Research Keyword: xanthine oxidase

The Molecular Mechanism of Polysaccharides from Polygonatum cyrtonema Hua in Improving Hyperuricemia by Regulating Key Targets of Uric Acid Metabolism in Mice

This research demonstrates that a traditional Chinese medicinal plant called Polygonatum cyrtonema contains beneficial polysaccharides that can help lower high uric acid levels in the blood, which is a major cause of gout and kidney disease. The study found that these polysaccharides work by reducing the enzyme that produces uric acid and helping the kidneys excrete more of it, while also reducing inflammation. Importantly, this natural treatment protected kidney tissue better than the standard pharmaceutical drug allopurinol, suggesting it could be a safer long-term option for managing high uric acid levels.

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Anti-Xanthine Oxidase 5′-Hydroxyhericenes A–D from the Edible Mushroom Hericium erinaceus and Structure Revision of 3-[2,3-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-1-yl]-pyridine-4,5-diol

Researchers isolated new compounds from Lion’s mane mushroom (Hericium erinaceus) that can inhibit xanthine oxidase, an enzyme linked to breast cancer development. One compound called hericerin showed strong activity against a specific type of breast cancer cell (T47D cells) while being less harmful to normal cells. The study also corrected a misidentification from previous research, confirming that a compound previously thought to have a different structure was actually adenosine. These findings suggest Lion’s mane could be developed into a natural anti-cancer treatment.

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