Research Keyword: triazole antifungals

Histoplasma capsulatum prosthetic valve endocarditis treated with oral isavuconazole

A 76-year-old man developed a rare fungal infection of his artificial heart valve caused by Histoplasma capsulatum. After surgically replacing the infected valve, he was treated with isavuconazole, an antifungal medication taken by mouth. Unlike traditional antifungal treatments, isavuconazole was better tolerated and easier to take. The patient successfully recovered after nine months of treatment with no complications.

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Isavuconazonium Utilization in Pediatric Patients at a Free-Standing Children’s Hospital

Researchers at Children’s Hospital Los Angeles studied how well a newer antifungal medication called isavuconazonium works in children with cancer and blood disorders who are at high risk for serious fungal infections. The medication was recently approved for use in children ages 1 and older. The study found that the medication was generally safe and effective, though doctors need to monitor liver function and drug levels to ensure proper dosing and catch any side effects early.

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