Research Keyword: tryptophan metabolism

Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder

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This review examines how edible mushrooms, particularly Lion’s mane, Reishi, and Caterpillar mushroom, might help treat depression as part of a dietary approach. These mushrooms contain compounds that may influence brain chemistry, especially serotonin levels, which are important for mood regulation. While early studies show promising results, especially for Lion’s mane, more research is needed to confirm these benefits in larger groups of patients.

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Cinchona-based liquid formulation exhibits antifungal activity through Tryptophan starvation and disruption of mitochondrial respiration in Rhizoctonia Solani

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Scientists discovered that a liquid extract from Cinchona bark, which contains quinine, can effectively kill a fungus that damages rice crops. The treatment works by blocking the fungus’s ability to absorb tryptophan (an important amino acid) and damaging its energy-producing mitochondria. When tryptophan was added back to the treatment, the fungus recovered, confirming this is the main way the extract works. This natural, plant-based approach could provide an eco-friendly alternative to chemical fungicides while reducing the risk of the fungus developing resistance.

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Genetic regulation of l-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis

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Researchers studied how magic mushrooms (Psilocybe mexicana) control their chemical processes to make psilocybin. They found that when mushrooms start producing psilocybin, they turn on genes that make more of an amino acid called tryptophan, while turning off genes that would break it down. They also discovered and studied an enzyme that helps control tryptophan use. This understanding could help grow these mushrooms with more consistent psilocybin levels for legitimate medical research into treating depression.

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