A 59-year-old man with a weakened immune system developed a serious fungal infection of his spine caused by Aspergillus nidulans, a type of mold. The infection was diagnosed through imaging tests and laboratory cultures from a biopsy of the affected vertebrae. Treatment with an antifungal medication called voriconazole for six months successfully cleared the infection without requiring surgery, offering hope for managing this rare and previously often-fatal condition.