Research Keyword: VBNC phenotype

Immunometabolic reprogramming in macrophages infected with active and dormant Cryptococcus neoformans: differential modulation of respiration, glycolysis, and fatty acid utilization

mycolabadmin

Researchers discovered that when fungal yeast cells enter a dormant state inside immune cells, they trigger different metabolic changes compared to actively growing yeast. While active yeast pushes immune cells to work harder metabolically, dormant yeast causes minimal stress but increases fat uptake by immune cells. This difference may explain how some fungal infections can remain hidden in the body for long periods without causing symptoms.

Read More »

Immunometabolic reprogramming in macrophages infected with active and dormant Cryptococcus neoformans: differential modulation of respiration, glycolysis, and fatty acid utilization

mycolabadmin

This research examines how immune cells (macrophages) respond differently to active versus dormant forms of a dangerous fungus called Cryptococcus neoformans. The dormant form causes the immune cells to accumulate fatty acids differently than the active fungus, which may help the fungus establish long-term infections. Understanding these differences could lead to better treatments for cryptococcal infections, which are particularly dangerous for immunocompromised individuals.

Read More »
Scroll to Top