Research Keyword: whole-genome sequencing

Infection caused by a cryptic fungal species, Blastomyces gilchristii, in a tiger

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A tiger in Tennessee became ill with a serious fungal infection caused by a lesser-known fungus called Blastomyces gilchristii. While blastomycosis is typically caused by a different fungus species, this case represents the first detection of this particular cryptic fungal species in the southeastern United States. Scientists used advanced genetic sequencing to identify the fungus when standard laboratory methods failed. This discovery suggests that this dangerous fungus is spreading to areas where it was not previously thought to exist.

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First report of infections due to Candidozyma (formerly Candida) auris in Botswana, 2022–2024

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Researchers in Botswana discovered the first documented cases of a dangerous fungal infection called Candidozyma auris in their country. This yeast was found in 10 patients at a major hospital, mostly in intensive care units, between 2022 and 2024. The fungus was resistant to common antifungal drugs like fluconazole but could still be treated with other medications. The findings highlight how this emerging pathogen is spreading across Africa and stress the importance of improved laboratory testing and disease monitoring in developing countries.

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Phylogeny, taxonomy and geographic distribution of novel and known fungi with holoblastic-denticulate conidiogenesis in Rhamphoriales and Pleurotheciales (Sordariomycetes)

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Researchers have discovered and described four new fungal species that live in decaying wood and soil, particularly in temperate forests. These fungi share a unique way of producing spores (conidiogenesis) that helps scientists classify and understand their relationships. Using genetic sequencing and environmental DNA data from around the world, scientists mapped where these fungi are found and learned that different species prefer different climates. This research improves our understanding of fungal diversity and how these decomposer organisms are distributed globally.

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Genome characterization of Trichophyton mentagrophytes genotype VII strain PG12DES from Italy

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Researchers in Italy studied a fungal strain that causes skin infections, particularly ringworm and related conditions. This strain is spreading globally and can potentially be transmitted through sexual contact. The study found that the Italian strain is closely related to another strain found in Moldova and is susceptible to currently used antifungal medications. Understanding this fungus at the genetic level helps doctors monitor its spread and identify if it develops resistance to treatments.

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Whole-genome sequencing of Fusarium oxysporum K326-S isolated from tobacco

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Scientists have sequenced the complete genetic blueprint of a fungus that causes root rot in tobacco plants. This fungus, Fusarium oxysporum K326-S, damages tobacco crops by causing roots to brown and wilt. The detailed genome map they created contains over 17,000 genes and will help farmers and researchers develop better strategies to prevent and control this destructive disease in the future.

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