whole-genome sequencing – Page 2

Screening, identification, metabolic pathway of di-n-butyl phthalate degrading Priestia megaterium P-7 isolated from long-term film mulched cotton field soil in Xinjiang

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This research identifies a special bacterium called Priestia megaterium P-7 that can efficiently break down di-n-butyl phthalate (DBP), a harmful plastic chemical that accumulates in cotton field soils. Scientists found that this bacterium can completely remove DBP from contaminated soil within 20 hours under optimal conditions. By studying the bacterium’s genes and metabolism, they discovered the specific enzymes and pathways it uses to degrade DBP into harmless compounds. This finding offers a practical biological solution for cleaning up contaminated agricultural soils, particularly in Xinjiang where plastic film mulching is widely used in cotton farming.

Echoes of 1816: microbial footprints in heritage artifacts from Argentina’s museum of independence

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Scientists studied bacteria living on historic artifacts at Argentina’s Independence Museum to understand how microbes damage precious heritage items. They found 49 different bacterial species on artifacts like 200-year-old photographs, wooden furniture, and textiles, discovering that each artifact hosts a unique microbial community. The study shows that understanding these bacteria is crucial for preserving cultural treasures and protecting museum workers from potential health risks caused by microbial exposure during artifact handling and conservation.

Clinical Isolate of Candida tropicalis from a Patient in North Carolina: Identification, Whole-Genome Sequence Analysis, and Anticandidal Activity of Ganoderma lucidum

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Researchers in North Carolina identified a drug-resistant yeast infection (Candida tropicalis) from a hospital patient and tested whether extracts from reishi mushrooms (Ganoderma lucidum) could kill it. Using genetic analysis, they found mutations in the yeast that help it resist antifungal drugs. All three types of mushroom extracts tested successfully stopped the yeast’s growth and damaged its cells, suggesting that reishi mushrooms could be a promising natural treatment option for hard-to-treat candida infections.

Three new Pseudogymnoascus species (Pseudeurotiaceae, Thelebolales) described from Antarctic soils

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Scientists discovered three new types of fungi living in Antarctic soils, naming them Pseudogymnoascus russus, P. irelandiae, and P. ramosus. Using genetic analysis and genome sequencing, researchers showed these fungi are adapted to survive in extremely cold conditions and represent previously unknown members of the Pseudogymnoascus family. This discovery adds to our understanding of Antarctic microbial life and suggests many more undescribed fungi may exist in Earth’s coldest environments.

Clinical and Genomic Insights into Antifungal Resistance in Aspergillus Isolates from Thailand

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Researchers in Thailand identified a dangerous fungal infection caused by Aspergillus fumigatus that is resistant to azole antifungal drugs. This is the first time this specific drug-resistant strain has been found in a patient sample in Thailand, though it had been previously detected in environmental samples. The study used genetic testing to understand how the fungus developed resistance and found that it has altered genes that help it survive the antifungal medications commonly used to treat infections.

Candida auris: Outbreak, surveillance and epidemiological monitoring in Northern Greece

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A dangerous fungus called Candida auris caused an outbreak in hospitals in Northern Greece starting in October 2022. This fungus is particularly concerning because it is resistant to many commonly used antifungal drugs, especially fluconazole. Researchers monitored and tracked the outbreak across multiple hospitals, finding that all cases belonged to the same genetic type (Clade I) and were treatable with certain alternative antifungal medications. The study emphasizes the importance of careful laboratory surveillance and coordinated infection control measures to prevent further spread of this serious infection.

Screening microbial inhibitors of Pseudogymnoascus destructans in Northern China

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Scientists in Northern China have found bacteria living on bat skin and in cave soil that can kill the fungus responsible for white-nose syndrome, a disease devastating bat populations worldwide. These bacteria produce various antifungal compounds including volatile organic compounds that diffuse through the air and damage the fungus’s structure. By analyzing the genetic makeup of these bacteria, researchers identified specific genes responsible for producing these antifungal compounds, offering hope for developing biological control treatments that could protect bats and reduce fungal loads in cave environments.

Aspergillus terreus sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism

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This study investigated why some strains of the fungus Aspergillus terreus are resistant to amphotericin B, an important antifungal medicine. Researchers compared a resistant strain with a mutated version that became susceptible to the drug. They found that certain genes called P-type ATPases are more active in resistant strains and may help the fungus pump ions and alter its cell membrane to survive the drug. Additionally, mutations in genes responsible for producing secondary metabolites were linked to the visible changes seen when fungal cultures degenerate.

Whole-genome sequencing of Fusarium oxysporum K326-S isolated from tobacco

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Scientists have sequenced the complete genetic code of a fungus called Fusarium oxysporum that infects tobacco plant roots, causing them to wilt and turn brown. This fungus is a major problem for tobacco farmers because it lives in soil and is difficult to control. By mapping out all 17,272 genes in this fungus, researchers now have detailed information that will help them develop better ways to prevent and manage this disease.

Spread of Antifungal-Resistant Trichophyton indotineae, United Kingdom, 2017–2024

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A fungal infection called Trichophyton indotineae, which originated in Asia, is rapidly spreading throughout the United Kingdom and becoming resistant to common antifungal treatments. The infection typically starts in the groin area and can spread to other parts of the body, and many cases fail to respond to standard antifungal drugs like terbinafine. Researchers tracked 157 cases over seven years and found the fungus now accounts for over a third of all dermatophyte infections sent to the UK reference laboratory. Doctors and laboratory professionals are being urged to recognize this emerging threat and consider better diagnostic and treatment strategies.

Research Keyword: whole-genome sequencing