Research Keyword: transcriptomics

Comparative Multi-Omics Analysis and Antitumor Activity of Phylloporia crataegi and Phylloporia fontanesiae

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Two species of medicinal fungi were studied to understand why one was better at fighting cancer cells. Researchers analyzed the chemicals, genes, and proteins in both fungi and found that Phylloporia crataegi had much higher levels of cancer-fighting compounds and activated special cellular defense pathways that harm cancer cells. This research shows that medicinal fungi could be promising sources for developing new cancer treatments.

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New insights into the stress response mechanisms of stress-resistant Listeria monocytogenes via multi-omics and cell morphological changes

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Researchers studied how a dangerous food-poisoning bacterium called Listeria monocytogenes survives in harsh conditions like cold temperatures, acidic environments, and salty food products. Using advanced molecular analysis techniques, they identified specific genes and proteins that help the bacteria survive these stressful conditions. They also observed that the bacteria changed shape when exposed to stress, becoming elongated and bumpy. This research helps food safety experts better understand and combat this persistent food contaminant.

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Comparative Multi-Omics Analysis and Antitumor Activity of Phylloporia crataegi and Phylloporia fontanesiae

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Researchers compared two types of medicinal fungi (Phylloporia crataegi and P. fontanesiae) to understand why one is more effective at fighting cancer. Using advanced molecular analysis techniques, they found that P. crataegi contains higher levels of cancer-fighting compounds and activates more genes related to cancer cell death. These findings suggest that these fungi could be promising sources for developing new cancer treatments.

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The antifungal mechanism of EntV-derived peptides is associated with a reduction in extracellular vesicle release

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Researchers discovered that a small peptide derived from a bacterium called EntV can fight Candida fungal infections by targeting specialized vesicles (tiny sacs) that fungi use to spread infections. Unlike traditional antifungal drugs that kill fungi, EntV works by blocking the release of these vesicles, reducing the fungus’s ability to infect and form protective biofilms. This new approach could lead to treatments that work against drug-resistant fungi without the toxicity issues of current antifungals.

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Transcriptomic profiling revealed important roles of amino acid metabolism in fruiting body formation at different ripening times in Hypsizygus marmoreus

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Researchers studied why the marbled puffball mushroom takes such a long time to produce fruit bodies by analyzing gene expression at different growth stages. They found that genes involved in amino acid processing and lignin breakdown are particularly important during fruiting body formation. By understanding these molecular processes, scientists can potentially develop ways to shorten cultivation time and improve mushroom farming efficiency.

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Differential hypo-osmotic stress responses and regulatory mechanisms of Aspergillus sydowii in amphipod guts and hadal sediments

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Scientists isolated a fungus from the gut of deep-sea amphipods in the Mariana Trench and discovered how it uniquely adapts to low-salt conditions. Unlike other fungal strains from different habitats, this gut fungus showed special abilities to survive and even thrive when salt levels dropped dramatically. The researchers found that the fungus rapidly rewired its genes and cellular structures to maintain water balance and protect itself, revealing how life in extreme deep-sea environments drives evolution of novel survival strategies.

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