Untargeted metabolomics

Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies

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This study shows how adding olive mill waste to mushroom growing substrate can increase beneficial compounds in mushrooms while reducing harmful toxins. Researchers grew two types of edible mushrooms (lion’s mane and king oyster) on substrate containing different amounts of olive mill waste and used advanced chemical analysis to identify how the waste affected the mushrooms’ medicinal compounds. Adding olive mill waste increased healthy compounds like hericenones and erinacerins while decreasing toxic enniatin compounds, potentially creating safer and more nutritious mushrooms for consumers.

Metabolomics Profiling of White Button, Crimini, Portabella, Lion’s Mane, Maitake, Oyster, and Shiitake Mushrooms Using Untargeted Metabolomics and Targeted Amino Acid Analysis

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Researchers analyzed seven popular mushroom varieties to understand their chemical makeup. They found over 10,000 different compounds across all mushrooms, with each variety having its own unique set of chemicals. Lion’s mane and oyster mushrooms were particularly rich in L-ergothioneine, a special amino acid thought to have antioxidant and anti-aging properties. The common white button, crimini, and portabella mushrooms had similar nutrient profiles, while specialty mushrooms had distinct chemical signatures.

Untargeted metabolomics as a tool to assess the impact of dietary approaches on pig gut health: a review

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This review examines how different types of food and feed additives affect the chemical compounds in pig digestive systems. By analyzing thousands of tiny molecules in pig samples using advanced laboratory techniques, researchers can understand which dietary approaches help pigs maintain healthy guts and resist disease. The study shows that adjusting the levels of carbohydrates, proteins, and fats in pig feed can influence beneficial bacteria and protective compounds in their intestines.

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

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Researchers discovered a new compound in white button mushrooms called 2-amino-4-methylbenzothiazole that activates the aryl hydrocarbon receptor, which helps regulate gut health and immunity. Using a computational approach called molecular networking to compare mushroom compounds with known beneficial substances, scientists identified this previously unknown compound and confirmed its activity in laboratory cells. This discovery demonstrates how certain mushrooms may contribute to health through specific bioactive compounds and provides a faster method for finding similar compounds in other foods.

Comparative Metabolite Profiling Between Cordyceps sinensis and Other Cordyceps by Untargeted UHPLC-MS/MS

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This research compares the chemical compounds found in authentic Cordyceps sinensis with four similar but different Cordyceps species to identify which ones are real. Using advanced laboratory techniques, scientists detected thousands of chemical differences between the species. They found that genuine C. sinensis contains higher levels of specific beneficial compounds like nucleosides and certain fatty acids. These findings help consumers and merchants distinguish authentic Cordyceps from counterfeit products and lower-quality substitutes.

Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies

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Researchers studied how adding olive mill waste to mushroom growing substrate affects the beneficial compounds in two edible mushrooms. They used advanced computer analysis of chemical data to find that this waste product increases healthy compounds like hericenones while reducing potentially harmful mycotoxins. This discovery could help make mushroom farming more sustainable and produce safer, healthier mushrooms for consumers.

Exo-metabolome profiling of soybean endophytes: a road map of antagonism against Fusarium oxysporum

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Scientists discovered that certain beneficial bacteria living inside soybean roots can protect the plant from a harmful fungus that causes root rot and reduces crop yield. By analyzing the chemical compounds these bacteria produce, researchers identified specific antifungal substances that kill or inhibit the pathogenic fungus. These findings suggest that instead of using harmful chemical fungicides, farmers could use these beneficial bacteria as a natural, environmentally-friendly way to protect soybean crops and improve agricultural sustainability.

Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides

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Researchers discovered five potent anti-cancer compounds from Arctic fungi called Acremonium strains. Using advanced chemical analysis techniques, they identified and tested these cyclic depsipeptides against various cancer cell types. The most active compound showed promising results against breast cancer and melanoma cells with extremely low concentrations needed for effect. These findings suggest Arctic microorganisms could be valuable sources for developing new cancer treatments.

Exploring Psilocybe spp. mycelium and fruiting body chemistry for potential therapeutic compounds

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Scientists studied magic mushrooms at different growth stages to understand their chemical makeup. They found that mature mushroom caps contain high levels of psilocybin (the psychedelic compound) but the root-like mycelium contains different beneficial compounds like ergothioneine and choline. This suggests mycelium could be developed as a therapeutic product without the psychedelic effects, potentially offering health benefits while avoiding the mind-altering properties.

Mass Spectrometry-Based Untargeted Metabolomics and α-Glucosidase Inhibitory Activity of Lingzhi (Ganoderma lingzhi) During the Developmental Stages

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Scientists studied how the medicinal mushroom Lingzhi changes chemically as it grows from mycelium through various stages to mature fruiting bodies. They found that the mushroom contains many beneficial compounds, including special molecules called triterpenoids, that help block α-glucosidase, an enzyme involved in blood sugar control. Interestingly, the immature mushroom stage showed the strongest anti-diabetic activity, suggesting farmers should harvest at specific times depending on desired health benefits rather than always waiting for full maturity.

Research Keyword: Untargeted metabolomics