transcriptomics – Page 9

Volatile Metabolome and Transcriptomic Analysis of Kosakonia cowanii Ch1 During Competitive Interaction with Sclerotium rolfsii Reveals New Biocontrol Insights

mycolabadmin

Researchers found that a bacterium called K. cowanii produces special gases (volatile organic compounds) that kill fungal plant diseases like those caused by Sclerotium rolfsii. When grown together with this fungus, the bacterium produces these toxic gases which inhibit fungal growth by up to 80%. The study identified specific genes the bacteria activate to produce these antifungal compounds, offering a natural alternative to chemical fungicides for protecting crops.

Transcriptome and Metabolome Integration Reveals the Impact of Fungal Elicitors on Triterpene Accumulation in Sanghuangporus sanghuang

mycolabadmin

Researchers studied how special fungal compounds called elicitors can boost the production of healing substances in a medicinal mushroom called Sanghuangporus sanghuang. By analyzing genes and metabolites, they found that adding elicitors increased beneficial compounds like betulinic acid and 2-hydroxyoleanolic acid by up to 114-fold. These findings suggest a practical way to produce more medicinal compounds from this mushroom for health applications.

UV-Induced Mutants of Metarhizium anisopliae: Improved Biological Parameters, Resistance to Stressful Factors, and Comparative Transcriptomic Analysis

mycolabadmin

Scientists used UV light to create improved mutant strains of a fungus that naturally kills insect pests. The best mutant strain showed increased ability to survive harsh environmental conditions like heat and oxidative stress, while becoming more effective at infecting target pest insects. This improvement makes the fungus more practical for use as a natural pesticide in fields exposed to sunlight. Gene analysis revealed the mutant fungi enhanced certain protective proteins while reducing reliance on traditional antioxidant systems.

Kinome analysis of Madurella mycetomatis identified kinases in the cell wall integrity pathway as novel potential therapeutic drug targets in eumycetoma caused by Madurella mycetomatis

mycolabadmin

Eumycetoma is a serious fungal infection that causes large skin lesions and is very difficult to treat, even with long-term medication and surgery. Researchers used computer analysis to identify proteins called kinases that are essential for the fungus to survive. They found that targeting kinases involved in building the fungal cell wall could potentially lead to new treatments. By testing existing drugs, they discovered eight compounds that could inhibit fungal growth, offering hope for better treatment options.

Comparative Study and Transcriptomic Analysis on the Antifungal Mechanism of Ag Nanoparticles and Nanowires Against Trichosporon asahii

mycolabadmin

Researchers compared two types of tiny silver particles (nanoparticles and nanowires) as potential treatments for a dangerous fungal infection caused by Trichosporon asahii. Silver nanowires were found to be more effective than nanoparticles at killing the fungus by damaging its cell membranes and disrupting its energy production. The study identified 15 key genes involved in how silver nanowires attack the fungus, suggesting these nanomaterials could become useful alternatives to traditional antifungal drugs.

Putative Transcriptional Regulation of HaWRKY33-AOA251SVV7 Complex-Mediated Sunflower Head Rot by Transcriptomics and Proteomics

mycolabadmin

Sunflower head rot caused by a fungus is a major problem for farmers worldwide. Scientists studied how sunflower plants defend themselves against this fungus by examining a special protein called HaWRKY33. They found that this protein works with another protein (AOA251SVV7) to help sunflowers resist the disease. By identifying the specific parts of these proteins that are important for fighting off the fungus, researchers have provided tools for developing sunflower varieties that are naturally resistant to this damaging disease.

Quorum-driven microbial consortium for Bioplastic production from agro-waste

mycolabadmin

Scientists created a partnership between a fungus and bacteria to make eco-friendly plastic (PHA) from brewery and cooking waste. The fungus breaks down the tough plant material while the bacteria converts the released compounds into bioplastic. By adding a natural chemical signal (farnesol), they improved the process and scaled it up successfully in a larger reactor without needing expensive pretreatment steps.

Integrated transcriptome and metabolome profiling reveals mechanisms underlying the infection of Cytospora mali in “Jin Hong” branches

mycolabadmin

This research examined how apple trees defend themselves against a serious fungal disease called Valsa canker caused by Cytospora mali. Scientists used advanced genetic and chemical analysis techniques to identify which genes and protective compounds are activated when apple branches are infected. They found that healthy apple trees fight the infection by strengthening their cell walls, producing special protective enzymes, and accumulating defense chemicals like α-linolenic acid and betaine. These discoveries could help develop better ways to prevent or manage this destructive disease in apple orchards.

Transcriptomic Insights into the Degradation Mechanisms of Fomitopsis pinicola and Its Host Preference for Coniferous over Broadleaf Deadwood

mycolabadmin

This research examined how a common forest fungus called Fomitopsis pinicola breaks down different types of wood. Scientists found that this fungus much prefers coniferous trees like pine and is much better at degrading them than broadleaf trees like birch. By analyzing which genes the fungus turns on when degrading different woods, they discovered the fungus activates more genes related to breaking down the tough lignin component when working on pine wood, explaining why it naturally chooses conifers in forests.

Fungal-fungal cocultivation alters secondary metabolites of marine fungi mediated by reactive oxygen species (ROS)

mycolabadmin

Researchers discovered that when two types of ocean fungi grow together, one of them produces a protective chemical called alternariol that can kill bacteria and cancer cells. This happens because the fungi recognize each other as competitors and trigger special stress signals that activate defensive chemical production. Interestingly, fungi from the ocean respond differently than those from land, suggesting they have evolved unique survival strategies for harsh marine environments.

Research Keyword: transcriptomics