tyrosinase inhibition

Synergistic impact of arbutin and kaempferol-7-O-α-l-rhamnopyranoside from Nephelium lappaceum L. on whitening efficacy and stability of cosmetic formulations

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This research demonstrates that a natural compound from rambutan seeds works synergistically with arbutin to create more effective skin whitening products. The combination is 35 times more potent than arbutin alone at preventing melanin production in skin cells. The resulting cosmetic formulation maintains its effectiveness and stability for approximately 5.2 months, offering a safer natural alternative to conventional skin lightening agents that can cause irritation.

Synthesis of silver nanoparticles using Eucommia ulmoides extract and their potential biological function in cosmetics

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Scientists created tiny silver particles using a Chinese medicinal plant extract and found they could help skin look lighter and younger. These particles work by reducing dark pigments and protecting skin from oxidative damage. The nanoparticles were safe at low doses and didn’t harm skin cells, making them promising for use in cosmetic products.

Nomilin from Yuzu Seed Has In Vitro Antioxidant Activity and Downregulates Melanogenesis in B16F10 Melanoma Cells through the PKA/CREB Signaling Pathway

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Scientists extracted a compound called nomilin from yuzu seeds and tested whether it could lighten skin by reducing melanin production. They found that nomilin works by blocking an enzyme called tyrosinase that makes melanin, and it reduces the activity of cell signaling pathways involved in skin darkening. The study shows nomilin could be used as a natural skin-whitening ingredient in cosmetics without the side effects of synthetic alternatives.

Multidirectional Characterization of Phytochemical Profile and Health-Promoting Effects of Ziziphora bungeana Juz. Extracts

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Ziziphora bungeana, a traditional medicinal plant from Kazakhstan, was studied for its health benefits. Scientists found it contains powerful plant compounds that fight bacteria and fungal infections, especially those causing skin problems. The extracts work similarly to commercial skin-lightening agents and show promise for treating infections and skin conditions without significant harm to healthy cells.

Mechanistic Insights into Tyrosinase-Catalyzed Metabolism of Hydroquinone: Implications for the Etiology of Exogenous Ochronosis and Cytotoxicity to Melanocytes

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Hydroquinone is a common ingredient in skin-lightening products that works through enzyme-mediated chemical reactions. This research revealed how an enzyme called tyrosinase processes hydroquinone through different chemical pathways, ultimately producing melanin-like compounds. The study found that long-term hydroquinone use may cause a darkening side effect called exogenous ochronosis through continued enzyme activity, and identified a new chemical marker to track this process.

Assessment of Cucurbita spp. Peel Extracts as Potential Sources of Active Substances for Skin Care and Dermatology

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This study examined pumpkin peels as a sustainable source of natural compounds for skincare products. Researchers extracted active ingredients using water and plant-based solvents, then tested their antioxidant properties, ability to protect skin from sun damage, and safety for use on skin. The findings show that pumpkin peel extracts, particularly those made with water, could be safe and effective ingredients in cosmetic products.

Anti-Melanogenic Activity of Calocedrus formosana Wood Essential Oil and Its Chemical Composition Analysis

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Researchers tested an essential oil from Taiwan’s precious Calocedrus formosana wood to see if it could lighten skin by blocking melanin production. The oil worked very well at stopping melanin synthesis in laboratory cells, with a compound called thymol being responsible for most of the lightening effect. This natural product could potentially be used in skin whitening cosmetics and offers a safer alternative to synthetic ingredients.

The Major Stilbene Compound Accumulated in the Roots of a Resistant Variety of Phoenix dactylifera L. Activates Proteasome for a Path in Anti-Aging Strategy

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Researchers found that date palm roots from disease-resistant varieties contain a special compound called 3,3′,4,5,5′-pentahydroxy-trans-stilbene that acts as a natural antioxidant and anti-aging agent. This compound can protect aging skin cells by activating the proteasome, which is like the cell’s recycling system that removes damaged proteins. The findings suggest this natural compound could potentially help slow down skin aging and protect against age-related diseases.

Tyrosinase Inhibitors Derived from Chemical Constituents of Dianella ensifolia

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Researchers isolated four new plant compounds and 67 known compounds from Dianella ensifolia, a traditional Asian medicinal plant. Two of these compounds (11 and 14) were found to inhibit tyrosinase, the enzyme responsible for melanin production, making them approximately 13 times more effective than arbutin, a common cosmetic whitening ingredient. These findings suggest that D. ensifolia could be developed as a natural source of skin-whitening agents for treating age spots, freckles, and other pigmentation disorders.

Research Keyword: tyrosinase inhibition