tyrosinase inhibitor

Molecular Docking, Synthesis, and Tyrosinase Inhibition Activity of Acetophenone Amide: Potential Inhibitor of Melanogenesis

mycolabadmin

Researchers developed new chemical compounds that can inhibit tyrosinase, an enzyme responsible for producing melanin (the pigment that colors skin). One compound, called 5c, proved exceptionally effective at blocking this enzyme—significantly more potent than existing skin-lightening agents. These acetophenone-based compounds could lead to improved cosmetic treatments for unwanted pigmentation like age spots and melasma, with better safety profiles than current options.

Development of dihydrooxyresveratrol-loaded nanostructured lipid carriers for safe and effective treatment of hyperpigmentation

mycolabadmin

This research developed a new skin-brightening treatment using nanoparticles to deliver oxyresveratrol and its modified form (DHO) more effectively to the skin. The scientists improved the stability of these compounds by creating tiny lipid-based carriers that protect them from light damage and help them penetrate the skin barrier. Testing showed these formulations safely reduced melanin production without harming healthy skin cells, offering promise for cosmetic products to treat dark spots and hyperpigmentation.

Novel tyrosinase-inhibitory peptides derived from Locusta migratoria protein hydrolysates: Preparation, identification and molecular docking analysis

mycolabadmin

Scientists have discovered that peptides from locusts can effectively inhibit tyrosinase, an enzyme responsible for skin pigmentation. These peptide extracts showed strong ability to prevent melanin production, comparable to existing skin-whitening agents but with much lower toxicity to normal cells. The research identified over 1100 different peptide sequences that could be useful in cosmetic and pharmaceutical products for treating age spots, freckles, and other pigmentation issues.

Synthesis and biological assessment of novel 4H-chromene-3-carbonitrile derivatives as tyrosinase inhibitors

mycolabadmin

Researchers developed new chemical compounds that can block tyrosinase, an enzyme responsible for producing excessive skin pigment that causes dark spots and discoloration. The most effective compound (6f) works better than kojic acid, a commonly used skin-lightening ingredient, and could lead to safer treatments for hyperpigmentation and related skin conditions. Computer simulations showed that one form of the compound fits better into the enzyme’s active site, making it more effective at preventing melanin production.

Antioxidant Potential-Rich Betel Leaves (Piper betle L.) Exert Depigmenting Action by Triggering Autophagy and Downregulating MITF/Tyrosinase In Vitro and In Vivo

mycolabadmin

This research shows that betel leaves, a traditional herb used in Asian cultures, can lighten skin pigmentation through multiple mechanisms. The extract works by reducing tyrosinase enzyme activity, activating cellular cleanup processes called autophagy, and boosting the body’s natural antioxidant defenses. In both laboratory cells and living mice exposed to UV radiation, betel leaves extract effectively reduced unwanted skin darkening, suggesting it could be developed into safe natural skin-whitening products.

Kojic Acid Showed Consistent Inhibitory Activity on Tyrosinase from Mushroom and in Cultured B16F10 Cells Compared with Arbutins

mycolabadmin

This study compared four skin-whitening compounds to find the best one for use as a testing standard in laboratories. Kojic acid was found to be the most reliable choice because it effectively blocks the enzyme tyrosinase, which produces skin pigment, without damaging cells. The researchers tested these compounds both in test tubes and in actual melanoma cells to understand how they work differently.

Acetophenone-Based 3,4-Dihydropyrimidine-2(1H)-Thione as Potential Inhibitor of Tyrosinase and Ribonucleotide Reductase: Facile Synthesis, Crystal Structure, In-Vitro and In-Silico Investigations

mycolabadmin

Scientists created a new chemical compound that shows promise in fighting skin cancer, particularly melanoma. The compound is seven times more effective at blocking tyrosinase, an enzyme involved in skin pigmentation and cancer growth, compared to existing drugs. Computer simulations and laboratory tests confirmed that this compound can also interfere with DNA replication processes that cancer cells depend on, suggesting it could be developed into a new cancer treatment with fewer side effects.

Research Keyword: tyrosinase inhibitor

Molecular Docking, Synthesis, and Tyrosinase Inhibition Activity of Acetophenone Amide: Potential Inhibitor of Melanogenesis

Development of dihydrooxyresveratrol-loaded nanostructured lipid carriers for safe and effective treatment of hyperpigmentation

Novel tyrosinase-inhibitory peptides derived from Locusta migratoria protein hydrolysates: Preparation, identification and molecular docking analysis

Synthesis and biological assessment of novel 4H-chromene-3-carbonitrile derivatives as tyrosinase inhibitors

Antioxidant Potential-Rich Betel Leaves (Piper betle L.) Exert Depigmenting Action by Triggering Autophagy and Downregulating MITF/Tyrosinase In Vitro and In Vivo

Kojic Acid Showed Consistent Inhibitory Activity on Tyrosinase from Mushroom and in Cultured B16F10 Cells Compared with Arbutins

Acetophenone-Based 3,4-Dihydropyrimidine-2(1H)-Thione as Potential Inhibitor of Tyrosinase and Ribonucleotide Reductase: Facile Synthesis, Crystal Structure, In-Vitro and In-Silico Investigations