1)
- potential gastric irritation (1)
- potential gastrointestinal discomfort at high doses including bloating and gas production (1)
- potential gastrointestinal discomfort from excessive fiber intake (1)
- potential hallucinogen persisting perception disorder (1)
- Potential harm to endophytes from aggressive sterilization protocols (1)
- potential harm to silkworm breeding industry (1)
- potential harm-related thoughts (1)
- potential health concerns in certain contexts (1)
- Potential health risk from 2-ethylhexanol inhalation exposure (1)
- potential health risk through fungal pathogen vectoring (1)
- Potential hemolysis (1)
- Potential hepatotoxicity and gastrointestinal irritation with oral terbinafine (1)
- Potential hepatotoxicity and gastrointestinal irritation with oral terbinafine (1)
- potential hepatotoxicity and visual disturbances with comparative agents (1)
- Potential hepatotoxicity at very high daily consumption (1)
- potential hepatotoxicity considerations (1)
- Potential hepatotoxicity from azoles (1)
- Potential herb-drug interactions via cytochrome P450 enzymes and drug transporters (1)
- potential host plant infection (1)
- potential immune interference (1)
- potential immunosuppressive effects at certain concentrations (1)
- Potential impacts on beneficial soil microorganisms require further study (1)
- potential in vivo toxicity (1)
- potential inadequate pharmacokinetic achievement with standard dosing in obese patients (1)
- potential increased fall risk with vitamin D supplementation (1)
- potential increased suicidality in some cases (1)
- Potential inflammation from accumulated lectins (1)
- Potential inflammatory response activation (1)
- potential inflammatory responses (1)
- potential inhalation toxicity of hydrogen sulfide (1)
- Potential inhibition at temperatures exceeding 75°C (1)
- potential inhibition of beneficial endophytic fungi (3)
- potential inhibition of cotton seed germination and growth at concentrations exceeding 200 µg/mL (1)
- potential insecticide effects through reactive oxygen species production (1)
- potential interaction with doxorubicin when glutathione used (1)
- potential interactions with antipsychotics (1)
- potential interference with antibiotic therapy (1)
- potential interference with antibiotic therapy (1)
- potential interference with apoptosis (1)
- potential interference with binding sites (1)
- potential interference with psilocybin mode of action (1)
- Potential intestinal barrier damage with certain carrageenans (1)
- potential intestinal inflammation at excessive secondary metabolite concentrations (1)
- potential intolerance in inflammatory bowel disease patients to incompletely fermented fructans (1)
- potential intrinsic azole resistance (1)
- Potential invasive species concerns (1)
- potential iron leaching at extreme pH levels (1)
- potential irritation and dermatitis from conventional agents like hydroquinone and kojic acid (1)
- Potential issues with mechanical durability and abrasion resistance in some applications (1)
- potential issues with sourcing sustainability and water footprint (1)
- potential kidney damage from excess gallium (1)
- potential kidney stone formation (1)
- potential limitations in treating high dye concentrations (1)
- potential limitations include incomplete removal in complex wastewater (1)
- Potential long-term health effects (1)
- Potential loss of bioactivity due to excessive heat or harsh chemical extraction (1)
- potential loss of native microbial diversity with genetic modifications (1)
- potential loss of native microbial diversity with genetic modifications (1)
- potential loss of strain-specificity (1)
- potential Maillard reactions during thermal hydrolysis (1)
- potential maladaptation under extreme conditions (1)
- potential mechanical damage to active ingredients during microwave extraction (1)
- potential medication interaction (1)
- Potential metal release under acidic gastric conditions (1)
- potential microbiota imbalance if consumed in excess (1)
- potential misdiagnosis leading to incomplete removal (1)
- Potential moderate acute toxicity (LD50 710 mg/kg predicted) (1)
- Potential mycelial growth inhibition by certain insecticides (Tanidil®-T showed 93.60% growth inhibition) (1)
- potential mycotoxin production exacerbating airway pathology (1)
- potential mycotoxin production from some fungi species (1)
- Potential mycotoxins (sansalvamide-like compounds) may impact host plants or other microorganisms (1)
- Potential N-nitroso compound formation (1)
- potential nanoparticle accumulation (1)
- potential nanoparticle agglomeration at excessive concentrations (1)
- Potential nanoparticle migration (1)
- potential need for further screening optimization (1)
- potential need for genetic engineering for improved stability (1)
- potential negative effects at high inclusion rates in animal diets (1)
- potential negative effects of excessive meat intake (1)
- potential negative effects on beneficial soil microorganisms (1)
- Potential negative effects on non-target fungi (1)
- Potential negative effects on non-target organisms (1)
- potential negative host effects on AMF development (1)
- potential negative host effects on AMF development (1)
- potential nitrogen immobilization in soils leading to plant deficiencies if not properly managed (1)
- potential non-target organism impacts requiring assessment (1)
- potential nutrient absorption limitation (1)
- potential off-flavors and off-odors at high essential oil doses (1)
- potential off-target effects from α-methylene-γ-butyrolactone structure forming covalent bonds with cysteine residues (1)
- potential off-target effects requiring investigation (1)
- potential off-target effects with synthetic agents mentioned as less likely with fungal metabolites (1)
- potential off-target genetic modifications (1)
- potential organ damage (1)
- potential organ failure from daughter cyst implantation (1)
- potential organ-specific toxicity in renal tissues (1)
- Potential overheating concerns (mitigated by results) (1)
- Potential overheating concerns from melanin's solar radiation absorption capacity (not observed in practice) (1)
- potential particle agglomeration in dissolution (1)
- Potential pathogen transmission (1)
- Potential pathogenic activity as fungal immune evasion compound (1)
- potential pathogenic agents in disseminated fungal infections (1)
- potential pathogenic bacteria (Listeria spp., Bacillus spp.) (1)
- potential pathogenic behavior as opportunistic pathogens (1)
- potential pathogenic fungal colonization (1)
- potential pathogenic fungal transmission (1)
- Potential pathogenicity causing crop yield reduction and commercial losses in hawthorn cultivation (1)
- potential pathogenicity of Candida orthopsilosis (1)
- Potential pathogenicity risk (1)
- potential pathogenicity to some cash crops including Passiflora edulis (1)
- potential pathogenicity to some cash crops such as Passiflora edulis and Solanum lycopersicum (1)
- Potential pathogens in plants and animals (Corynebacterium, Mycobacterium, Nocardia) (1)
- potential patient harm from unfamiliar organism names (1)
- Potential pesticide residues (1)
- potential pharmacokinetic interactions with anticancer drugs (1)
- Potential pharmacokinetic limitations regarding tissue distribution (1)
- Potential phytotoxic effects at high concentrations (1)
- Potential phytotoxicity at high concentrations (6)
- Potential phytotoxicity at high concentrations causing chlorosis (1)
- Potential phytotoxicity at higher doses (1)
- potential phytotoxicity at very high concentrations not evaluated (1)
- Potential phytotoxicity at very low pH values or high chlorine concentrations (1)
- potential phytotoxicity concerns with high copper concentrations (1)
- potential phytotoxicity in plant applications (1)
- potential phytotoxicity not yet evaluated (1)
- potential phytotoxicity to non-target plants (1)
- Potential promotion of dermatophyte growth by Malassezia through consumption of antifungal fatty acids (1)
- potential protein degradation under certain fermentation conditions (1)
- potential protein denaturation (1)
- potential protein structure degradation with excessive heating (1)
- potential protein synthesis inhibition from ledodin protein (1)
- potential psychological harms from dissociative or psychedelic experiences (1)
- potential psychosis induction (1)
- Potential psychosis or mania triggers in genetically predisposed individuals (1)
- potential psychotic breaks in vulnerable individuals (1)
- potential publication bias (1)
- potential quality degradation with improper processing (1)
- potential radiation exposure from foraged mushrooms in contaminated areas (1)
- potential radiation exposure to surrounding structures (1)
- potential recurrence if risk factors persist (1)
- potential redistribution of nitrogen metabolism (1)
- potential reduced activity over prolonged exposure (1)
- potential reduced susceptibility to triazoles (1)
- potential reduction in mechanical strength from cell wall thinning (1)
- potential reduction of bioavailability of imatinib (1)
- Potential reduction of photosynthetic pigments when applied alone without pathogen pressure (1)
- potential resistance considerations addressed (1)
- Potential resistance development (1)
- potential resistance development concerns with single-pathway targeting (1)
- potential resistance mechanisms (1)
- potential resistance to echinocandins (1)
- Potential resistance variation in emerging pathogen (1)
- potential resource competition in some symbioses (1)
- potential reversal to toxic forms (1)
- potential risk of steroid therapy worsening NTM infection (1)
- potential risk of subsequent psychiatric disorders (1)
- Potential risk to non-target plant species if released as biocontrol agent (1)
- Potential risk to non-target plant species requires further assessment (1)
- potential risk to non-target plants requires further assessment (1)
- Potential safety considerations with larger group sizes (1)
- Potential seizure exacerbation at high doses (1)
- potential self-digestion through secreted lytic enzymes (1)
- Potential sensitivity issues in treated seed populations (1)
- Potential sensitivity to pathogens in PSKR mutants (1)
- potential sensory impact on food products (1)
- potential septic shock contribution in specific experimental models with indomethacin (1)
- Potential serotonin syndrome with concurrent medications (1)
- potential side effects associated with existing inhibitors: permanent depigmentation (1)
- potential side effects from combination therapy (1)
- Potential side effects from conventional treatments including ulceration (1)
- potential side effects from TRPC6 overactivation in lungs and kidneys (1)
- potential side effects in chemotherapy and radiotherapy (1)
- potential side effects of conventional antifungals (azole, polyene, echinomycin) (1)
- potential side effects of herbal medications (1)
- potential side effects of herbal medications (1)
- potential side effects of long-term chemical medications including joint inflammation (1)
- Potential skin irritation and allergic reactions at high concentrations (1)
- potential soil fertility depletion from accelerated organic matter degradation (1)
- potential soil fertility depletion from accelerated organic matter degradation (1)
- potential species-specific chemical composition variations may affect therapeutic efficacy (1)
- potential stress-induced toxin activation (1)
- potential structural damage to wooden materials under high humidity (1)
- potential structural degradation during extraction (1)
- potential suicidal ideation in non-responders (1)
- Potential superinfections in severely ill individuals (1)
- potential survival of acid-resistant pathogens in low-pH fermented dairy (1)
- potential systemic effects including vomiting and tachycardia (1)
- potential taste alterations (1)
- potential therapy-induced resistance (1)
- potential therapy-induced resistance (1)
- potential threat to cultural heritage from black fungi colonization (1)
- potential threat to subterranean cultural heritage (1)
- Potential threats to subterranean cultural heritage from black fungi colonization (1)
- Potential tissue damage from excessive microwave heating (1)
- Potential toxicity at high concentrations (5)
- Potential toxicity at high concentrations (for silver nanoparticles) (1)
- potential toxicity at high doses (1)
- Potential toxicity at high doses requiring regulatory assessment for food applications (1)
- potential toxicity concerns (not detailed in review) (1)
- Potential toxicity concerns at higher concentrations (1)
- potential toxicity concerns with Monascus kaoliang B6 limiting food applications (1)
- potential toxicity concerns with Monascus kaoliang B6 pigment for food applications (1)
- potential toxicity concerns with nanoparticle exposure (1)
- potential toxicity concerns with some beauveriolide derivatives (1)
- potential toxicity from hydrocarbon transformation products (1)
- Potential toxicity from pesticide mixtures (tebuconazole and propiconazole combination) (1)
- potential toxicity from reactive oxygen species generation (1)
- Potential toxicity issues with traditional chemical carriers (1)
- potential toxicity noted for Tricholoma equestre in some regions (1)
- Potential toxicity of nanoparticles depending on size (1)
- potential toxicity of wild mushroom species (1)
- potential toxicity requiring further safety investigation (1)
- potential toxicity requiring SAR studies (1)
- Potential toxicity to current microbial hosts limiting production of some terpenoids (1)
- potential toxicity to fungal cells at elevated concentrations (1)
- potential toxicity to mammals requires further safety studies (1)
- potential toxicity to non-targeted organisms (2)
- potential toxicity with prolonged fermentation times (1)
- potential trade-off between defense and growth (1)
- potential triazole resistance (1)
- potential unpleasant dose-free days (1)
- potential vaccine side effects (1)
- potential valvular fibrosis with chronic microdosing (1)
- potential variable therapeutic responses between sexes (1)
- potential virulence factors in certain E. faecalis strains (1)
- potential virulence factors in some populations (1)
- potential volatility loss during processing (1)
- potential volatility of essential oil components (1)
- potential wastewater generation during extraction (1)
- Potential wood surface discoloration with prolonged immersion (1)
- potential yin-yang or cold-heat imbalances (1)
- potential yin-yang or cold-heat imbalances (1)
- potential zoonotic transmission to beekeepers (1)
- potentially limiting consumer adoption (1)
- potentially useful for disease control strategies (1)
- PR toxin causes liver toxicity and subacute symptoms in livestock through silage contamination (1)
- pre-existing antibody-mediated immunity (1)
- pre-harvest sprouting reduces grain quality and yield (1)
- Prednisone associated with disease flares upon discontinuation (1)
- Preferent carbon and nitrogen sources suppress parasitic gene expression through catabolic repression (1)
- pregnancy (2)
- pregnancy may further compromise cell-mediated immunity (1)
- Pregnancy-related immune changes increased vulnerability to fungal infections (1)
- premature defoliation (1)
- premature leaf drop (1)
- premature needle shedding (1)
- presence of anti-nutritional factors affecting digestibility (1)
- presence of contaminants including aflatoxins and heavy metals (1)
- presence of heavy metals (arsenic, cadmium) in some extracts (1)
- presence of heavy metals (within safe limits) (1)
- presence of heavy metals (within safe limits) (1)
- preservation constraints (1)
- prevent fertilization (1)
- prevention of aberrant axon crossing (1)
- prevents complement activation (1)
- prevents outcome devaluation (1)
- Previous agents (kojic acid, hydroquinone) cause skin cancer (1)
- Previous low regeneration efficiency (1)
- Primary resistance to antifungal drugs in some isolates (1)
- Prior antifungal therapy decreases diagnostic sensitivity (1)
- Prior antifungal therapy decreases test sensitivity (1)
- Prior antifungal treatment failures with griseofulvin (1)
- prior steroid therapy reduces test performance (1)
- PRMT5 silencing reduces cellulase activity and enzyme production capacity (1)
- pro-cancer properties (1)
- pro-inflammatory diets exacerbate nephrotoxicity (1)
- Pro-inflammatory effects (Malassezia) (1)
- pro-inflammatory properties noted for some compounds (7,22-ergostadienone via Toll-like receptor activation) (1)
- pro-inflammatory response worsens prognosis (1)
- pro-inflammatory responses (1)
- pro-oxidative effects at high doses (1)
- proallergenic activity (2)
- probiotic viability loss in harsh gastrointestinal conditions (1)
- probiotic-induced dysbiosis (1)
- processed foods with preservatives and nitrates (1)
- processed foods with preservatives and nitrates (1)
- produces mycotoxins (1)
- produces teratogenicity (1)
- product degradation from excessive mechanical or thermal stress (1)
- product degradation under excessive mechanical or chemical stress (1)
- product deterioration (1)
- production cost concerns (1)
- production of biogenic amines and aflatoxins by spoilage organisms (1)
- production of more persistent transformation products (1)
- production of mycotoxins (citrinin) by Monascus purpureus raises safety concerns (1)
- Production of mycotoxins harmful to humans and animals (1)
- production of thaxtomin phytotoxins (1)
- production of unexpected metabolites in complex food ecosystems (1)
- production of virulence factors and invasive conidia (1)
- profound neutropenia increases vulnerability (1)
- progressive dieback (1)
- progressive lesion enlargement on voriconazole (1)
- progressive vegetation enlargement (1)
- progressive vision loss with delayed diagnosis (1)
- proinflammatory cytokine induction (IL-1, IL-36) (1)
- proinflammatory effects (3)
- Prolonged antibiotic use can promote fungal growth (1)
- prolonged anticoccidial drug use may lead to drug resistance (1)
- prolonged antifungal exposure (1)
- prolonged antifungal use without diagnostic confirmation (1)
- prolonged BDG positivity linked to poor prognosis (1)
- Prolonged betamethasone corticosteroid use suppresses immune function and predisposes to opportunistic candida infections (1)
- prolonged betamethasone use increases infection risk (1)
- Prolonged broad-spectrum antibiotic administration and glucocorticoid treatment contributed to fungal proliferation and disease progression (1)
- Prolonged broad-spectrum antibiotic exposure (28 days) likely contributed to fungal overgrowth and nosocomial infection development (1)
- Prolonged broad-spectrum antibiotic therapy and glucocorticoid administration facilitated fungal proliferation and dissemination (1)
- prolonged broad-spectrum antibiotic use increasing NIC risk (1)
- Prolonged corticosteroid use as immunosuppressive risk factor (1)
- prolonged glucocorticoid use exacerbates risk (1)
- prolonged glucocorticoid use in ABPA may trigger tuberculosis reactivation (1)
- prolonged hospital stay (1)
- prolonged immunosuppression increases infection risk (1)
- prolonged lymphopenia from treatment (1)
- prolonged lymphopenia increases mucormycosis susceptibility (1)
- Prolonged mechanical ventilation requirement (1)
- Prolonged moisture exposure (1)
- prolonged mycelium colonization can reduce mechanical properties in composite materials (1)
- prolonged neutropenia (1)
- Prolonged oxygen therapy increases susceptibility (1)
- prolonged therapy often necessary (1)
- prolonged treatment courses with frequent adverse effects (1)
- Prolonged turnaround times reduce clinical utility (1)
- Prolonged wear of occlusive footwear (1)
- prominent adverse effects (1)
- promote biofilm formation complicating antibiotic treatment (1)
- promote senescence (1)
- promoter leakage observed in some regulatory elements (1)
- promotes immunosuppressive environment (1)
- promoting disease progression (1)
- Promotion of fungal growth (1)
- promotion of fungal growth in macrophage infections (1)
- promotion of Th17 responses (1)
- prooxidant activity at high concentrations or with metal ions (1)
- Prooxidant effects at high concentrations (1)
- Protease activity is essential for spherule development and endospore release (1)
- protective effect against chemotherapy-induced cytotoxicity which may be risky for oncology patients (1)
- protective effects diminished (1)
- protein allergens (1)
- protein content reduction in some conditions (1)
- protein degradation (1)
- protein destabilization (1)
- protein synthesis inhibition (2)
- proteins (2)
- proteinuria (1)
- Proteobacteria and Escherichia-Shigella linked to cardiovascular risk through TMAO production (1)
- Proteolytic degradation (1)
- provocation of asthmatic reactions (1)
- Pruning during high spore release periods increases infection risk (1)
- Pruritic plaques (1)
- PSI did not alter natural reward behavior or analgesic effects of opioids (1)
- Psidium guajava (1)
- psilocybin (1)
- psilocybin alone showed limited efficacy compared to combination treatments (1)
- PSK suppresses bacterial immunity (1)
- psychedelic effects (3)
- Psychedelic effects may be contraindicated in individuals with family history of psychotic disorder (1)
- Psychedelic experiences (1)
- Psychedelic visual disturbances (1)
- psychedelic-induced acute or persistent psychotic symptoms (1)
- psychiatric concerns including restlessness and insomnia (1)
- Psychoactive effects (3)
- psychological challenge (reported by some participants) (1)
- psychological dependence (1)
- psychological destabilization (3)
- psychological difficulties (1)
- psychological discomfort (1)
- psychological distress (2)
- Psychological distress requiring interpersonal support (1)
- Psychological stress exacerbating metabolic dysfunction (1)
- psychological vulnerability during acute drug effects (1)
- psychologically challenging experiences (1)
- psychosis (3)
- psychosis induction (2)
- psychosis risk (3)
- Psychosis-like symptoms (1)
- psychotic disorders (1)
- psychotic symptom exacerbation (1)
- psychotic symptoms (3)
- psychotomimetic effects (4)
- Psychotropic effects (1)
- Psychotropic side effects from cannabinoids (1)
- Psychotropic/psychedelic effects (1)
- PTP1B deficiency increases susceptibility to systemic fungal infection (1)
- PTP1B inhibition leads to impaired neutrophil ROS production (1)
- PTSD (1)
- Ptx3 instability at elevated temperatures compromises diagnostic accuracy (1)
- pulmonary arterial hypertension (1)
- pulmonary edema (1)
- pulmonary hypertension (1)
- pupil dilation (1)
- Purpureocillium lilacinum is resistant to amphotericin B and most azole derivatives with minimal or no activity (1)
- PYC1 deletion leads to loss of virulence in F. oxysporum but not F. graminearum (1)
- pyroptotic cell death (1)
Q
- QT interval prolongation (1)
- QT prolongation (3)
- QT prolongation with voriconazole and amiodarone (1)
- QTc prolongation (1)
- QTc prolongation associated with fluconazole use (1)
- QTc prolongation risk (1)
- QTc prolongation with ibogaine (1)
- QTc prolongation with itraconazole (1)
- quality defects (1)
- quality reduction (1)
- quality reduction (1)
- Quantitative BAL cell composition not predictive of IPA outcomes (1)
- quercetin inhibits protein digestion (1)
- quercetin may act as immunosuppressant in certain contexts (1)
- quinolinic acid induces cognitive impairment (1)
R
- racemization at high temperatures (1)
- Radiation exposure with PET/SPECT (1)
- Radiation health risks from contaminated mushroom consumption (1)
- Radiation-induced mutations (2)
- radioactive cesium-137 contamination (1)
- radioactive contamination (1)
- Radioactive contamination risk (137Cs bioaccumulation) (1)
- Radiocaesium accumulation (1)
- radiocaesium accumulation in mushrooms poses potential radiation exposure through ingestion (1)
- Radiocaesium contamination from environmental pollution (1)
- Radiocaesium contamination from environmental pollution (1)
- radiofrequency radiation (1)
- radiological or mycological progression (1)
- rancid odor (1)
- Random insertions and deletions in genome during transformation (1)
- RAP1 deletion leads to increased fluconazole resistance under low-iron conditions (1)
- rapid adaptation mechanisms that enable pathogen escape from control measures (1)
- rapid bioluminescence quenching (1)
- Rapid clearance by reticuloendothelial system (3)
- rapid degradation at elevated temperatures (1)
- rapid development of resistance to monotherapy (1)
- rapid disease progression despite antifungal therapy (1)
- rapid disease progression despite maximal therapy (1)
- rapid disease progression without surgical intervention (1)
- rapid FAC decrease in presence of organic material (1)
- rapid fermentation causing bloating (1)
- rapid heartbeat (1)
- rapid larval mortality (2)
- rapid metabolism (1)
- rapid pharmacokinetics requiring PEGylation or encapsulation (1)
- rapid plasma elimination (1)
- rapid progression in immunocompromised patients (1)
- rapid resistance development (1)
- rapid resistance development (1)
- rapid resistance development to 5-fluorocytosine (1)
- rapid resistance development with monotherapy (1)
- Rapid spore dispersal in high humidity fluctuation conditions with wind (1)
- Rapid spore release and dispersal leading to disease spread (1)
- rare allergic reactions (1)
- rare bacteremia risk with Lactobacillus use (less than 1 case per 1 million) (1)
- rare bacteremia risk with Lactobacillus use (less than 1 case per 1 million) (1)
- rare cases of anxiety episodes (1)
- rare cases of anxiety episodes (1)
- rare psychotic episodes (1)
- rare toxicity reports (1)
- rash (1)
- re-traumatization (2)
- Reactivation of dissociated traumatic material (1)
- reactive oxygen species generation (4)
- recalcitrance to protoplast technology in monocots (1)
- recalcitrant xenobiotics (1)
- recalcitrant xenobiotics (1)
- receptor downregulation and tachyphylaxis with β-arrestin-biased compounds (1)
- receptor downregulation and tachyphylaxis with β-arrestin-biased compounds (1)
- recurrence after surgical excision (1)
- recurrence after surgical excision (1)
- Recurrence after treatment discontinuation (1)
- Recurrence and relapse of infection after antifungal discontinuation (1)
- Recurrence of infection (1)
- recurrent aspergillus colonization if untreated (1)
- recurrent fever and inflammatory markers (1)
- recurrent infections (3)
- red meat at high temperatures (1)
- reduce nitrogen levels (1)
- reduce seed and fruit yield (1)
- reduced abundance of protective yeasts (1)
- Reduced accumulation of selenium and zinc when cultured together due to complex formation (1)
- reduced accuracy in conflict monitoring and response inhibition at higher doses (1)
- reduced accuracy on immediate word recall following acute dose (1)
- reduced agricultural productivity (1)
- reduced AMF colonization under high nutrient conditions (1)
- Reduced antagonistic activity in nutrient-rich conditions (1)
- reduced antagonistic effects upon deletion of biosynthetic genes (1)
- Reduced antibiotic effectiveness (1)
- reduced antibiotic efficacy (1)
- reduced antifungal efficacy (1)
- reduced antifungal sensitivity to some drugs (1)
- reduced antifungal susceptibility (2)
- reduced antifungal susceptibility in some isolates (1)
- reduced antioxidant capacity after storage (1)
- reduced ATP synthesis (1)
- reduced ATP synthesis impairs seedling growth (1)
- reduced available phosphorus and available nitrogen in short term due to microbial immobilization (1)
- reduced azole susceptibility (1)
- reduced bacterial viability in planktonic form (1)
- reduced binding affinity of phenamacril to mutant myosin proteins (1)
- Reduced bioavailability (1)
- reduced bioavailability of bioactive compounds in complex cell matrix (1)
- reduced biomass accumulation (2)
- reduced blood-brain barrier transcytosis (1)
- reduced capsule synthesis (1)
- reduced cell wall thickness (1)
- reduced cerebral connectivity (1)
- reduced chlorophyll content in mycorrhizal plants under certain conditions (1)
- reduced clock protein expression (1)
- reduced colonization efficiency under high salt stress (>250 mM) (1)
- reduced community sensitivity to fungicides with repeated applications (1)
- reduced conidiation under sugar limitation (1)
- reduced conidiation under sugar limitation (1)
- reduced diets without supplementation showed poor meat quality and performance metrics (1)
- reduced diets without supplementation showed poor meat quality and performance metrics (1)
- reduced digestibility due to anti-nutritional factors and polyphenols (1)
- reduced drug accumulation (1)
- Reduced drug binding affinity (2)
- reduced drug efficacy (2)
- reduced drug efficacy against persister cells (1)
- reduced drug permeability (1)
- reduced drug susceptibility (1)
- reduced effectiveness at 10°C (1)
- reduced effectiveness at high salinity levels (1)
- reduced effectiveness of benomyl and kresoxim-methyl (1)
- reduced effectiveness with increased incubation time (1)
- reduced effects with SSRIs through receptor competition (1)
- Reduced efficacy against biofilm forms (1)
- Reduced efficacy at excessively high fermentation filtrate concentrations (1)
- reduced efficacy in immunocompromised individuals (2)
- reduced efficacy in immunocompromised individuals (1)
- Reduced efficacy in obese individuals due to altered microbiota diversity and increased baseline inflammation (1)
- Reduced efficacy in older larval instars (1)
- reduced efficacy in soil environments (1)
- reduced efficacy of both agricultural and clinical fungicides (1)
- reduced efficacy of fluconazole (1)
- reduced efficacy of triazole therapy (1)
- reduced efficacy of voriconazole (1)
- Reduced efficacy when used with gastrointestinal or anti-infective medications (1)
- reduced elasticity and cohesiveness (1)
- reduced environmental toxicity compared to commercial fungicides (1)
- reduced enzyme secretion (1)
- reduced enzyme secretion (1)
- reduced enzyme synthesis capacity (1)
- reduced fatty acid content in mutants compared to wild-type (1)
- reduced fecundity and developmental delays on suboptimal diets (1)
- reduced fertility (1)
- reduced fitness in haploid cells (2)
- Reduced fluconazole susceptibility under acidic conditions (1)
- reduced fruiting body quality (1)
- reduced fungal fitness in virus-cured strains (1)
- reduced fungicide efficacy in field and laboratory conditions (1)
- reduced GABA levels (1)
- reduced germination energy (1)
- reduced germination on nutrient-poor media (1)
- reduced germination rates (1)
- reduced grain quality (2)
- reduced growth (2)
- reduced growth and remediation efficiency under elevated substrate concentrations (1)
- reduced growth and reproduction (1)
- reduced growth performance (2)
- reduced growth rate (1)
- Reduced growth under zinc stress (1)
- reduced growth when applied directly to plants (1)
- reduced hatching success (1)
- reduced hydrophobicity of microcycle conidia compared to aerial conidia (1)
- reduced IL-1β production (2)
- reduced immune response (1)
- reduced inhibitory potential of interneurons (1)
- reduced insect performance (1)
- reduced lifespan (1)
- reduced market value (1)
- Reduced mechanical durability and wear resistance of fatty acid coatings limiting applications requiring high abrasion resistance (1)
- reduced mechanical properties (1)
- reduced mechanical strength at high essential oil concentrations (1)
- reduced metabolite production with polysorbate 80 co-supplementation in most strains (1)
- reduced mitochondrial membrane potential (1)
- reduced mycelial thickness (1)
- reduced mycorrhizal colonization (1)
- reduced neurogenesis (2)
- reduced neuroplasticity (1)
- reduced nutritional value from oxidative stress (1)
- reduced outdoor recreation participation (1)
- reduced oviposition inhibition may be less effective at later time points (1)
- reduced pathogenic fungi (1)
- Reduced pathogenicity under light conditions (1)
- Reduced pathogenicity under light exposure (1)
- reduced photosynthesis in aquatic systems (1)
- reduced photosynthetic capacity (1)
- Reduced photosynthetic efficiency (2)
- reduced plant and fungal growth (1)
- reduced plant biomass and chlorophyll content (1)
- reduced plant biomass at fungal front (1)
- reduced plant immunity (1)
- reduced plant survival (1)
- reduced plant vigor and xylem function (1)
- reduced pollen and nectar foraging at high doses (1)
- reduced production of harmful protein fermentation metabolites (1)
- reduced productivity (2)
- reduced protein digestibility at highest PE substitution level (17.24%) (1)
- reduced reproductive success in sensitive species (1)
- reduced root growth (1)
- reduced seed germination (1)
- reduced seed weight (1)
- reduced seedling vigor (1)
- reduced signaling efficacy (1)
- reduced soil nutrient availability (1)
- reduced soil nutrient availability (1)
- reduced spine head volume on apical dendrites (1)
- reduced stress tolerance (1)
- Reduced subjective effects when combined with SRIs (1)
- reduced survival (1)
- reduced susceptibility (1)
- reduced susceptibility after radiotherapy exposure (1)
- reduced susceptibility to amphotericin B (1)
- reduced susceptibility to antifungal agents (2)
- reduced susceptibility to azole fungicides (1)
- Reduced susceptibility to azoles (5)
- reduced susceptibility to caspofungin (1)
- reduced susceptibility to clinical triazoles (1)
- reduced susceptibility to ergosterol biosynthesis inhibitors (1)
- reduced susceptibility to itraconazole and voriconazole (1)
- reduced susceptibility to itraconazole in A. fumigatiaffinis (1)
- reduced susceptibility to multiple drug classes (1)
- reduced susceptibility to voriconazole and itraconazole (1)
- reduced susceptibility to voriconazole in non-albicans Candida species (1)
- Reduced synaptic markers with high-dose repeated treatment (1)
- reduced task performance (1)
- reduced test weight (1)
- reduced Th17 expansion (1)
- Reduced thermal stress resistance with SCFA exposure (1)
- reduced tolerance to oxidative stress and high hydrostatic pressure in hog1 knockout mutant (1)
- reduced triazole susceptibility (1)
- Reduced underground dry weight in some treatments (1)
- reduced viability during processing and storage (1)
- reduced viability in direct seed contact (1)
- reduced vigilance (1)
- reduced vigor index (1)
- reduced virulence (1)
- Reduced viscosity and gel elasticity (1)
- reduced visual perception (1)
- reduced vitality (2)
- Reduced workability with NT addition (1)
- reduced yield (2)
- reduces antifungal susceptibility (1)
- reduces BDNF levels (1)
- reduces economic value of tea plants (1)
- reduces fruiting capacity (1)
- reduces gray matter volume (1)
- reduces microbial community stability (1)
- reduces mushroom spine density (1)
- reduces mycelial growth (1)
- reduces nNOS expression (1)
- reduces Reelin+ cell populations (1)
- reduces synaptic plasticity (1)
- reducing crop quality and yield (1)
- reducing its effectiveness as a biological control agent (1)
- reducing plant defense efficacy (1)
- Reduction in carotenoid content during processing (1)
- reduction in microbial abundance (1)
- reduction in osteoblast function (1)
- Reduction of lobetyolin content (1)
- Reduction of naturally occurring off-flavors (bitter almond, grassy notes) from unprocessed mushroom powder (1)
- reduction of soil nutrients (1)
- Reduction of unnecessary prophylactic seed treatments with synthetic plant protection products (1)
- REE toxicity at high concentrations (1)
- REE toxicity at high concentrations (1)
- refined sugars (1)
- regional differences in fungicide use affect pathogen prevalence (1)
- regulatory approval challenges (1)
- regulatory barriers limiting market access (1)
- regulatory limitations on novel strains (1)
- regulatory restrictions limiting fungicide concentrations (1)
- regulatory restrictions on genome editing in Europe (1)
- Regulatory T cell accumulation (1)
- regulatory uncertainties (1)
- reinforcement of maladaptive narratives (1)
- relapse risk with treatment discontinuation (1)
- relationship between AChE and SHP2 inhibition in muscle cells requires further investigation (1)
- relatively high production costs (1)
- relatively low antibiotic resistance (1)
- relatively low potency compared to vancomycin (1)
- Reliance on pigmentation for differentiation (1)
- removal of fungi providing stress tolerance (1)
- renal disease (1)
- renal dysfunction (2)
- renal dysfunction from prolonged voriconazole use (1)
- renal failure requiring dialysis (1)
- renal toxicity (1)
- renal toxicity from amphotericin B (2)
- renal toxicity from polyenes (1)
- renal toxicity of amphotericin B (1)
- reoperation increases infection risk (1)
- Repeated subculturing induces culture degeneration (1)
- reproductive disorders (1)
- reproductive dysregulation (1)
- reproductive failure (2)
- reproductive hormone suppression (1)
- reproductive impairment in sensitive species (1)
- reproductive system damage (1)
- reproductive toxicity (4)
- reproductive toxicity in aquatic species (1)
- required antidepressant medication tapering (1)
- requirement for higher superplasticizer content (1)
- requires careful dilution for therapeutic use (1)
- requires in vivo validation for biocompatibility and safety assessment (1)
- requires optimization of application concentrations (1)
- requires safe concentration thresholds (1)
- requires skilled practitioners for diagnosis (1)
- requires skilled practitioners for diagnosis (1)
- requires washout period (1)
- requiring cultivation in low-pollution areas (1)
- residues (1)
- Resinous compounds inhibit spore germination and mycelial growth of E. vermicola (1)
- resistance development (3)
- Resistance development in dermatophytes (1)
- resistance development in immunocompromised patients (1)
- resistance development in ntp1 deletion mutants (1)
- resistance development to echinocandins and azoles (1)
- resistance formation to NaPT observed (1)
- resistance mechanisms (1)
- Resistance to amphotericin B (1)
- resistance to amphotericin B and echinocandins in Fereydounia khargensis (1)
- Resistance to amphotericin B and most azole derivatives (1)
- resistance to amphotericin B in Purpureocillium sodanum (1)
- resistance to amphotericin B reported in over 50% of Basidiobolomycosis cases (1)
- resistance to amphotericin B reported in over 50% of Basidiobolus cases (1)
- Resistance to antifungal agents such as azoles in certain Candida species (1)
- Resistance to azoles (fluconazole, voriconazole, itraconazole, posaconazole) (1)
- resistance to azoles (voriconazole, posaconazole, fluconazole, itraconazole) (1)
- resistance to azoles and terbinafine noted in some isolates (1)
- resistance to caspofungin (1)
- resistance to clotrimazole and fluconazole in C. zonatum strain (1)
- resistance to conventional fungicides (1)
- resistance to echinocandins (1)
- resistance to echinocandins (caspofungin) (1)
- resistance to experience (1)
- resistance to fluconazole (7)
- Resistance to fluconazole and amphotericin B in the isolated B. bassiana strain (1)
- resistance to fluconazole and voriconazole in Candida tropicalis (1)
- Resistance to flucytosine (1)
- Resistance to itraconazole and posaconazole in some Lasiodiplodia species strains (1)
- resistance to membrane and osmotic stress (1)
- resistance to micafungin (1)
- resistance to nystatin (1)
- resistance to oral fluconazole (1)
- resistance to oral terbinafine (1)
- resistance to posaconazole (2)
- resistance to programmed cell death (1)
- resistance to terbinafine (1)
- Resistance to topical tavaborole (1)
- Resistance to VOCs observed in Fusarium oxysporum strains (1)
- Resistance to voriconazole (4)
- Resistance to voriconazole observed in 55.5% of resistant Candida isolates (1)
- resistance-driven treatment failure (1)
- resource-intensive treatment protocols (1)
- respiratory and inflammatory responses (1)
- respiratory depression (2)
- respiratory depression (1)
- respiratory diseases (1)
- respiratory diseases (1)
- respiratory disorders (1)
- respiratory infection risk from spore inhalation (1)
- respiratory infections (1)
- respiratory irritation (1)
- respiratory issues (1)
- respiratory issues (1)
- Responsible for diseases in commercial mushroom production (1)
- restenosis (1)
- restricted availability of alternative antifungal agents (1)
- restriction-modification barriers in clinical isolates (1)
- resulting in discoloration (1)
- results in disseminated intravascular coagulation (1)
- resveratrol reduced oxidative burst capacity of phagocytes (1)
- retarded mycelial regeneration (1)
- retinal toxicity (illudin S derivative) (1)
- Retromer mutations impair fungal pathogenicity and plant infection (1)
- Retromer mutations impair fungal pathogenicity and plant infection (1)
- reversible metal-biosorbent binding (1)
- Reversible pancytopenia reported in Korea (1)
- review emphasizes safety and lower side effects compared to conventional medicines (1)
- review focuses on beneficial effects (1)
- Rhabdomyolysis risk with Tricholoma equestre consumption in large quantities (1)
- rhinorrhea/lacrimation (1)
- Rhizopus oryzae causes root rot and seedling wilting (1)
- Rhodotorula resistant to echinocandins and azoles (1)
- Rifampicin contraindicated with voriconazole due to CYP3A4 enzyme induction (1)
- rifampicin interaction with voriconazole reducing serum concentration (1)
- rigidity (1)
- Risk 2 biosafety level organisms excluded from study (1)
- Risk factors for disease introduction: proximity to outbreaks (1)
- Risk factors include broad-spectrum antibiotic use (1)
- risk of acute intoxication (1)
- risk of adverse effects requiring clinical monitoring (1)
- risk of adverse effects requiring clinical monitoring (1)
- risk of altered consciousness requiring specialized supervision (1)
- risk of altered drug metabolism (1)
- risk of anaphylactic reaction from cyst rupture (1)
- Risk of anaphylaxis and local recurrence if diagnosis not made pre-operatively (1)
- risk of corneal perforation (1)
- Risk of expectancy effects in psychedelic studies (1)
- risk of gouty arthritis (1)
- risk of identity disruption (1)
- Risk of inducing psychotic episodes in predisposed individuals (1)
- Risk of infection following dental procedures (1)
- Risk of ischemic stroke (1)
- risk of negative expectations in control groups (1)
- Risk of non-target pathogenicity to native or economically important plants (1)
- Risk of overdose due to variable concentrations (1)
- Risk of personality alterations (1)
- Risk of poisoning from confusion with deadly poisonous webcap (Cortinarius rubellus) (1)
- Risk of psychological distress (1)
- Risk of psychological trauma if given without informed consent (1)
- Risk of psychotic episodes (1)
- risk of psychotic episodes in susceptible individuals (1)
- Risk of relapse requiring extended maintenance therapy (1)
- Risk of scarring alopecia (1)
- Risk of secondary pollution if not properly managed (1)
- risk of spinal cord injury (1)
- Risk of vascular damage from surgical intervention (1)
- risk of wild mushroom intoxication (1)
- risks associated with genetically modified organism release into environment (1)
- RNA polymerase II inhibition (1)
- RNAi knockdown reduced heat tolerance and development (1)
- RNAi-aox strains showed increased ROS production and reduced heat stress tolerance (1)
- ROCK2 deficiency induces anxiety-like behaviors (1)
- root corrosion (1)
- root decay (1)
- root desiccation (1)
- root growth inhibition (1)
- root histopathological changes (1)
- root infection (1)
- root medullary rot (1)
- Root rot causes plant damage (1)
- Root rot disease caused by F. cugenangense severely compromises the medicinal value and yield of A. crenata Sims (1)
- roquefortine C and PR toxin are mycotoxins with bioactive toxicity (1)
- ROS accumulation (1)
- ROS accumulation causes cell death and tissue necrosis (1)
- ROS generation (2)
- ROS generation (1)
- ROS production (2)
- rot (1)
- RsCAP3 increases plant susceptibility (1)
- RttA deletion increases azole susceptibility (1)
- ruxolitinib increases infection risk (1)
S
- S. aureus inhibits A. niger biofilm formation and gene expression (1)
- SA antagonizes JA biosynthesis (1)
- Saccharomyces cerevisiae fungemia with S. boulardii in high-risk patients (1)
- sadness (1)
- safe alternative to synthetic antioxidants (1)
- safe for consumers and environment (1)
- safe for in ovo administration (1)
- safe for non-target organisms and environment (1)
- safe for normal cells (1)
- safe for use with integrated pest management (1)
- safe fungal VOCs for environmental use (1)
- safety and intervention protocol concerns remain (1)
- safety and intervention protocol concerns remain (1)
- Safety concerns (1)
- Safety concerns under medical supervision (particularly perceived by psychiatrists) (1)
- safety concerns with repeated long-term microdosing practices (1)
- safety confirmed for food application at tested concentrations (1)
- safety of VOCs requires further evaluation for brood development (1)
- safety profile emphasized for commercialized species (1)
- safety profile established for D-fraction treatment (1)
- salt (1)
- Salt crystal formation in DESS samples reduced DNA quality and PCR success rates (1)
- salt stress at excessive concentrations (1)
- sanitary and epidemiological risk (1)
- saturated fats (1)
- saturated fatty acids increase melanin synthesis and tyrosinase activity (1)
- saturated fatty acids may increase LDL cholesterol and contribute to cancer development (1)
- scar tissue formation from therapeutic interventions (1)
- scarring alopecia as complication (1)
- Scedosporium shows resistance to many conventional antifungal treatments (1)
- Schedule 1 drug classification (1)
- Schedule I controlled substance (1)
- Schedule I controlled substance restrictions (1)
- scheduling as controlled substances (1)
- schizophrenia-like symptoms (1)
- schizostatin showed no antimicrobial activity at certain concentrations against some microorganisms (1)
- scleroderma (1)
- Screening excluded individuals with psychotic disorders (1)
- seasonal fluctuations in biological control effectiveness (1)
- sec-butylamine inhalation hazards (1)
- Sec2p deletion inhibits autophagy pathway and reduces nutrient homeostasis (1)
- Secondary bacterial infection emergence (1)
- Secondary bacterial infection with Citrobacter freundii (1)
- secondary bacterial infection with MSSA complicated recovery (1)
- secondary contamination risk (1)
- secondary contamination risk (1)
- secondary environmental risks from conventional chemical treatments (1)
- secondary infections (2)
- secondary metabolites compromise extraction efficiency (1)
- Secondary metabolites produced by dermatophytes act as toxins and immunomodulators to evade host immunity (1)
- secondary pollutants from chemical pretreatment methods (1)
- secondary pollution from chemical modifications (1)
- Secondary pollution from physicochemical methods (1)
- secondary pollution from thermal treatment (1)
- secondary pollution potential at excessive dosages (1)
- Secondary pollution risks (1)
- secretion of cell wall degrading enzymes (1)
- sedation (2)
- sedation and dry mouth from ketanserin (1)
- sedative effects (1)
- seed germination inhibition (1)
- seed rot (1)
- seedling collapse (1)
- seizure disorder (1)
- seizure induction (1)
- seizure risk (1)
- seizures (3)
- Selection for antibiotic-resistant bacteria (1)
- selective activity against certain pathogens with variable efficacy (1)
- selective outcome reporting bias (1)
- selectively targets scale insects with minimal non-target effects (1)
- selectivity challenges under multi-ion conditions (1)
- selenium overdosing can inhibit enzyme activity (1)
- selenium overdosing can inhibit enzyme activity (1)
- selenium toxicity (1)
- selenium toxicity risk with improper dosing (1)
- selenosis from chronic high-dose exposure (1)
- self-harm and suicide risk with delayed treatment response (1)
- self-harm risk (1)
- Self-harming behavior (1)
- Self-inhibitory effects on producer strains N11 and N12 (1)
- self-medication with corticosteroids delayed diagnosis (1)
- sensitivity to oxidative stress (1)
- sensitivity to strains not in training dataset (1)
- sensorimotor gating impairments (2)
- sensory acceptability issues (1)
- sensory acceptability issues (1)
- sensory impacts from plant-based antioxidants at high doses (1)
- sensory off-flavors (1)
- sensory overstimulation (1)
- sensory quality challenges with certain inactivation methods (1)
- septin inhibition may lead to incomplete compensatory mechanisms (1)
- sequence variation preventing cross-species protection with single antigen (1)
- sequesters calcium (1)
- serious adverse events (1)
- serious drug interactions with MAOIs and other medications (1)
- serious liver and kidney diseases (1)
- serious side effects including renal failure (1)
- serious suicide attempts (1)
- serious suicide attempts (1)
- serotonergic antidepressants (1)
- Serotonergic psychedelics (LSD, psilocybin, DMT) induce psychotic symptoms (1)
- Serotonergic toxicity risk (1)
- serotonin fluctuations with 5-HTP supplementation (1)
- Serotonin syndrome (1)
- serotonin syndrome risk (2)
- serotonin syndrome risk when combined with antidepressants (1)
- serotonin syndrome risk when combined with antidepressants (1)
- serotonin syndrome risk with certain medications (1)
- serotonin syndrome risk with certain medications (1)
- serotonin toxicity (1)
- serotonin toxicity with SSRI-ayahuasca combination (1)
- severe acute and chronic toxicities (1)
- severe adverse events comparable to placebo (1)
- Severe adverse events including seizures (1)
- Severe adverse immunosuppression from HLH therapy (1)
- severe anxiety (1)
- Severe ataxia (1)
- Severe ataxia (1)
- Severe cases may require euthanasia (1)
- severe cytokine release syndrome requiring corticosteroid treatment (1)
- severe defoliation (2)
- severe hepatotoxicity (1)
- severe hepatotoxicity (1)
- severe inflammatory lesions and quality of life impairment in humans (1)
- Severe inflammatory lesions reported in humans infected with T. mentagrophytes var. mentagrophytes genotype III* (1)
- Severe inflammatory lesions reported in humans infected with T. mentagrophytes var. mentagrophytes genotype III* (1)
- severe invasive fungal disease complications (1)
- severe malaise and loss of taste with itraconazole (1)
- severe periorbital damage requiring surgical removal (1)
- severe reactions in susceptible individuals (1)
- severe yet reversible paralysis (1)
- Sex-specific differential effects (1)
- sexual arousal (1)
- sexual dysfunction (3)
- Sexual reproduction of host fungus can limit virus spread (1)
- shape (1)
- shared facilities facilitating transmission (1)
- Shared humid facilities (1)
- sharing machinery (1)
- shelf-life failure (1)
- Shiga-like toxins (1)
- shiitake dermatitis with raw mushroom consumption (1)
- shiitake dermatitis with raw mushroom consumption (1)
- shivering (1)
- shoot die-off (1)
- short and long-term side effects (1)
- short duration of efficacy with conventional antidepressants (1)
- short duration of protection (1)
- Short half-life requiring continuous infusion (1)
- Short plasma half-life (1)
- short shelf life (1)
- Short shelf life of biological preparations (1)
- Short shelf life of certain propagules (1)
- Short-term anxiety (1)
- short-term dysphoria and anxiety at higher macrodoses (1)
- short-term dysphoria and anxiety at higher macrodoses (1)
- short-term effectiveness (1)
- short-term study limitations not capturing chronic disease progression (1)
- shortened shoot and root length (1)
- sickness responses (1)
- side effects (1)
- side effects from antifungal drugs (1)
- side effects from chemotherapy drugs (1)
- side effects from fatty liver drugs that may prevent optimal efficacy (1)
- side effects from hallucinogenic doses (1)
- side effects from pharmaceutical interventions (1)
- side effects from pharmaceutical interventions (1)
- side effects in clinical trials (1)
- side effects including headache (1)
- side effects including weight gain and bloating (1)
- side effects of antifungal therapy (1)
- side effects of conventional chemotherapy (1)
- side effects of conventional chemotherapy (1)
- Side effects of synthetic antidiabetic drugs include hypoglycemic coma (1)
- significantly diminishing forage nutritional value (1)
- silencing chitinase genes reduced sporulation and mycelial growth rate (1)
- Silencing of PcLRR-RK3 reduces pathogen virulence and growth (1)
- silver migration remained well below safety limits (1)
- simultaneous co-inoculation may stimulate mycotoxin production when pathogen is not fully inhibited (1)
- Simultaneous resistance to antifungal drugs and disinfectants (1)
- single dose showed stronger responses than double dose (1)
- skin barrier disruption (1)
- skin cancer risk (noted for existing inhibitors) (1)
- skin disorders (1)
- skin infection (1)
- skin infections (1)
- Skin irritation and chemical instability (associated with kojic acid) (1)
- skin irritation from direct bulb contact (1)
- Skin irritation from handling bulb material (1)
- skin lesions from excessive grooming in untreated mice (1)
- skin rash (1)
- Skin rashes (2)
- sleep disorders (1)
- sleep disruption (1)
- sleep disruption (1)
- sleep disturbance (3)
- sleep disturbances (2)
- sleep hallucinations (1)
- sleep loss (1)
- sleepiness (1)
- sleepiness (1)
- slight cytotoxicity to mammalian cells at elevated doses (1)
- slight cytotoxicity toward normal keratinocytes at 200 µg/mL for Z2 extract (1)
- Slight hydrolysis of immunoglobulin G and serum albumin (1)
- Slight PARP cleavage induction suggesting potential involvement of nonapoptotic pathways (1)
- Slight reduction in bonding strength of treated plybamboo (1)
- slight reduction in meat yellowness with no practical implications (1)
- slight reduction in sensory properties at higher mushroom ratios (1)
- slightly increased moisture uptake (1)
- Slow degradation rates (1)
- slowed cognitive processing (1)
- slower biodegradation with BBE addition compared to pure PBAT (1)
- slower degradation of very long-chain alkanes (C36) (1)
- slower hyphal growth (1)
- slower killing compared to chemical insecticides (1)
- slower response compared to treatment-resistant infections (1)
- slows nutrient absorption (1)
- SM disease reduces photosynthesis (1)
- SMS bacterial toxicity mitigated through PGPR treatment (1)
- SO4(2-) demonstrates competitive inhibitory effect (1)
- social interaction deficits (1)
- social isolation (1)
- social isolation risks (1)
- sodium alginate supplementation above 4.0 g/kg showed diminishing returns in some parameters (1)
- Sodium azide disrupts ATP production (1)
- Sodium azide impacts spore germination (1)
- soil compaction (1)
- soil degradation (2)
- soil nutrient imbalance (1)
- soil quality degradation (1)
- soil sodicity (1)
- soil structure destruction (1)
- soil-derived pathogenic contamination (1)
- solanine poisoning (1)
- Solanum lycopersicum (1)
- some acetaminophen effects depend on forgiveness levels (1)
- Some Artemisia species exhibit hepatotoxic effects (1)
- some Bacillus species (B. cereus) are pathogenic and can cause food poisoning (1)
- some bacteria and Candida spp. inhibit white-rot fungi development (1)
- Some bacterial strains enhance fungal pathogen activity and wood degradation (1)
- some chemical insecticides adversely affect entomopathogenic fungi (1)
- some crops and soils show limited or adverse responses to AMF inoculation (1)
- some cross-linking agents are toxic (1)
- Some cyanobacteria produce cytotoxic compounds that may adversely affect treated plants (2)
- some decrease in certain defense compounds (PRO, MDA) indicating improved plant health (1)
- some degradation products may be toxic (1)
- some degradation products potentially toxic (1)
- Some derivatives showed reduced mycelial inhibition activity compared to parent compound (1)
- Some derivatives showed reduced mycelial inhibition capacity compared to parent compound due to structural modifications interfering with binding sites (1)
- Some derivatives showed reduced mycelial inhibition compared to parent compound (2)
- some diterpenoids from Sarcodon scabrosus inhibited neurite outgrowth (1)
- some enzyme transformations may produce more toxic oxon derivatives (1)
- some evidence of reduced altruistic punishment in specific contexts (1)
- some fungal isolates showed limited efficacy on older pupae (1)
- some fungal proteins may have detrimental effects requiring determination (1)
- Some fungal species produce insecticidal compounds that reduced BSFL growth and survival (1)
- Some fungal species produce mycotoxins (e.g., Stachybotrys chartarum) (1)
- Some fungal strains like Fusarium oxysporum show resistance to VOCs (1)
- Some fungi contribute to mucosal inflammation (1)
- Some fungi identified have dual roles as potential pathogens (1)
- some fungi in Cladosporiaceae associated with plant and health hazards (1)
- Some fungi make mosquitoes more susceptible to pathogen infection (1)
- Some fungi showed limited tolerance to fiberbank toxicity and increased PAH concentrations in certain conditions (1)
- Some Fusarium species are plant and animal pathogens (1)
- some genotoxic activity noted in Z. mays seeds in related research (1)
- Some interventions reported mixed effects or no significant changes (1)
- some isolates resistant to fluconazole (1)
- some isolates showed incomplete fungal growth (1)
- some isolates showed limited biodegradation capacity (1)
- some isolates with high carbon utilization showed reduced antagonistic abilities against pathogens (1)
- some microbial metabolites are potentially toxic at high concentrations (1)
- Some moulds promoted growth in response to certain yeast volatiles (1)
- Some mushroom extracts contained cytotoxic substances reducing cell viability despite high Aβ inhibitory activity (1)
- some mushroom species are toxic if consumed improperly (1)
- some mushroom species cause severe poisoning or deadly reactions (1)
- some natural preservatives have poor chemical stability (1)
- some normal cells showed sensitivity to certain fractions alongside cancer cell cytotoxicity (1)
- some normal cells showed sensitivity to certain fractions alongside cancer cell cytotoxicity (1)
- Some Penicillium and Talaromyces species show reduced azole sensitivity (1)
- some Penicillium species (P. allii, P. glabrum) are crop pathogens (1)
- Some Penicillium strains are pathogens (1)
- some peptides enhance susceptibility to specific pathogens (1)
- some pleasant compounds such as pyrazines with meaty flavor decreased with spice addition (1)
- some polyphenolic compounds may cause alterations in cytoplasmic membrane structure (1)
- some polyphenols cause hepatotoxicity (1)
- Some polysaccharide sizes may promote pro-inflammatory responses (1)
- Some species are opportunistic pathogens causing invasive infections in immunocompromised patients (1)
- Some species are pathogenic causing green mold disease in cultivated mushrooms (1)
- some species show intrinsic antifungal resistance (azole-resistant Aspergillus species) (1)
- Some Stachybotrys species produce mycotoxins with veterinary and medical significance (2)
- some steaming treatments reduced yield (1)
- some strains ineffective for maintaining remission (1)
- some strains produce beta-lactamase (1)
- Some strains showed moderate diesel growth inhibition (18-36%) (1)
- some studies noted variability in bioactivity depending on extraction methods and fungal strains (1)
- some studies show inconsistent results with vitamin D supplementation (1)
- some studies showed no significant improvements (1)
- Some Talaromyces species are opportunistic pathogens causing invasive talaromycosis in immunocompromised patients (1)
- Some Talaromyces species are opportunistic pathogens causing talaromycosis in humans and animals (1)
- some tests show poor performance in specific populations (1)
- some treatments reduced α-amylase activity (1)
- Some Trichoderma species are pathogenic (1)
- Some Trichoderma species cause green mold disease in mushroom cultivation (1)
- Some VOCs stimulate AFB1 production (1)
- Some Xenorhabdus strains show variable efficacy or reduced potency against certain pest species (1)
- somnolence (1)
- soursop fruit showed no cytotoxic activity against HeLa cells (1)
- soybean and maize (1)
- spawn-burning symptoms (1)
- SPdS classified as severe irritant (1)
- species confirmed safe without hallucinogenic compounds (1)
- species loss (2)
- species-dependent efficacy variations (1)
- species-specific variation in metabolism (1)
- specific species inhibit fungal diversity (1)
- specific to fungal pathogens (1)
- specificity limited to certain insect groups may restrict application range (1)
- Spent oil waste causes soil pollution (1)
- sperm dysfunction (1)
- SPF1 deletion reduces fungal infectivity but is not a direct treatment approach (1)
- Sphaeropsis ulmicola causes shoot canker and dieback (1)
- sphingoid base accumulation (1)
- sphingolipid biosynthesis inhibition (1)
- Sphingosine accumulation exacerbates inflammation (1)
- spiritual betrayal (1)
- spiritual bypassing (1)
- split-thickness skin graft failure (1)
- Spoilage risk from uncontrolled yeast growth (1)
- sporadic voriconazole resistance (1)
- spore dissemination via dust storms causing respiratory infections (1)
- spore formation under metal stress (1)
- spore germination inhibition (1)
- spore production concerns for biodiversity (1)
- Spore suspensions yield lower DNA concentrations than mycelium (1)
- spore viability reduction incomplete (1)
- Sporekill® poses environmental toxicity and health concerns including skin sensitivity and respiratory irritation (1)
- spores can be allergenic in some strains (1)
- sporulated oocysts persist in poorly sanitized environments (1)
- Sporulating oyster mushroom strains cause respiratory sensitization and allergic reactions in workers (1)
- sporulation risk (1)
- SsMet1 deletion results in loss of virulence (1)
- SsMet1 deletion results in loss of virulence (1)
- SSRI nonresponse (1)
- SSRI nonresponse (1)
- Stachybotrys species produce mycotoxins with veterinary and medical significance (1)
- standardized protocols without individualization (1)
- starch degradation (1)
- states of high reification (1)
- steaming of green compost and grass A reduced yield (1)
- sterigmatocystin (1)
- steroid combinations contributing to resistance (1)
- steroid immunosuppression increases infection severity (1)
- steroid immunosuppression increases susceptibility (1)
- steroid therapy (1)
- steroid therapy decreases test sensitivity and specificity (1)
- Steroid therapy reduces diagnostic accuracy (1)
- steroids may reduce fungal detection in samples (1)
- Stevens-Johnson syndrome (1)
- stigma barriers (1)
- stigmatization and criminalization may reduce positive effects and increase harm (1)
- stimulation of fungal growth by certain compounds (1)
- stimulation of fungal growth by certain LAB-CFS treatments due to nutrient availability in some cases (1)
- stinging (1)
- stomach ache (1)
- stomach discomfort (1)
- stomach pain (1)
- strain belongs to Risk 1 biosafety level (1)
- strain degeneration (3)
- strain degeneration reduces antioxidant capacity and flavonoid production (1)
- strain degradation (1)
- strain differentiation challenges (1)
- strain HY85 is non-pathogenic to coffee plants (1)
- Strain inhibition at later anaerobic ensiling stages (1)
- strain selection is critical to avoid pathogenic species (1)
- strain-specific effects (1)
- Strain-specific efficacy (1)
- strain-specific variability (1)
- Strain-specific variability in efficacy (1)
- strains are safe for humans and beneficial organisms (1)
- stratospheric ozone depletion (1)
- stray bacterial infection (1)
- stress inhibition of fungal growth (1)
- stress-related behaviors (1)
- Strobilurin fungicides are ineffective against M. perniciosa due to multiple tolerance mechanisms (1)
- stromal keratolysis (1)
- strong flavor limiting direct food use (1)
- strong inflammatory responses (C. neoformans DNA) (1)
- strong side effects of some compounds (1)
- strong taste and aroma at effective concentrations (1)
- structural cell wall disruptions (1)
- structural changes from autoclaving (1)
- Structural damage from high temperature and pressure autoclaving (1)
- Structural instability in solution (3)
- structural weakening (1)
- Structures designed to prevent cell attachment may not be suitable for applications requiring cell adhesion or tissue integration (1)
- study demonstrated minimal impact on plant growth at tested concentrations (1)
- study demonstrated safety at all tested concentrations (1)
- study demonstrates absence of environmental toxicity compared to chemical alternatives (1)
- study demonstrates negative regulation of pathogenicity (1)
- Study did not assess adverse effects or interactions with antidepressants and anxiolytics (1)
- study excluded participants with history of psychosis (1)
- study focused on beneficial effects (1)
- study focused on biocontrol efficacy (1)
- study focused on pathogen elimination (1)
- study focused on pest control efficacy (1)
- study focuses on beneficial actions (1)
- study focuses on biocontrol applications (1)
- study focuses on remediation of toxic lead (1)
- study focuses on removing antibiotics from environment (1)
- Study limited to female animals only (1)
- study notes need for further experimental validation (1)
- stunted growth (1)
- SUB6 deletion leads to compensatory protease upregulation (1)
- SUB6 not essential for virulence (1)
- suboptimal concentrations may stimulate mycotoxin production (1)
- suboptimal pharmacokinetics (2)
- suboptimal sensitivity in certain specimen types may miss infection (1)
- suboptimal treatment due to healthcare disparities (1)
- substance abuse history (1)
- substance use disorders (3)
- substance use disorders (1)
- substrate drying (1)
- substrate instability (1)
- substrate modification by plasma (1)
- substrate specificity variability (1)
- substrate toxicity at high concentrations (1)
- Subtherapeutic drug levels (1)
- subtherapeutic drug levels due to chronic gut GvHD absorption issues (1)
- sudden death (1)
- suggesting limited spectrum against some pathogens (1)
- suggesting potential for generating attenuated strains (1)
- suggesting potential for generating attenuated strains (1)
- suggesting potential interference with biological targets (1)
- suggesting potential target for disease control (1)
- suggesting potential toxicity or adaptive pathogen responses (1)
- suicidal ideation (2)
- suicidal ideation (in one case) (1)
- suicidal ideation (rare) (1)
- Suicidal ideation (rarely reported) (1)
- suicidal ideation in some cases (1)
- suicidality (1)
- suicidality (1)
- suicidality risk (1)
- suicide attempts (41.1% of psychiatric patients) (1)
- Suicide ideation (1)
- suicide risk (1)
- sunflower (1)
- superior safety profile compared to standard antifungals (1)
- supplement-induced hyperoxaluria (1)
- suppress beneficial bacteria (1)
- suppress beneficial bacteria (1)
- Suppress innate immune activation (1)
- suppressed IL-17A production (1)
- suppresses antioxidant gene expression (1)
- suppresses growth (1)
- suppresses mycelium growth (1)
- Suppression of ACC signaling through claustrum may affect cognitive control and information processing (1)
- suppression of antimicrobial compound biosynthesis (1)
- suppression of antioxidant genes (sod-3, skn-1) (1)
- suppression of beneficial epiphytic and endophytic fungi (1)
- suppression of defense gene expression (1)
- suppression of hypocrellin production by certain bacteria (1)
- Suppression of total flavonoid content and flavone biosynthesis at high LY9 concentrations (1)
- suppression of vegetative growth (1)
- surface cracking in potatoes under rainfed conditions (1)
- surface wrinkling at higher concentrations (16 mmol·L⁻¹) (1)
- Surface-dependent toxicity (1)
- Surgery alone associated with highest mortality (83.78%) (1)
- surgical site infection (1)
- surgical sponges (1)
- Susceptibility in certain sunflower varieties when exposed to dominant MCG1 race (1)
- Susceptibility to antifungal agents including ketoconazole (1)
- susceptibility to degradation in vivo (1)
- susceptibility to degradation in vivo (1)
- Susceptibility to drought stress (1)
- susceptibility to fungal diseases (canker, white mold) (1)
- Susceptibility to fungal infection (1)
- Susceptibility to fungal infection in Japonica rice genotypes (1)
- susceptibility to high temperature stress above 42°C (1)
- Susceptibility to infection (1)
- Susceptibility to S. sclerotiorum infection in non-resistant varieties (1)
- Susceptibility to stem canker pathogens increased under shaded conditions (1)
- Susceptible maize varieties show increased fungal colonization and reduced seedling development (1)
- sustainability concerns from overharvesting (1)
- Swainsonine is toxic to grazing livestock (1)
- swainsonine toxic to livestock (1)
- Swainsonine toxicity to grazing livestock (1)
- swallowing difficulties (1)
- sweating (1)
- sweats/chills (1)
- Sympathetic overactivation (1)
- symptom relapse after initial improvement (1)
- synaptic blockade (1)
- synaptic blockade (1)
- synaptic damage (1)
- synaptic degeneration (1)
- synaptic dysfunction (1)
- synaptic loss (1)
- Synbiotic supplementation associated with very high mortality (1)
- syncope (1)
- syncope (1)
- syncope risk (1)
- Synergistic increase in disease severity when Xff co-infects with S. sclerotiorum (1)
- Synergistic toxicity (1)
- synesthetic phenomena (1)
- synthetic agrotextiles generate soil pollution and microplastic emissions (1)
- Synthetic colorants associated with carcinogenic (1)
- Synthetic dyes environmental and health impacts avoided (1)
- Synthetic dyes: mutagenicity (1)
- synthetic fungicide resistance development (1)
- synthetic fungicide resistance noted as challenge (1)
- Synthetic surfactant toxicity (1)
- Systemic complications (1)
- systemic effects (1)
- Systemic glucocorticoids contraindicated in CPA as they may worsen disease progression and increase invasive aspergillosis risk (2)
- Systemic glucocorticoids contraindicated in CPA as they may worsen disease progression and increase invasive aspergillosis risk (1)
- systemic inflammation (1)
- systemic sclerosis (1)
- systemic toxicity concerns with oral antifungal agents (1)
T
- T cell anergy (1)
- T-cell depleting agents increase IFI risk (1)
- T. afroharzianum reported as pathogen causing ear rot in maize (1)
- T. asahii intrinsically resistant to echinocandins (1)
- T. harzianum combined with compost reduced biocontrol agent biomass (1)
- T. longibrachiatum considered emerging pathogen in immunocompromised individuals (1)
- T. rutilans reported to cause diarrhea and vomiting when ingested (1)
- tachycardia (7)
- tachyphylaxis from prolonged steroid use (1)
- Talcum powder addition suppresses stempholone A production and reduces chemical diversity (1)
- Tea polyphenols sensitive to light (1)
- tebuconazole reduces plant growth parameters and yield compared to biological control (1)
- technocratic model of birth (1)
- technocratic/industrial models of care (1)
- Temperature and UV sensitivity of uncoated conidia (1)
- Temperature and UV sensitivity of uncoated conidia (1)
- temperature fluctuations reduce disease severity unpredictably (1)
- Temperature-driven mortality risk (1)
- temperatures above 29-30°C inhibit fruiting body development (1)
- temporary confusion (1)
- Temporary destabilization following trauma emergence (1)
- temporary exacerbation of psychotic symptoms in predisposed patients (1)
- temporary inhibition of complex organic matter-degrading microorganisms (1)
- temporary inhibition of complex organic matter-degrading microorganisms (1)
- temporary mental distress (1)
- temporary reduction in lobetyolin content (1)
- temporary shifts in medicinal component profiles (1)
- teratogenic (1)
- teratogenic (2)
- teratogenic effects (2)
- Teratogenic risk with oral azoles in pregnancy (1)
- teratogenicity (7)
- teratogenicity concerns with oteseconazole (1)
- teratogenicity risk (1)
- terbinafine (4)
- Terbinafine ineffective due to resistance (1)
- terbinafine resistance (6)
- Terbinafine resistance documented in 74.2% of isolates (1)
- Terbinafine resistance documented in T. indotineae strains (1)
- Terbinafine resistance due to SQLE gene mutations (2)
- Terbinafine resistance in isolates with SQLE gene mutations (Phe397Leu) (1)
- terbinafine resistance in T. indotineae (2)
- Terbinafine resistance in T. rubrum and T. mentagrophytes (1)
- terbinafine resistance mediated by squalene epoxidase mutations (1)
- Terbinafine toxicity to aquatic organisms (1)
- terbinafine treatment failure (1)
- terpenes may exhibit antifungal properties limiting biosynthesis at high concentrations (1)
- terrifying dissociative experiences (1)
- test unavailability at some facilities (1)
- testing outsourcing causes diagnostic delays affecting treatment timing (1)
- tetrandrine toxicity dependent on treatment duration and dosage (1)
- Th1/Th17 cell expansion (1)
- Th2-mediated immune dysfunction allowing pathogen survival (1)
- Th2-mediated impairment of Th17 function (1)
- thalamic dysfunction exacerbates psychotic presentation (1)
- Theobromine in cocoa husks toxic to animals (1)
- therapeutic drift (1)
- therapeutic drug level reduction (1)
- therapeutic failure (1)
- therapeutic failure (1)
- therapeutic failure despite antifungal treatment (1)
- therapeutic failure with fluconazole in resistant strains (1)
- therapeutic failures in 25-40% of dermatophytosis cases (1)
- therapeutic resistance (1)
- thermal degradation above 200°C (1)
- thermal inhibition at temperatures above optimal range (1)
- thermal instability of phytase enzymes (1)
- thermal stress inducing apoptosis (1)
- thermally stable mycotoxins show resistance to degradation (1)
- thermally stable mycotoxins show resistance to degradation (1)
- These are pathogenic fungi that cause disease in cultivated mushrooms (1)
- though both were generally well-tolerated (1)
- though offset by improved nutritive value (1)
- though predicted non-pathogenic to humans (1)
- though resistance carries fitness costs (1)
- thought disorder (1)
- thought disorders (1)
- threatened by overharvesting and climate change (1)
- threatening food supplies and biodiversity (1)
- thrombocytopenia (1)
- thrombosis (3)
- thrombotic events (1)
- thyroid cancer (1)
- time-consuming fabrication of hybrid aerogels (1)
- TIMP2 deletion leads to memory impairment (1)
- tissue accumulation (1)
- tissue damage (1)
- tissue damage from excessive irradiation dosage above 2.0 kGy (1)
- tissue damage from excessive irradiation dosage above 2.0 kGy (1)
- tissue damage including chlorosis and necrosis (1)
- tissue degradation (1)
- tissue destruction (3)
- tissue deterioration (1)
- tissue discoloration (1)
- Tissue invasion (3)
- tissue necrosis (9)
- tissue softening (1)
- tissue-based enzyme inhibition (1)
- Titan cell formation and morphotype switching enable immune evasion and drug resistance mechanisms (1)
- titan cells confer protection from phagocytosis (1)
- TMV can establish persistent infections in fungal pathogens (1)
- TMV infection of fungi does not reduce fungal pathogenicity on host plants despite viral replication (1)
- TNF-α production (1)
- Tocilizumab and anakinra immunosuppression increased infection risk (1)
- tolerance (1)
- topical antibacterials were ineffective (1)
- topical betamethasone and ketoconazole worsened lesions (1)
- Topical corticosteroid misuse exacerbates infection and masks symptoms (1)
- Topical corticosteroid use exacerbated the infection (1)
- Topical corticosteroids associated with recurrent dermatophytosis (1)
- topical corticosteroids worsen tinea infections (1)
- topical dexamethasone acetate cream exacerbated condition and led to misdiagnosis (1)
- Topical nadifloxacin was ineffective (1)
- Topical steroids (betamethasone dipropionate) previously applied may have exacerbated infection (1)
- Torsade de Pointes (1)
- toxic and hypersensitive reactions causing dermatitis (1)
- Toxic biotransformation products (1)
- toxic chemical residues from conventional methods (1)
- toxic compounds (1)
- toxic contamination (1)
- toxic drug accumulation (1)
- toxic effects from elevated metal concentrations (1)
- toxic effects on ecosystems (1)
- Toxic intermediates (epoxides, diols) can be more mutagenic than original compounds if not rapidly degraded (1)
- toxic metabolite production (1)
- toxic metal accumulation (1)
- toxic mushroom species (Amanita phalloides, Cortinarius orellanus, Gyromitra esculenta) are cytotoxic (1)
- toxic reactions (1)
- Toxic side effects (1)
- Toxicity (5)
- Toxicity (alpha-amanitin) (1)
- Toxicity and carcinogenic risks associated with previous media components like PCNB and pimaricin (1)
- toxicity at high concentrations (1)
- Toxicity at high concentrations (>2.5 mg/mL) causing embryo mortality (1)
- toxicity at high doses (1)
- toxicity at high levels (transaminitis, diarrhea, nausea) (1)
- Toxicity at high metal concentrations (1)
- toxicity at low concentrations (1)
- toxicity concerns (3)
- toxicity concerns at high concentrations (1)
- toxicity concerns with anticancer compounds (1)
- toxicity concerns with certain fungicides (1)
- toxicity considerations with increased dosing (1)
- toxicity dependent on extract concentration (1)
- toxicity dosage-dependent (1)
- toxicity from chemical treatments (1)
- Toxicity from consumption of poisonous mushroom species (2)
- toxicity from heavy metals (mercury, lead, cadmium, arsenic) (1)
- toxicity from high concentrations of petroleum hydrocarbons (1)
- toxicity from high contaminant concentrations (1)
- toxicity from high Cr(VI) concentrations inhibits bacterial growth and metabolic activity (1)
- Toxicity from lentinan polysaccharide (1)
- Toxicity in Gyromitra esculenta (1)
- toxicity increase from biotransformation products (1)
- toxicity noted in Amanita muscaria (fly agaric) (1)
- toxicity of acetylcholine chloride-based DESs at high concentrations (1)
- toxicity of high anthracene concentrations (1)
- toxicity of hydrogen peroxide at high concentrations to microorganisms (1)
- Toxicity of non-edible species (1)
- toxicity of polyene antibiotics (1)
- toxicity of some compounds (1)
- toxicity of some natural lectin sources (ricin, abrin, robin) (1)
- toxicity of xenobiotic compounds to yeast cells (1)
- toxicity risks in defensive metabolites (1)
- toxicity to blood (1)
- Toxicity to eastern spruce budworm larvae (1)
- toxicity to fruit flies (1)
- toxicity to fungal and human cells lacking resistance mechanisms (1)
- toxicity to host organisms when TrsA is expressed (1)
- toxicity to insect herbivores (1)
- toxicity to insect larvae (1)
- toxicity to melanocytic cells (1)
- toxicity to microorganisms (1)
- Toxicity to nematodes may impact beneficial soil nematode populations (1)
- toxicity to non-target organisms (1)
- toxicity to sensitive herbivores (1)
- Toxicity with long-term chemotherapy (1)
- toxicological assessment needed (1)
- toxin exposure (1)
- toxin generation (1)
- toxin production (1)
- toxin production (1)
- Toxin production (DON, ZEA) by pathogen (1)
- Toxin production (DON, ZEA) by pathogen (1)
- toxin production (ipomeamarone, ipomeanol, ipomeanine) (1)
- toxin production potential (1)
- Toxin production potential (mycotoxins mentioned as secondary metabolites) (1)
- toxins are heat-resistant and difficult to remove by conventional water treatment (1)
- toxins produced by A. alternata are harmful to human health (1)
- Traditional adsorbents show reduced capacity and poor regeneration (1)
- traditional antiparasitic drugs mentioned have toxic side effects on heart (1)
- Trailing effect with luliconazole at high concentrations (1)
- training and healthcare infrastructure challenges identified (1)
- training and healthcare infrastructure challenges identified (1)
- Trametes hirsuta causes severe wood degradation (1)
- trans-fatty acids (1)
- transaminitis (2)
- transaminitis (1)
- transaminitis from caspofungin (1)
- transboundary pollution (1)
- transformation of non-pathogenic fungi into phytopathogenic forms by certain viruses (1)
- Transfusion-associated complications (1)
- Transient 5HT2A receptor downregulation (1)
- Transient altered perception (1)
- transient and manageable side effects with sublingual and intramuscular administration (1)
- Transient anxiety (3)
- transient blood pressure increases (1)
- transient cognitive impairment (1)
- transient destabilization of brain dynamics (1)
- Transient dissociation (1)
- transient effect duration (not persistent beyond 30 minutes) (1)
- transient effect duration (not persistent beyond 30 minutes) (1)
- transient gastrointestinal symptoms (1)
- Transient headaches (1)
- Transient headaches (1)
- transient increase in negative affect (1)
- transient nausea (1)
- transient paranoia during treatment sessions only (1)
- transient stimulation of aflatoxin production at moderate concentrations (1)
- Transient stress urinary incontinence (1)
- transient tachycardia (1)
- transient tremors at 30 mg/kg (1)
- transition to schizophrenia (1)
- trauma responses (1)
- traumatic emotional responses (1)
- Treatment access barriers due to pricing and reimbursement restrictions (1)
- treatment aimed at complete degradation (1)
- treatment challenges in low-resource settings (1)
- Treatment complications in Candida auris infections (1)
- treatment delays due to diagnostic delays (2)
- treatment delays due to diagnostic outsourcing (1)
- Treatment delays leading to amputation (1)
- Treatment dropout (associated with higher baseline state anxiety) (1)
- treatment emergent affective switching (1)
- treatment failure (16)
- Treatment failure after 18 days of initial therapy (1)
- treatment failure and relapse with fluconazole (1)
- treatment failure associated with resistant strains (1)
- Treatment failure associated with severe COVID-19 (1)
- treatment failure classification (1)
- treatment failure despite appropriate antifungal therapy (1)
- Treatment failure despite drug-susceptible isolates (1)
- Treatment failure despite maximal HLH-specific therapy and antimicrobial escalation (1)
- treatment failure due to emergence of resistant populations (1)
- treatment failure in 31.8% of cases (1)
- Treatment failure in immunocompromised patients (1)
- treatment failure predisposition (1)
- treatment failure risk (1)
- treatment failure with amphotericin B (1)
- treatment failure with caspofungin (1)
- Treatment failure with emerging resistant species (1)
- Treatment failure with initial prophylaxis (1)
- treatment failure with non-albicans species (1)
- treatment failure with polymicrobial infections (1)
- treatment failure with previous antifungal regimens (1)
- treatment failure with resistant strains (1)
- Treatment failure with terbinafine (1)
- treatment failure with terbinafine in resistant strains (1)
- treatment failure with topical corticosteroid-antifungal combinations masking presentations (1)
- treatment failures (3)
- treatment failures in polymicrobial infections (1)
- treatment failures with antifungal-resistant strains (1)
- Treatment non-response in 44-56% of participants (1)
- treatment resistance (5)
- Treatment resistance in severe cases (1)
- treatment resistance in severely immunocompromised patients (1)
- Treatment resistance requiring therapy switching (1)
- treatment toxicity (1)
- treatment unavailability (1)
- treatment with hydrocortisone butyrate cream and antihistamines resulted in worsening of symptoms (1)
- Treatment with liposomal amphotericin B may affect antigen detectability in BAL samples (1)
- treatment-emergent adverse events (1)
- Treatment-refractory infections (1)
- treatment-related adverse effects (1)
- Treatment-resistant depression (1)
- Treatment-resistant depression (1)
- treatment-resistant infections (1)
- Tree damage and forest decline caused by ambrosia beetle attacks with fungal symbionts (1)
- tree death (1)
- tree death after 3-5 years of infection (1)
- tree death within 3-5 years (1)
- tree death within 3-5 years if untreated (1)
- tree decline (2)
- tree decline associated (1)
- tree dieback (1)
- Tree diseases (1)
- Tree mortality (4)
- tree mortality acceleration when associated with wood-boring insects (1)
- tree mortality in 10% of severely infected trees after heavy rains (1)
- tree pathogens (Onnia and Porodaedalea genera) (1)
- Treg expansion promotes immunosuppression (1)
- tremorgenic (1)
- tremors (1)
- triazole resistance (1)
- Triazole resistance development (1)
- Triazole resistance development (1)
- Triazole resistance in A. fumigatus with TR34/L98H mutations in cyp51A gene (1)
- Trichoderma afroharzianum reported as pathogen causing ear rot disease in maize (1)
- Trichoderma can inhibit beneficial ectomycorrhizal fungi growth under certain conditions (1)
- Trichoderma harzianum inhibited T. melanosporum mycorrhization due to fungicidal activity (1)
- Trichoderma species cause yield loss (1)
- Trichoderma spp. produce chitinolytic enzymes and secondary metabolites that are repellent or toxic to springtails (1)
- Trichoderma virens inhibits mycelial growth and fruiting body development in S. vaninii (1)
- Trichophyton indotineae resistance to terbinafine noted (1)
- Trichophyton indotineae resistance to terbinafine noted as a diagnostic challenge (1)
- Trichophyton mentagrophytes (1)
- Trichophyton rubrum (1)
- Trichophyton species (1)
- Trichosporon asahii resistance to amphotericin B (1)
- Trichosporon shows reduced susceptibility to amphotericin B (1)
- trichothecene mycotoxin production (1)
- trichothecene production (toxic to animals) (1)
- trichothecene toxins (1)
- trichothecenes (1)
- trichothecenes suppress immune system (1)
- triclosan bioaccumulation (1)
- tricuspid insufficiency (1)
- triggering of fungal defense mechanisms including DNA repair upregulation and filamentation (1)
- triggers allergic reactions (1)
- triggers allergic reactions in sensitive individuals (1)
- triggers premature aging (1)
- triglycerides (1)
- triptolide may impair kidney antioxidant system and cause nephrotoxicity (1)
- triticale (1)
- Tryptophan starvation may affect fungal nutritional status (1)
- tryptophan supplementation reverses antifungal effects (1)
- Tubulointerstitial nephritis (1)
- tumor cell proliferation in untreated controls (1)
- Tumor immune escape (1)
- tumor progression (1)
- twig withering (1)
- type II diabetes (1)
- type II diabetes (1)
- tyrosinase activation at high concentrations (1)
- Tyrosol alone suppressed Akkermansia and mucin-degrading commensals (1)
U
- ubiquitin-proteasome system activation (1)
- ulceration (1)
- Ultra-processed food consumption associated with increased depression and anxiety risk (1)
- Unbalanced phenolic acid ratios (2:1) reduced antibacterial efficacy (1)
- unblinding due to obvious psychoactive effects (1)
- uncertain safety profiles for some compounds (1)
- uncertainty about antifungal necessity in colonization cases (1)
- uncontrolled diabetes (1)
- uncontrolled inflammation (1)
- uncontrolled inflammatory responses (1)
- Underdiagnosis and underreporting of fungal infections (1)
- underreporting and misdiagnosis (1)
- Underreporting and underdiagnosis issues affecting disease surveillance (1)
- underservice of vulnerable populations including migrants (1)
- Undue or excessive inflammation may contribute to immunopathology and poor prognosis (1)
- uneven development (1)
- unintended consequences from radical microbiome alterations (1)
- unknown effects on non-targeted organisms (1)
- unknown health risks from synthetic analogues (1)
- unknown long-term effects on plant development (1)
- unknown long-term health effects (1)
- Unnecessary antimicrobial therapy leading to drug resistance (1)
- unnecessary interventions (1)
- unnecessary medical interventions (1)
- unnecessary treatment adverse effects (1)
- unpleasant experiences reported in less than 2% of cases (1)
- Unpredictable alkaloid content in preserved specimens (1)
- unpredictable effects (1)
- unpurified material may contain residual compounds affecting compatibility (1)
- unsafe environments (1)
- unsafe environments can cause negative experiences (1)
- unstable compost quality (1)
- unsteady gait (1)
- Unsteamed grass B increased blotch incidence (1)
- unsteamed grass B material increased blotch incidence (1)
- unsuitable application to vulnerable populations (1)
- unsuitable during pregnancy and lactation (1)
- Untreated dye effluent causes toxicity (1)
- Untreated dye effluent causes toxicity (1)
- untreated fungal sinusitis progression (1)
- untreated gout associated with AA amyloidosis development (1)
- untreated soybean whey contains heat-stable Bowman-Birk trypsin inhibitor and beany off-flavors that reduce palatability (1)
- unusual farm events (1)
- Upregulation of circRIMS2 induces synaptic and memory impairments (1)
- uranium toxicity (1)
- Urban center fungal exposure associated with increased allergic inflammation (1)
- Urea as nitrogen source showed inhibitory effects on pathogen growth with potential biocontrol applications (1)
- urethral stricture (1)
- Urological toxicity (chronic use) (1)
- urticaria (1)
- UV exposure reduces fungal spore production and pathogenicity (1)
- UV irradiation reduces spore production and viability (1)
- UV light biodegradation of lignin (1)
- UV radiation sensitivity in some formulations (1)
- UV treatment caused mycelial deformation (1)
- UV-induced DNA damage (1)
- uveitis (1)
V
- vaccine hesitancy (1)
- valvular heart disease (1)
- valvular heart disease (5-HT2BR activation) (1)
- valvular thickening (1)
- valvular thickening (1)
- Vancomycin and meropenem associated with severe neutropenia (1)
- Vancomycin and meropenem associated with severe neutropenia (1)
- Vancomycin and meropenem-induced neutropenia (1)
- variability in effectiveness across populations (1)
- variability in protein extraction methods (1)
- variability in protein extraction methods (1)
- variability in secondary metabolite production (1)
- variable activity across species (1)
- variable activity against Fusarium species (1)
- variable antagonistic interactions depending on isolate origin (1)
- variable antifungal activity depending on fungal species (1)
- Variable antifungal susceptibility in S. radiatum isolates (1)
- variable azole susceptibilities (1)
- variable bioavailability (1)
- variable composition in commercial extracts (1)
- Variable control effects under complex field conditions (1)
- variable cytotoxicity depending on plant part and extraction method (1)
- variable cytotoxicity depending on plant part and extraction method (1)
- Variable dissociative effects (1)
- variable effectiveness across species (1)
- Variable effectiveness against Mucorales strains (1)
- variable effectiveness depending on concentration and bacterial species (1)
- variable effects across different fungal species (1)
- variable effects across different fungal species (1)
- Variable efficacy (1)
- variable efficacy across different mould species (1)
- variable efficacy across different mould species (1)
- variable efficacy across different strains and formulations (1)
- variable efficacy at extreme temperatures (1)
- Variable efficacy based on environmental temperature (1)
- variable efficacy compared to synthetic fungicides in some contexts (1)
- variable efficacy depending on composition (1)
- Variable efficacy depending on concentration and application method (1)
- variable efficacy depending on fungal species (1)
- Variable efficacy depending on fungal strain and substrate type (1)
- variable efficacy depending on strain and environmental conditions (1)
- variable experiences (1)
- variable individual tolerance (1)
- variable nutritional outcomes (1)
- variable outcomes across populations with different compositions and genetic backgrounds (1)
- Variable results depending on mite population stage (1)
- variable results with native high molecular weight pectins (1)
- variable sensitivity depending on clinical presentation (1)
- Variable sensitivity to antifungal agents among isolates (1)
- Variable sensitivity to antifungal agents among isolates (1)
- variable structural composition affecting consistency (1)
- variable susceptibility among fungal strains (1)
- variable virulence among strains (1)
- Various diagnostic techniques show variable sensitivity depending on patient immune status (1)
- Varying effectiveness against different fungal species (1)
- Varying effectiveness against different fungal species (1)
- varying minimum inhibitory concentrations among isolates (1)
- vascular blockage preventing nutrient transport (1)
- vascular bundle destruction (1)
- vascular cankers (1)
- vascular damage (1)
- vascular damage exacerbation (1)
- vascular necrosis (1)
- vascular rot (1)
- vasoconstriction (1)
- vasopressor use at transplantation associated with poor outcomes (1)
- vasospasm (1)
- VBNC cells represent a challenge for antifungal therapy due to reduced metabolic activity and potential resistance mechanisms (1)
- VdKeR1 deletion confers resistance to terbinafine (1)
- vegetation degradation (1)
- vegetation dieback (2)
- Ver-A showed no toxicity to sugarcane plants (1)
- vertigo (1)
- very low tyrosinase inhibition (1)
- Vessel dilatation (1)
- violence history (1)
- violent fusion with nihilistic universe (noted as inadequately captured in current mystical experience measures) (1)
- Viomellein shows cytotoxicity against mammalian cells including L5178Y mouse lymphoma and A2780 human ovarian carcinoma cell lines (1)
- Viral infection reduces host virulence rather than causing disease (1)
- viral reactivation increases cognitive decline (1)
- virtual format lacks social influence benefits of in-person instruction (1)
- Virtual reality sickness (eyestrain, nausea, headache) (1)
- virulence (2)
- virulence factor ToxA enhances pathogenicity in wheat (1)
- virulence factors presence (1)
- Virulence potential (1)
- virulence reduction (1)
- virus demonstrates mutualistic rather than pathogenic relationship with host fungus (1)
- Virus infection reduces plant vigor (1)
- vision loss despite treatment (2)
- vision threat (1)
- visionary restructuring (1)
- visual deterioration (1)
- Visual distortion (1)
- Visual distortions and illusions (1)
- visual disturbances (4)
- visual disturbances (HPPD) (1)
- visual disturbances (HPPD) (1)
- visual disturbances (lower incidence than voriconazole) (1)
- visual hallucinations (3)
- visual impairment (1)
- visual impairment and vision loss in right eye (1)
- vitamin C toxicity causing acute kidney injury (1)
- vitamin D2 photodegradation under dry conditions (1)
- VOC and ammonia emissions causing nasal and throat irritation (1)
- VOCs induce sunken lesions (1)
- volatile compound evaporation in free extracts (1)
- volatile organic compounds (1)
- volatility of bioactive compounds limiting sustained activity (1)
- Volume overload (1)
- vomiting (1)
- vomiting (13)
- vomiting induction contraindicated due to aspiration risk (1)
- voriconazole (3)
- Voriconazole affects ergosterol production (1)
- Voriconazole and isavuconazole show intrinsic resistance with very high MICs (1)
- voriconazole and isavuconazole showed high MIC values limiting therapeutic options (1)
- Voriconazole and other antifungals as second-line only (1)
- Voriconazole disrupts ergosterol production (1)
- Voriconazole hepatotoxicity (1)
- Voriconazole ineffective for mucormycosis and may increase infection risk (1)
- Voriconazole phototoxicity (1)
- Voriconazole prophylaxis associated with increased mucormycosis breakthrough infections (1)
- Voriconazole prophylaxis associated with increased mucormycosis incidence (1)
- voriconazole reserved for cases where itraconazole or glucocorticoids cannot be used (1)
- voriconazole resistance (1)
- voriconazole resistance (13.3%) (1)
- Voriconazole resistance development (1)
- Voriconazole showed immunosuppressive effects on polymorphonuclear neutrophils (1)
- Voriconazole toxicity including photosensitivity dermatitis (1)
- Voriconazole toxicity: photosensitivity (1)
- vulnerability to abuse in altered states of consciousness (1)
- vulnerability to adverse effects with pre-existing mental health conditions (1)
- vulnerability to biological degradation (1)
- vulnerability to biotic stresses including fungal diseases and pest infestations (1)
- vulnerability to suggestibility during altered states (1)
W
- warm humid environments promote infection (1)
- water absorption (1)
- Water activity below 0.92 inhibits mycotoxin production but may still allow fungal growth (1)
- water contamination (1)
- water eutrophication (1)
- water loss (1)
- water sensitivity leading to fiber degradation and mechanical strength reduction with prolonged exposure (1)
- water solubility issues (1)
- water-soaked soft rot (1)
- Weak adsorption of Pb(II) (1)
- weak cytotoxicity against some cell lines (1)
- weak direct antibacterial activity at tested concentrations (1)
- weak DPPH scavenging activity in white mushrooms compared to brown (1)
- weak DPPH scavenging activity in white mushrooms compared to brown (1)
- weak overall evidence quality (1)
- weakened critical thinking (1)
- weakened host defenses (1)
- weakened stress resistance (1)
- weight gain (2)
- weight loss after day 30 (1)
- well tolerated at doses up to 9 g/day (1)
- well-tolerated at inclusion levels up to 5% (1)
- Western diet promotes dysbiosis and chronic inflammation (1)
- Western dietary pattern associated with declining mental component summary scores in men (1)
- wet contamination events can introduce pathogens (1)
- wheat (1)
- Whole mushroom extract showed overall antagonistic AHR activity in vivo despite individual agonist compounds (1)
- widening creative disparities based on personality (1)
- widespread lesions due to ineffective treatment (1)
- Wild mushroom consumption (1)
- wild-type A. fumigatus shows resistance to antifungals and high virulence (1)
- wild-type SQLE gene confirmed susceptibility (1)
- Wilt causing pathogenic effects in solanaceous crops (1)
- wilting (2)
- withdrawal symptoms (1)
- Wnt/β-catenin pathway activation in some compounds (1)
- Wnt/β-catenin pathway activation in some compounds (1)
- women (1)
- Wood browning (1)
- wood damage (1)
- Wood decay (3)
- Wood decay (1)
- wood decay and structural compromise (historical concern) (1)
- wood degradation (2)
- wood deterioration (1)
- wood discoloration (1)
- Wood tissue degradation (1)
- working memory deficits (1)
- Worsened career (4.8%) (1)
- Worsened relationships (5.5%) (1)
- Worsening of skin lesions after initial antifungal treatment (1)
- worsening of symptoms with inappropriate therapy (1)
- worsening of underlying disease during immunosuppression reduction (1)
- wounds remain susceptible for up to 45 days post-pruning (1)
Y
- yellowing (1)
- yield loss (3)
- yield loss (1)
- yield losses (1)
- yield reduction (3)
Z
- zearalenone (1)
- zearalenone disrupts reproduction in pigs (1)
- zinc (1)
- zinc accumulation (1)
- Zn2+ (1)
- Zn2+ toxicity causes cell membrane damage (1)
- ZnO NPs harmful to plants at higher dosages (1)
- zoonotic infection risk to beekeepers (1)
#
- 'bad trip' experiences with intense anxiety or paranoia (1)
- (S)-5f shows higher toxicity to zebrafish (LC50 = 0.59 mg/L) compared to R-enantiomer (LC50 = 7.54 mg/L) (1)
- (Z)-β-santalol showed toxicity at higher concentrations (1)
- (Z)-β-santalol showed toxicity to larvae at higher concentrations (1)
- (Z)-β-santalol showed toxicity to larvae at higher concentrations (1)
- 1-Hz stimulation inhibited calcium transients and reduced dendritic spine density (1)
- 100% of R. mucilaginosa resistant to fluconazole and voriconazole (1)
- 17.9% sought emergency medical treatment following use (1)
- 3-glucan masking enables fungal immune evasion and reduces recognition by macrophages and neutrophils (1)
- 3-glucan masking reduces fungal recognition and killing by innate immune cells such as neutrophils and macrophages (1)
- 5-HT2B agonism associated with cardiotoxicity (1)
- 5-iodouracil (1)
- 50% reduction in antifungal potency compared to pimaricin (1)
- 6-glucan not essential for resistance to standard antifungals like caspofungin (1)
- 95% resistance to Voriconazole (1)
- α-amanitin exposure (1)
- β-1 (3)
- β-cyclodextrin nephrotoxicity with intravenous use (1)
- β-glucan shielding by N-mannans may reduce immune recognition (1)
- ΔFON-NPS6 deletion reduces virulence (1)