transcriptomics – Page 5

The very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase Phs1 regulates ATP levels and virulence in Cryptococcus neoformans

mycolabadmin

Researchers found that a protein called Phs1, which helps Cryptococcus neoformans (a dangerous fungus) produce essential fatty acids, is important for the fungus to cause disease. When this protein was removed, the fungus produced less melanin (a pigment), couldn’t grow well at body temperature, and had a weaker cell wall. Most importantly, the fungus produced less energy (ATP) and was much less deadly in infected mice, suggesting that blocking Phs1 could potentially be a new way to treat cryptococcal infections.

Effects of a biotechnologically produced Pleurotus sapidus mycelium on gut microbiome, liver transcriptome and plasma metabolome of broilers

mycolabadmin

Researchers tested whether mushroom mycelium (the root structure of mushrooms) grown in large bioreactors could be used as a supplement in chicken feed as a sustainable alternative to traditional ingredients. Over 5 weeks, broilers received feed with 0%, 2.5%, or 5% mushroom mycelium, with no negative effects on growth, digestion, or overall health observed. The study suggests that this biotechnologically produced mushroom biomass is a safe and potentially sustainable feed ingredient for poultry production.

Aspergillus terreus sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism

mycolabadmin

This study investigated why some strains of the fungus Aspergillus terreus are resistant to amphotericin B, an important antifungal medicine. Researchers compared a resistant strain with a mutated version that became susceptible to the drug. They found that certain genes called P-type ATPases are more active in resistant strains and may help the fungus pump ions and alter its cell membrane to survive the drug. Additionally, mutations in genes responsible for producing secondary metabolites were linked to the visible changes seen when fungal cultures degenerate.

Targeted metabolomic and transcriptomic reveal the regulatory network of ultrasound on polyphenol biosynthesis in tender coconut flesh during storage

mycolabadmin

Researchers studied how ultrasound treatment affects the polyphenolic compounds (natural antioxidants) in coconut flesh during storage. By analyzing both the chemicals and genes involved, they found that ultrasound helps preserve important polyphenols like catechin and epicatechin by controlling the expression of genes that break them down. This discovery could help extend the shelf life of tender coconut products and maintain their nutritional value.

A high-quality genome assembly of angel-wing mushroom Pleurocybella porrigens that causes acute encephalopathy

mycolabadmin

Scientists created a detailed genetic blueprint of the angel-wing mushroom, which caused serious poisonings in Japan. They identified three toxic compounds in the mushroom and found a gene that likely produces one of the most dangerous toxins responsible for brain damage. This research helps explain how the mushroom makes its poison and could lead to better understanding of foodborne illness prevention.

Transcriptomic changes in the PacC transcription factor deletion mutant of the plant pathogenic fungus Botrytis cinerea under acidic and neutral conditions

mycolabadmin

Gray mold is a common fungal disease affecting many plants, and it survives by adjusting to different pH levels in plant tissues. Scientists studied a specific protein called PacC that acts like a switch controlling which genes turn on or off based on acidity levels. By comparing normal fungi to mutants without this protein, researchers identified hundreds of genes that help the fungus adapt and cause disease, offering insights into how to potentially combat this agricultural problem.

Integrated Transcriptomics and Metabolomics Provide Insight into Degeneration-Related Molecular Mechanisms of Morchella importuna During Repeated Subculturing

mycolabadmin

Morel mushrooms lose quality when repeatedly cultured in laboratories, becoming slower-growing and less vibrant. Scientists discovered this happens because genes controlling antioxidant production shut down, allowing harmful free radicals to damage cells. By avoiding frequent subculturing and using cold storage or antioxidant supplements, farmers can keep their morel strains healthy and productive for longer.

Transcriptome Analysis of Dimethyl Fumarate Inhibiting the Growth of Aspergillus carbonarius

mycolabadmin

Researchers found that dimethyl fumarate, a chemical preservative, can effectively stop the growth of a common fruit fungus called Aspergillus carbonarius that causes rot and produces a harmful toxin in grapes. By studying how the fungus responds to this treatment at the genetic level, scientists discovered that the chemical damages the fungus’s protective outer layer and interferes with its ability to develop and reproduce. This research could lead to better ways to preserve fruit and prevent toxin contamination in the food industry.

In vitro and in vivo inhibitory effects and transcriptional reactions of graphene oxide on Verticillium dahliae

mycolabadmin

Scientists discovered that graphene oxide, a nanomaterial, can effectively kill or inhibit the growth of Verticillium dahliae, a harmful fungus that causes wilt disease in cotton and other crops. The graphene oxide works by damaging the fungus’s cell membranes and disrupting its ability to grow and spread. When applied to cotton plants infected with this fungus, graphene oxide treatment reduced disease symptoms and prevented the fungus from multiplying. This research suggests graphene oxide could become a valuable alternative to chemical fungicides for controlling this destructive plant disease.

Genetic variation among progeny shapes symbiosis in a basidiomycete with poplar

mycolabadmin

This research examines how different genetic variations within a single fungal species affect its ability to form beneficial partnerships with poplar tree roots. Scientists studied 40 genetically distinct fungal strains derived from the same parent and found that they varied greatly in their success at colonizing tree roots, ranging from complete failure to excellent colonization. By analyzing the genes and gene expression of these strains, the team identified specific genetic regions that influence symbiosis formation and discovered that genetic diversity within this fungal species plays an important role in how effectively forest ecosystems function.

Research Keyword: transcriptomics