Research Keyword: zinc homeostasis

New insights toward personalized therapies for vulvovaginal candidiasis and vaginal co-infections

Vaginal yeast infections (vulvovaginal candidiasis) and bacterial vaginosis are very common conditions affecting millions of women worldwide. Current treatments often fail or lead to antibiotic resistance. This review explores new personalized approaches including zinc supplementation, specific probiotics, and immune-boosting therapies that are tailored to each woman’s unique vaginal environment to prevent recurring infections.

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A zinc-chelating cyclic alkyl polyamine compound is efficient and safe in a murine model of multidrug-resistant Candida auris infection

Researchers tested a new drug called APC6 that works by trapping zinc, which fungi need to survive. In mouse studies of a dangerous resistant fungus called Candida auris, APC6 saved all treated mice while most untreated mice died. The drug also reduced fungal infections in organs without causing serious side effects, suggesting it could become a new treatment option for serious fungal infections resistant to current medicines.

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