Research Keyword: voriconazole

Life-threatening airway stenosis due to Scedosporium infection during nontuberculous mycobacteria treatment: A case report

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A 73-year-old woman with arthritis treated with immunosuppressive drugs and a lung infection developed a life-threatening narrowing of her airway caused by a rare fungal infection called Scedosporium apiospermum. Doctors used a combination of emergency measures including a breathing support machine, insertion of a special tube to keep the airway open, and strong antifungal medication to treat the infection. After six months of treatment, the fungal infection was completely gone and the special airway tube was successfully removed, allowing normal healing.

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A Case of Pulmonary Infection Due to Magnusiomyces capitatus in a Non-Immunocompromised Patient with Cerebral Palsy

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A young man with cerebral palsy developed a rare lung infection caused by Magnusiomyces capitatus, a fungus that usually only affects people with weakened immune systems. Doctors diagnosed the infection by analyzing fluid from his lungs and identified the fungus using advanced laboratory techniques. The patient improved after being treated with an antifungal medication called voriconazole. This case highlights that this rare fungal infection can occur in otherwise healthy people, especially those with conditions affecting their ability to clear lung secretions.

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Candidemia due to Candida lambica in a neutropenic oncology patient: A rare case report

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A 56-year-old cancer patient developed a rare blood infection caused by an unusual yeast called Candida lambica while receiving chemotherapy. Despite taking antifungal medication for prevention, the patient developed a serious fever and low white blood cell count. Doctors identified the infection through genetic testing and treated it with a different antifungal drug called voriconazole, which successfully cleared the infection.

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First report of Stemphylium lycopersici keratitis, a complex corneal infection case

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A 66-year-old man developed a severe corneal infection from a stone chip injury that didn’t improve with standard antibiotics. Doctors discovered the infection was caused by a rare plant fungus called Stemphylium lycopersici, combined with a herpes virus. Using advanced genetic testing (mNGS) to identify the exact pathogens, they prescribed targeted antifungal and antiviral medications along with a corneal transplant, successfully healing the infection and preserving his vision.

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Efficacy and safety of isavuconazole for invasive fungal infections: A systematic review and meta-analysis of randomized controlled trials

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Isavuconazole is an antifungal medication used to treat serious fungal infections in people with weakened immune systems. This study reviewed and analyzed three clinical trials to compare how well isavuconazole works compared to other antifungal drugs. The results showed that isavuconazole is just as effective as other antifungals but has fewer side effects, particularly fewer problems with liver health and drug-related adverse events. This makes isavuconazole a good alternative choice for patients who cannot use other antifungal medications or who are at risk of liver damage.

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