Research Keyword: tryptophan starvation

Cinchona-based liquid formulation exhibits antifungal activity through Tryptophan starvation and disruption of mitochondrial respiration in Rhizoctonia Solani

Researchers found that an extract from Cinchona bark, containing the compound quinine, effectively kills rice-damaging fungus Rhizoctonia solani through two mechanisms: starving the fungus of the amino acid tryptophan and disrupting its energy-producing mitochondria. This natural plant-based treatment could serve as an eco-friendly alternative to synthetic fungicides, reducing crop losses from fungal diseases while avoiding the environmental damage and resistance problems associated with chemical pesticides.

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